Joseph T. Barbieri, PhD

Professor, Microbiology & Immunology; Associate Director, Medical Scientist Training Program

Locations

Microbiology & Immunology
BSB B2830

Contact Information

General Interests

Microbial Pathogenesis

Education

PhD, Microbiology, University of Massachusetts, Amherst, 1980

Learn more about the Barbieri Lab

Research Interests

My laboratory studies the molecular basis of microbial pathogenesis in Cellular Microbiology where components of the pathogen and host are analyzed to understand the pathogenic process. My research involves the study of bacterial toxins. Several families of bacterial toxins are under investigation: botulinum and tetanus neurotoxins; Certhrax, an ADP-ribosylating exotoxin from Bacillus cereus; and ExoS, a type III cytotoxin of Pseudomonas aeruginosa.

Genetically detoxified tetanus toxin as a vaccine and conjugate carrier protein.

(Chang MJ, Ollivault-Shiflett M, Schuman R, Ngoc Nguyen S, Kaltashov IA, Bobst C, Rajagopal SP, Przedpelski A, Barbieri JT, Lees A.) Vaccine. 2022 Aug 19;40(35):5103-5113 PMID: 35871872 SCOPUS ID: 2-s2.0-85134728035 07/26/2022
Multiple Domains of Staphylococcal Superantigen-like Protein 11 (SSL11) Contribute to Neutrophil Inhibition.

(Yang C, Barbieri JT, Dahms NM, Chen C.) Biochemistry. 2022 Apr 05;61(7):616-624 PMID: 35285627 SCOPUS ID: 2-s2.0-85127145605 03/15/2022
Resolution of Two Steps in Botulinum Neurotoxin Serotype A1 Light Chain Localization to the Intracellular Plasma Membrane.

(Gardner A, Tepp WH, Bradshaw M, Barbieri JT, Pellett S.) Int J Mol Sci. 2021 Oct 15;22(20) PMID: 34681775 PMCID: PMC8539409 SCOPUS ID: 2-s2.0-85116984877 10/24/2021
A Novel High-Potency Tetanus Vaccine.

(Przedpelski A, Tepp WH, Pellett S, Johnson EA, Barbieri JT.) mBio. 2020 Aug 11;11(4) PMID: 32788381 PMCID: PMC7439469 SCOPUS ID: 2-s2.0-85089602052 08/14/2020
Tetanus Toxin cis-Loop Contributes to Light-Chain Translocation.

(Zuverink M, Bluma M, Barbieri JT.) mSphere. 2020 May 06;5(3) PMID: 32376703 PMCID: PMC7203457 SCOPUS ID: 2-s2.0-85084398090 05/08/2020
Resolving the Molecular Steps in Clostridial Neurotoxin Light Chain Translocation.

(Zuverink M, Barbieri JT.) J Exp Neurol. 2020;1(4):123-134 PMID: 33615314 PMCID: PMC7894615 02/23/2021
Staphylococcal Superantigen-like protein 11 mediates neutrophil adhesion and motility arrest, a unique bacterial toxin action.

(Chen C, Yang C, Barbieri JT.) Sci Rep. 2019 Mar 12;9(1):4211 PMID: 30862940 PMCID: PMC6414612 SCOPUS ID: 2-s2.0-85062821069 03/14/2019
Exotoxins

(Blum FC, Barbieri JT.) Encyclopedia of Microbiology. 1 January 2019:197-205 SCOPUS ID: 2-s2.0-85079533166 01/01/2019
Light Chain Diversity among the Botulinum Neurotoxins.

(Gardner AP, Barbieri JT.) Toxins (Basel). 2018 Jul 02;10(7) PMID: 30004421 PMCID: PMC6070880 SCOPUS ID: 2-s2.0-85049650896 07/14/2018
The Light Chain Defines the Duration of Action of Botulinum Toxin Serotype A Subtypes.

(Pellett S, Bradshaw M, Tepp WH, Pier CL, Whitemarsh RCM, Chen C, Barbieri JT, Johnson EA.) mBio. 2018 Mar 27;9(2) PMID: 29588398 PMCID: PMC5874905 SCOPUS ID: 2-s2.0-85046411664 03/29/2018
Detection of ADP-Ribosylating Bacterial Toxins.

(Chen C, Barbieri JT.) Methods Mol Biol. 2018;1813:287-295 PMID: 30097876 SCOPUS ID: 2-s2.0-85051506237 08/12/2018
Protein Toxins That Utilize Gangliosides as Host Receptors.

(Zuverink M, Barbieri JT.) Prog Mol Biol Transl Sci. 2018;156:325-354 PMID: 29747819 PMCID: PMC6243200 SCOPUS ID: 2-s2.0-85043989897 05/12/2018