
Justin L. Grobe, PhD
Associate Professor, Physiology & Biomedical Engineering; Director, Comprehensive Rodent Metabolic Phenotyping Core
Locations
- Physiology
HRC 4875
Contact Information
Education
2006, PhD, Pharmacodynamics, University of Florida, Gainesville, FL
2006-2010, Postdoc (Internal Medicine & Pharmacology), University of Iowa, Iowa City, IA
Biography
Justin L. Grobe, PhD moved to the Medical College of Wisconsin’s Department of Physiology in June 2019. He holds a secondary appointment in the Department of Biomedical Engineering, and serves as the founding director of the Comprehensive Rodent Metabolic Phenotyping Core facility. Before joining the faculty at MCW, Dr. Grobe was a tenured associate professor in the Department of Pharmacology at the University of Iowa.
Research Areas of Interest
- Adiposity
- Agouti-Related Protein
- Arcuate Nucleus of Hypothalamus
- Basal Metabolism
- Blood Pressure
- Body Composition
- Body Water
- Body Weight
- Brain
- Central Nervous System
- Dehydration
- Disease Models, Animal
Research Experience
- Arginine Vasopressin
- Blood Pressure
- Energy Metabolism
- Gastrointestinal Microbiome
- Hypertension
- Hypothalamus
- Obesity
- Pre-Eclampsia
- Pregnancy
- Receptors, G-Protein-Coupled
- Renin-Angiotensin System
- Water-Electrolyte Balance
Methodologies and Techniques
- Analysis of Variance
- Basal Metabolism
- Calorimetry
- Dose-Response Relationship, Drug
- Eating
- Energy Metabolism
- Feeding Behavior
- Humans
- Mice
- Rats
- Sensitivity and Specificity
- Statistics
Leadership Positions
- Course Director, MCW PHYS 08220: Biostatistics for Health Sciences
- Director, MCW Comprehensive Rodent Metabolic Phenotyping Core
- Member, MCW MSTP Admissions Committee
- Vice-Chair, MCW Institutional Animal Care & Use Committee
MCW Program / Core Facilities
- Comprehensive Rodent Metabolic Phenotyping Core
Educational Expertise
- Basal Metabolism
- Biostatistics
- Energy Metabolism
- Hypertension
- Neurosciences
- Pre-Eclampsia
Research Interests
Our team is focused on understanding the physiological interplay among cardiovascular and metabolic control systems. Our primary area of inquiry is the neurobiology controlling blood pressure and resting metabolic rate, which has implications for our understanding of the pathogenesis and potential treatments for obesity and obesity-associated hypertension. Our work also focuses on contributions of neuroendocrine and G protein signaling systems to the hypertensive cardiovascular disorder of pregnancy, preeclampsia. Further, we are working to develop novel techniques to quantitate anaerobic metabolism in vivo, and thereby understanding the role of the gut microbiota in energy homeostasis.
Fields of major interest:
- Neurogenic hypertension
- Obesity and obesity-associated hypertension
- Hypothalamic control of blood pressure and resting metabolism
- Cross-talk of blood pressure and metabolic rate, and selective leptin resistance
- Water & electrolyte homeostasis
- Renin-angiotensin system
- Arginine vasopressin
- Anaerobic metabolism
- Gut microbiota
- Development of novel calorimetry methods
- Mathematical modeling and biostatistics
Publications
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Genetic background in the rat affects endocrine and metabolic outcomes of Bisphenol F exposure.
(Wagner VA, Holl KL, Clark KC, Reho JJ, Dwinell MR, Lehmler HJ, Raff H, Grobe JL, Kwitek AE.) Toxicol Sci. 2023 May 16 PMID: 37191987 05/16/2023
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(Alexander BT, South AM, August P, Bertagnolli M, Ferranti EP, Grobe JL, Jones EJ, Loria AS, Safdar B, Sequeira-Lopez MLS, American Heart Association Council on the Kidney in Cardiovascular Disease; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; Council on Hypertension; and Council on Lifestyle and Cardiometabolic Health.) Hypertension. 2023 May;80(5):e75-e89 PMID: 36951054 03/24/2023
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Elucidating the role of Rgs2 expression in the PVN for metabolic homeostasis in mice.
(Deng Y, Dickey JE, Saito K, Deng G, Singh U, Jiang J, Toth BA, Zhu Z, Zingman LV, Resch JM, Grobe JL, Cui H.) Mol Metab. 2022 Dec;66:101622 PMID: 36307046 PMCID: PMC9638802 SCOPUS ID: 2-s2.0-85141285048 10/29/2022
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(Ritter ML, Deng G, Reho JJ, Deng Y, Sapouckey SA, Opichka MA, Balapattabi K, Wackman KK, Brozoski DT, Lu KT, Paradee WJ, Gibson-Corley KN, Cui H, Nakagawa P, Morselli LL, Sigmund CD, Grobe JL.) Hypertension. 2022 Dec;79(12):2843-2853 PMID: 36259376 PMCID: PMC9649888 SCOPUS ID: 2-s2.0-85141891708 10/20/2022
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ARRB2 (β-Arrestin-2) Deficiency Alters Fluid Homeostasis and Blood Pressure Regulation.
(Mathieu NM, Nakagawa P, Grobe CC, Reho JJ, Brozoski DT, Lu KT, Wackman KK, Ritter ML, Segar JL, Grobe JL, Sigmund CD.) Hypertension. 2022 Nov;79(11):2480-2492 PMID: 36215165 PMCID: PMC9669141 SCOPUS ID: 2-s2.0-85140375825 10/11/2022
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(Oliveira V, Reho JJ, Balapattabi K, Ritter ML, Mathieu NM, Opichka MA, Lu KT, Grobe CC, Silva SD Jr, Wackman KK, Nakagawa P, Segar JL, Sigmund CD, Grobe JL.) Am J Physiol Regul Integr Comp Physiol. 2022 Oct 01;323(4):R410-R421 PMID: 35816717 PMCID: PMC9512112 SCOPUS ID: 2-s2.0-85138457982 07/12/2022
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(Oliveira V, Riedl RA, Claflin KE, Mathieu NM, Ritter ML, Balapattabi K, Wackman KK, Reho JJ, Brozoski DT, Morgan DA, Cui H, Rahmouni K, Burnett CML, Nakagawa P, Sigmund CD, Morselli LL, Grobe JL.) Physiol Genomics. 2022 Jun 01;54(6):196-205 PMID: 35476598 PMCID: PMC9131927 SCOPUS ID: 2-s2.0-85131018208 04/28/2022
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(Patil CN, Ritter ML, Wackman KK, Oliveira V, Balapattabi K, Grobe CC, Brozoski DT, Reho JJ, Nakagawa P, Mouradian GC Jr, Kriegel AJ, Kwitek AE, Hodges MR, Segar JL, Sigmund CD, Grobe JL.) Am J Physiol Regul Integr Comp Physiol. 2022 Jun 01;322(6):R467-R485 PMID: 35348007 PMCID: PMC9054347 SCOPUS ID: 2-s2.0-85129779185 03/30/2022
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(Mouradian GC Jr, Liu P, Nakagawa P, Duffy E, Gomez Vargas J, Balapattabi K, Grobe JL, Sigmund CD, Hodges MR.) Front Synaptic Neurosci. 2022;14:910820 PMID: 35844900 PMCID: PMC9280690 SCOPUS ID: 2-s2.0-85134237459 07/19/2022
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(Clark KC, Wagner VA, Holl KL, Reho JJ, Tutaj M, Smith JR, Dwinell MR, Grobe JL, Kwitek AE.) Front Genet. 2022;13:903971 PMID: 35812759 PMCID: PMC9263446 07/12/2022
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(Wu J, Fang S, Lu KT, Kumar G, Reho JJ, Brozoski DT, Otanwa AJ, Hu C, Nair AR, Wackman KK, Agbor LN, Grobe JL, Sigmund CD.) Function (Oxf). 2022;3(3):zqac017 PMID: 35493997 PMCID: PMC9045850 05/03/2022
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(Reho JJ, Nakagawa P, Mouradian GC Jr, Grobe CC, Saravia FL, Burnett CML, Kwitek AE, Kirby JR, Segar JL, Hodges MR, Sigmund CD, Grobe JL.) Front Physiol. 2022;13:855054 PMID: 35283781 PMCID: PMC8914175 SCOPUS ID: 2-s2.0-85126220642 03/15/2022