Evgenii Chulkov, PhD
- Jonathan S. Marchant, MA, PhD
- Cell Biology, Neurobiology and Anatomy
MS, Applied Math and Physics, St. Petersburg State Polytechnic University, St.-Petersburg, Russia, 2012
BS, Technical Physics, St. Petersburg State Polytechnic University, St.-Petersburg, Russia, 2010
Ion channels regulation, membrane active drugs, anthelminthic drug development
Ion channels are important drug targets because of their crucial role in controlling a variety of physiological processes. Clarification of the basic molecular mechanisms underlying physiological process associated with ion channel activity in cells will aid drug development.
The Marchant Lab recently identified a target of the anthelmintic drug praziquantel used for treatment of schistosomiasis, a major parasitic disease caused by Schistosoma sp., The target protein is an ion channel of the TRP family expressed in Schistosoma sp. Currently, I am working on the molecular mechanism of channel–drug interaction via electrophysiology and imaging. In the future, I intent to create a comprehensive model of the channel to aid antiparasitic drug development.