Microbiology & Immunology
Viral Immune EvasionView Amy Hudson Bio
We are interested in how viruses escape detection by the immune system.
As a response to selective pressures exerted by the host immune system, many viruses have developed an equally complex set of immunoevasive strategies. Perhaps most interesting is the array of unique strategies that viruses employ to interfere with the presentation of viral antigens on the surface of host cells for recognition by cytotoxic T lymphocytes.
Many viruses, including all known members of the Herpesvirus family, target antigen presentation by class I MHC molecules as a means of undermining the anti-viral immune response. We focus on two recently discovered human herpesviruses, HHV-6 and -7. Little is known about the immunobiology of these two beta-herpesviruses. They are most closely related to human cytomegalovirus (HCMV), and like all other herpesviruses, HHV-6 and -7 remain latent or establish persistent infections. Thus, it seemed likely that HHV-6 and -7 would also encode unique mechanisms of immune evasion. Because so many of the viral immunoevasins affect trafficking or stability of class I MHC molecules, we took a biochemical approach to examine the maturation and stability of class I molecules in HHV-7-infected T cells.
Research Technologist I
Corrigendum: Structural Models for Roseolovirus U20 And U21: Non-Classical MHC-I Like Proteins From HHV-6A, HHV-6B, and HHV-7.
(Weaver GC, Arya R, Schneider CL, Hudson AW, Stern LJ.) Front Immunol. 2022;13:936968 PMID: 35677042 PMCID: PMC9169504 SCOPUS ID: 2-s2.0-85131659986 06/10/2022
Structural Models for Roseolovirus U20 And U21: Non-Classical MHC-I Like Proteins From HHV-6A, HHV-6B, and HHV-7.
(Weaver GC, Arya R, Schneider CL, Hudson AW, Stern LJ.) Front Immunol. 2022;13:864898 PMID: 35444636 PMCID: PMC9013968 SCOPUS ID: 2-s2.0-85128490952 04/22/2022
iNKT cells coordinate immune pathways to enable engraftment in nonconditioned hosts.
(Hess NJ, S Bharadwaj N, Bobeck EA, McDougal CE, Ma S, Sauer JD, Hudson AW, Gumperz JE.) Life Sci Alliance. 2021 Jul;4(7) PMID: 34112724 PMCID: PMC8200291 SCOPUS ID: 2-s2.0-85108045175 06/12/2021
The Roseoloviruses Downregulate the Protein Tyrosine Phosphatase PTPRC (CD45).
(Whyte ML, Smith KA, Buchberger A, Berg Luecke L, Tjan LH, Mori Y, Gundry RL, Hudson AW.) J Virol. 2021 Jun 24;95(14):e0162820 PMID: 33952641 PMCID: PMC8223955 SCOPUS ID: 2-s2.0-85108871238 05/07/2021
Early T Cell Activation Metrics Predict Graft-versus-Host Disease in a Humanized Mouse Model of Hematopoietic Stem Cell Transplantation.
(Hess NJ, Hudson AW, Hematti P, Gumperz JE.) J Immunol. 2020 Jul 01;205(1):272-281 PMID: 32444392 PMCID: PMC7329317 SCOPUS ID: 2-s2.0-85088373153 05/24/2020
HHV-7 U21 exploits Golgi quality control carriers to reroute class I MHC molecules to lysosomes.
(Dirck AT, Whyte ML, Hudson AW.) Mol Biol Cell. 2020 Feb 01;31(3):196-208 PMID: 31851583 PMCID: PMC7001482 SCOPUS ID: 2-s2.0-85081146090 12/19/2019
Different Human Immune Lineage Compositions Are Generated in Non-Conditioned NBSGW Mice Depending on HSPC Source.
(Hess NJ, Lindner PN, Vazquez J, Grindel S, Hudson AW, Stanic AK, Ikeda A, Hematti P, Gumperz JE.) Front Immunol. 2020;11:573406 PMID: 33193358 PMCID: PMC7604455 SCOPUS ID: 2-s2.0-85094894828 11/17/2020
Adoptively transferred Vγ9Vδ2 T cells show potent antitumor effects in a preclinical B cell lymphomagenesis model.
(Zumwalde NA, Sharma A, Xu X, Ma S, Schneider CL, Romero-Masters JC, Hudson AW, Gendron-Fitzpatrick A, Kenney SC, Gumperz JE.) JCI Insight. 2017 Jul 06;2(13) PMID: 28679955 PMCID: PMC5499361 SCOPUS ID: 2-s2.0-85045321193 07/07/2017
Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus.
(Sturgill ER, Malouli D, Hansen SG, Burwitz BJ, Seo S, Schneider CL, Womack JL, Verweij MC, Ventura AB, Bhusari A, Jeffries KM, Legasse AW, Axthelm MK, Hudson AW, Sacha JB, Picker LJ, Früh K.) PLoS Pathog. 2016 Aug;12(8):e1005868 PMID: 27580123 PMCID: PMC5006984 SCOPUS ID: 2-s2.0-84984830187 09/01/2016
Roseoloviruses and their modulation of host defenses.
(Hudson AW.) Curr Opin Virol. 2014 Dec;9:178-87 PMID: 25462451 SCOPUS ID: 2-s2.0-84915759618 12/03/2014
Human herpesvirus 7 U21 tetramerizes to associate with class I major histocompatibility complex molecules.
(May NA, Wang Q, Balbo A, Konrad SL, Buchli R, Hildebrand WH, Schuck P, Hudson AW.) J Virol. 2014 Mar;88(6):3298-308 PMID: 24390327 PMCID: PMC3957921 SCOPUS ID: 2-s2.0-84894543495 01/07/2014
Adaptor protein complexes AP-1 and AP-3 are required by the HHV-7 Immunoevasin U21 for rerouting of class I MHC molecules to the lysosomal compartment.
(Kimpler LA, Glosson NL, Downs D, Gonyo P, May NA, Hudson AW.) PLoS One. 2014;9(6):e99139 PMID: 24901711 PMCID: PMC4047081 SCOPUS ID: 2-s2.0-84902477273 06/06/2014