Ashraf El-Meanawy, MD, MS, PhD, FASN

Publications

• Lack of xanthine dehydrogenase leads to a remarkable renal decline in a novel hypouricemic rat model.

  (Dissanayake LV, Zietara A, Levchenko V, Spires DR, Burgos Angulo M, El-Meanawy A, Geurts AM, Dwinell MR, Palygin O, Staruschenko A.) iScience. 2022 Sep 16;25(9):104887 PMID: 36039296 PMCID: PMC9418856 08/31/2022

• Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension.

  (Rinschen MM, Palygin O, El-Meanawy A, Domingo-Almenara X, Palermo A, Dissanayake LV, Golosova D, Schafroth MA, Guijas C, Demir F, Jaegers J, Gliozzi ML, Xue J, Hoehne M, Benzing T, Kok BP, Saez E, Bleich M, Himmerkus N, Weisz OA, Cravatt BF, Krüger M, Benton HP, Siuzdak G, Staruschenko A.) Nat Commun. 2022 Jul 14;13(1):4099 PMID: 35835746 PMCID: PMC9283537 SCOPUS ID: 2-s2.0-85134142317 07/15/2022

• Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes According to Baseline HbA1c and Insulin Use: An Analysis From the FIDELIO-DKD Study.

  (Rossing P, Burgess E, Agarwal R, Anker SD, Filippatos G, Pitt B, Ruilope LM, Gillard P, MacIsaac RJ, Wainstein J, Joseph A, Brinker M, Roessig L, Scott C, Bakris GL, FIDELIO-DKD Investigators:, Augusto Vallejos (Argentina), Richard MacIsaac (Australia), Guntram Schernthaner (Austria), Pieter Gillard (Belgium), Maria Eugenia F. Canziani (Brazil), Theodora Temelkova-Kurktschiev (Bulgaria), Ellen Burgess and Sheldon Tobe (Canada), Fernando González (Chile), Zhi-Hong Liu (China), Andrés Ángelo Cadena Bonfanti and Carlos Francisco Jaramillo (Colombia), Martin Prazny (Czech Republic), Peter Rossing (Denmark), Jorma Strand (Finland), Michel Marre (France), Roland Schmieder and Christoph Wanner (Germany), Pantelis A. Sarafidis (Greece), Juliana Chan (Hong Kong), László Rosivall (Hungary), Joseph Eustace (Ireland), Ehud Grossman and Yoram Yagil (Israel), Giuseppe Remuzzi (Italy), Daisuke Koya and Takashi Wada (Japan), Magdalena Madero Rovalo (Mexico), Ron Gansevoort and Adriaan Kooy (Netherlands), Trine Finnes (Norway), Froilan De Leon (Philippines), Janusz Gumprecht (Poland), Fernando Teixeira e Costa (Portugal), Alexander Dreval (Russia), Anantharaman Vathsala (Singapore), Aslam Amod (South Africa), Sin Gon Kim and Byung Wan Lee (South Korea), Julio Pascual Santos (Spain), Bengt-Olov Tengmark (Sweden), Michel Burnier (Switzerland), Chien-Te Lee (Taiwan), Sukit Yamwong (Thailand), Ramazan Sari (Turkey), Kieran McCafferty (United Kingdom), Borys Mankovsky (Ukraine), Sharon Adler, Linda Fried, Robert Toto, and Mark Williams (United States), Tran Quang Khanh (Vietnam), National lead investigators:, Augusto Vallejos (Argentina), Richard MacIsaac (Australia), Guntram Schernthaner (Austria), Pieter Gillard (Belgium), Maria Eugenia F. Canziani (Brazil), Theodora Temelkova-Kurktschiev (Bulgaria), Ellen Burgess and Sheldon Tobe (Canada), Fernando González (Chile), Zhi-Hong Liu (China), Andrés Ángelo Cadena Bonfanti and Carlos Francisco Jaramillo (Colombia), Martin Prazny (Czech Republic), Peter Rossing (Denmark), Jorma Strand (Finland), Michel Marre (France), Roland Schmieder and Christoph Wanner (Germany), Pantelis A. Sarafidis (Greece), Juliana Chan (Hong Kong), László Rosivall (Hungary), Joseph Eustace (Ireland), Ehud Grossman and Yoram Yagil (Israel), Giuseppe Remuzzi (Italy), Daisuke Koya and Takashi Wada (Japan), Magdalena Madero Rovalo (Mexico), Ron Gansevoort and Adriaan Kooy (Netherlands), Trine Finnes (Norway), Froilan De Leon (Philippines), Janusz Gumprecht (Poland), Fernando Teixeira e Costa (Portugal), Alexander Dreval (Russia), Anantharaman Vathsala (Singapore), Aslam Amod (South Africa), Sin Gon Kim and Byung Wan Lee (South Korea), Julio Pascual Santos (Spain), Bengt-Olov Tengmark (Sweden), Michel Burnier (Switzerland), Chien-Te Lee (Taiwan), Sukit Yamwong (Thailand), Ramazan Sari (Turkey), Kieran McCafferty (United Kingdom), Borys Mankovsky (Ukraine), Sharon Adler, Linda Fried, Robert Toto, and Mark Williams (United States), Tran Quang Khanh (Vietnam), Diego Aizenberg, Inés Bartolacci, Diego Besada, Julio Bittar, Mariano Chahin, Alicia Elbert, Elizabeth Gelersztein, Alberto Liberman, Laura Maffei, Federico Pérez Manghi, Hugo Sanabria, Augusto Vallejos, Gloria Viñes, Alfredo Wassermann, Walter Abhayaratna, Shamasunder Acharya, Elif Ekinci, Darren Lee, Richard MacIsaac, Peak Mann Mah, Craig Nelson, David Packham, Alexia Pape, Simon Roger, Hugo Stephenson, Michael Suranyi, Gary Wittert, Elizabeth Vale, Martin Clodi, Christoph Ebenbichler, Evelyn Fliesser-Görzer, Ursula Hanusch, Michael Krebs, Karl Lhotta, Bernhard Ludvik, Gert Mayer, Peter Neudorfer, Bernhard Paulweber, Rudolf Prager, Wolfgang Preiß, Friedrich Prischl, Gerit-Holger Schernthaner, Harald Sourij, Martin Wiesholzer, Peter Doubel, Wendy Engelen, Pieter Gillard, Jean-Michel Hougardy, Jean-Marie Krzesinski, Bart Maes, Marijn Speeckaert, Koen Stas, Luc van Gaal, Hilde Vanbelleghem, Daniela Antunes, Roberto Botelho, Claudia Brito, Luis Canani, Maria Eugenia.) Diabetes Care. 2022 Apr 01;45(4):888-897 PMID: 35061867 PMCID: PMC9271031 01/22/2022

• Lack of xanthine dehydrogenase leads to a remarkable renal decline in a novel hypouricemic rat model

  (Dissanayake LV, Zietara A, Levchenko V, Spires DR, Burgos Angulo M, El-Meanawy A, Geurts AM, Dwinell MR, Palygin O, Staruschenko A.) iScience. 16 September 2022;25(9) SCOPUS ID: 2-s2.0-85136236916 09/16/2022

• p66Shc-mediated hydrogen peroxide production impairs nephrogenesis causing reduction of number of glomeruli.

  (Miller B, Palygin O, El-Meanawy A, Mattson DL, Geurts AM, Staruschenko A, Sorokin A.) Life Sci. 2021 Aug 15;279:119661 PMID: 34087282 PMCID: PMC8265215 SCOPUS ID: 2-s2.0-85107260373 06/05/2021

• Long-term kidney function and survival in recipients of allografts from living kidney donors with hypertension: a national cohort study.

  (Al Ammary F, Yu S, Muzaale AD, Segev DL, Liyanage L, Crews DC, Brennan DC, El-Meanawy A, Alqahtani S, Atta MG, Levan ML, Caffo BS, Welling PA, Massie AB.) Transpl Int. 2021 Aug;34(8):1530-1541 PMID: 34129713 SCOPUS ID: 2-s2.0-85109388213 06/16/2021

• Role of opioid signaling in kidney damage during the development of salt-induced hypertension.

  (Golosova D, Palygin O, Bohovyk R, Klemens CA, Levchenko V, Spires DR, Isaeva E, El-Meanawy A, Staruschenko A.) Life Sci Alliance. 2020 Dec;3(12) PMID: 33046522 PMCID: PMC7556751 SCOPUS ID: 2-s2.0-85092887222 10/14/2020

• Upregulated proteoglycan-related signaling pathways in fluid flow shear stress-treated podocytes.

  (Srivastava T, Joshi T, Jiang Y, Heruth DP, Rezaiekhaligh MH, Novak J, Staggs VS, Alon US, Garola RE, El-Meanawy A, McCarthy ET, Zhou J, Boinpelly VC, Sharma R, Savin VJ, Sharma M.) Am J Physiol Renal Physiol. 2020 Aug 01;319(2):F312-F322 PMID: 32628542 PMCID: PMC7473905 SCOPUS ID: 2-s2.0-85089301199 07/07/2020

• Urinary prostaglandin E2 is a biomarker of early adaptive hyperfiltration in solitary functioning kidney.

  (Srivastava T, Ju W, Milne GL, Rezaiekhaligh MH, Staggs VS, Alon US, Sharma R, Zhou J, El-Meanawy A, McCarthy ET, Savin VJ, Sharma M.) Prostaglandins Other Lipid Mediat. 2020 Feb;146:106403 PMID: 31838197 PMCID: PMC9356765 SCOPUS ID: 2-s2.0-85076524994 12/16/2019

• Vibrodissociation method for isolation of defined nephron segments from human and rodent kidneys.

  (Isaeva E, Fedoriuk M, Bohovyk R, Klemens CA, Khedr S, Golosova D, Levchenko V, El-Meanawy A, Palygin O, Staruschenko A.) Am J Physiol Renal Physiol. 2019 Nov 01;317(5):F1398-F1403 PMID: 31588797 PMCID: PMC6879945 SCOPUS ID: 2-s2.0-85074674820 10/08/2019

• Improving sensitivity of amyloid detection by Congo red stain by using polarizing microscope and avoiding pitfalls.

  (El-Meanawy A, Mueller C, Iczkowski KA.) Diagn Pathol. 2019 Jun 14;14(1):57 PMID: 31200733 PMCID: PMC6567537 SCOPUS ID: 2-s2.0-85067289424 06/16/2019

• Increased ENaC activity during kidney preservation in Wisconsin solution.

  (Khedr S, Palygin O, Pavlov TS, Blass G, Levchenko V, Alsheikh A, Brands MW, El-Meanawy A, Staruschenko A.) BMC Nephrol. 2019 Apr 29;20(1):145 PMID: 31035971 PMCID: PMC6489205 SCOPUS ID: 2-s2.0-85065255744 05/01/2019