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Research Bench Lab
Microbiology & Immunology
Mark McNally, PhD

Mark T. McNally, PhD

Associate Professor

Locations

  • Microbiology & Immunology
    BSB B2235

Contact Information

General Interests

RNA Processing (splicing and polyadenylation) in Cells and Viruses

Education

PhD, Molecular Biology, SUNY Buffalo, 1988

Research Experience

  • Alternative Splicing
  • Avian Leukosis Virus
  • Avian Sarcoma Viruses
  • Cleavage Stimulation Factor
  • Heterogeneous-Nuclear Ribonucleoprotein Group A-B
  • Heterogeneous-Nuclear Ribonucleoprotein Group F-H
  • Introns
  • mRNA Cleavage and Polyadenylation Factors
  • Polyadenylation
  • Ribonucleoproteins, Small Nuclear
  • RNA 3' Polyadenylation Signals
  • RNA Precursors

Leadership Positions

  • Chair, Course Evaluation Committee, Graduate School
  • Course Director, IAHI, M1 Medical School
  • Faculty Advisor, Research and Education Program, AHW

Research Interests

My laboratory uses molecular, genetic, biochemical, and cell biological approaches to study post-transcriptional mechanisms of gene regulation, including RNA splicing and polyadenylation control. One area of focus uses the simple retrovirus, Rous sarcoma virus (RSV), to understand the role of RNA processing in the virus life cycle. We are also exploiting antisense oligonucleotide technologies to alter RNA splicing as an approach to develop a breast cancer therapeutic.

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