Ashraf El-Meanawy, MD, MS, PhD, FASN

Publications

• Salt-sensitive hypertension after reversal of unilateral ureteral obstruction.

  (Imig JD, Khan MAH, Stavniichuk A, Jankiewicz WK, Goorani S, Yeboah MM, El-Meanawy A.) Biochem Pharmacol. 2023 Apr;210:115438 PMID: 36716827 PMCID: PMC10107073 SCOPUS ID: 2-s2.0-85148360442 01/31/2023

• Lack of xanthine dehydrogenase leads to a remarkable renal decline in a novel hypouricemic rat model.

  (Dissanayake LV, Zietara A, Levchenko V, Spires DR, Burgos Angulo M, El-Meanawy A, Geurts AM, Dwinell MR, Palygin O, Staruschenko A.) iScience. 2022 Sep 16;25(9):104887 PMID: 36039296 PMCID: PMC9418856 08/31/2022

• Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension.

  (Rinschen MM, Palygin O, El-Meanawy A, Domingo-Almenara X, Palermo A, Dissanayake LV, Golosova D, Schafroth MA, Guijas C, Demir F, Jaegers J, Gliozzi ML, Xue J, Hoehne M, Benzing T, Kok BP, Saez E, Bleich M, Himmerkus N, Weisz OA, Cravatt BF, Krüger M, Benton HP, Siuzdak G, Staruschenko A.) Nat Commun. 2022 Jul 14;13(1):4099 PMID: 35835746 PMCID: PMC9283537 SCOPUS ID: 2-s2.0-85134142317 07/15/2022

• Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes According to Baseline HbA1c and Insulin Use: An Analysis From the FIDELIO-DKD Study.

  (Rossing P, Burgess E, Agarwal R, Anker SD, Filippatos G, Pitt B, Ruilope LM, Gillard P, MacIsaac RJ, Wainstein J, Joseph A, Brinker M, Roessig L, Scott C, Bakris GL, FIDELIO-DKD Investigators.) Diabetes Care. 2022 Apr 01;45(4):888-897 PMID: 35061867 PMCID: PMC9271031 01/22/2022

• Lack of xanthine dehydrogenase leads to a remarkable renal decline in a novel hypouricemic rat model

  (Dissanayake LV, Zietara A, Levchenko V, Spires DR, Burgos Angulo M, El-Meanawy A, Geurts AM, Dwinell MR, Palygin O, Staruschenko A.) iScience. 16 September 2022;25(9) SCOPUS ID: 2-s2.0-85136236916 09/16/2022

• p66Shc-mediated hydrogen peroxide production impairs nephrogenesis causing reduction of number of glomeruli.

  (Miller B, Palygin O, El-Meanawy A, Mattson DL, Geurts AM, Staruschenko A, Sorokin A.) Life Sci. 2021 Aug 15;279:119661 PMID: 34087282 PMCID: PMC8265215 SCOPUS ID: 2-s2.0-85107260373 06/05/2021

• Long-term kidney function and survival in recipients of allografts from living kidney donors with hypertension: a national cohort study.

  (Al Ammary F, Yu S, Muzaale AD, Segev DL, Liyanage L, Crews DC, Brennan DC, El-Meanawy A, Alqahtani S, Atta MG, Levan ML, Caffo BS, Welling PA, Massie AB.) Transpl Int. 2021 Aug;34(8):1530-1541 PMID: 34129713 SCOPUS ID: 2-s2.0-85109388213 06/16/2021

• Role of opioid signaling in kidney damage during the development of salt-induced hypertension.

  (Golosova D, Palygin O, Bohovyk R, Klemens CA, Levchenko V, Spires DR, Isaeva E, El-Meanawy A, Staruschenko A.) Life Sci Alliance. 2020 Dec;3(12) PMID: 33046522 PMCID: PMC7556751 SCOPUS ID: 2-s2.0-85092887222 10/14/2020

• Upregulated proteoglycan-related signaling pathways in fluid flow shear stress-treated podocytes.

  (Srivastava T, Joshi T, Jiang Y, Heruth DP, Rezaiekhaligh MH, Novak J, Staggs VS, Alon US, Garola RE, El-Meanawy A, McCarthy ET, Zhou J, Boinpelly VC, Sharma R, Savin VJ, Sharma M.) Am J Physiol Renal Physiol. 2020 Aug 01;319(2):F312-F322 PMID: 32628542 PMCID: PMC7473905 SCOPUS ID: 2-s2.0-85089301199 07/07/2020

• Urinary prostaglandin E2 is a biomarker of early adaptive hyperfiltration in solitary functioning kidney.

  (Srivastava T, Ju W, Milne GL, Rezaiekhaligh MH, Staggs VS, Alon US, Sharma R, Zhou J, El-Meanawy A, McCarthy ET, Savin VJ, Sharma M.) Prostaglandins Other Lipid Mediat. 2020 Feb;146:106403 PMID: 31838197 PMCID: PMC9356765 SCOPUS ID: 2-s2.0-85076524994 12/16/2019

• Vibrodissociation method for isolation of defined nephron segments from human and rodent kidneys.

  (Isaeva E, Fedoriuk M, Bohovyk R, Klemens CA, Khedr S, Golosova D, Levchenko V, El-Meanawy A, Palygin O, Staruschenko A.) Am J Physiol Renal Physiol. 2019 Nov 01;317(5):F1398-F1403 PMID: 31588797 PMCID: PMC6879945 SCOPUS ID: 2-s2.0-85074674820 10/08/2019

• Improving sensitivity of amyloid detection by Congo red stain by using polarizing microscope and avoiding pitfalls.

  (El-Meanawy A, Mueller C, Iczkowski KA.) Diagn Pathol. 2019 Jun 14;14(1):57 PMID: 31200733 PMCID: PMC6567537 SCOPUS ID: 2-s2.0-85067289424 06/16/2019