Paula E. North, MD, PhD

Professor

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Locations

Children's Wisconsin - Milwaukee
Froedtert Hospital
Pathology - Children's

Specialties

Pathology
Pediatric Pathology

Languages

English

Children's Central Scheduling

(414) 266-2860

Education

MD - Doctor of Medicine
PhD

Biography

Dr. North is Professor of Pathology at the Medical College of Wisconsin with a secondary appointment in the MCW Institute for Health and Society. Her primary clinical service responsibilities are in the Division of Pediatric Pathology at Children's Wisconsin. She currently serves as Department Chief for the Children's Medical and Dental Staff in Pathology and Laboratory Medicine. She founded and continues as Scientific Director of the Children's Research Institute Histology Core, a state-of-the-art research-supportive facility that has continually offered a wide range of histology services and Pathology expertise to investigators at MCW and its affiliated institutions since 2006. Dr. North's research program and anatomic clinical practice is most focused in the areas of vascular anomalies and global environmental health.

Research Interests

Pathogenic mechanisms in vascular tumors and malformations of infancy and childhood

Pediatric molecular diagnostics

Global laboratory medicine – development of sustainable models for telepathology-supported laboratory testing in challenging environments

Unusual Deep Infantile Hemangioma Presentation with Orbital Involvement.

(Hammond A, North P, Stiff H.) Ophthalmology. 2024 May;131(5):567 PMID: 37480910 SCOPUS ID: 2-s2.0-85165684276 07/23/2023
Profibrotic COVID-19 subphenotype exhibits enhanced localized ER-dependent HSP47+ expression in cardiac myofibroblasts in situ.

(Jacobs ER, Ross GR, Padilla N, Pan AY, Liegl M, Puzyrenko A, Lai S, Dai Q, Uche N, Rubenstein JC, North PE, Ibrahim EH, Sun Y, Felix JC, Rui H, Benjamin IJ.) J Mol Cell Cardiol. 2023 Dec;185:1-12 PMID: 37839656 PMCID: PMC11000691 SCOPUS ID: 2-s2.0-85174455933 10/16/2023
Nuclear Cell-Free DNA Predicts Adverse Events After Pediatric Cardiothoracic Surgery.

(Tanem JM, Scott JP, Hoffman GM, Niebler RA, Tomita-Mitchell A, Stamm KD, Liang HL, North PE, Bertrandt RA, Woods RK, Hraska V, Mitchell ME.) Ann Thorac Surg. 2023 Aug;116(2):349-356 PMID: 36332680 SCOPUS ID: 2-s2.0-85150823960 11/05/2022
Collagen-Specific HSP47+ Myofibroblasts and CD163+ Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS-CoV-2 Infections.

(Puzyrenko A, Jacobs ER, Padilla N, Devine A, Aljadah M, Gantner BN, Pan AY, Lai S, Dai Q, Rubenstein JC, North PE, Simpson PM, Willoughby RE, O'Meara CC, Flinn MA, Lough JW, Ibrahim EH, Zheng Z, Sun Y, Felix J, Hunt BC, Ross G, Rui H, Benjamin IJ.) J Am Heart Assoc. 2023 Feb 21;12(4):e027990 PMID: 36789856 PMCID: PMC10111490 SCOPUS ID: 2-s2.0-85148479620 02/16/2023
Validation of donor fraction cell-free DNA with biopsy-proven cardiac allograft rejection in children and adults.

(Richmond ME, Deshpande SR, Zangwill SD, Bichell DP, Kindel SJ, Mahle WT, Schroder JN, Wigger MA, Knecht KR, Pahl E, Gaglianello NA, Goetsch MA, Simpson P, Dasgupta M, Zhang L, North PE, Tomita-Mitchell A, Mitchell ME.) J Thorac Cardiovasc Surg. 2023 Feb;165(2):460-468.e2 PMID: 35643770 PMCID: PMC9617812 SCOPUS ID: 2-s2.0-85130912386 06/02/2022
Clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors-A prospective study and guidelines for clinical testing.

(Galbraith K, Vasudevaraja V, Serrano J, Shen G, Tran I, Abdallat N, Wen M, Patel S, Movahed-Ezazi M, Faustin A, Spino-Keeton M, Roberts LG, Maloku E, Drexler SA, Liechty BL, Pisapia D, Krasnozhen-Ratush O, Rosenblum M, Shroff S, Boué DR, Davidson C, Mao Q, Suchi M, North P, Hopp A, Segura A, Jarzembowski JA, Parsons L, Johnson MD, Mobley B, Samore W, McGuone D, Gopal PP, Canoll PD, Horbinski C, Fullmer JM, Farooqui MS, Gokden M, Wadhwani NR, Richardson TE, Umphlett M, Tsankova NM, DeWitt JC, Sen C, Placantonakis DG, Pacione D, Wisoff JH, Teresa Hidalgo E, Harter D, William CM, Cordova C, Kurz SC, Barbaro M, Orringer DA, Karajannis MA, Sulman EP, Gardner SL, Zagzag D, Tsirigos A, Allen JC, Golfinos JG, Snuderl M.) Neurooncol Adv. 2023;5(1):vdad076 PMID: 37476329 PMCID: PMC10355794 07/21/2023
Validation of donor fraction cell-free DNA with biopsy-proven cardiac allograft rejection in children and adults

(Richmond ME, Deshpande SR, Zangwill SD, Bichell DP, Kindel SJ, Mahle WT, Schroder JN, Wigger MA, Knecht KR, Pahl E, Gaglianello NA, Goetsch MA, Simpson P, Dasgupta M, Zhang L, North PE, Tomita-Mitchell A, Mitchell ME.) Journal of Thoracic and Cardiovascular Surgery. February 2023;165(2):460-468.e2 SCOPUS ID: 2-s2.0-85130912386 02/01/2023
A novel somatic mutation in GNAQ in a capillary malformation provides insight into molecular pathogenesis.

(Galeffi F, Snellings DA, Wetzel-Strong SE, Kastelic N, Bullock J, Gallione CJ, North PE, Marchuk DA.) Angiogenesis. 2022 Nov;25(4):493-502 PMID: 35635655 PMCID: PMC9529792 SCOPUS ID: 2-s2.0-85131102273 06/01/2022
Elevated nuclear and mitochondrial cell-free deoxyribonucleic acid measurements are associated with death after infant cardiac surgery.

(Scott JP, Tanem JM, Tomita-Mitchell A, Hoffman GM, Niebler RA, Liang HL, Simpson PM, Stamm KD, North PE, Mitchell ME.) J Thorac Cardiovasc Surg. 2022 Aug;164(2):367-375 PMID: 35144816 SCOPUS ID: 2-s2.0-85120861361 02/12/2022
Relationship between donor fraction cell-free DNA and clinical rejection in heart transplantation.

(Deshpande SR, Zangwill SD, Kindel SJ, Schroder JN, Bichell DP, Wigger MA, Richmond ME, Knecht KR, Pahl E, Gaglianello NA, Mahle WT, Stamm KD, Simpson PM, Dasgupta M, Zhang L, North PE, Tomita-Mitchell A, Mitchell ME.) Pediatr Transplant. 2022 Jun;26(4):e14264 PMID: 35258162 SCOPUS ID: 2-s2.0-85125904987 03/09/2022
Introduction of Mutant GNAQ into Endothelial Cells Induces a Vascular Malformation Phenotype with Therapeutic Response to Imatinib.

(Sasaki M, Jung Y, North P, Elsey J, Choate K, Toussaint MA, Huang C, Radi R, Perricone AJ, Corces VG, Arbiser JL.) Cancers (Basel). 2022 Jan 14;14(2) PMID: 35053574 PMCID: PMC8773683 01/22/2022
Increase in nuclear cell-free DNA is associated with major adverse events in adult and pediatric heart transplant recipients.

(Zangwill SD, Deshpande SR, Simpson PM, Liang HL, Zhang L, Dasgupta M, Richmond ME, Kindel SJ, Bichell DP, Mahle WT, Wigger MA, Schroder JN, Knecht KR, Pahl E, Gaglianello NA, North PE, Tomita-Mitchell A, Mitchell ME.) Clin Transplant. 2022 Jan;36(1):e14509 PMID: 34649304 SCOPUS ID: 2-s2.0-85120575732 10/15/2021