James Verbsky, MD, PhD

Professor, Pediatrics (Rheumatology) and Microbiology & Immunology; Medical Director, Clinical Immunology Research Laboratory; Medical Director, Clinical and Translational Research

Locations

Children's Wisconsin
Children's Corporate Center
Suite C465

Contact Information

General Interests

Primary Immune Deficiency, Immune Dysregulation Syndromes

Education

PhD, Immunology, Washington University, 2000
MD, Washington University, 2000
Fellowship, Pediatric Rheumatology, Washington University

Research Interests

My research interests focus on immune regulation, and my research program is based on the premise of taking genetically defined immune deficiencies from humans and modeling these diseases in the laboratory. Since I see patients with immune deficiencies and inflammatory disorders, the first step in this program is to define the immune deficiency in these patients. Using genetic technologies, such as copy number variation analysis, targeted gene sequencing, and next generation genetic sequencing, we have been successful at defining several primary immune deficiencies, and have used these findings to model these diseases in the laboratory to help us understand immunity and immune regulation.

Common Variable Immunodeficiency

(Remiker A, Bolling K, Verbsky J.) Medical Clinics of North America. January 2024;108(1):107-121 SCOPUS ID: 2-s2.0-85165659522 01/01/2024
Health Equity Implications of Missing Data Among Youths With Childhood-Onset Systemic Lupus Erythematosus: A Proof-of-Concept Study in the Childhood Arthritis and Rheumatology Research Alliance Registry.

(Woo JMP, Simmonds F, Dennos A, Son MBF, Lewandowski LB, Rubinstein TB, CARRA Registry investigators.) Arthritis Care Res (Hoboken). 2023 Nov;75(11):2285-2294 PMID: 37093036 PMCID: PMC10593908 SCOPUS ID: 2-s2.0-85161293940 04/24/2023
Impaired Response to Polysaccharide Vaccine in Selective IgE Deficiency.

(Noonan E, Straesser MD, Makin T, Williams A, Al-Hazaymeh A, Routes JM, Verbsky J, Borish L, Lawrence MG.) J Clin Immunol. 2023 Aug;43(6):1448-1454 PMID: 37169968 SCOPUS ID: 2-s2.0-85159076588 05/12/2023
Dysregulated Lymphocyte Antigen Receptor Signaling in Common Variable Immunodeficiency with Granulomatous Lymphocytic Interstitial Lung Disease.

(Lui VG, Ghosh T, Rymaszewski A, Chen S, Baxter RM, Kong DS, Ghosh D, Routes JM, Verbsky JW, Hsieh EWY.) J Clin Immunol. 2023 Aug;43(6):1311-1325 PMID: 37093407 PMCID: PMC10524976 SCOPUS ID: 2-s2.0-85153408410 04/24/2023
Impaired Response to Polysaccharide Vaccine in Selective IgE Deficiency

(Noonan E, Straesser MD, Makin T, Williams A, Al-Hazaymeh A, Routes JM, Verbsky J, Borish L, Lawrence MG.) Journal of Clinical Immunology. August 2023;43(6):1448-1454 SCOPUS ID: 2-s2.0-85159076588 08/01/2023
Childhood-Onset Lupus Nephritis in the Childhood Arthritis and Rheumatology Research Alliance Registry: Short-Term Kidney Status and Variation in Care

(Smitherman EA, Chahine RA, Beukelman T, Lewandowski LB, Rahman AKMF, Wenderfer SE, Curtis JR, Hersh AO, Abel N, Abulaban K, Adams A, Adams M, Agbayani R, Aiello J, Akoghlanian S, Alejandro C, Allenspach E, Alperin R, Alpizar M, Amarilyo G, Ambler W, Anderson E, Ardoin S, Armendariz S, Baker E, Balboni I, Balevic S, Ballenger L, Ballinger S, Balmuri N, Barbar-Smiley F, Barillas-Arias L, Basiaga M, Baszis K, Becker M, Bell-Brunson H, Beltz E, Benham H, Benseler S, Bernal W, Beukelman T, Bigley T, Binstadt B, Black C, Blakley M, Bohnsack J, Boland J, Boneparth A, Bowman S, Bracaglia C, Brooks E, Brothers M, Brown A, Brunner H, Buckley M, Buckley M, Bukulmez H, Bullock D, Cameron B, Canna S, Cannon L, Carper P, Cartwright V, Cassidy E, Cerracchio L, Chalom E, Chang J, Chang-Hoftman A, Chauhan V, Chira P, Chinn T, Chundru K, Clairman H, Co D, Confair A, Conlon H, Connor R, Cooper A, Cooper J, Cooper S, Correll C, Corvalan R, Costanzo D, Cron R, Curiel-Duran L, Curington T, Curry M, Dalrymple A, Davis A, Davis C, Davis C, Davis T, De Benedetti F, De Ranieri D, Dean J, Dedeoglu F, DeGuzman M, Delnay N, Dempsey V, DeSantis E.) Arthritis Care and Research. July 2023;75(7):1553-1562 SCOPUS ID: 2-s2.0-85143289701 07/01/2023
Race, ethnicity and patient-reported outcomes in childhood-onset systemic lupus erythematosus.

(Borgia RE, Gurka MJ, Filipp SL, Elder M, Cardel M, Shiff NJ, CARRA Registry Investigators.) Clin Exp Rheumatol. 2023 Jan;41(1):186-194 PMID: 36135940 SCOPUS ID: 2-s2.0-85147047208 09/23/2022
Patient-Reported Outcomes Among Transition-Age Young Adults With Juvenile Idiopathic Arthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry.

(Smitherman EA, Chahine RA, Bitencourt N, Rahman AKMF, Lawson EF, Chang JC, CARRA Registry Investigators and CARRA Transition Workgroup.) J Rheumatol. 2023 Jan;50(1):98-106 PMID: 36109074 SCOPUS ID: 2-s2.0-85145425209 09/16/2022
Intraarticular steroids as DMARD-sparing agents for juvenile idiopathic arthritis flares: Analysis of the Childhood Arthritis and Rheumatology Research Alliance Registry.

(Hahn T, Daymont C, Beukelman T, Groh B, Hays K, Bingham CA, Scalzi L, CARRA Registry investigators.) Pediatr Rheumatol Online J. 2022 Nov 25;20(1):107 PMID: 36434731 PMCID: PMC9701017 SCOPUS ID: 2-s2.0-85142929640 11/27/2022
GATA2 deficiency detected by newborn screening for SCID: A case report.

(Escobar Vasco A, Broglie L, Talano JA, Routes J, Verbsky J, Remiker A.) Front Pediatr. 2022;10:1031106 PMID: 36726998 PMCID: PMC9886089 SCOPUS ID: 2-s2.0-85147166600 02/03/2023
Donor chimerism and immune reconstitution following haploidentical transplantation in sickle cell disease.

(Chu Y, Talano JA, Baxter-Lowe LA, Verbsky JW, Morris E, Mahanti H, Ayello J, Keever-Taylor C, Johnson B, Weinberg RS, Shi Q, Moore TB, Fabricatore S, Grossman B, van de Ven C, Shenoy S, Cairo MS.) Front Immunol. 2022;13:1055497 PMID: 36569951 PMCID: PMC9780682 SCOPUS ID: 2-s2.0-85144637382 12/27/2022
Baseline characteristics of children with juvenile dermatomyositis enrolled in the first year of the new Childhood Arthritis and Rheumatology Research Alliance registry

(Neely J, Ardalan K, Huber A, Kim S, Abel N, Abulaban K, Adams A, Adams M, Agbayani R, Aiello J, Akoghlanian S, Alejandro C, Allenspach E, Alperin R, Alpizar M, Amarilyo G, Ambler W, Anderson E, Ardoin S, Armendariz S, Baker E, Balboni I, Balevic S, Ballenger L, Ballinger S, Balmuri N, Barbar-Smiley F, Barillas-Arias L, Basiaga M, Baszis K, Becker M, Bell-Brunson H, Beltz E, Benham H, Benseler S, Bernal W, Beukelman T, Bigley T, Binstadt B, Black C, Blakley M, Bohnsack J, Boland J, Boneparth A, Bowman S, Bracaglia C, Brooks E, Brothers M, Brown A, Brunner H, Buckley M, Buckley M, Bukulmez H, Bullock D, Cameron B, Canna S, Cannon L, Carper P, Cartwright V, Cassidy E, Cerracchio L, Chalom E, Chang J, Chang-Hoftman A, Chauhan V, Chira P, Chinn T, Chundru K, Clairman H, Co D, Confair A, Conlon H, Connor R, Cooper A, Cooper J, Cooper S, Correll C, Corvalan R, Costanzo D, Cron R, Curiel-Duran L, Curington T, Curry M, Dalrymple A, Davis A, Davis C, Davis C, Davis T, De Benedetti F, De Ranieri D, Dean J, Dedeoglu F, DeGuzman M, Delnay N, Dempsey V, DeSantis E, Dickson T, Dingle J, Donaldson B, Dorsey E.) Pediatric Rheumatology. December 2022;20(1) SCOPUS ID: 2-s2.0-85134362198 12/01/2022