Kelly J. Henrickson, MD

Professor, Pediatrics (Infectious Diseases) and Microbiology & Immunology; Director, Midwest Respiratory Virus Program

Contact Information

General Interests

Negative strand respiratory virus molecular epidemiology and natural history

Education

MD, University of Washington, Seattle, 1984

MCW Program / Core Facilities

Director of the Midwest Respiratory Virus Program (MRVP)

Research Interests

I have been interested in molecular evolution, antigenic variation of surface glycoprotein’s, epidemiology and natural history of parainfluenza and influenza viruses and the development of rapid molecular diagnostic assays. My most recent awards from the NIAID include working on advances in molecular diagnostics for influenza subtyping (including avian and swine) (2006-2011), bioterrorism agents (2003-2012), and working on multiplex point of care diagnostic assays for community acquired respiratory viruses (2008-2014). Other funded research grants and contracts include a BARDA contract for evaluating influenza diagnostic assays (2010-2015) and the development of molecular diagnostic assays for community acquired pneumonia and sepsis including influenza virus type A and B. In addition my most recent work includes close collaborations with the NIH to describe the epidemiology and evolution of the 2009 pandemic H1N1 virus and extending the knowledge base for paramyxovirus genomic data (1st author on NIAID white paper-2010). My laboratory has developed more than a dozen multiplex molecular diagnostic assays to bioterrorism agents, viruses and respiratory pathogens.

henrickson_figure1

Figure 1. Respiratory virus epidemiology in Southeast Wisconsin

Sequencing and analysis of globally obtained human parainfluenza viruses 1 and 3 genomes.

(Bose ME, Shrivastava S, He J, Nelson MI, Bera J, Fedorova N, Halpin R, Town CD, Lorenzi HA, Amedeo P, Gupta N, Noyola DE, Videla C, Kok T, Buys A, Venter M, Vabret A, Cordey S, Henrickson KJ.) PLoS One. 2019;14(7):e0220057 PMID: 31318956 PMCID: PMC6638977 SCOPUS ID: 2-s2.0-85069749885 07/19/2019
Establishment of a lethal aged mouse model of human respiratory syncytial virus infection.

(Zhang K, Li C, Luo YS, Wen L, Yuan S, Wang D, Ho-Yin Wong B, Zhao X, Chiu MC, Ye ZW, Sun Z, Zhao H, Zhang X, Hu M, Yang D, Shuai H, Wang Y, He J, Bose ME, Henrickson KJ, Huang JD, Zheng B, Chu H, Zhou J.) Antiviral Res. 2019 01;161:125-133 PMID: 30503888 SCOPUS ID: 2-s2.0-85057775335 12/07/2018
Simulated Respiratory Secretion for Use in the Development of Influenza Diagnostic Assays.

(Bose ME, McCaul KC, Mei H, Sasman A, He J, Kramp W, Shively R, Yan K, Henrickson KJ.) PLoS One. 2016;11(11):e0166800 PMID: 27870895 PMCID: PMC5117718 SCOPUS ID: 2-s2.0-84995923573 11/22/2016
The Underrecognized Burden of Respiratory Syncytial Virus Among Infants Presenting to US Emergency Departments.

(Makari D, Staat MA, Henrickson KJ, Wu X, Ambrose CS.) Clin Pediatr (Phila). 2015 Jun;54(6):594-7 PMID: 25104728 PMCID: PMC4512526 SCOPUS ID: 2-s2.0-84936998281 08/12/2014
Complete genome sequences of one human respiratory syncytial antigenic group a virus from china and its four mouse-adapted isolates.

(Zhang K, He J, Li C, Bose ME, Henrickson KJ, Zhou J, Zheng BJ.) Genome Announc. 2015 Mar 05;3(2) PMID: 25744999 PMCID: PMC4358386 03/07/2015
Sequencing and analysis of globally obtained human respiratory syncytial virus A and B genomes.

(Bose ME, He J, Shrivastava S, Nelson MI, Bera J, Halpin RA, Town CD, Lorenzi HA, Noyola DE, Falcone V, Gerna G, De Beenhouwer H, Videla C, Kok T, Venter M, Williams JV, Henrickson KJ.) PLoS One. 2015;10(3):e0120098 PMID: 25793751 PMCID: PMC4368745 SCOPUS ID: 2-s2.0-84925842700 03/21/2015
Analytical reactivity of 13 commercially available rapid influenza diagnostic tests with H3N2v and recently circulating influenza viruses.

(Bose ME, Sasman A, Mei H, McCaul KC, Kramp WJ, Chen LM, Shively R, Williams TL, Beck ET, Henrickson KJ.) Influenza Other Respir Viruses. 2014 Jul;8(4):474-81 PMID: 24698134 PMCID: PMC4181808 SCOPUS ID: 2-s2.0-84902373550 04/05/2014
Prevalence of respiratory syncytial virus-associated lower respiratory infection and apnea in infants presenting to the emergency department.

(Staat MA, Henrickson K, Elhefni H, Groothuis J, Makari D.) Pediatr Infect Dis J. 2013 Aug;32(8):911-4 PMID: 23429553 SCOPUS ID: 2-s2.0-84880646169 02/23/2013
Distribution of respiratory syncytial virus subtypes A and B among infants presenting to the emergency department with lower respiratory tract infection or apnea.

(Jafri HS, Wu X, Makari D, Henrickson KJ.) Pediatr Infect Dis J. 2013 Apr;32(4):335-40 PMID: 23337904 SCOPUS ID: 2-s2.0-84876288773 01/23/2013
Update on influenza diagnostics: lessons from the novel H1N1 influenza A pandemic.

(Kumar S, Henrickson KJ.) Clin Microbiol Rev. 2012 Apr;25(2):344-61 PMID: 22491775 PMCID: PMC3346302 SCOPUS ID: 2-s2.0-84859544682 04/12/2012
Genome sequencing and phylogenetic analysis of 39 human parainfluenza virus type 1 strains isolated from 1997-2010.

(Beck ET, He J, Nelson MI, Bose ME, Fan J, Kumar S, Henrickson KJ.) PLoS One. 2012;7(9):e46048 PMID: 23029382 PMCID: PMC3459887 SCOPUS ID: 2-s2.0-84866940758 10/03/2012
Whole genome sequencing and evolutionary analysis of human respiratory syncytial virus A and B from Milwaukee, WI 1998-2010.

(Rebuffo-Scheer C, Bose M, He J, Khaja S, Ulatowski M, Beck ET, Fan J, Kumar S, Nelson MI, Henrickson KJ.) PLoS One. 2011;6(10):e25468 PMID: 21998661 PMCID: PMC3188560 SCOPUS ID: 2-s2.0-80053593773 10/15/2011

Microbiology & Immunology