header-logo
GettyImages-609179959-hero
Pathology & Laboratory Medicine
Gustavo W. Leone, PhD

Gustavo W. Leone, PhD

Professor; Director, MCW Cancer Center; Senior Associate Dean of Cancer Research

Locations

  • CCC C5317

Contact Information

Education

Post-doctoral Training, Duke University Medical Center, 1994-1998
PhD, Virology, University of Calgary, 1994
BS, Biochemistry, University of Calgary, 1988

Biography

Gustavo W. Leone, PhD, started in his role as Director of the MCW Cancer Center, Senior Associate Dean of Cancer Research, and Professor of Biochemistry on April 15, 2020. Prior to his arrival at MCW, Dr. Leone served as the Director of the NCI-designated Hollings Cancer Center at the Medical University of South Carolina from March 2017 to April 2020. Dr. Leone’s past research includes graduate work in biochemical and biophysical approaches to study protein function and virology (reovirus), with a specific emphasis on mechanisms of viral mediated entry into host cells. As a postdoctoral fellow at Duke University, he had the seminal finding linking Cyclin Dependent Kinases to the control of E2F transcription factors and regulation of the cell cycle.

Research Interests

Currently, Dr. Leone has an active research program that utilizes genetic models (cell-based systems, worms, and mice) to study Rb/E2F & PTEN signaling in the context of cell cycle control, endoreduplication, developmental biology and cancer (endometrial, liver, pancreatic, and breast cancers), as well as the genetics and biology of PTEN and the tumor microenvironment. Dr. Leone’s research group has made seminal contributions in two broad areas of research, one in the role of the Rb/E2F pathway in development and cancer, and the other in signaling between cells within the tumor microenvironment.

Publications

Publications of Gustavo Leone PhD from the Faculty Collaboration Database

© 2025 Medical College of Wisconsin.  All rights reserved.  | Terms and Privacy | Web Accessibility Statement

Non-Discrimination Statement
The Medical College of Wisconsin (MCW) is committed to fostering a diverse community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual's race, color, national origin, religion, age, disability, sex, gender identity/expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, or military status. Employees, students, applicants or other members of the MCW community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic. MCW’s policy as well as federal and state laws and regulations prohibit unlawful discrimination and harassment.

Notice of Compliance with Laws and Commitment to Civil Rights
The Medical College of Wisconsin is committed to full compliance with all applicable federal, state, and local laws and regulations in the pursuit of our missions. Consistent with recent federal guidance, we affirm our commitment to individual merit, fairness, and equal treatment in all aspects of academic and institutional decision-making. As part of this commitment, we are actively reviewing our policies and materials to ensure they align with federal nondiscrimination obligations.