
Anne E. Kwitek, PhD
Associate Professor, Physiology & Medicine
Locations
- Physiology
Contact Information
Education
PhD, Interdisciplinary Graduate Program in Genetics, University of Iowa
Biography
Dr. Kwitek is an Associate Professor in Physiology and Medicine. Before being recruited to MCW in 2019, she was a faculty member of the Pharmacology Department and the Associate Director of the Iowa Institute of Human Genetics at the University of Iowa. Dr Kwitek has 103 papers, reviews, and chapters with over 8000 citations and has been funded by the NIH, VA, USDA, and the American Heart Association. Dr Kwitek has also been an active teacher and mentor. She directly mentored over 30 students ranging from high school level through postdoctoral fellows, most of whom are pursuing careers in academic research or health care professions. Dr Kwitek is a fellow of the American Heart Association (AHA), has served on numerous committees in the AHA and the American Physiological Society and has served on national and international advisory boards involving human and rat genomic resources. She has participated in several NIH study sections as an ad hoc member and is currently a regular member of the NHLBI PPG Parent Committee (HLBP).
Research Areas of Interest
- Cardiovascular Diseases
- Computational Biology
- Database Management Systems
- Databases, Genetic
- Disease Models, Animal
- Gene Expression Regulation
- Genetic Linkage
- Genetic Predisposition to Disease
- Genetic Variation
- Genome, Human
- Genomics
- Hypertension
Research Interests
Dr. Kwitek’s major research focus involves understanding the genetic susceptibility to complex human diseases, with a focus on obesity, hypertension, and cardiometabolic disease. The approach involves integrating genetics, genomics, and other ‘omics’ approaches to identify genes and mechanisms leading to complex disease using rat models and human populations. Her studies also involve how genomic variation affects and is affected by environmental stimuli to influence susceptibility to cardiometabolic disease.
Publications
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(Patil CN, Ritter ML, Wackman KK, Oliveira V, Balapattabi K, Grobe CC, Brozoski DT, Reho JJ, Nakagawa P, Mouradian GC Jr, Kriegel AJ, Kwitek AE, Hodges MR, Segar JL, Sigmund CD, Grobe JL.) Am J Physiol Regul Integr Comp Physiol. 2022 Jun 01;322(6):R467-R485 PMID: 35348007 PMCID: PMC9054347 03/30/2022
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(Vedi M, Nalabolu HS, Lin CW, Hoffman MJ, Smith JR, Brodie K, De Pons JL, Demos WM, Gibson AC, Hayman GT, Hill ML, Kaldunski ML, Lamers L, Laulederkind SJF, Thorat K, Thota J, Tutaj M, Tutaj MA, Wang SJ, Zacher S, Dwinell MR, Kwitek AE.) Genetics. 2022 Apr 04;220(4) PMID: 35380657 PMCID: PMC8982048 SCOPUS ID: 2-s2.0-85128160560 04/06/2022
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Harmonizing model organism data in the Alliance of Genome Resources.
(Alliance of Genome Resources Consortiumn.) Genetics. 2022 Apr 04;220(4) PMID: 35380658 PMCID: PMC8982023 SCOPUS ID: 2-s2.0-85128598390 04/06/2022
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(Kaldunski ML, Smith JR, Hayman GT, Brodie K, De Pons JL, Demos WM, Gibson AC, Hill ML, Hoffman MJ, Lamers L, Laulederkind SJF, Nalabolu HS, Thorat K, Thota J, Tutaj M, Tutaj MA, Vedi M, Wang SJ, Zacher S, Dwinell MR, Kwitek AE.) Mamm Genome. 2022 03;33(1):66-80 PMID: 34741192 PMCID: PMC8570235 SCOPUS ID: 2-s2.0-85118526605 11/07/2021
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(Reho JJ, Nakagawa P, Mouradian GC Jr, Grobe CC, Saravia FL, Burnett CML, Kwitek AE, Kirby JR, Segar JL, Hodges MR, Sigmund CD, Grobe JL.) Front Physiol. 2022;13:855054 PMID: 35283781 PMCID: PMC8914175 SCOPUS ID: 2-s2.0-85126220642 03/15/2022
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Multi-Omic Approaches to Identify Genetic Factors in Metabolic Syndrome.
(Clark KC, Kwitek AE.) Compr Physiol. 2021 12 29;12(1):3045-3084 PMID: 34964118 SCOPUS ID: 2-s2.0-85123037507 12/30/2021
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PhenoGeneRanker: Gene and Phenotype Prioritization Using Multiplex Heterogeneous Networks.
(Dursun C, Kwitek A, Bozdag S.) IEEE/ACM Trans Comput Biol Bioinform. 2021 Jul 20;PP PMID: 34283720 07/21/2021
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Bisphenol F Exposure in Adolescent Heterogeneous Stock Rats Affects Growth and Adiposity.
(Wagner VA, Clark KC, Carrillo-Sáenz L, Holl KA, Velez-Bermudez M, Simonsen D, Grobe JL, Wang K, Thurman A, Solberg Woods LC, Lehmler HJ, Kwitek AE.) Toxicol Sci. 2021 05 27;181(2):246-261 PMID: 33755180 PMCID: PMC8163043 SCOPUS ID: 2-s2.0-85107319418 03/24/2021
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(Oliveira V, Kwitek AE, Sigmund CD, Morselli LL, Grobe JL.) Hypertension. 2021 04;77(4):1061-1068 PMID: 33611936 PMCID: PMC7990288 SCOPUS ID: 2-s2.0-85102906743 02/23/2021
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The genome sequence of the Norway rat, Rattus norvegicus Berkenhout 1769.
(Howe K, Dwinell M, Shimoyama M, Corton C, Betteridge E, Dove A, Quail MA, Smith M, Saba L, Williams RW, Chen H, Kwitek AE, McCarthy SA, Uliano-Silva M, Chow W, Tracey A, Torrance J, Sims Y, Challis R, Threlfall J, Blaxter M.) Wellcome Open Res. 2021;6:118 PMID: 34660910 PMCID: PMC8495504 10/19/2021
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The Case for Standardising Gene Nomenclature Across Vertebrates
(McCarthy, F.M.; Jones, T.E.; Kwitek, A.E.; Smith, C.L.; Vize, P.D.; Westerfield, M.; Bruford, E.A..) Preprints. Preprints 2021, 2021090485 (doi: 10.20944/preprints202109.0485.v1). 09/29/2021
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NECo: A node embedding algorithm for multiplex heterogeneous networks.
(Dursun C, Smith JR, Hayman GT, Kwitek AE, Bozdag S.) Proceedings (IEEE Int Conf Bioinformatics Biomed). 2020 Dec;2020:146-149 PMID: 34584774 PMCID: PMC8466723 09/30/2021