Weiguo Cui, PhD
Associate Investigator, Versiti Blood Research Institute; Associate Professor, Microbiology & Immunology
- Versiti Blood Research Institute (Immunology)
Blood Center of Wisconsin
Memory T cell Biology
During an acute viral or bacterial infection, naïve T cells can differentiate into multiple types of effector and memory T cells that help to mediate pathogen clearance and provide long-term protective immunity. The main goal of our research in the lab is to elucidate how TCR and cytokine signaling and their downstream transcriptional programs regulate pathogen-specific T cells to proliferate, differentiate into either short-lived effector cells or long-lived memory cells.
Activated T cells receive and integrate a myriad of signals from their microenvironment. These signals differ in type, quality, quantity and duration, and could have significant impact on T cell activation, differentiation and survival. One area of our research interest is to study how these different signals cooperate with each other to regulate T cell expansion and acquisition of their effector function, and concurrently differ in their activities to control the short- or long-term fate decision. We aim to further investigate where and when these signals are produced and emanated, which will help to better understand how the distinct cellular niches influence effector and memory T cell fate decision and functional maturation.
JAK-STAT pathways are the important mediators to transmit extracellular signals into transcriptional programs that ultimately regulate effector and memory T cell differentiation, survival and homeostasis. Our recent work has demonstrated that STAT4 and STAT3 largely promote distinct cell fate commitment, and terminal effector versus memory cells respectively. A major focus in the lab currently is to better define how these different STAT pathways act in a synergistic or divergent fashion to regulate both terminal cell-fate commitment and permit plasticity in effector and memory T cells.
(Darrah EJ, Jondle CN, Johnson KE, Xin G, Lange PT, Cui W, Olteanu H, Tarakanova VL.) J Virol. 2019 Apr 15;93(8).
(Xin G, Zander R, Schauder DM, Chen Y, Weinstein JS, Drobyski WR, Tarakanova V, Craft J, Cui W.) Nat Commun. 2018 11 28;9(1):5037.
(Newman DK, Fu G, McOlash L, Schauder D, Newman PJ, Cui W, Rao S, Johnson BD, Gershan JA, Riese MJ.) J Leukoc Biol. 2018 11;104(5):883-893.
Diacylglycerol kinase ζ (DGKζ) and Casitas b-lineage proto-oncogene b-deficient mice have similar functional outcomes in T cells but DGKζ-deficient mice have increased T cell activation and tumor clearance.
(Wesley EM, Xin G, McAllister D, Malarkannan S, Newman DK, Dwinell MB, Cui W, Johnson BD, Riese MJ.) Immunohorizons. 2018 Apr 01;2(4):107-118.
(Chen Y, Zander R, Khatun A, Schauder DM, Cui W.) Front Immunol. 2018;9:2826.
(Zander R, Cui W.) Hum Vaccin Immunother. 2017 10 03;13(10):2269-2271.
(Darrah EJ, Kulinski JM, Mboko WP, Xin G, Malherbe LP, Gauld SB, Cui W, Tarakanova VL.) J Virol. 2017 10 01;91(19).
(Xin G, Schauder DM, Zander R, Cui W.) Immunotherapy. 2017 09;9(10):837-849.
(Chen Y, Huang W, Yang M, Xin G, Cui W, Xie Z, Silverstein RL.) Arterioscler Thromb Vasc Biol. 2017 08;37(8):1462-1469.
(Xin G, Schauder DM, Jing W, Jiang A, Joshi NS, Johnson B, Cui W.) Proc Natl Acad Sci U S A. 2017 01 24;114(4):740-745.
(Newman DK, Fu G, Adams T, Cui W, Arumugam V, Bluemn T, Riese MJ.) Sci Signal. 2016 Mar 08;9(418):ra27.
(Kutty RG, Xin G, Schauder DM, Cossette SM, Bordas M, Cui W, Ramchandran R.) PLoS One. 2016;11(12):e0167246.