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Justin L. Grobe, PhD, FAHA

Justin L. Grobe, PhD

Associate Professor, Physiology & Biomedical Engineering; Director, Comprehensive Rodent Metabolic Phenotyping Core

Locations

  • Physiology
    HRC 4875

Contact Information

Education

2001, BS (Biology) & BA (Chemistry), Hope College, Holland, MI
2006, PhD, Pharmacodynamics, University of Florida, Gainesville, FL
2006-2010, Postdoc (Internal Medicine & Pharmacology), University of Iowa, Iowa City, IA

Biography

Justin L. Grobe, PhD moved to the Medical College of Wisconsin’s Department of Physiology in June 2019. He holds a secondary appointment in the Department of Biomedical Engineering, and serves as the founding director of the Comprehensive Rodent Metabolic Phenotyping Core facility. Before joining the faculty at MCW, Dr. Grobe was a tenured associate professor in the Department of Pharmacology at the University of Iowa.

Research Experience

  • Arginine Vasopressin
  • Blood Pressure
  • Energy Metabolism
  • Gastrointestinal Microbiome
  • Hypertension
  • Hypothalamus
  • Obesity
  • Pre-Eclampsia
  • Pregnancy
  • Receptors, G-Protein-Coupled
  • Renin-Angiotensin System
  • Water-Electrolyte Balance

Methodologies and Techniques

  • Analysis of Variance
  • Basal Metabolism
  • Calorimetry
  • Dose-Response Relationship, Drug
  • Eating
  • Energy Metabolism
  • Feeding Behavior
  • Humans
  • Mice
  • Rats
  • Sensitivity and Specificity
  • Statistics

Leadership Positions

  • Course Director, PHYS 08220: Biostatistics for Health Sciences
  • Director, Comprehensive Rodent Metabolic Phenotyping Core
  • Member, Institutional Animal Care & Use Committee
  • Member, MSTP Admissions Committee

MCW Program / Core Facilities

  • Comprehensive Rodent Metabolic Phenotyping Core

Educational Expertise

  • Basal Metabolism
  • Biostatistics
  • Energy Metabolism
  • Hypertension
  • Neurosciences
  • Pre-Eclampsia

Research Interests

Our team is focused on understanding the physiological interplay among cardiovascular and metabolic control systems. Our primary area of inquiry is the neurobiology controlling blood pressure and resting metabolic rate, which has implications for our understanding of the pathogenesis and potential treatments for obesity and obesity-associated hypertension. Our work also focuses on contributions of neuroendocrine and G protein signaling systems to the hypertensive cardiovascular disorder of pregnancy, preeclampsia. Further, we are working to develop novel techniques to quantitate anaerobic metabolism in vivo, and thereby understanding the role of the gut microbiota in energy homeostasis.

Fields of major interest:

  • Neurogenic hypertension
  • Obesity and obesity-associated hypertension
  • Hypothalamic control of blood pressure and resting metabolism
  • Cross-talk of blood pressure and metabolic rate, and selective leptin resistance
  • Water & electrolyte homeostasis
  • Renin-angiotensin system
  • Arginine vasopressin
  • Anaerobic metabolism
  • Gut microbiota
  • Development of novel calorimetry methods
  • Mathematical modeling and biostatistics

Lab Staff

  • Ko-Ting Lu, MS – Laboratory Manager
  • Kelsey Wackman – Research Technician
  • John Reho, PhD – Research Scientist
  • Chetan Patil, PhD – Postdoctoral Fellow
  • Vanessa A. De Oliveira, PhD – Postdoctoral Fellow
  • Kirthikaa Balappatabi, PhD – Postdoctoral Fellow

Publications