Matthew D. Budde, PhD

Associate Professor

Locations

Neurosurgery
8701 Watertown Plank Rd.
Milwaukee, WI 53226

Education

Postdoctoral Fellow, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, 2011
PhD, Neuroscience, Washington University, St Louis, MO, 2008
BS, Psychology, University of Wisconsin-Madison, WI, 2001

Biography

Dr. Matthew Budde is an associate professor of neurosurgery at the Medical College of Wisconsin. He received his PhD in Neuroscience from Washington University in St. Louis in 2008. He completed his postdoctoral training at the National Institutes of Health in Bethesda, MD and was a recipient of the Fellows Award for Research Excellence in 2011.

Dr. Budde’s primary research interest is to develop and employ magnetic resonance imaging techniques to diagnosis and monitor injuries and diseases of the central nervous system. He has made significant contributions to the field and has over 20 peer-reviewed publications. He is an active member and Junior Fellow of the International Society for Magnetic Resonance in Medicine and a member of the Society for Neuroscience.

Honors and Awards

05/2006 – Young Investigator Award Finalist, International Society for Magnetic Resonance in Medicine
05/2010 – Junior Fellow Recipient, International Society for Magnetic Resonance in Medicine
02/2011 – Fellows Award for Research Excellence (FARE), National Institutes of Health, Bethesda, National Institutes of Health

Research Experience

Brain Concussion
Brain Injuries
Diffuse Axonal Injury
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
Disease Models, Animal
Histology
Hypoxia-Ischemia, Brain
Magnetic Resonance Imaging
Microscopy
Multiple Sclerosis
Neurosciences

MCW Program / Core Facilities

Center for Imaging Research
Neuroscience Research Center

Research Interests

Development and application of magnetic resonance imaging techniques to diagnose and monitor brain and spinal cord injury.

Apply advanced MRI techniques, including diffusion tensor imaging (DTI), to detect and monitor injury to the central nervous system noninvasively
Define the specific biological features that give rise to the MRI findings using animal models of neurological injury
Determine the prognostic capabilities of MRI in acute brain and spinal cord trauma

Oscillating gradient spin echo diffusion time effects implicate variations in neurite beading for the heterogeneous reduced diffusion in human acute ischemic stroke lesions.

(Zhou M, Stobbe R, Budde M, Buck B, Kate M, Lloret M, Fairall P, Butcher K, Shuaib A, Emery D, Feiweier T, Beaulieu C.) Magn Reson Med. 2025 Nov;94(5):2158-2172 PMID: 40554725 PMCID: PMC12393189 SCOPUS ID: 2-s2.0-105009276833 06/24/2025
Serum protein biomarkers for degenerative cervical myelopathy: a prospective study.

(Vedantam A, Rahman M, Salam S, Banerjee A, Satkunendrarajah K, Budde MD, Meier TB.) J Neurosurg Spine. 2025 Jun 01;42(6):718-726 PMID: 40215624 PMCID: PMC12624368 SCOPUS ID: 2-s2.0-105007067019 04/12/2025
Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 2-Ex vivo imaging: Added value and acquisition.

(Schilling KG, Grussu F, Ianus A, Hansen B, Howard AFD, Barrett RLC, Aggarwal M, Michielse S, Nasrallah F, Syeda W, Wang N, Veraart J, Roebroeck A, Bagdasarian AF, Eichner C, Sepehrband F, Zimmermann J, Soustelle L, Bowman C, Tendler BC, Hertanu A, Jeurissen B, Verhoye M, Frydman L, van de Looij Y, Hike D, Dunn JF, Miller K, Landman BA, Shemesh N, Anderson A, McKinnon E, Farquharson S, Dell'Acqua F, Pierpaoli C, Drobnjak I, Leemans A, Harkins KD, Descoteaux M, Xu D, Huang H, Santin MD, Grant SC, Obenaus A, Kim GS, Wu D, Le Bihan D, Blackband SJ, Ciobanu L, Fieremans E, Bai R, Leergaard TB, Zhang J, Dyrby TB, Johnson GA, Cohen-Adad J, Budde MD, Jelescu IO.) Magn Reson Med. 2025 Jun;93(6):2535-2560 PMID: 40035293 PMCID: PMC11971501 SCOPUS ID: 2-s2.0-105001807462 03/04/2025
Considerations and recommendations from the ISMRM Diffusion Study Group for preclinical diffusion MRI: Part 3-Ex vivo imaging: Data processing, comparisons with microscopy, and tractography.

(Schilling KG, Howard AFD, Grussu F, Ianus A, Hansen B, Barrett RLC, Aggarwal M, Michielse S, Nasrallah F, Syeda W, Wang N, Veraart J, Roebroeck A, Bagdasarian AF, Eichner C, Sepehrband F, Zimmermann J, Soustelle L, Bowman C, Tendler BC, Hertanu A, Jeurissen B, Verhoye M, Frydman L, van de Looij Y, Hike D, Dunn JF, Miller K, Landman BA, Shemesh N, Anderson A, McKinnon E, Farquharson S, Dell'Acqua F, Pierpaoli C, Drobnjak I, Leemans A, Harkins KD, Descoteaux M, Xu D, Huang H, Santin MD, Grant SC, Obenaus A, Kim GS, Wu D, Le Bihan D, Blackband SJ, Ciobanu L, Fieremans E, Bai R, Leergaard TB, Zhang J, Dyrby TB, Johnson GA, Cohen-Adad J, Budde MD, Jelescu IO.) Magn Reson Med. 2025 Jun;93(6):2561-2582 PMID: 40008460 PMCID: PMC11971500 SCOPUS ID: 2-s2.0-85219588052 02/26/2025
Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 1: In vivo small-animal imaging.

(Jelescu IO, Grussu F, Ianus A, Hansen B, Barrett RLC, Aggarwal M, Michielse S, Nasrallah F, Syeda W, Wang N, Veraart J, Roebroeck A, Bagdasarian AF, Eichner C, Sepehrband F, Zimmermann J, Soustelle L, Bowman C, Tendler BC, Hertanu A, Jeurissen B, Verhoye M, Frydman L, van de Looij Y, Hike D, Dunn JF, Miller K, Landman BA, Shemesh N, Anderson A, McKinnon E, Farquharson S, Dell'Acqua F, Pierpaoli C, Drobnjak I, Leemans A, Harkins KD, Descoteaux M, Xu D, Huang H, Santin MD, Grant SC, Obenaus A, Kim GS, Wu D, Le Bihan D, Blackband SJ, Ciobanu L, Fieremans E, Bai R, Leergaard TB, Zhang J, Dyrby TB, Johnson GA, Cohen-Adad J, Budde MD, Schilling KG.) Magn Reson Med. 2025 Jun;93(6):2507-2534 PMID: 40008568 PMCID: PMC11971505 SCOPUS ID: 2-s2.0-105002179184 02/26/2025
Investigating microstructural changes between in vivo and perfused ex vivo marmoset brains using oscillating gradient and b-tensor encoded diffusion MRI at 9.4 T.

(Santini T, Shim A, Liou JJ, Rahman N, Varela-Mattatall G, Budde MD, Inoue W, Everling S, Baron CA.) Magn Reson Med. 2025 Feb;93(2):788-802 PMID: 39323069 PMCID: PMC11604852 SCOPUS ID: 2-s2.0-85205058687 09/26/2024
Body size and intracranial volume interact with the structure of the central nervous system: A multi-center in vivo neuroimaging study.

(Labounek R, Bondy MT, Paulson AL, Bédard S, Abramovic M, Alonso-Ortiz E, Atcheson NT, Barlow LR, Barry RL, Barth M, Battiston M, Büchel C, Budde MD, Callot V, Combes A, De Leener B, Descoteaux M, de Sousa PL, Dostál M, Doyon J, Dvorak AV, Eippert F, Epperson KR, Epperson KS, Freund P, Finsterbusch J, Foias A, Fratini M, Fukunaga I, Wheeler-Kingshott CAMG, Germani G, Gilbert G, Giove F, Grussu F, Hagiwara A, Henry PG, Horák T, Hori M, Joers JM, Kamiya K, Karbasforoushan H, Keřkovský M, Khatibi A, Kim JW, Kinany N, Kitzler H, Kolind S, Kong Y, Kudlička P, Kuntke P, Kurniawan ND, Kusmia S, Laganà MM, Laule C, Law CSW, Leutritz T, Liu Y, Llufriu S, Mackey S, Martin AR, Martinez-Heras E, Mattera L, O'Grady KP, Papinutto N, Papp D, Pareto D, Parrish TB, Pichiecchio A, Prados F, Rovira À, Ruitenberg MJ, Samson RS, Savini G, Seif M, Seifert AC, Smith AK, Smith SA, Smith ZA, Solana E, Suzuki Y, Tackley GW, Tinnermann A, Valošek J, Van De Ville D, Yiannakas MC, Weber Ii KA, Weiskopf N, Wise RG, Wyss PO, Xu J, Cohen-Adad J, Lenglet C, Nestrašil I.) Imaging Neurosci (Camb). 2025;3 PMID: 40800833 PMCID: PMC12319740 08/13/2025
Spectral principal axis system (SPAS) and tuning of tensor-valued encoding for microscopic anisotropy and time-dependent diffusion in the rat brain.

(Lasič S, Just N, Nilsson M, Szczepankiewicz F, Budde M, Lundell H.) Imaging Neurosci (Camb). 2025;3 PMID: 40800797 PMCID: PMC12319979 08/13/2025
Progressive Remote Axonal Degeneration Following Spinal Cord Injury: A Histological and MRI Study.

(David G, Motovylyak A, Schlegel F, Kovacs Z, Kündig C, Filous AR, Schwab JM, Budde MD, Klohs J, Freund P.) Neurotrauma Rep. 2025;6(1):443-464 PMID: 40677997 PMCID: PMC12270540 07/18/2025
Subclinical brain manifestations of repeated mild traumatic brain injury are changed by chronic exposure to sleep loss, caffeine, and sleep aids.

(Everson CA, Szabo A, Plyer C, Hammeke TA, Stemper BD, Budde MD.) Exp Neurol. 2024 Nov;381:114928 PMID: 39168169 SCOPUS ID: 2-s2.0-85201764724 08/22/2024
Body size interacts with the structure of the central nervous system: A multi-center in vivo neuroimaging study.

(Labounek R, Bondy MT, Paulson AL, Bédard S, Abramovic M, Alonso-Ortiz E, Atcheson NT, Barlow LR, Barry RL, Barth M, Battiston M, Büchel C, Budde MD, Callot V, Combes A, De Leener B, Descoteaux M, de Sousa PL, Dostál M, Doyon J, Dvorak AV, Eippert F, Epperson KR, Epperson KS, Freund P, Finsterbusch J, Foias A, Fratini M, Fukunaga I, Gandini Wheeler-Kingshott CAM, Germani G, Gilbert G, Giove F, Grussu F, Hagiwara A, Henry PG, Horák T, Hori M, Joers JM, Kamiya K, Karbasforoushan H, Keřkovský M, Khatibi A, Kim JW, Kinany N, Kitzler H, Kolind S, Kong Y, Kudlička P, Kuntke P, Kurniawan ND, Kusmia S, Laganà MM, Laule C, Law CSW, Leutritz T, Liu Y, Llufriu S, Mackey S, Martin AR, Martinez-Heras E, Mattera L, O'Grady KP, Papinutto N, Papp D, Pareto D, Parrish TB, Pichiecchio A, Prados F, Rovira À, Ruitenberg MJ, Samson RS, Savini G, Seif M, Seifert AC, Smith AK, Smith SA, Smith ZA, Solana E, Suzuki Y, Tackley GW, Tinnermann A, Valošek J, Van De Ville D, Yiannakas MC, Weber KA 2nd, Weiskopf N, Wise RG, Wyss PO, Xu J, Cohen-Adad J, Lenglet C, Nestrašil I.) bioRxiv. 2024 May 01 PMID: 38746371 PMCID: PMC11092490 05/15/2024
Tensor-valued diffusion MRI of human acute stroke

(Zhou M, Stobbe R, Szczepankiewicz F, Budde M, Buck B, Kate M, Lloret M, Fairall P, Butcher K, Shuaib A, Emery D, Nilsson M, Westin CF, Beaulieu C.) Magnetic Resonance in Medicine. May 2024;91(5):2126-2141 SCOPUS ID: 2-s2.0-85181197209 05/01/2024