Anne E. Kwitek | Associate Professor | Medical College of Wisconsin

Anne E. Kwitek, PhD

Associate Professor, Physiology & Medicine

Locations

Physiology

Contact Information

Education

BS, Biology and Chemistry, University of Wisconsin at Stevens Point
PhD, Interdisciplinary Graduate Program in Genetics, University of Iowa

Biography

Dr. Kwitek is an Associate Professor in Physiology and Medicine. Before being recruited to MCW in 2019, she was a faculty member of the Pharmacology Department and the Associate Director of the Iowa Institute of Human Genetics at the University of Iowa. Dr Kwitek has 103 papers, reviews, and chapters with over 8000 citations and has been funded by the NIH, VA, USDA, and the American Heart Association. Dr Kwitek has also been an active teacher and mentor. She directly mentored over 30 students ranging from high school level through postdoctoral fellows, most of whom are pursuing careers in academic research or health care professions. Dr Kwitek is a fellow of the American Heart Association (AHA), has served on numerous committees in the AHA and the American Physiological Society and has served on national and international advisory boards involving human and rat genomic resources. She has participated in several NIH study sections as an ad hoc member and is currently a regular member of the NHLBI PPG Parent Committee (HLBP).

Research Interests

Dr. Kwitek’s major research focus involves understanding the genetic susceptibility to complex human diseases, with a focus on obesity, hypertension, and cardiometabolic disease. The approach involves integrating genetics, genomics, and other ‘omics’ approaches to identify genes and mechanisms leading to complex disease using rat models and human populations. Her studies also involve how genomic variation affects and is affected by environmental stimuli to influence susceptibility to cardiometabolic disease.

Chromosome 2 Fragment Substitutions in Dahl Salt-Sensitive Rats and RNA Sequencing Identified Enpep and Hs2st1 as Vascular Inflammatory Modulators.

(Berillo O, Ouerd S, Idris-Khodja N, Rehman A, Richer C, Sinnett D, Kwitek AE, Paradis P, Schiffrin EL.) Hypertension. 2020 Nov 09:HYPERTENSIONAHA12015690 PMID: 33161775 11/10/2020
Single-Nucleus RNA Sequencing of the Hypothalamic Arcuate Nucleus of C57BL/6J Mice After Prolonged Diet-Induced Obesity.

(Deng G, Morselli LL, Wagner VA, Balapattabi K, Sapouckey SA, Knudtson KL, Rahmouni K, Cui H, Sigmund CD, Kwitek AE, Grobe JL.) Hypertension. 2020 Aug;76(2):589-597 PMID: 32507042 PMCID: PMC7347451 SCOPUS ID: 2-s2.0-85087901067 06/09/2020
Reduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice.

(Perschbacher KJ, Deng G, Sandgren JA, Walsh JW, Witcher PC, Sapouckey SA, Owens CE, Zhang SY, Scroggins SM, Pearson NA, Devor EJ, Sebag JA, Pierce GL, Fisher RA, Kwitek AE, Santillan DA, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL.) Hypertension. 2020 02;75(2):569-579 PMID: 31865781 PMCID: PMC7027931 SCOPUS ID: 2-s2.0-85077761676 12/24/2019
The Year of the Rat: The Rat Genome Database at 20: a multi-species knowledgebase and analysis platform.

(Smith JR, Hayman GT, Wang SJ, Laulederkind SJF, Hoffman MJ, Kaldunski ML, Tutaj M, Thota J, Nalabolu HS, Ellanki SLR, Tutaj MA, De Pons JL, Kwitek AE, Dwinell MR, Shimoyama ME.) Nucleic Acids Res. 2020 01 08;48(D1):D731-D742 PMID: 31713623 PMCID: PMC7145519 SCOPUS ID: 2-s2.0-85077666371 11/13/2019
Targeted broad-based genetic testing by next-generation sequencing informs diagnosis and facilitates management in patients with kidney diseases.

(Mansilla MA, Sompallae RR, Nishimura CJ, Kwitek AE, Kimble MJ, Freese ME, Campbell CA, Smith RJ, Thomas CP.) Nephrol Dial Transplant. 2019 Nov 18 PMID: 31738409 11/19/2019
Rat Models of Metabolic Syndrome.

(Kwitek AE.) Methods Mol Biol. 2019;2018:269-285 PMID: 31228162 PMCID: PMC7315404 06/23/2019
Cervical vagal nerve stimulation impairs glucose tolerance and suppresses insulin release in conscious rats.

(Stauss HM, Stangl H, Clark KC, Kwitek AE, Lira VA.) Physiol Rep. 2018 12;6(24):e13953 PMID: 30569658 PMCID: PMC6300710 12/21/2018
Genome variation and conserved regulation identify genomic regions responsible for strain specific phenotypes in rat.

(Martín-Gálvez D, Dunoyer de Segonzac D, Ma MCJ, Kwitek AE, Thybert D, Flicek P.) BMC Genomics. 2017 12 22;18(1):986 PMID: 29272997 PMCID: PMC5741965 12/24/2017
Screening of Living Kidney Donors for Genetic Diseases Using a Comprehensive Genetic Testing Strategy.

(Thomas CP, Mansilla MA, Sompallae R, Mason SO, Nishimura CJ, Kimble MJ, Campbell CA, Kwitek AE, Darbro BW, Stewart ZA, Smith RJ.) Am J Transplant. 2017 02;17(2):401-410 PMID: 27434427 PMCID: PMC5297870 07/20/2016
Contribution of independent and pleiotropic genetic effects in the metabolic syndrome in a hypertensive rat.

(Ma MCJ, Pettus JM, Jakoubek JA, Traxler MG, Clark KC, Mennie AK, Kwitek AE.) PLoS One. 2017;12(8):e0182650 PMID: 28792545 PMCID: PMC5549746 08/10/2017
Systems biology with high-throughput sequencing reveals genetic mechanisms underlying the metabolic syndrome in the Lyon hypertensive rat.

(Wang J, Ma MC, Mennie AK, Pettus JM, Xu Y, Lin L, Traxler MG, Jakoubek J, Atanur SS, Aitman TJ, Xing Y, Kwitek AE.) Circ Cardiovasc Genet. 2015 Apr;8(2):316-26 PMID: 25573024 PMCID: PMC4406788 01/13/2015
An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge.

(Brownstein CA, Beggs AH, Homer N, Merriman B, Yu TW, Flannery KC, DeChene ET, Towne MC, Savage SK, Price EN, Holm IA, Luquette LJ, Lyon E, Majzoub J, Neupert P, McCallie D Jr, Szolovits P, Willard HF, Mendelsohn NJ, Temme R, Finkel RS, Yum SW, Medne L, Sunyaev SR, Adzhubey I, Cassa CA, de Bakker PI, Duzkale H, Dworzyński P, Fairbrother W, Francioli L, Funke BH, Giovanni MA, Handsaker RE, Lage K, Lebo MS, Lek M, Leshchiner I, MacArthur DG, McLaughlin HM, Murray MF, Pers TH, Polak PP, Raychaudhuri S, Rehm HL, Soemedi R, Stitziel NO, Vestecka S, Supper J, Gugenmus C, Klocke B, Hahn A, Schubach M, Menzel M, Biskup S, Freisinger P, Deng M, Braun M, Perner S, Smith RJ, Andorf JL, Huang J, Ryckman K, Sheffield VC, Stone EM, Bair T, Black-Ziegelbein EA, Braun TA, Darbro B, DeLuca AP, Kolbe DL, Scheetz TE, Shearer AE, Sompallae R, Wang K, Bassuk AG, Edens E, Mathews K, Moore SA, Shchelochkov OA, Trapane P, Bossler A, Campbell CA, Heusel JW, Kwitek A, Maga T, Panzer K, Wassink T, Van Daele D, Azaiez H, Booth K, Meyer N, Segal MM, Williams MS, Tromp G, White P, Corsmeier D, Fitzgerald-Butt S, Herman G, Lamb-Thrush D, McBride KL, Newsom D, Pierson CR, Rakowsky AT, Maver A, Lovrečić L, Palandačić A, Peterlin B, Torkamani A, Wedell A, Huss M, Alexeyenko A, Lindvall JM, Magnusson M, Nilsson D, Stranneheim H, Taylan F, Gilissen C, Hoischen A, van Bon B, Yntema H, Nelen M, Zhang W, Sager J, Zhang L, Blair K, Kural D, Cariaso M, Lennon GG, Javed A, Agrawal S, Ng PC, Sandhu KS, Krishna S, Veeramachaneni V, Isakov O, Halperin E, Friedman E, Shomron N, Glusman G, Roach JC, Caballero J, Cox HC, Mauldin D, Ament SA, Rowen L, Richards DR, San Lucas FA, Gonzalez-Garay ML, Caskey CT, Bai Y, Huang Y, Fang F, Zhang Y, Wang Z, Barrera J, Garcia-Lobo JM, González-Lamuño D, Llorca J, Rodriguez MC, Varela I, Reese MG, De La Vega FM, Kiruluta E, Cargill M, Hart RK, Sorenson JM, Lyon GJ, Stevenson DA, Bray BE, Moore BM, Eilbeck K, Yandell M, Zhao H, Hou L, Chen X, Yan X, Chen M, Li C, Yang C, Gunel M, Li P, Kong Y, Alexander AC, Albertyn ZI, Boycott KM, Bulman DE, Gordon PM, Innes AM, Knoppers BM, Majewski J, Marshall CR, Parboosingh JS, Sawyer SL, Samuels ME, Schwartzentruber J, Kohane IS, Margulies DM.) Genome Biol. 2014 Mar 25;15(3):R53 PMID: 24667040 PMCID: PMC4073084 03/29/2014

Physiology