Weiguo Cui, PhD
Associate Investigator, Versiti Blood Research Institute; Associate Professor, Microbiology & Immunology
- Versiti Blood Research Institute (Immunology)
Blood Center of Wisconsin
Memory T cell Biology
During an acute viral or bacterial infection, naïve T cells can differentiate into multiple types of effector and memory T cells that help to mediate pathogen clearance and provide long-term protective immunity. The main goal of our research in the lab is to elucidate how TCR and cytokine signaling and their downstream transcriptional programs regulate pathogen-specific T cells to proliferate, differentiate into either short-lived effector cells or long-lived memory cells.
Activated T cells receive and integrate a myriad of signals from their microenvironment. These signals differ in type, quality, quantity and duration, and could have significant impact on T cell activation, differentiation and survival. One area of our research interest is to study how these different signals cooperate with each other to regulate T cell expansion and acquisition of their effector function, and concurrently differ in their activities to control the short- or long-term fate decision. We aim to further investigate where and when these signals are produced and emanated, which will help to better understand how the distinct cellular niches influence effector and memory T cell fate decision and functional maturation.
JAK-STAT pathways are the important mediators to transmit extracellular signals into transcriptional programs that ultimately regulate effector and memory T cell differentiation, survival and homeostasis. Our recent work has demonstrated that STAT4 and STAT3 largely promote distinct cell fate commitment, and terminal effector versus memory cells respectively. A major focus in the lab currently is to better define how these different STAT pathways act in a synergistic or divergent fashion to regulate both terminal cell-fate commitment and permit plasticity in effector and memory T cells.
(Unsworth AJ, Bye AP, Sage T, Gaspar RS, Eaton N, Drew C, Stainer A, Kriek N, Volberding PJ, Hutchinson JL, Riley R, Jones S, Mundell SJ, Cui W, Falet H, Gibbins JM.) Haematologica. 2020 May 28 PMID: 32467143
(Xin G, Khatun A, Topchyan P, Zander R, Volberding PJ, Chen Y, Shen J, Fu C, Jiang A, See WA, Cui W.) Cancer Immunol Res. 2020 Jan;8(1):7-18 PMID: 31719059 PMCID: PMC6946848 SCOPUS ID: 2-s2.0-85077667188 11/14/2019
(Zander R, Schauder D, Xin G, Nguyen C, Wu X, Zajac A, Cui W.) Immunity. 2019 12 17;51(6):1028-1042.e4 PMID: 31810883 PMCID: PMC6929322 SCOPUS ID: 2-s2.0-85076189014 12/08/2019
(Johnson KE, Lange PT, Jondle CN, Volberding PJ, Lorenz UM, Cui W, Dittel BN, Tarakanova VL.) J Virol. 2019 12 12;94(1) PMID: 31597758 PMCID: PMC6912115 SCOPUS ID: 2-s2.0-85076447506 10/11/2019
(Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte ML, Volberding P, Gerbec Z, Zimmermann MT, Zeighami A, Demos W, Zhang J, Knaack DA, Smith BC, Cui W, Malarkannan S, Sodhi K, Shapiro JI, Xie Z, Sahoo D, Silverstein RL.) Circ Res. 2019 Dec 06;125(12):1087-1102 PMID: 31625810 PMCID: PMC6921463 SCOPUS ID: 2-s2.0-85076330129 10/19/2019
(Jing W, Chen J, Cai Y, Chen Y, Schroeder JA, Johnson BD, Cui W, Shi Q.) Blood Adv. 2019 10 22;3(20):3099-3110 PMID: 31648333 PMCID: PMC6849959 SCOPUS ID: 2-s2.0-85074935557 10/28/2019
(Chen Y, Yu M, Zheng Y, Fu G, Xin G, Zhu W, Luo L, Burns R, Li QZ, Dent AL, Zhu N, Cui W, Malherbe L, Wen R, Wang D.) Nat Commun. 2019 09 27;10(1):4415 PMID: 31562329 PMCID: PMC6765049 SCOPUS ID: 2-s2.0-85072692451 09/29/2019
(Darrah EJ, Jondle CN, Johnson KE, Xin G, Lange PT, Cui W, Olteanu H, Tarakanova VL.) J Virol. 2019 04 15;93(8) PMID: 30728267 PMCID: PMC6450124 SCOPUS ID: 2-s2.0-85064240079 02/08/2019
(Xin G, Zander R, Schauder DM, Chen Y, Weinstein JS, Drobyski WR, Tarakanova V, Craft J, Cui W.) Nat Commun. 2018 11 28;9(1):5037 PMID: 30487586 PMCID: PMC6261948 SCOPUS ID: 2-s2.0-85057571059 11/30/2018
(Newman DK, Fu G, McOlash L, Schauder D, Newman PJ, Cui W, Rao S, Johnson BD, Gershan JA, Riese MJ.) J Leukoc Biol. 2018 11;104(5):883-893 PMID: 30063264 PMCID: PMC6195461 SCOPUS ID: 2-s2.0-85053248137 08/01/2018
Diacylglycerol kinase ζ (DGKζ) and Casitas b-lineage proto-oncogene b-deficient mice have similar functional outcomes in T cells but DGKζ-deficient mice have increased T cell activation and tumor clearance.
(Wesley EM, Xin G, McAllister D, Malarkannan S, Newman DK, Dwinell MB, Cui W, Johnson BD, Riese MJ.) Immunohorizons. 2018 Apr 01;2(4):107-118 PMID: 30027154 PMCID: PMC6048965 07/22/2018
(Chen Y, Zander R, Khatun A, Schauder DM, Cui W.) Front Immunol. 2018;9:2826 PMID: 30581433 PMCID: PMC6292868 SCOPUS ID: 2-s2.0-85058916852 12/26/2018