Hui-Zi Chen, MD, PhD

Publications

• Fibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance.

  (Krook MA, Reeser JW, Ernst G, Barker H, Wilberding M, Li G, Chen HZ, Roychowdhury S.) Br J Cancer. 2021 Mar;124(5):880-892 PMID: 33268819 PMCID: PMC7921129 12/04/2020

• Characterization of Clonal Evolution in Microsatellite Unstable Metastatic Cancers through Multiregional Tumor Sequencing.

  (Bonneville R, Paruchuri A, Wing MR, Krook MA, Reeser JW, Chen HZ, Dao T, Samorodnitsky E, Smith AM, Yu L, Nowacki N, Chen W, Roychowdhury S.) Mol Cancer Res. 2021 Mar;19(3):465-474 PMID: 33229401 PMCID: PMC7939074 11/25/2020

• Efficacy of FGFR Inhibitors and Combination Therapies for Acquired Resistance in FGFR2-Fusion Cholangiocarcinoma.

  (Krook MA, Lenyo A, Wilberding M, Barker H, Dantuono M, Bailey KM, Chen HZ, Reeser JW, Wing MR, Miya J, Samorodnitsky E, Smith AM, Dao T, Martin DM, Ciombor KK, Hays J, Freud AG, Roychowdhury S.) Mol Cancer Ther. 2020 Mar;19(3):847-857 PMID: 31911531 PMCID: PMC7359896 01/09/2020

• Research Autopsy Demonstrates Polyclonal Acquired Resistance in a Patient With Metastatic GI Stromal Tumor.

  (Paruchuri A, Chen HZ, Bonneville R, Reeser JW, Wing MR, Krook MA, Samorodnitsky E, Miya J, Dao T, Smith A, Freud AG, Allenby P, Roychowdhury S.) JCO Precis Oncol. 2020;4 PMID: 32923900 PMCID: PMC7446505 09/15/2020

• Detection of Microsatellite Instability Biomarkers via Next-Generation Sequencing.

  (Bonneville R, Krook MA, Chen HZ, Smith A, Samorodnitsky E, Wing MR, Reeser JW, Roychowdhury S.) Methods Mol Biol. 2020;2055:119-132 PMID: 31502149 PMCID: PMC7010320 09/11/2019

• Characterization of a KLK2-FGFR2 fusion gene in two cases of metastatic prostate cancer.

  (Krook MA, Barker H, Chen HZ, Reeser JW, Wing MR, Martin D, Smith AM, Dao T, Bonneville R, Samorodnitsky E, Miya J, Freud AG, Monk JP, Clinton SK, Roychowdhury S.) Prostate Cancer Prostatic Dis. 2019 Dec;22(4):624-632 PMID: 31043681 PMCID: PMC6824932 05/03/2019

• Tumor heterogeneity and acquired drug resistance in FGFR2-fusion-positive cholangiocarcinoma through rapid research autopsy.

  (Krook MA, Bonneville R, Chen HZ, Reeser JW, Wing MR, Martin DM, Smith AM, Dao T, Samorodnitsky E, Paruchuri A, Miya J, Baker KR, Yu L, Timmers C, Dittmar K, Freud AG, Allenby P, Roychowdhury S.) Cold Spring Harb Mol Case Stud. 2019 Aug;5(4) PMID: 31371345 PMCID: PMC6672025 08/03/2019

• Implementing precision cancer medicine in the genomic era.

  (Chen HZ, Bonneville R, Roychowdhury S.) Semin Cancer Biol. 2019 Apr;55:16-27 PMID: 29857039 06/02/2018

• Genomic characterization of metastatic ultra-hypermutated interdigitating dendritic cell sarcoma through rapid research autopsy.

  (Chen HZ, Bonneville R, Yu L, Wing MR, Reeser JW, Krook MA, Miya J, Samorodnitsky E, Smith A, Martin D, Dao T, Guo Q, Liebner D, Freud AG, Allenby P, Roychowdhury S.) Oncotarget. 2019 Jan 08;10(3):277-288 PMID: 30719225 PMCID: PMC6349455 02/06/2019

• Rapid Research Autopsy: Piecing the Puzzle of Tumor Heterogeneity.

  (Krook MA, Chen HZ, Bonneville R, Allenby P, Roychowdhury S.) Trends Cancer. 2019 Jan;5(1):1-5 PMID: 30616752 01/09/2019

• Metastatic Calcinosis Cutis Associated With a Selective FGFR Inhibitor.

  (Carr DR, Pootrakul L, Chen HZ, Chung CG.) JAMA Dermatol. 2019 Jan 01;155(1):122-123 PMID: 30476938 11/27/2018

• Tumor spread through air space (STAS) is an important predictor of clinical outcome in stage IA lung adenocarcinoma.

  (Chen HZ, Bertino EM, He K.) J Thorac Dis. 2017 Aug;9(8):2283-2285 PMID: 28932525 PMCID: PMC5594112 09/22/2017