Research Areas

My laboratory uses molecular, genetic, biochemical, and cell biological approaches to study post-transcriptional mechanisms of gene regulation, including RNA splicing and polyadenylation control. One area of focus uses the simple retrovirus, Rous sarcoma virus (RSV), to understand the role of RNA processing in the virus life cycle. We are also exploiting antisense oligonucleotide technologies to alter RNA splicing as an approach to develop a breast cancer therapeutic.

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Splice switching an oncogenic ratio of SmgGDS isoforms as a strategy to diminish malignancy.

(Brandt AC, McNally L, Lorimer EL, Unger B, Koehn OJ, Suazo KF, Rein L, Szabo A, Tsaih SW, Distefano MD, Flister MJ, Rigo F, McNally MT, Williams CL.) Proc Natl Acad Sci U S A. 2020 Feb 18;117(7):3627-3636 PMID: 32019878 PMCID: PMC7035473 SCOPUS ID: 2-s2.0-85079538992 02/06/2020
Evidence that a threshold of serine/arginine-rich (SR) proteins recruits CFIm to promote rous sarcoma virus mRNA 3' end formation.

(Hudson SW, McNally LM, McNally MT.) Virology. 2016 Nov;498:181-191 PMID: 27596537 PMCID: PMC5045808 SCOPUS ID: 2-s2.0-84985990676 09/07/2016
A novel otoferlin splice-site mutation in siblings with auditory neuropathy spectrum disorder.

(Runge CL, Erbe CB, McNally MT, Van Dusen C, Friedland DR, Kwitek AE, Kerschner JE.) Audiol Neurootol. 2013;18(6):374-82 PMID: 24135434 PMCID: PMC3877672 SCOPUS ID: 2-s2.0-84885522606 10/19/2013
Juxtaposition of two distant, serine-arginine-rich protein-binding elements is required for optimal polyadenylation in Rous sarcoma virus.

(Hudson SW, McNally MT.) J Virol. 2011 Nov;85(21):11351-60 PMID: 21849435 PMCID: PMC3194969 SCOPUS ID: 2-s2.0-80055120941 08/19/2011
A glycine-rich domain of hnRNP H/F promotes nucleocytoplasmic shuttling and nuclear import through an interaction with transportin 1.

(Van Dusen CM, Yee L, McNally LM, McNally MT.) Mol Cell Biol. 2010 May;30(10):2552-62 PMID: 20308327 PMCID: PMC2863714 SCOPUS ID: 2-s2.0-77951990307 03/24/2010
The waved with open eyelids (woe) locus is a hypomorphic mouse mutation in Adam17.

(Hassemer EL, Le Gall SM, Liegel R, McNally M, Chang B, Zeiss CJ, Dubielzig RD, Horiuchi K, Kimura T, Okada Y, Blobel CP, Sidjanin DJ.) Genetics. 2010 May;185(1):245-55 PMID: 20194968 PMCID: PMC2870960 SCOPUS ID: 2-s2.0-77956635945 03/03/2010
Articular cartilage vesicles contain RNA.

(Mitton E, Gohr CM, McNally MT, Rosenthal AK.) Biochem Biophys Res Commun. 2009 Oct 23;388(3):533-8 PMID: 19679100 PMCID: PMC2754773 SCOPUS ID: 2-s2.0-69549117350 08/15/2009
Characterization of Rous sarcoma virus polyadenylation site use in vitro.

(Maciolek NL, McNally MT.) Virology. 2008 May 10;374(2):468-76 PMID: 18272196 PMCID: PMC2413101 SCOPUS ID: 2-s2.0-42649140232 02/15/2008
RNA processing control in avian retroviruses.

(McNally MT.) Front Biosci. 2008 May 01;13:3869-83 PMID: 18508481 PMCID: PMC2575692 SCOPUS ID: 2-s2.0-42649114510 05/30/2008
Serine/arginine-rich proteins contribute to negative regulator of splicing element-stimulated polyadenylation in rous sarcoma virus.

(Maciolek NL, McNally MT.) J Virol. 2007 Oct;81(20):11208-17 PMID: 17670832 PMCID: PMC2045511 SCOPUS ID: 2-s2.0-35148860145 08/03/2007
Urea-nuclease treatment of concentrated retrovirions preserves viral RNA and removes polymerase chain reaction-amplifiable cellular RNA and DNA.

(Sun HY, McNally MT, Jackson VE, Grossberg SE.) J Virol Methods. 2006 Nov;137(2):304-8 PMID: 16920200 PMCID: PMC2575689 SCOPUS ID: 2-s2.0-33748714112 08/22/2006
Analysis of RNA splicing defects in PITX2 mutants supports a gene dosage model of Axenfeld-Rieger syndrome.

(Maciolek NL, Alward WL, Murray JC, Semina EV, McNally MT.) BMC Med Genet. 2006 Jul 11;7:59 PMID: 16834779 PMCID: PMC1553432 SCOPUS ID: 2-s2.0-33748048489 07/13/2006

McNally Laboratory

Research Areas

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