Wei Liu, PhD

Publications

• CXXC5 drove inflammation and ovarian cancer proliferation via transcriptional activation of ZNF143 and EGR1.

  (Geng T, Sun Q, He J, Chen Y, Cheng W, Shen J, Liu B, Zhang M, Wang S, Asan K, Song M, Gao Q, Song Y, Liu R, Liu X, Ding Y, Jing A, Ye X, Ren H, Zeng K, Zhou Y, Zhang B, Ma S, Liu W, Liu S, Ji J.) Cell Signal. 2024 Apr 19;119:111180 PMID: 38642782 SCOPUS ID: 2-s2.0-85190884720 04/21/2024

• FBXO5-mediated RNF183 degradation prevents endoplasmic reticulum stress-induced apoptosis and promotes colon cancer progression.

  (Ji J, Jing A, Ding Y, Ma X, Qian Q, Geng T, Cheng W, Zhang M, Sun Q, Ma S, Wang X, Yuan Q, Xu M, Qin J, Ma L, Yang J, He J, Du Q, Xia M, Xu Y, Chen Z, Zhu L, Liu W, Liu S, Liu B.) Cell Death Dis. 2024 Jan 11;15(1):33 PMID: 38212299 PMCID: PMC10784456 SCOPUS ID: 2-s2.0-85182091692 01/12/2024

• Structure-Based Lead Optimization of Enterovirus D68 2A Protease Inhibitors.

  (Tan B, Liu C, Li K, Jadhav P, Lambrinidis G, Zhu L, Olson L, Tan H, Wen Y, Kolocouris A, Liu W, Wang J.) J Med Chem. 2023 Nov 09;66(21):14544-14563 PMID: 37857371 SCOPUS ID: 2-s2.0-85176509223 10/20/2023

• Editorial: Protein modifications in epigenetic dysfunctional diseases: mechanisms and potential therapeutic strategies.

  (Ji J, Jing A, Geng T, Ma X, Liu W, Liu B.) Front Cell Dev Biol. 2023;11:1216637 PMID: 37255602 PMCID: PMC10225621 SCOPUS ID: 2-s2.0-85161055462 05/31/2023

• Cryo-EM structure of the human adenosine A2B receptor-Gs signaling complex.

  (Chen Y, Zhang J, Weng Y, Xu Y, Lu W, Liu W, Liu M, Hua T, Song G.) Sci Adv. 2022 Dec 23;8(51):eadd3709 PMID: 36563137 PMCID: PMC9788782 12/24/2022

• An Isochroman Analog of CD3254 and Allyl-, Isochroman-Analogs of NEt-TMN Prove to Be More Potent Retinoid-X-Receptor (RXR) Selective Agonists Than Bexarotene.

  (Jurutka PW, di Martino O, Reshi S, Mallick S, Sausedo MA, Moen GA, Lee IJ, Ivan DJ, Krall TD, Peoples SJ, Perez A, Tromba L, Le A, Khadka I, Petros R, Savage BM, Salama E, Salama J, Ziller JW, Noh Y, Lee MY, Liu W, Welch JS, Marshall PA, Wagner CE.) Int J Mol Sci. 2022 Dec 19;23(24) PMID: 36555852 PMCID: PMC9782500 12/24/2022

• Structural basis for receptor selectivity and inverse agonism in S1P5 receptors.

  (Lyapina E, Marin E, Gusach A, Orekhov P, Gerasimov A, Luginina A, Vakhrameev D, Ergasheva M, Kovaleva M, Khusainov G, Khorn P, Shevtsov M, Kovalev K, Bukhdruker S, Okhrimenko I, Popov P, Hu H, Weierstall U, Liu W, Cho Y, Gushchin I, Rogachev A, Bourenkov G, Park S, Park G, Hyun HJ, Park J, Gordeliy V, Borshchevskiy V, Mishin A, Cherezov V.) Nat Commun. 2022 Aug 12;13(1):4736 PMID: 35961984 PMCID: PMC9374744 SCOPUS ID: 2-s2.0-85135832975 08/13/2022

• Structures of β1-adrenergic receptor in complex with Gs and ligands of different efficacies.

  (Su M, Paknejad N, Zhu L, Wang J, Do HN, Miao Y, Liu W, Hite RK, Huang XY.) Nat Commun. 2022 Jul 14;13(1):4095 PMID: 35835792 PMCID: PMC9283524 SCOPUS ID: 2-s2.0-85134147752 07/15/2022

• Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.

  (Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY.) Nat Commun. 2022 Feb 08;13(1):731 PMID: 35136060 PMCID: PMC8826421 SCOPUS ID: 2-s2.0-85124279039 02/10/2022

• Modeling, Synthesis, and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahyro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(4-isobutoxy-3-isopropylphenyl)amino)nicotinic Acid (NEt-4IB).

  (Jurutka PW, di Martino O, Reshi S, Mallick S, Sabir ZL, Staniszewski LJP, Warda A, Maiorella EL, Minasian A, Davidson J, Ibrahim SJ, Raban S, Haddad D, Khamisi M, Suban SL, Dawson BJ, Candia R, Ziller JW, Lee MY, Liu C, Liu W, Marshall PA, Welch JS, Wagner CE.) Int J Mol Sci. 2021 Nov 16;22(22) PMID: 34830251 PMCID: PMC8624485 SCOPUS ID: 2-s2.0-85119007925 11/28/2021

• Protein expression and purification of G-protein coupled receptor kinase 6 (GRK6), toward structure-based drug design and discovery for multiple myeloma.

  (Olson TL, Zhang S, Labban D, Kaschner E, Aceves M, Iyer S, Meza-Aguilar JD, Zook JD, Chun E, Craciunescu FM, Liu W, Shi CX, Stewart AK, Hansen DT, Meurice N, Fromme P.) Protein Expr Purif. 2021 Sep;185:105890 PMID: 33971243 SCOPUS ID: 2-s2.0-85106932337 05/11/2021

• Molecular basis for lipid recognition by the prostaglandin D2 receptor CRTH2.

  (Liu H, Deepak RNVK, Shiriaeva A, Gati C, Batyuk A, Hu H, Weierstall U, Liu W, Wang L, Cherezov V, Fan H, Zhang C.) Proc Natl Acad Sci U S A. 2021 Aug 10;118(32) PMID: 34341104 PMCID: PMC8364189 SCOPUS ID: 2-s2.0-85111810793 08/04/2021