Medical College of Wisconsin
Medical College of Wisconsin Medical College of Wisconsin
Research Lab Bench
Physiology
Anne E. Kwitek, PhD

Anne E. Kwitek, PhD

Professor, Physiology & Medicine

Locations

  • Physiology

Contact Information

Education

BS, Biology and Chemistry, University of Wisconsin at Stevens Point
PhD, Interdisciplinary Graduate Program in Genetics, University of Iowa

Biography

Dr. Anne Kwitek is a tenured Professor in the Department of Physiology. She earned her PhD in Genetics at the University of Iowa then came to MCW as a postdoctoral fellow. After growing the ranks to Associate Professor at MCW, Dr. Kwitek was recruited back to the University of Iowa where she remained until her return to MCW in 2019.

Dr. Kwitek is an animal and human geneticist whose research revolves around the genetics of complex disease with an emphasis on hypertension, obesity, diabetes, and the metabolic syndrome (MetS). She currently has two major laboratory research interests. The first involves understanding the genetic susceptibility to complex human diseases, with a focus on obesity, hypertension, diabetes, and cardiometabolic disease. The approach involves integrating genetics, genomics, and other ‘omics’ approaches to identify genes and mechanisms leading to complex disease using rat models and human populations. She is also studying how genomic variation affects and is affected by environmental stimuli to influence susceptibility to cardiometabolic disease.

Dr. Kwitek also leads the Rat Genome Database (RGD) and is a member of the Alliance of Genome Resources (Alliance). The goal of RGD (and the Alliance) is to provide a research platform that delivers the data and tools necessary for investigators to advance preclinical and translational research. This involves acquiring, validating, and integrating comprehensive genetic, genomic, phenotype and disease datasets for rat as well as human, mouse and other mammals used as human disease models. RGD has numerous disease portals dedicated to providing a centralized disease-based data and analysis environment for diseases such as obesity and metabolic syndrome, diabetes, renal disease, and cardiovascular disease to name a few.

Research Areas of Interest

  • Cardiovascular Diseases
  • Computational Biology
  • Database Management Systems
  • Databases, Genetic
  • Disease Models, Animal
  • Gene Expression Regulation
  • Genetic Linkage
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Genome, Human
  • Genomics
  • Hypertension

MCW Program / Core Facilities

  • Biomedical Engineering (PhD)
  • CTSI Obesity Ensemble
  • Interdisciplinary Doctoral Program in Biomedical Sciences
  • Physiology (PhD)

Research Interests

Dr. Kwitek’s major research focus involves understanding the genetic susceptibility to complex human diseases, with a focus on obesity, hypertension, and cardiometabolic disease. The approach involves integrating genetics, genomics, and other ‘omics’ approaches to identify genes and mechanisms leading to complex disease using rat models and human populations. Her studies also involve how genomic variation affects and is affected by environmental stimuli to influence susceptibility to cardiometabolic disease.

Publications

  • Genetic background in the rat affects endocrine and metabolic outcomes of Bisphenol F exposure.

    (Wagner VA, Holl KL, Clark KC, Reho JJ, Dwinell MR, Lehmler HJ, Raff H, Grobe JL, Kwitek AE.) Toxicol Sci. 2023 May 16 PMID: 37191987 05/16/2023

  • 2022 updates to the Rat Genome Database: a Findable, Accessible, Interoperable, and Reusable (FAIR) resource.

    (Vedi M, Smith JR, Thomas Hayman G, Tutaj M, Brodie KC, De Pons JL, Demos WM, Gibson AC, Kaldunski ML, Lamers L, Laulederkind SJF, Thota J, Thorat K, Tutaj MA, Wang SJ, Zacher S, Dwinell MR, Kwitek AE.) Genetics. 2023 May 04;224(1) PMID: 36930729 SCOPUS ID: 2-s2.0-85159551813 03/18/2023

  • The Gene Ontology knowledgebase in 2023.

    (Gene Ontology Consortium, Aleksander SA, Balhoff J, Carbon S, Cherry JM, Drabkin HJ, Ebert D, Feuermann M, Gaudet P, Harris NL, Hill DP, Lee R, Mi H, Moxon S, Mungall CJ, Muruganugan A, Mushayahama T, Sternberg PW, Thomas PD, Van Auken K, Ramsey J, Siegele DA, Chisholm RL, Fey P, Aspromonte MC, Nugnes MV, Quaglia F, Tosatto S, Giglio M, Nadendla S, Antonazzo G, Attrill H, Dos Santos G, Marygold S, Strelets V, Tabone CJ, Thurmond J, Zhou P, Ahmed SH, Asanitthong P, Luna Buitrago D, Erdol MN, Gage MC, Ali Kadhum M, Li KYC, Long M, Michalak A, Pesala A, Pritazahra A, Saverimuttu SCC, Su R, Thurlow KE, Lovering RC, Logie C, Oliferenko S, Blake J, Christie K, Corbani L, Dolan ME, Drabkin HJ, Hill DP, Ni L, Sitnikov D, Smith C, Cuzick A, Seager J, Cooper L, Elser J, Jaiswal P, Gupta P, Jaiswal P, Naithani S, Lera-Ramirez M, Rutherford K, Wood V, De Pons JL, Dwinell MR, Hayman GT, Kaldunski ML, Kwitek AE, Laulederkind SJF, Tutaj MA, Vedi M, Wang SJ, D'Eustachio P, Aimo L, Axelsen K, Bridge A, Hyka-Nouspikel N, Morgat A, Aleksander SA, Cherry JM, Engel SR, Karra K, Miyasato SR, Nash RS, Skrzypek MS, Weng S, Wong ED, Bakker E, Berardini TZ, Reiser L, Auchincloss A, Axelsen K, Argoud-Puy G, Blatter MC, Boutet E, Breuza L, Bridge A, Casals-Casas C, Coudert E, Estreicher A, Livia Famiglietti M, Feuermann M, Gos A, Gruaz-Gumowski N, Hulo C, Hyka-Nouspikel N, Jungo F, Le Mercier P, Lieberherr D, Masson P, Morgat A, Pedruzzi I, Pourcel L, Poux S, Rivoire C, Sundaram S, Bateman A, Bowler-Barnett E, Bye-A-Jee H, Denny P, Ignatchenko A, Ishtiaq R, Lock A, Lussi Y, Magrane M, Martin MJ, Orchard S, Raposo P, Speretta E, Tyagi N, Warner K, Zaru R, Diehl AD, Lee R, Chan J, Diamantakis S, Raciti D, Zarowiecki M, Fisher M, James-Zorn C, Ponferrada V, Zorn A, Ramachandran S, Ruzicka L, Westerfield M.) Genetics. 2023 May 04;224(1) PMID: 36866529 PMCID: PMC10158837 03/04/2023

  • Rare Disease Research Resources at the Rat Genome Database.

    (Kaldunski ML, Smith JR, Brodie KC, De Pons JL, Demos WM, Gibson AC, Hayman GT, Lamers L, Laulederkind SJF, Thorat K, Thota J, Tutaj MA, Tutaj M, Vedi M, Wang SJ, Zacher S, Dwinell MR, Kwitek AE.) Genetics. 2023 Apr 29 PMID: 37119810 04/30/2023

  • A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats.

    (de Jong TV, Pan Y, Rastas P, Munro D, Tutaj M, Akil H, Benner C, Chitre AS, Chow W, Colonna V, Dalgard CL, Demos WM, Doris PA, Garrison E, Geurts A, Gunturkun HM, Guryev V, Hourlier T, Howe K, Huang J, Kalbfleisch T, Kim P, Li L, Mahaffey S, Martin FJ, Mohammadi P, Ozel AB, Polesskaya O, Pravenec M, Prins P, Sebat J, Smith JR, Woods LCS, Tabakoff B, Tracey A, Uliano-Silva M, Villani F, Wang H, Sharp BM, Telese F, Jiang Z, Saba L, Wang X, Murphy TD, Palmer AA, Kwitek AE, Dwinell MMR, Williams RW, Li JZ, Chen H.) bioRxiv. 2023 Apr 14 PMID: 37214860 PMCID: PMC10197727 05/22/2023

  • The case for standardizing gene nomenclature in vertebrates.

    (McCarthy FM, Jones TEM, Kwitek AE, Smith CL, Vize PD, Westerfield M, Bruford EA.) Nature. 2023 Feb;614(7948):E31-E32 PMID: 36792746 PMCID: PMC9931569 SCOPUS ID: 2-s2.0-85148114697 02/16/2023

  • Ontological Analysis of Coronavirus Associated Human Genes at the COVID-19 Disease Portal.

    (Wang SJ, Brodie KC, De Pons JL, Demos WM, Gibson AC, Hayman GT, Hill ML, Kaldunski ML, Lamers L, Laulederkind SJF, Nalabolu HS, Thota J, Thorat K, Tutaj MA, Tutaj M, Vedi M, Zacher S, Smith JR, Dwinell MR, Kwitek AE.) Genes (Basel). 2022 Dec 07;13(12) PMID: 36553571 PMCID: PMC9777590 12/24/2022

  • Cardiometabolic effects of DOCA-salt in male C57BL/6J mice are variably dependent on sodium and nonsodium components of diet.

    (Patil CN, Ritter ML, Wackman KK, Oliveira V, Balapattabi K, Grobe CC, Brozoski DT, Reho JJ, Nakagawa P, Mouradian GC Jr, Kriegel AJ, Kwitek AE, Hodges MR, Segar JL, Sigmund CD, Grobe JL.) Am J Physiol Regul Integr Comp Physiol. 2022 Jun 01;322(6):R467-R485 PMID: 35348007 PMCID: PMC9054347 SCOPUS ID: 2-s2.0-85129779185 03/30/2022

  • MOET: a web-based gene set enrichment tool at the Rat Genome Database for multiontology and multispecies analyses.

    (Vedi M, Nalabolu HS, Lin CW, Hoffman MJ, Smith JR, Brodie K, De Pons JL, Demos WM, Gibson AC, Hayman GT, Hill ML, Kaldunski ML, Lamers L, Laulederkind SJF, Thorat K, Thota J, Tutaj M, Tutaj MA, Wang SJ, Zacher S, Dwinell MR, Kwitek AE.) Genetics. 2022 Apr 04;220(4) PMID: 35380657 PMCID: PMC8982048 SCOPUS ID: 2-s2.0-85128160560 04/06/2022

  • Harmonizing model organism data in the Alliance of Genome Resources.

    (Alliance of Genome Resources Consortium.) Genetics. 2022 Apr 04;220(4) PMID: 35380658 PMCID: PMC8982023 SCOPUS ID: 2-s2.0-85128598390 04/06/2022

  • Body Composition and Metabolic Changes in a Lyon Hypertensive Congenic Rat and Identification of Ercc6l2 as a Positional Candidate Gene.

    (Clark KC, Wagner VA, Holl KL, Reho JJ, Tutaj M, Smith JR, Dwinell MR, Grobe JL, Kwitek AE.) Front Genet. 2022;13:903971 PMID: 35812759 PMCID: PMC9263446 07/12/2022

  • Methods for the Comprehensive in vivo Analysis of Energy Flux, Fluid Homeostasis, Blood Pressure, and Ventilatory Function in Rodents.

    (Reho JJ, Nakagawa P, Mouradian GC Jr, Grobe CC, Saravia FL, Burnett CML, Kwitek AE, Kirby JR, Segar JL, Hodges MR, Sigmund CD, Grobe JL.) Front Physiol. 2022;13:855054 PMID: 35283781 PMCID: PMC8914175 SCOPUS ID: 2-s2.0-85126220642 03/15/2022

Publications of Anne E. Kwitek PhD from the Faculty Collaboration Database