Our research will help to answer three major questions related to human heart repair:
1. Does a subpopulation of human cardiomyocytes possess a proliferative potential? If so, is it caused by ploidy composition and how can it be controlled?
2. What role does polyploid cardiomyocytes play in cardiac growth and repair?
3. How to induce human iPSC maturation in-vitro with further comprehension of the mechanisms directing cardiomyocyte terminal differentiation?
Ultimately, we will provide a cell biology view to better understand human heart disease and develop regenerative strategies.
Herma Heart Institute, Division of Pediatric Cardiology, Children’s Wisconsin
Cell biology, Neurobiology and Anatomy (CBNA), Cardiovascular Center, Medical College of Wisconsin
PhD in Molecular and Cell Biology, Chinese Academy of Science, Beijing, China
Post Doctoral Fellowship, University of Pittsburgh, Pittsburgh, PA
Browse my Research Profile in Medical College of Wisconsin Website.
- Congenital heart disease
- Cell biology in heart development and disease
Ankur is interested in understanding how polyploidy affects heart regeneration and also the gene expression differences at spatial-temporal levels in a regenerating heart.