Paula E North, MD, PhD | Medical College of Wisconsin

Paula E. North, MD, PhD

Professor

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Locations

Children's Wisconsin - Milwaukee
Froedtert Hospital
Pathology - Children's

Specialties

Pathology
Pediatric Pathology

Languages

English

Children's Central Scheduling

(414) 266-2860

Education

MD - Doctor of Medicine
PhD

Biography

Dr. North is Professor of Pathology at the Medical College of Wisconsin with a secondary appointment in the MCW Institute for Health and Society. Her primary clinical service responsibilities are in the Division of Pediatric Pathology at Children's Wisconsin. She currently serves as Department Chief for the Children's Medical and Dental Staff in Pathology and Laboratory Medicine. She founded and continues as Scientific Director of the Children's Research Institute Histology Core, a state-of-the-art research-supportive facility that has continually offered a wide range of histology services and Pathology expertise to investigators at MCW and its affiliated institutions since 2006. Dr. North's research program and anatomic clinical practice is most focused in the areas of vascular anomalies and global environmental health.

Research Interests

Pathogenic mechanisms in vascular tumors and malformations of infancy and childhood

Pediatric molecular diagnostics

Global laboratory medicine – development of sustainable models for telepathology-supported laboratory testing in challenging environments

Introduction of Mutant GNAQ into Endothelial Cells Induces a Vascular Malformation Phenotype with Therapeutic Response to Imatinib.

(Sasaki M, Jung Y, North P, Elsey J, Choate K, Toussaint MA, Huang C, Radi R, Perricone AJ, Corces VG, Arbiser JL.) Cancers (Basel). 2022 Jan 14;14(2) PMID: 35053574 PMCID: PMC8773683 01/22/2022
Increase in nuclear cell-free DNA is associated with major adverse events in adult and pediatric heart transplant recipients.

(Zangwill SD, Deshpande SR, Simpson PM, Liang HL, Zhang L, Dasgupta M, Richmond ME, Kindel SJ, Bichell DP, Mahle WT, Wigger MA, Schroder JN, Knecht KR, Pahl E, Gaglianello NA, North PE, Tomita-Mitchell A, Mitchell ME.) Clin Transplant. 2022 01;36(1):e14509 PMID: 34649304 SCOPUS ID: 2-s2.0-85120575732 10/15/2021
Elevated nuclear and mitochondrial cell-free deoxyribonucleic acid measurements are associated with death after infant cardiac surgery.

(Scott JP, Tanem JM, Tomita-Mitchell A, Hoffman GM, Niebler RA, Liang HL, Simpson PM, Stamm KD, North PE, Mitchell ME.) J Thorac Cardiovasc Surg. 2021 Dec 24 PMID: 35144816 SCOPUS ID: 2-s2.0-85120861361 02/12/2022
Adverse Maternal Environment and Postweaning Western Diet Alter Hepatic CD36 Expression and Methylation Concurrently with Nonalcoholic Fatty Liver Disease in Mouse Offspring.

(Fu Q, North PE, Ke X, Huang YW, Fritz KA, Majnik AV, Lane RH.) J Nutr. 2021 10 01;151(10):3102-3112 PMID: 34486661 PMCID: PMC8485909 SCOPUS ID: 2-s2.0-85117314320 09/07/2021
Total Cell-Free DNA Predicts Death and Infection Following Pediatric and Adult Heart Transplantation.

(Scott JP, Ragalie WS, Stamm KD, Mahnke DK, Liang HL, Simpson PM, Dasgupta M, Katz R, North PE, Tomita-Mitchell A, Zangwill SD, Kindel SJ, Mitchell ME.) Ann Thorac Surg. 2021 10;112(4):1282-1289 PMID: 33039362 SCOPUS ID: 2-s2.0-85103701202 10/12/2020
Pneumocytes are distinguished by highly elevated expression of the ER stress biomarker GRP78, a co-receptor for SARS-CoV-2, in COVID-19 autopsies.

(Puzyrenko A, Jacobs ER, Sun Y, Felix JC, Sheinin Y, Ge L, Lai S, Dai Q, Gantner BN, Nanchal R, North PE, Simpson PM, Rui H, Benjamin IJ.) Cell Stress Chaperones. 2021 09;26(5):859-868 PMID: 34382151 PMCID: PMC8357488 SCOPUS ID: 2-s2.0-85112285201 08/13/2021
NOGOB receptor-mediated RAS signaling pathway is a target for suppressing proliferating hemangioma.

(Hu W, Liu Z, Salato V, North PE, Bischoff J, Kumar SN, Fang Z, Rajan S, Hussain MM, Miao QR.) JCI Insight. 2021 02 08;6(3) PMID: 33400686 PMCID: PMC7934876 SCOPUS ID: 2-s2.0-85102090712 01/06/2021
Irradiation of the kidneys causes pathologic remodeling in the nontargeted heart: A role for the immune system.

(Lenarczyk M, Laiakis EC, Mattson DL, Johnson BD, Kronenberg A, North PE, Komorowski R, Mäder M, Baker JE.) FASEB Bioadv. 2020 Dec;2(12):705-719 PMID: 33336158 PMCID: PMC7734425 12/19/2020
Core Hippo pathway components act as a brake on Yap and Taz in the development and maintenance of the biliary network.

(Brandt ZJ, Echert AE, Bostrom JR, North PN, Link BA.) Development. 2020 06 22;147(12) PMID: 32439761 PMCID: PMC7328147 SCOPUS ID: 2-s2.0-85087440712 05/23/2020
Donor fraction cell-free DNA and rejection in adult and pediatric heart transplantation.

(Richmond ME, Zangwill SD, Kindel SJ, Deshpande SR, Schroder JN, Bichell DP, Knecht KR, Mahle WT, Wigger MA, Gaglianello NA, Pahl E, Simpson PM, Dasgupta M, North PE, Hidestrand M, Tomita-Mitchell A, Mitchell ME.) J Heart Lung Transplant. 2020 05;39(5):454-463 PMID: 31983667 SCOPUS ID: 2-s2.0-85078178592 01/28/2020
Early changes in cell-free DNA levels in newly transplanted heart transplant patients.

(Zangwill SD, Kindel SJ, Ragalie WS, North PE, Pollow A, Hidestrand M, Tomita-Mitchell A, Stamm KD, Mitchell ME.) Pediatr Transplant. 2020 02;24(1):e13622 PMID: 31825144 PMCID: PMC7065377 SCOPUS ID: 2-s2.0-85076338475 12/12/2019
Cell-free DNA donor fraction analysis in pediatric and adult heart transplant patients by multiplexed allele-specific quantitative PCR: Validation of a rapid and highly sensitive clinical test for stratification of rejection probability.

(North PE, Ziegler E, Mahnke DK, Stamm KD, Thomm A, Daft P, Goetsch M, Liang HL, Baker MA, Vepraskas A, Rosenau C, Dasgupta M, Simpson P, Mitchell ME, Tomita-Mitchell A.) PLoS One. 2020;15(1):e0227385 PMID: 31929557 PMCID: PMC6957190 SCOPUS ID: 2-s2.0-85077765307 01/14/2020