Andrew D. Spearman, MD

Assistant Professor

Locations

Pediatric Cardiology
TBRC/CRI C2415

Contact Information

aspearman@mcw.edu

Education

Post-doctoral fellowship, Medical College of Wisconsin, 2019
Fellowship, Medical College of Wisconsin/Children's Wisconsin, 2018
Residency, University of Chicago, Comer Children's Hospital, 2015
MD, New York University School of Medicine, 2012
BS, The Ohio State University, 2008

Biography

Dr. Spearman is a physician-scientist and Assistant Professor of Pediatrics at the Medical College Wisconsin. He holds a secondary appointment in the Department of Cell and Developmental Biology at Medical College of Wisconsin. His research focuses on the pulmonary vascular complications of single ventricle congenital heart disease – specifically arteriovenous malformations and aortopulmonary collaterals. His research utilizes basic and translational approaches to study the mechanisms of vascular remodeling.

Research Interests

Vascular remodeling
Endothelial cell biology
Single ventricle congenital heart disease
Arteriovenous malformations

Glenn circulation causes early and progressive shunting in a surgical model of pulmonary arteriovenous malformations.

(Wan T, Rousseau H, Mattern C, Tabor M, Hodges MR, Ramchandran R, Spearman AD.) bioRxiv. 2024 Apr 05 PMID: 38617317 PMCID: PMC11014550 04/15/2024
Objective Quantification of Bilateral Bubble Contrast Echocardiography Correlates with Systemic Oxygenation in Patients with Single Ventricle Circulation.

(Phimister A, Bushee C, Merbach M, Challa SA, Pan AY, Spearman AD.) J Cardiovasc Dev Dis. 2024 Mar 01;11(3) PMID: 38535107 PMCID: PMC10971280 SCOPUS ID: 2-s2.0-85188897711 03/27/2024
Consistency of the continuous flow pressure gradient despite aortic arch anomalies co-existing with coarctation.

(Ghorbannia A, Spearman AD, Sawalhi S, Woods RK, Maadooliat M, LaDisa JF Jr.) medRxiv. 2023 Oct 30 PMID: 37961134 PMCID: PMC10635219 11/14/2023
Respiratory viral infections are prevalent but uncomplicated in single ventricle CHD.

(Calley BJ, Zhang L, Pan AY, Ginde S, Kindel SJ, Spearman AD.) Cardiol Young. 2023 Apr;33(4):557-563 PMID: 35438065 SCOPUS ID: 2-s2.0-85129367725 04/20/2022
Clinical Variables Associated with Pre-Fontan Aortopulmonary Collateral Burden.

(Segar DE, Pan AY, McLennan DI, Kindel SJ, Handler SS, Ginde S, Woods RK, Goot BH, Spearman AD.) Pediatr Cardiol. 2023 Jan;44(1):228-236 PMID: 36156171 PMCID: PMC10155213 SCOPUS ID: 2-s2.0-85138742613 09/27/2022
Pulmonary Vascular Sequelae of Palliated Single Ventricle Circulation: Arteriovenous Malformations and Aortopulmonary Collaterals.

(Spearman AD, Ginde S.) J Cardiovasc Dev Dis. 2022 Sep 17;9(9) PMID: 36135454 PMCID: PMC9501802 09/23/2022
Cilia proteins are biomarkers of altered flow in the vasculature.

(Gupta A, Thirugnanam K, Thamilarasan M, Mohieldin AM, Zedan HT, Prabhudesai S, Griffin MR, Spearman AD, Pan A, Palecek SP, Yalcin HC, Nauli SM, Rarick KR, Zennadi R, Ramchandran R.) JCI Insight. 2022 Mar 22;7(6) PMID: 35143420 PMCID: PMC8986075 SCOPUS ID: 2-s2.0-85127051401 02/11/2022
Hepatic factor may not originate from hepatocytes.

(Merbach M, Ramchandran R, Spearman AD.) Front Cardiovasc Med. 2022;9:999315 PMID: 36148055 PMCID: PMC9486074 SCOPUS ID: 2-s2.0-85138339927 09/24/2022
Increases in oxygen saturation following discharge from Fontan palliation - an indicator of resolution of pulmonary arteriovenous malformations?

(Van Galder H, Schaal AM, Feng M, Pan AY, Frommelt MA, Ginde S, Spearman AD.) Cardiol Young. 2021 Nov;31(11):1807-1813 PMID: 33691814 SCOPUS ID: 2-s2.0-85102391562 03/12/2021
sVEGFR1 Is Enriched in Hepatic Vein Blood-Evidence for a Provisional Hepatic Factor Candidate?

(Spearman AD, Gupta A, Pan AY, Gudausky TM, Foerster SR, Konduri GG, Ramchandran R.) Front Pediatr. 2021;9:679572 PMID: 34195162 PMCID: PMC8236596 SCOPUS ID: 2-s2.0-85115450112 07/02/2021
Echocardiographic Identification of Pulmonary Artery Flow Reversal: An Indicator of Adverse Outcomes in Single Ventricle Physiology.

(Spearman AD, Ginde S, Goot BH, Schaal AM, Feng M, Pan AY, Frommelt MA, Frommelt PC.) Pediatr Cardiol. 2020 Dec;41(8):1632-1638 PMID: 32710282 SCOPUS ID: 2-s2.0-85088376513 07/28/2020
Hepatic Vein Blood Increases Lung Microvascular Angiogenesis and Endothelial Cell Survival-Toward an Understanding of Univentricular Circulation.

(Spearman AD, Gupta A, Pan AY, Gronseth EI, Thirugnanam K, Gudausky TM, Foerster SR, Ramchandran R.) Semin Thorac Cardiovasc Surg. 2020 Winter;32(4):980-987 PMID: 32387780 PMCID: PMC7647938 SCOPUS ID: 2-s2.0-85086171858 05/11/2020