Justin L. Grobe, PhD

Associate Professor, Physiology & Biomedical Engineering; Director, Comprehensive Rodent Metabolic Phenotyping Core

Locations

Physiology
HRC 4875

Contact Information

Education

2001, BS (Biology) & BA (Chemistry), Hope College, Holland, MI
2006, PhD, Pharmacodynamics, University of Florida, Gainesville, FL
2006-2010, Postdoc (Internal Medicine & Pharmacology), University of Iowa, Iowa City, IA

Biography

Justin L. Grobe, PhD moved to the Medical College of Wisconsin’s Department of Physiology in June 2019. He holds a secondary appointment in the Department of Biomedical Engineering, and serves as the founding director of the Comprehensive Rodent Metabolic Phenotyping Core facility. Before joining the faculty at MCW, Dr. Grobe was a tenured associate professor in the Department of Pharmacology at the University of Iowa.

                
                    Research Areas of Interest
                

                    Adiposity
Agouti-Related Protein
Arcuate Nucleus of Hypothalamus
Basal Metabolism
Blood Pressure
Body Composition
Body Water
Body Weight
Brain
Central Nervous System
Dehydration
Disease Models, Animal

            

                
                    Research Experience
                

                    Arginine Vasopressin
Blood Pressure
Energy Metabolism
Gastrointestinal Microbiome
Hypertension
Hypothalamus
Obesity
Pre-Eclampsia
Pregnancy
Receptors, G-Protein-Coupled
Renin-Angiotensin System
Water-Electrolyte Balance

            

                
                    Methodologies and Techniques
                

                    Analysis of Variance
Basal Metabolism
Calorimetry
Dose-Response Relationship, Drug
Eating
Energy Metabolism
Feeding Behavior
Humans
Mice
Rats
Sensitivity and Specificity
Statistics

            

                
                    Leadership Positions
                

                    Course Director, MCW PHYS 08220: Biostatistics for Health Sciences
Director, MCW Comprehensive Rodent Metabolic Phenotyping Core
Member, MCW MSTP Admissions Committee
Vice-Chair, MCW Institutional Animal Care & Use Committee

            

                
                    MCW Program / Core Facilities
                

                    Comprehensive Rodent Metabolic Phenotyping Core

            

                
                    Educational Expertise
                

                    Basal Metabolism
Biostatistics
Energy Metabolism
Hypertension
Neurosciences
Pre-Eclampsia

            

Research Interests

Our team is focused on understanding the physiological interplay among cardiovascular and metabolic control systems. Our primary area of inquiry is the neurobiology controlling blood pressure and resting metabolic rate, which has implications for our understanding of the pathogenesis and potential treatments for obesity and obesity-associated hypertension. Our work also focuses on contributions of neuroendocrine and G protein signaling systems to the hypertensive cardiovascular disorder of pregnancy, preeclampsia. Further, we are working to develop novel techniques to quantitate anaerobic metabolism in vivo, and thereby understanding the role of the gut microbiota in energy homeostasis.

Fields of major interest:

Neurogenic hypertension
Obesity and obesity-associated hypertension
Hypothalamic control of blood pressure and resting metabolism
Cross-talk of blood pressure and metabolic rate, and selective leptin resistance
Water & electrolyte homeostasis
Renin-angiotensin system
Arginine vasopressin
Anaerobic metabolism
Gut microbiota
Development of novel calorimetry methods
Mathematical modeling and biostatistics

Genetic background in the rat affects endocrine and metabolic outcomes of Bisphenol F exposure.

(Wagner VA, Holl KL, Clark KC, Reho JJ, Dwinell MR, Lehmler HJ, Raff H, Grobe JL, Kwitek AE.) Toxicol Sci. 2023 May 16 PMID: 37191987 05/16/2023
Appraising the Preclinical Evidence of the Role of the Renin-Angiotensin-Aldosterone System in Antenatal Programming of Maternal and Offspring Cardiovascular Health Across the Life Course: Moving the Field Forward: A Scientific Statement From the American Heart Association.

(Alexander BT, South AM, August P, Bertagnolli M, Ferranti EP, Grobe JL, Jones EJ, Loria AS, Safdar B, Sequeira-Lopez MLS, American Heart Association Council on the Kidney in Cardiovascular Disease; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; Council on Hypertension; and Council on Lifestyle and Cardiometabolic Health.) Hypertension. 2023 May;80(5):e75-e89 PMID: 36951054 03/24/2023
Elucidating the role of Rgs2 expression in the PVN for metabolic homeostasis in mice.

(Deng Y, Dickey JE, Saito K, Deng G, Singh U, Jiang J, Toth BA, Zhu Z, Zingman LV, Resch JM, Grobe JL, Cui H.) Mol Metab. 2022 Dec;66:101622 PMID: 36307046 PMCID: PMC9638802 SCOPUS ID: 2-s2.0-85141285048 10/29/2022
Cardiometabolic Consequences of Deleting the Regulator of G protein Signaling-2 (Rgs2) From Cells Expressing Agouti-Related Peptide or the ANG (Angiotensin) II Type 1A Receptor in Mice.

(Ritter ML, Deng G, Reho JJ, Deng Y, Sapouckey SA, Opichka MA, Balapattabi K, Wackman KK, Brozoski DT, Lu KT, Paradee WJ, Gibson-Corley KN, Cui H, Nakagawa P, Morselli LL, Sigmund CD, Grobe JL.) Hypertension. 2022 Dec;79(12):2843-2853 PMID: 36259376 PMCID: PMC9649888 SCOPUS ID: 2-s2.0-85141891708 10/20/2022
ARRB2 (β-Arrestin-2) Deficiency Alters Fluid Homeostasis and Blood Pressure Regulation.

(Mathieu NM, Nakagawa P, Grobe CC, Reho JJ, Brozoski DT, Lu KT, Wackman KK, Ritter ML, Segar JL, Grobe JL, Sigmund CD.) Hypertension. 2022 Nov;79(11):2480-2492 PMID: 36215165 PMCID: PMC9669141 SCOPUS ID: 2-s2.0-85140375825 10/11/2022
Chronic intracerebroventricular infusion of angiotensin II causes dose- and sex-dependent effects on intake behaviors and energy homeostasis in C57BL/6J mice.

(Oliveira V, Reho JJ, Balapattabi K, Ritter ML, Mathieu NM, Opichka MA, Lu KT, Grobe CC, Silva SD Jr, Wackman KK, Nakagawa P, Segar JL, Sigmund CD, Grobe JL.) Am J Physiol Regul Integr Comp Physiol. 2022 Oct 01;323(4):R410-R421 PMID: 35816717 PMCID: PMC9512112 SCOPUS ID: 2-s2.0-85138457982 07/12/2022
Melanocortin MC4R receptor is required for energy expenditure but not blood pressure effects of angiotensin II within the mouse brain.

(Oliveira V, Riedl RA, Claflin KE, Mathieu NM, Ritter ML, Balapattabi K, Wackman KK, Reho JJ, Brozoski DT, Morgan DA, Cui H, Rahmouni K, Burnett CML, Nakagawa P, Sigmund CD, Morselli LL, Grobe JL.) Physiol Genomics. 2022 Jun 01;54(6):196-205 PMID: 35476598 PMCID: PMC9131927 SCOPUS ID: 2-s2.0-85131018208 04/28/2022
Cardiometabolic effects of DOCA-salt in male C57BL/6J mice are variably dependent on sodium and nonsodium components of diet.

(Patil CN, Ritter ML, Wackman KK, Oliveira V, Balapattabi K, Grobe CC, Brozoski DT, Reho JJ, Nakagawa P, Mouradian GC Jr, Kriegel AJ, Kwitek AE, Hodges MR, Segar JL, Sigmund CD, Grobe JL.) Am J Physiol Regul Integr Comp Physiol. 2022 Jun 01;322(6):R467-R485 PMID: 35348007 PMCID: PMC9054347 SCOPUS ID: 2-s2.0-85129779185 03/30/2022
Patch-to-Seq and Transcriptomic Analyses Yield Molecular Markers of Functionally Distinct Brainstem Serotonin Neurons.

(Mouradian GC Jr, Liu P, Nakagawa P, Duffy E, Gomez Vargas J, Balapattabi K, Grobe JL, Sigmund CD, Hodges MR.) Front Synaptic Neurosci. 2022;14:910820 PMID: 35844900 PMCID: PMC9280690 SCOPUS ID: 2-s2.0-85134237459 07/19/2022
Body Composition and Metabolic Changes in a Lyon Hypertensive Congenic Rat and Identification of Ercc6l2 as a Positional Candidate Gene.

(Clark KC, Wagner VA, Holl KL, Reho JJ, Tutaj M, Smith JR, Dwinell MR, Grobe JL, Kwitek AE.) Front Genet. 2022;13:903971 PMID: 35812759 PMCID: PMC9263446 07/12/2022
Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension.

(Wu J, Fang S, Lu KT, Kumar G, Reho JJ, Brozoski DT, Otanwa AJ, Hu C, Nair AR, Wackman KK, Agbor LN, Grobe JL, Sigmund CD.) Function (Oxf). 2022;3(3):zqac017 PMID: 35493997 PMCID: PMC9045850 05/03/2022
Methods for the Comprehensive in vivo Analysis of Energy Flux, Fluid Homeostasis, Blood Pressure, and Ventilatory Function in Rodents.

(Reho JJ, Nakagawa P, Mouradian GC Jr, Grobe CC, Saravia FL, Burnett CML, Kwitek AE, Kirby JR, Segar JL, Hodges MR, Sigmund CD, Grobe JL.) Front Physiol. 2022;13:855054 PMID: 35283781 PMCID: PMC8914175 SCOPUS ID: 2-s2.0-85126220642 03/15/2022

Justin L. Grobe, PhD

Associate Professor, Physiology & Biomedical Engineering; Director, Comprehensive Rodent Metabolic Phenotyping Core

Locations

Contact Information

Education

Biography

Research Areas of Interest

Research Experience

Methodologies and Techniques

Leadership Positions

MCW Program / Core Facilities

Educational Expertise

Research Interests

Publications