Weiguo Cui, PhD
Associate Investigator, Versiti Blood Research Institute; Associate Professor, Microbiology & Immunology
- Versiti Blood Research Institute (Immunology)
Blood Center of Wisconsin
Memory T cell Biology
During an acute viral or bacterial infection, naïve T cells can differentiate into multiple types of effector and memory T cells that help to mediate pathogen clearance and provide long-term protective immunity. The main goal of our research in the lab is to elucidate how TCR and cytokine signaling and their downstream transcriptional programs regulate pathogen-specific T cells to proliferate, differentiate into either short-lived effector cells or long-lived memory cells.
Activated T cells receive and integrate a myriad of signals from their microenvironment. These signals differ in type, quality, quantity and duration, and could have significant impact on T cell activation, differentiation and survival. One area of our research interest is to study how these different signals cooperate with each other to regulate T cell expansion and acquisition of their effector function, and concurrently differ in their activities to control the short- or long-term fate decision. We aim to further investigate where and when these signals are produced and emanated, which will help to better understand how the distinct cellular niches influence effector and memory T cell fate decision and functional maturation.
JAK-STAT pathways are the important mediators to transmit extracellular signals into transcriptional programs that ultimately regulate effector and memory T cell differentiation, survival and homeostasis. Our recent work has demonstrated that STAT4 and STAT3 largely promote distinct cell fate commitment, and terminal effector versus memory cells respectively. A major focus in the lab currently is to better define how these different STAT pathways act in a synergistic or divergent fashion to regulate both terminal cell-fate commitment and permit plasticity in effector and memory T cells.
(Chen Y, Zhang J, Cui W, Silverstein RL.) J Exp Med. 2022 Jun 06;219(6) PMID: 35438721 PMCID: PMC9022290 SCOPUS ID: 2-s2.0-85128794972 04/20/2022
(Piper C, Hainstock E, Yin-Yuan C, Chen Y, Khatun A, Kasmani MY, Evans J, Miller JA, Gorski J, Cui W, Drobyski WR.) Blood Adv. 2022 May 10;6(9):2791-2804 PMID: 35015822 PMCID: PMC9092418 01/12/2022
(Gupta P, Kadamberi IP, Mittal S, Tsaih SW, George J, Kumar S, Vijayan DK, Geethadevi A, Parashar D, Topchyan P, McAlarnen L, Volkman BF, Cui W, Zhang KYJ, Di Vizio D, Chaluvally-Raghavan P, Pradeep S.) Adv Sci (Weinh). 2022 05;9(14):e2104452 PMID: 35289120 PMCID: PMC9108620 SCOPUS ID: 2-s2.0-85126251446 03/16/2022
(Zander R, Kasmani MY, Chen Y, Topchyan P, Shen J, Zheng S, Burns R, Ingram J, Cui C, Joshi N, Craft J, Zajac A, Cui W.) Immunity. 2022 03 08;55(3):475-493.e5 PMID: 35216666 PMCID: PMC8916994 SCOPUS ID: 2-s2.0-85125669793 02/27/2022
(Wu X, Kasmani MY, Zheng S, Khatun A, Chen Y, Winkler W, Zander R, Burns R, Taparowsky EJ, Sun J, Cui W.) Sci Immunol. 2022 Jan 14;7(67):eabc9934 PMID: 35030033 PMCID: PMC9005262 SCOPUS ID: 2-s2.0-85123160063 01/15/2022
(Wu X, Kasmani MY, Zheng S, Khatun A, Chen Y, Winkler W, Zander R, Burns R, Taparowsky EJ, Sun J, Cui W.) Science Immunology. January 2022;7(67) SCOPUS ID: 2-s2.0-85123160063 01/14/2022
(Stancill JS, Kasmani MY, Khatun A, Cui W, Corbett JA.) Function (Oxf). 2022;3(1):zqab063 PMID: 34927076 PMCID: PMC8674205 12/21/2021
(Ciecko AE, Schauder DM, Foda B, Petrova G, Kasmani MY, Burns R, Lin CW, Drobyski WR, Cui W, Chen YG.) J Immunol. 2021 10 15;207(8):1990-2004 PMID: 34507949 PMCID: PMC8492517 SCOPUS ID: 2-s2.0-85116529072 09/12/2021
(Connolly KA, Kuchroo M, Venkat A, Khatun A, Wang J, William I, Hornick NI, Fitzgerald BL, Damo M, Kasmani MY, Cui C, Fagerberg E, Monroy I, Hutchins A, Cheung JF, Foster GG, Mariuzza DL, Nader M, Zhao H, Cui W, Krishnaswamy S, Joshi NS.) Sci Immunol. 2021 Oct;6(64):eabg7836 PMID: 34597124 PMCID: PMC8593910 SCOPUS ID: 2-s2.0-85116904335 10/02/2021
(Chen Y, Shen J, Kasmani MY, Topchyan P, Cui W.) Cells. 2021 08 20;10(8) PMID: 34440912 PMCID: PMC8392357 SCOPUS ID: 2-s2.0-85115043864 08/28/2021
(Pan J, Chen Y, Zhang Q, Khatun A, Palen K, Xin G, Wang L, Yang C, Johnson BD, Myers CR, Sei S, Shoemaker RH, Lubet RA, Wang Y, Cui W, You M.) Commun Biol. 2021 07 23;4(1):906 PMID: 34302042 PMCID: PMC8302676 SCOPUS ID: 2-s2.0-85111091265 07/25/2021
(Chen Y, Zander RA, Wu X, Schauder DM, Kasmani MY, Shen J, Zheng S, Burns R, Taparowsky EJ, Cui W.) Nature Immunology. August 2021;22(8):996-1007 SCOPUS ID: 2-s2.0-85110654837 08/01/2021