Juan Felix, MD

Publications

• Collagen-Specific HSP47+ Myofibroblasts and CD163+ Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS-CoV-2 Infections.

  (Puzyrenko A, Jacobs ER, Padilla N, Devine A, Aljadah M, Gantner BN, Pan AY, Lai S, Dai Q, Rubenstein JC, North PE, Simpson PM, Willoughby RE, O'Meara CC, Flinn MA, Lough JW, Ibrahim EH, Zheng Z, Sun Y, Felix J, Hunt BC, Ross G, Rui H, Benjamin IJ.) J Am Heart Assoc. 2023 Feb 21;12(4):e027990 PMID: 36789856 PMCID: PMC10111490 SCOPUS ID: 2-s2.0-85148479620 02/16/2023

• Analytical validation and implementation of a pan cancer next-generation sequencing panel, CANSeqTMKids for molecular profiling of childhood malignancies.

  (Schilter KF, Smith BA, Nie Q, Stoll K, Felix JC, Jarzembowski JA, Reddi HV.) Front Genet. 2023;14:1067457 PMID: 36845394 PMCID: PMC9947346 02/28/2023

• Safety and Acceptability of Three Ablation Treatments for High-Grade Cervical Precancer: Early Data From a Randomized Noninferiority Clinical Trial.

  (Soler M, Alfaro K, Masch RJ, Conzuelo Rodriguez G, Qu X, Wu S, Sun J, Hernández Jovel DM, Bonilla J, Puentes LO, Murillo R, Alonzo TA, Felix JC, Castle P, Cremer M.) JCO Glob Oncol. 2022 Dec;8:e2200112 PMID: 36525620 PMCID: PMC10166394 SCOPUS ID: 2-s2.0-85144589856 12/17/2022

• Cervical Cancer Prevention in El Salvador: Gains to Date and Challenges for the Future.

  (Alfaro K, Soler M, Maza M, Flores M, López L, Rauda JC, Chacón A, Erazo P, Villatoro N, Mumenthaler E, Masch R, Conzuelo G, Felix JC, Cremer M.) Cancers (Basel). 2022 Jun 03;14(11) PMID: 35681756 PMCID: PMC9179345 06/11/2022

• Cytotoxic CD8-positive T-lymphocyte infiltration in the lungs as a histological pattern of SARS-CoV-2 pneumonitis.

  (Puzyrenko A, Felix JC, Ledeboer NA, Sun Y, Rui H, Sheinin Y.) Pathology. 2022 Jun;54(4):404-408 PMID: 34836647 PMCID: PMC8572726 SCOPUS ID: 2-s2.0-85119915379 11/28/2021

• Human papillomavirus vaccination history and diagnosis of cervical intraepithelial neoplasia grade ≥2 severe lesions among a cohort of women who underwent colposcopy in Kaiser Permanente Southern California.

  (Lonky NM, Xu L, Da Silva DM, Felix JC, Chao C.) Am J Obstet Gynecol. 2021 Dec;225(6):656.e1-656.e11 PMID: 34273278 SCOPUS ID: 2-s2.0-85111984342 07/18/2021

• Multisite Clinical Validation of Isothermal Amplification-Based SARS-CoV-2 Detection Assays Using Different Sampling Strategies.

  (Desai KT, Alfaro K, Mendoza L, Faron M, Mesich B, Maza M, Dominguez R, Valenzuela A, Acosta CD, Martínez M, Felix JC, Masch R, Smith JS, Gabrilovich S, Wu T, Plump M, Novetsky AP, Einstein MH, Douglas NC, Cremer M, Wentzensen N.) Microbiol Spectr. 2021 Oct 31;9(2):e0084621 PMID: 34668736 PMCID: PMC8528118 SCOPUS ID: 2-s2.0-85119105510 10/21/2021

• Pneumocytes are distinguished by highly elevated expression of the ER stress biomarker GRP78, a co-receptor for SARS-CoV-2, in COVID-19 autopsies.

  (Puzyrenko A, Jacobs ER, Sun Y, Felix JC, Sheinin Y, Ge L, Lai S, Dai Q, Gantner BN, Nanchal R, North PE, Simpson PM, Rui H, Benjamin IJ.) Cell Stress Chaperones. 2021 Sep;26(5):859-868 PMID: 34382151 PMCID: PMC8357488 SCOPUS ID: 2-s2.0-85112285201 08/13/2021

• Diffuse interstitial pneumonia-like/macrophage activation syndrome-like changes in patients with COVID-19 correlate with length of illness.

  (Felix JC, Sheinin YM, Suster D, Ronen N, Ratiani M, Vanden Heuvel T, Winge E, Patton MD, Rau MJ, Ge L, Sun Y, Udhane SS, Langenheim JF, Rui H.) Ann Diagn Pathol. 2021 Aug;53:151744 PMID: 33991784 PMCID: PMC8053602 SCOPUS ID: 2-s2.0-85105597450 05/16/2021

• Sensitive and Specific Immunohistochemistry Protocol for Nucleocapsid Protein from All Common SARS-CoV-2 Virus Strains in Formalin-Fixed, Paraffin Embedded Tissues.

  (Sun Y, Ge L, Udhane SS, Langenheim JF, Rau MJ, Patton MD, Gallan AJ, Felix JC, Rui H.) Methods Protoc. 2021 Jul 10;4(3) PMID: 34287344 PMCID: PMC8293419 SCOPUS ID: 2-s2.0-85111011758 07/22/2021

• Multi-site clinical validation of Isothermal Amplification based SARS-COV-2 detection assays using different sampling strategies.

  (Desai KT, Alfaro K, Mendoza L, Faron M, Mesich B, Maza M, Dominguez R, Valenzuela A, Acosta CD, Martínez M, Felix JC, Masch R, Gabrilovich S, Plump M, Novetsky AP, Einstein MH, Douglas NC, Cremer M, Wentzensen N.) medRxiv. 2021 Jul 06 PMID: 34268516 PMCID: PMC8282105 07/17/2021

• Reply to: Comments on Cervical cancer prevention in El Salvador: A prospective evaluation of screening and triage strategies incorporating high-resolution microendoscopy to detect cervical precancer.

  (Parra SG, López-Orellana LM, Molina Duque AR, Carns JL, Schwarz RA, Smith CA, Ortiz Silvestre M, Diaz Bazan S, Felix JC, Ramalingam P, Castle PE, Cremer ML, Maza M, Schmeler KM, Richards-Kortum RR.) Int J Cancer. 2021 Apr 04 PMID: 33817804 SCOPUS ID: 2-s2.0-85108245005 04/06/2021