John D. McCorvy, PhD
Associate Professor
Locations
- Cell Biology, Neurobiology and Anatomy
Contact Information
Education
PhD, Medicinal Chemistry and Molecular Pharmacology, Purdue University, 2012
BA, Biochemistry and Psychology, Texas Tech University, 2005
Research Interests
- Molecular and Structural Pharmacology of G protein-coupled Receptors (GPCRs)
- Structure-based Design and Discovery of GPCR Drugs
- Study of Biased Agonism and Pathway-Selective Compounds for GPCRs
- Psychedelic Drug Action at the Serotonin GPCRs
- Molecular Determinants of Opioid Receptor Signaling and Efficacy
- Medicinal Chemistry and Structure-Activity Relationships for Psychoactive Drugs
- Antipsychotic Polypharmacology
- High-throughput Screening (HTS) Technologies and Assay Development
- Protein Conformation Dynamics and Structure Determination
Publications
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(Canale V, Blicharz-Futera K, Bijata M, Cavalco NG, Partyka A, Stefaniak M, Kamiński M, Satała G, Warszycki D, Lanham JK, Gołębiowska J, Gawlik M, Smolik M, Bijata K, Jastrzębska-Więsek M, Kurczab R, Bojarski AJ, Walczak M, McCorvy JD, Włodarczyk J, Popik P, Zajdel P.) Eur J Med Chem. 2026 Jan 15;302(Pt 3):118369 PMID: 41289819 PMCID: PMC12698111 SCOPUS ID: 2-s2.0-105022479120 11/26/2025
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(Canale V, Blicharz-Futera K, Bijata M, Cavalco NG, Partyka A, Stefaniak M, Kamiński M, Satała G, Warszycki D, Lanham JK, Gołębiowska J, Gawlik M, Smolik M, Bijata K, Jastrzębska-Więsek M, Kurczab R, Bojarski AJ, Walczak M, McCorvy JD, Włodarczyk J, Popik P, Zajdel P.) European Journal of Medicinal Chemistry. 15 January 2026;302 SCOPUS ID: 2-s2.0-105022479120 01/15/2026
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Biased Signaling in Psychedelic Action.
(Wacker D, McCorvy JD.) Annu Rev Pharmacol Toxicol. 2026 Jan;66(1):241-260 PMID: 40796124 08/13/2025
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Transforming Amino Acids into Serotonin 5-HT2A Receptor Ligands Using Photochemistry.
(Beckett JOS, Buzdygon R, Nguyen S, Clark AA, Schalk SS, Svanholm LEH, Brasher TJ, Bazin M, Cuccurazzu B, Halberstadt AL, McCorvy JD, Mascal M.) J Am Chem Soc. 2025 Dec 31;147(52):48400-48415 PMID: 41400162 SCOPUS ID: 2-s2.0-105026446853 12/16/2025
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Next-Generation MDMA Analogue SDMA: Pharmacological and Metabolic Insights.
(Kastner N, Nadal-Gratacós N, Hemmer S, Alves da Silva L, McKee JL, Hell T, Cicalese G, Holy M, Kooti F, Jäntsch K, Baron R, Shacham N, Cuccurazzu B, Halberstadt AL, McCorvy JD, Stockner T, Meyer MR, López-Arnau R, Grill M, Sitte HH.) ACS Chem Neurosci. 2025 Dec 17;16(24):4725-4740 PMID: 41329099 PMCID: PMC12715756 SCOPUS ID: 2-s2.0-105024898462 12/02/2025
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The ABCs of psychedelics: a preclinical roadmap for drug discovery.
(Kwan AC, Mantsch JR, McCorvy JD.) Trends Pharmacol Sci. 2025 Dec;46(12):1224-1240 PMID: 40877079 PMCID: PMC12404667 SCOPUS ID: 2-s2.0-105014293898 08/29/2025
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Discovery of Highly Selective 5-HT2A Agonists Using Structure-Guided Design.
(Fenske TG, McKee JL, Cavalco NG, Schalk SS, Bonniwell EM, Lammers JC, Shacham N, Cuccurazzu B, Halberstadt AL, McCorvy JD.) J Med Chem. 2025 Oct 09;68(19):20619-20635 PMID: 40997862 PMCID: PMC12713736 SCOPUS ID: 2-s2.0-105018334639 09/26/2025
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Serotonin 5-HT2C Receptor Signaling Analysis Reveals Psychedelic Biased Agonism.
(Bonniwell EM, Alabdali R, Hennessey JJ, McKee JL, Cavalco NG, Lammers JC, Moore EJ, Franchini L, Orlandi C, McCorvy JD.) ACS Chem Neurosci. 2025 Oct 01;16(19):3899-3914 PMID: 40944639 PMCID: PMC12629614 SCOPUS ID: 2-s2.0-105017796655 09/13/2025
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A Novel Class of Complement 3a Receptor Agonists and Antagonists Derived from the TLQP-21 Peptide.
(Rodriguez P, Pallais JP, He R, Razzoli M, McKee JL, Bock HA, McCorvy JD, Sham YY, DiMarchi R, Bartolomucci A.) J Med Chem. 2025 Sep 25;68(18):19107-19121 PMID: 40903728 PMCID: PMC12481481 SCOPUS ID: 2-s2.0-105017063461 09/04/2025
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(Aarrestad IK, Cameron LP, Fenton EM, Casey AB, Rijsketic DR, Patel SD, Sambyal R, Johnson SB, Ly C, Viswanathan J, Barragan EV, Lozano SA, Seban N, Hu H, Powell NA, Chytil M, Meyer R, Rose D, Hempel C, Olson E, Hansen HD, Madsen CA, Knudsen GM, Redd C, Wheeler DG, Guanzon N, Muir J, Hennessey JJ, Quon G, McCorvy JD, Gandhi SP, Rasmussen K, Liston C, Gray JA, Heifets BD, Nord AS, Kim CK, Olson DE.) Nat Neurosci. 2025 Sep;28(9):1919-1931 PMID: 40760185 PMCID: PMC12373294 SCOPUS ID: 2-s2.0-105012563199 08/05/2025
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(Zajdel P, Matłoka M, Konieczny J, Kos T, Lammers JC, Cavalco NG, Clark AA, Lenda T, Satała G, Canale V, Grychowska K, Krawczyk M, Nikiforuk A, Partyka A, Jastrzębska-Więsek M, Berghauzen-Maciejewska K, Biała D, Janicka M, Janusz A, Piast R, Mulewski K, Smuga D, Pieczykolan J, Wieczorek M, Moszczyński-Pętkowski R, Dubiel K, Ossowska K, Bojarski AJ, Kamiński K, McCorvy JD, Popik P.) J Pharmacol Exp Ther. 2025 Feb;392(2):100055 PMID: 40023605 SCOPUS ID: 2-s2.0-85218008513 03/03/2025
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Assessing the Potential Cardiovascular Risk of Microdosing the Psychedelic LSD in Mice
(Effinger DP, Schalk SS, King JL, Wallingford JR, O’Connell CK, Calderon JR, Kopecky BJ, McCorvy JD, Thompson SM.) ACS Pharmacology and Translational Science. 14 November 2025;8(11):3923-3931 SCOPUS ID: 2-s2.0-105021866438 11/14/2025