Wei Liu, PhD

Publications

• Structural basis for receptor selectivity and inverse agonism in S1P5 receptors.

  (Lyapina E, Marin E, Gusach A, Orekhov P, Gerasimov A, Luginina A, Vakhrameev D, Ergasheva M, Kovaleva M, Khusainov G, Khorn P, Shevtsov M, Kovalev K, Bukhdruker S, Okhrimenko I, Popov P, Hu H, Weierstall U, Liu W, Cho Y, Gushchin I, Rogachev A, Bourenkov G, Park S, Park G, Hyun HJ, Park J, Gordeliy V, Borshchevskiy V, Mishin A, Cherezov V.) Nat Commun. 2022 Aug 12;13(1):4736 PMID: 35961984 PMCID: PMC9374744 SCOPUS ID: 2-s2.0-85135832975 08/13/2022

• Structures of β1-adrenergic receptor in complex with Gs and ligands of different efficacies.

  (Su M, Paknejad N, Zhu L, Wang J, Do HN, Miao Y, Liu W, Hite RK, Huang XY.) Nat Commun. 2022 Jul 14;13(1):4095 PMID: 35835792 PMCID: PMC9283524 SCOPUS ID: 2-s2.0-85134147752 07/15/2022

• Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.

  (Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY.) Nat Commun. 2022 Feb 08;13(1):731 PMID: 35136060 PMCID: PMC8826421 SCOPUS ID: 2-s2.0-85124279039 02/10/2022

• Modeling, Synthesis, and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahyro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(4-isobutoxy-3-isopropylphenyl)amino)nicotinic Acid (NEt-4IB).

  (Jurutka PW, di Martino O, Reshi S, Mallick S, Sabir ZL, Staniszewski LJP, Warda A, Maiorella EL, Minasian A, Davidson J, Ibrahim SJ, Raban S, Haddad D, Khamisi M, Suban SL, Dawson BJ, Candia R, Ziller JW, Lee MY, Liu C, Liu W, Marshall PA, Welch JS, Wagner CE.) Int J Mol Sci. 2021 Nov 16;22(22) PMID: 34830251 PMCID: PMC8624485 SCOPUS ID: 2-s2.0-85119007925 11/28/2021

• Protein expression and purification of G-protein coupled receptor kinase 6 (GRK6), toward structure-based drug design and discovery for multiple myeloma.

  (Olson TL, Zhang S, Labban D, Kaschner E, Aceves M, Iyer S, Meza-Aguilar JD, Zook JD, Chun E, Craciunescu FM, Liu W, Shi CX, Stewart AK, Hansen DT, Meurice N, Fromme P.) Protein Expr Purif. 2021 Sep;185:105890 PMID: 33971243 SCOPUS ID: 2-s2.0-85106932337 05/11/2021

• Evidence that specific interactions play a role in the cholesterol sensitivity of G protein-coupled receptors.

  (Geiger J, Sexton R, Al-Sahouri Z, Lee MY, Chun E, Harikumar KG, Miller LJ, Beckstein O, Liu W.) Biochim Biophys Acta Biomembr. 2021 Sep 01;1863(9):183557 PMID: 33444621 PMCID: PMC8656464 SCOPUS ID: 2-s2.0-85099613775 01/15/2021

• Molecular basis for lipid recognition by the prostaglandin D2 receptor CRTH2.

  (Liu H, Deepak RNVK, Shiriaeva A, Gati C, Batyuk A, Hu H, Weierstall U, Liu W, Wang L, Cherezov V, Fan H, Zhang C.) Proc Natl Acad Sci U S A. 2021 Aug 10;118(32) PMID: 34341104 PMCID: PMC8364189 SCOPUS ID: 2-s2.0-85111810793 08/04/2021

• Harnessing the power of an X-ray laser for serial crystallography of membrane proteins crystallized in lipidic cubic phase.

  (Lee MY, Geiger J, Ishchenko A, Han GW, Barty A, White TA, Gati C, Batyuk A, Hunter MS, Aquila A, Boutet S, Weierstall U, Cherezov V, Liu W.) IUCrJ. 2020 Nov 01;7(Pt 6):976-984 PMID: 33209312 PMCID: PMC7642783 11/20/2020

• Serial Crystallography for Structure-Based Drug Discovery.

  (Zhu L, Chen X, Abola EE, Jing L, Liu W.) Trends Pharmacol Sci. 2020 Nov;41(11):830-839 PMID: 32950259 PMCID: PMC7572805 SCOPUS ID: 2-s2.0-85091103704 09/21/2020

• Structure Determination from Lipidic Cubic Phase Embedded Microcrystals by MicroED.

  (Zhu L, Bu G, Jing L, Shi D, Lee MY, Gonen T, Liu W, Nannenga BL.) Structure. 2020 Oct 06;28(10):1149-1159.e4 PMID: 32735770 PMCID: PMC7544639 SCOPUS ID: 2-s2.0-85089367384 08/01/2020

• Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β1-Adrenergic Receptor.

  (Su M, Zhu L, Zhang Y, Paknejad N, Dey R, Huang J, Lee MY, Williams D, Jordan KD, Eng ET, Ernst OP, Meyerson JR, Hite RK, Walz T, Liu W, Huang XY.) Mol Cell. 2020 Oct 01;80(1):59-71.e4 PMID: 32818430 PMCID: PMC7541785 SCOPUS ID: 2-s2.0-85090205426 08/21/2020

• XFEL and NMR Structures of Francisella Lipoprotein Reveal Conformational Space of Drug Target against Tularemia.

  (Zook J, Shekhar M, Hansen D, Conrad C, Grant T, Gupta C, White T, Barty A, Basu S, Zhao Y, Zatsepin N, Ishchenko A, Batyuk A, Gati C, Li C, Galli L, Coe J, Hunter M, Liang M, Weierstall U, Nelson G, James D, Stauch B, Craciunescu F, Thifault D, Liu W, Cherezov V, Singharoy A, Fromme P.) Structure. 2020 May 05;28(5):540-547.e3 PMID: 32142641 PMCID: PMC9014820 SCOPUS ID: 2-s2.0-85083862415 03/07/2020