Allen W. Cowley, Jr., PhD
Harry & Gertrude Hack Term Professorship in Physiology
BA, Economics, Trinity College, 1961
Allen W. Cowley, Jr., PhD has been Professor and Chair of the Department of Physiology at the Medical College of Wisconsin since 1980. He earned his doctorate in Physiology from Hahnemann Medical College in Philadelphia, Pennsylvania working with Dr. John Scott before joining Dr. Arthur Guyton in the department of Physiology and Biophysics at the University of Mississippi Medical Center where he rose to the rank of Professor.
Dr. Cowley has served as President of the American Physiological Society (APS) as well as the President of the International Union of Physiological Sciences and Chair of the Council for High Blood Pressure Research of the American Heart Association (AHA). He has received the Walter Cannon, the Ernest Starling, the Carl Wiggers, and Ray Daggs Awards from the APS and the Novartis Award from the Council for High Blood Pressure Research and the Distinguished Scientist Award of the AHA. His research has been continuously funded by the National Institutes of Health since 1971 during which time he has mentored over fifty fellows and students in his laboratory resulting in over 325 publications in peer-reviewed journals.
- Professor and Chairman, Department of Physiology
Cardiovascular Physiology | Genetics and Genomics | Renal Physiology
Dr. Cowley has made seminal findings related to the role of the baroreceptor reflexes, the renin-angiotensin system and vasopressin in both the short and long-term regulation of arterial blood pressure. His research has revealed the importance of the renal medullary circulation in sodium homeostasis and the long-term control or arterial pressure. He proposed the novel hypothesis and then demonstrated that small reductions of blood flow to medulla of the kidney can produce chronic hypertension. More recent work has determined the impact of arterial pressure on the production of oxidative stress and renal injury in the renal medulla of hypertensive rats. During the past decade, he has pioneered efforts to attach systems level biology to the genome providing novel insights into the location of genes that underlie complex disease planting the seeds for the field now referred to as "physiological genomics".
Currently he directs two program project grants; one focused on the kidney and the physiological mechanism of blood pressure control and the second exploring the genetic basis of salt-sensitive hypertension.
Fields of major interest
Recently released report by The National Academies of Sciences, Engineering, and Medicine proposes significant changes in understanding and managing temporomandibular disorders.
(Greene CS, Kusiak JW, Cowley T, Cowley AW Jr.) J Prosthet Dent. 2022 Nov;128(5):845-846 PMID: 35491258 05/02/2022
Acute Increase of Renal Perfusion Pressure Causes Rapid Activation of mTORC1 (Mechanistic Target Of Rapamycin Complex 1) and Leukocyte Infiltration.
(Shimada S, Yang C, Kumar V, Mattson DL, Cowley AW Jr.) Hypertension. 2022 Jun;79(6):1180-1189 PMID: 35291809 PMCID: PMC9098670 03/17/2022
Divergent roles of angiotensin II upon the immediate and sustained increases of renal blood flow following unilateral nephrectomy.
(Shimada S, Yang C, Kurth T, Cowley AW Jr.) Am J Physiol Renal Physiol. 2022 May 01;322(5):F473-F485 PMID: 35224992 PMCID: PMC8977133 03/01/2022
Unique Associations of DNA Methylation Regions With 24-Hour Blood Pressure Phenotypes in Black Participants.
(Roberts ML, Kotchen TA, Pan X, Li Y, Yang C, Liu P, Wang T, Laud PW, Chelius TH, Munyura Y, Mattson DL, Liu Y, Cowley AW Jr, Kidambi S, Liang M.) Hypertension. 2022 Apr;79(4):761-772 PMID: 34994206 PMCID: PMC8917053 SCOPUS ID: 2-s2.0-85126152389 01/08/2022
Long-Term Continuous Measurement of Renal Blood Flow in Conscious Rats.
(Shimada S, Cowley AW Jr.) J Vis Exp. 2022 Feb 08(180) PMID: 35225288 03/01/2022
Substrate-dependent differential regulation of mitochondrial bioenergetics in the heart and kidney cortex and outer medulla.
(Tomar N, Zhang X, Kandel SM, Sadri S, Yang C, Liang M, Audi SH, Cowley AW Jr, Dash RK.) Biochim Biophys Acta Bioenerg. 2022 Feb 01;1863(2):148518 PMID: 34864090 PMCID: PMC8957717 SCOPUS ID: 2-s2.0-85120828118 12/06/2021
Advancing Physiology with Expanded Multi-Omics.
(Liang M, Cowley AW Jr, Greene AS, Geurts AM, Liu P, Liu Y, Rao S.) Function (Oxf). 2022;3(4):zqac031 PMID: 35801086 PMCID: PMC9247404 07/09/2022
Assuring the Future of Basic Biomedical Science.
(Cowley AW Jr.) Function (Oxf). 2022;3(2):zqac006 PMID: 35399492 PMCID: PMC8991019 04/12/2022
Recently Released Report by Major Scientific Academy Proposes Significant Changes in Understanding and Managing Temporomandibular Disorders.
(Greene CS, Kusiak JW, Cowley T, Cowley AW Jr.) J Oral Maxillofac Surg. 2022 Jan;80(1):8-9 PMID: 34252367 07/13/2021
Substrate- and Calcium-Dependent Differential Regulation of Mitochondrial Oxidative Phosphorylation and Energy Production in the Heart and Kidney.
(Zhang X, Tomar N, Kandel SM, Audi SH, Cowley AW Jr, Dash RK.) Cells. 2021 Dec 31;11(1) PMID: 35011693 PMCID: PMC8750792 SCOPUS ID: 2-s2.0-85122006134 01/12/2022
Theodore Allen Kotchen, MD: June 27, 1938-July 6, 2021.
(Cowley AW Jr, Kidambi S, Liang M, Grim C, Hamet P.) Hypertension. 2021 Dec;78(6):1674-1676 PMID: 34719936 SCOPUS ID: 2-s2.0-85121955751 11/02/2021
Global identification and characterization of tRNA-derived RNA fragment landscapes across human cancers.
(Sun X, Yang J, Yu M, Yao D, Zhou L, Li X, Qiu Q, Lin W, Lu B, Chen E, Wang P, Chen W, Tao S, Xu H, Williams A, Liu Y, Pan X, Cowley AW Jr, Lu W, Liang M, Liu P, Lu Y.) NAR Cancer. 2020 Dec;2(4):zcaa031 PMID: 34316691 PMCID: PMC8210304 07/29/2021