John D. McCorvy, PhD

Associate Professor

Locations

Cell Biology, Neurobiology & Anatomy

Contact Information

Education

Postdoctoral, Pharmacology, University of NC-Chapel Hill, 2018
PhD, Medicinal Chemistry and Molecular Pharmacology, Purdue University, 2012
BA, Biochemistry and Psychology, Texas Tech University, 2005

Research Interests

Molecular and Structural Pharmacology of G protein-coupled Receptors (GPCRs)
Structure-based Design and Discovery of GPCR Drugs
Study of Biased Agonism and Pathway-Selective Compounds for GPCRs
Psychedelic Drug Action at the Serotonin GPCRs
Molecular Determinants of Opioid Receptor Signaling and Efficacy
Medicinal Chemistry and Structure-Activity Relationships for Psychoactive Drugs
Antipsychotic Polypharmacology
High-throughput Screening (HTS) Technologies and Assay Development
Protein Conformation Dynamics and Structure Determination

N-(4-Bromo-2,5-Dimethoxyphenethyl)-6-(4-Phenylbutoxy)Hexan-1-Amine (XOB): A Novel Phenylalkylamine Antagonist of Serotonin 2A Receptors and Voltage-Gated Sodium Channels.

(Denomme N, Hernandez CC, Bock HA, Ohana RF, Bakshi S, Sherwood AM, McCorvy JD, Daley PF, Callaway WB, Hull JM, Alt A, Isom LL, Cozzi NV.) Mol Pharmacol. 2024 Jul 17;106(2):92-106 PMID: 38821630 PMCID: PMC11254453 SCOPUS ID: 2-s2.0-85199223647 06/01/2024
Bioisosteric analogs of MDMA: Improving the pharmacological profile?

(Alberto-Silva AS, Hemmer S, Bock HA, da Silva LA, Scott KR, Kastner N, Bhatt M, Niello M, Jäntsch K, Kudlacek O, Bossi E, Stockner T, Meyer MR, McCorvy JD, Brandt SD, Kavanagh P, Sitte HH.) J Neurochem. 2024 Jun 19 PMID: 38898705 06/20/2024
Structural basis for selectivity and antagonism in extracellular GPCR-nanobodies.

(Schlimgen RR, Peterson FC, Heukers R, Smit MJ, McCorvy JD, Volkman BF.) Nat Commun. 2024 May 30;15(1):4611 PMID: 38816420 PMCID: PMC11139983 SCOPUS ID: 2-s2.0-85194992751 05/31/2024
Bioisosteric analogs of MDMA with improved pharmacological profile.

(Alberto-Silva AS, Hemmer S, Bock HA, Alves da Silva L, Scott KR, Kastner N, Bhatt M, Niello M, Jäntsch K, Kudlacek O, Bossi E, Stockner T, Meyer MR, McCorvy JD, Brandt SD, Kavanagh P, Sitte HH.) bioRxiv. 2024 Apr 11 PMID: 38645142 PMCID: PMC11030374 04/22/2024
Psilocybin analog 4-OH-DiPT enhances fear extinction and GABAergic inhibition of principal neurons in the basolateral amygdala.

(Kelly TJ, Bonniwell EM, Mu L, Liu X, Hu Y, Friedman V, Yu H, Su W, McCorvy JD, Liu QS.) Neuropsychopharmacology. 2024 Apr;49(5):854-863 PMID: 37752222 PMCID: PMC10948882 SCOPUS ID: 2-s2.0-85172244117 09/27/2023
Functional profiling of the G protein-coupled receptor C3aR1 reveals ligand-mediated biased agonism.

(Rodriguez P, Laskowski LJ, Pallais JP, Bock HA, Cavalco NG, Anderson EI, Calkins MM, Razzoli M, Sham YY, McCorvy JD, Bartolomucci A.) J Biol Chem. 2024 Jan;300(1):105549 PMID: 38072064 PMCID: PMC10796979 SCOPUS ID: 2-s2.0-85181819143 12/11/2023
Identification of 5-HT2A receptor signaling pathways associated with psychedelic potential.

(Wallach J, Cao AB, Calkins MM, Heim AJ, Lanham JK, Bonniwell EM, Hennessey JJ, Bock HA, Anderson EI, Sherwood AM, Morris H, de Klein R, Klein AK, Cuccurazzu B, Gamrat J, Fannana T, Zauhar R, Halberstadt AL, McCorvy JD.) Nat Commun. 2023 Dec 15;14(1):8221 PMID: 38102107 PMCID: PMC10724237 SCOPUS ID: 2-s2.0-85179903706 12/16/2023
Beyond the 5-HT2A Receptor: Classic and Nonclassic Targets in Psychedelic Drug Action.

(Cameron LP, Benetatos J, Lewis V, Bonniwell EM, Jaster AM, Moliner R, Castrén E, McCorvy JD, Palner M, Aguilar-Valles A.) J Neurosci. 2023 Nov 08;43(45):7472-7482 PMID: 37940583 PMCID: PMC10634557 SCOPUS ID: 2-s2.0-85176431720 11/09/2023
Structure activity relationships of 5-HT2B and 5-HT2C serotonin receptor antagonists: N6, C2 and 5'-Modified (N)-methanocarba-adenosine derivatives.

(Tosh DK, Calkins MM, Ivancich MS, Bock HA, Campbell RG, Lewicki SA, Chen E, Gao ZG, McCorvy JD, Jacobson KA.) Eur J Med Chem. 2023 Nov 05;259:115691 PMID: 37562117 PMCID: PMC10529765 SCOPUS ID: 2-s2.0-85166945754 08/11/2023
Molecular insights into GPCR mechanisms for drugs of abuse.

(Sanchez-Reyes OB, Zilberg G, McCorvy JD, Wacker D.) J Biol Chem. 2023 Sep;299(9):105176 PMID: 37599003 PMCID: PMC10514560 SCOPUS ID: 2-s2.0-85171147748 08/21/2023
Angiotensin AT1A receptor signal switching in Agouti-related peptide neurons mediates metabolic rate adaptation during obesity.

(Balapattabi K, Yavuz Y, Jiang J, Deng G, Mathieu NM, Ritter ML, Opichka MA, Reho JJ, McCorvy JD, Nakagawa P, Morselli LL, Mouradian GC Jr, Atasoy D, Cui H, Hodges MR, Sigmund CD, Grobe JL.) Cell Rep. 2023 Aug 29;42(8):112935 PMID: 37540598 PMCID: PMC10530419 SCOPUS ID: 2-s2.0-85169503465 08/04/2023
Structure activity relationships of 5-HT2B and 5-HT2C serotonin receptor antagonists: N6, C2 and 5′-Modified (N)-methanocarba-adenosine derivatives

(Tosh DK, Calkins MM, Ivancich MS, Bock HA, Campbell RG, Lewicki SA, Chen E, Gao ZG, McCorvy JD, Jacobson KA.) European Journal of Medicinal Chemistry. 5 November 2023;259 SCOPUS ID: 2-s2.0-85166945754 11/05/2023