Gyujoon (Guy) Hwang, PhD

Publications

• Neuroimaging-AI endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders.

  (Wen J, Skampardoni I, Tian YE, Yang Z, Cui Y, Erus G, Hwang G, Varol E, Boquet-Pujadas A, Chand GB, Nasrallah I, Satterthwaite TD, Shou H, Shen L, Toga AW, Zalesky A, Davatzikos C.) medRxiv. 2025 Mar 28 PMID: 37662256 PMCID: PMC10473785 09/04/2023

• Neuroimaging endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders

  (Wen J, Skampardoni I, Tian YE, Yang Z, Cui Y, Erus G, Hwang G, Varol E, Boquet-Pujadas A, Chand GB, Nasrallah IM, Satterthwaite TD, Shou H, Shen L, Toga AW, Zalesky A, Davatzikos C.) Nature Biomedical Engineering. 2025 SCOPUS ID: 2-s2.0-105007361972 01/01/2025

• Amygdala-Centered Emotional Processing in Prolonged Grief Disorder: Relationship With Clinical Symptomatology.

  (Hwang G, Blair NP, Ward BD, McAuliffe TL, Claesges SA, Webber AR, Hainsworth KR, Wang Y, Reynolds CF, Stein EA, Goveas JS.) Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Dec 24 PMID: 39725082 PMCID: PMC12185774 SCOPUS ID: 2-s2.0-105000420540 12/27/2024

• Relationship between MRI brain-age heterogeneity, cognition, genetics and Alzheimer's disease neuropathology.

  (Antoniades M, Srinivasan D, Wen J, Erus G, Abdulkadir A, Mamourian E, Melhem R, Hwang G, Cui Y, Govindarajan ST, Chen AA, Zhou Z, Yang Z, Chen J, Pomponio R, Sotardi S, An Y, Bilgel M, LaMontagne P, Singh A, Benzinger T, Beason-Held L, Marcus DS, Yaffe K, Launer L, Morris JC, Tosun D, Ferrucci L, Bryan RN, Resnick SM, Habes M, Wolk D, Fan Y, Nasrallah IM, Shou H, Davatzikos C.) EBioMedicine. 2024 Nov;109:105399 PMID: 39437659 PMCID: PMC11536027 SCOPUS ID: 2-s2.0-85206914012 10/23/2024

• Neuropsychological correlates of early grief in bereaved older adults.

  (Hoffmann BM, Blair NP, McAuliffe TL, Hwang G, Larson E, Claesges SA, Webber A, Reynolds CF 3rd, Goveas JS.) Int Psychogeriatr. 2024 Nov;36(11):1064-1069 PMID: 38462965 PMCID: PMC11387951 SCOPUS ID: 2-s2.0-85187712212 03/11/2024

• Genetic and clinical correlates of two neuroanatomical AI dimensions in the Alzheimer's disease continuum.

  (Wen J, Yang Z, Nasrallah IM, Cui Y, Erus G, Srinivasan D, Abdulkadir A, Mamourian E, Hwang G, Singh A, Bergman M, Bao J, Varol E, Zhou Z, Boquet-Pujadas A, Chen J, Toga AW, Saykin AJ, Hohman TJ, Thompson PM, Villeneuve S, Gollub R, Sotiras A, Wittfeld K, Grabe HJ, Tosun D, Bilgel M, An Y, Marcus DS, LaMontagne P, Benzinger TL, Heckbert SR, Austin TR, Launer LJ, Espeland M, Masters CL, Maruff P, Fripp J, Johnson SC, Morris JC, Albert MS, Bryan RN, Resnick SM, Ferrucci L, Fan Y, Habes M, Wolk D, Shen L, Shou H, Davatzikos C.) Transl Psychiatry. 2024 Oct 05;14(1):420 PMID: 39368996 PMCID: PMC11455841 SCOPUS ID: 2-s2.0-85205758659 10/06/2024

• Dimensional Neuroimaging Endophenotypes: Neurobiological Representations of Disease Heterogeneity Through Machine Learning.

  (Wen J, Antoniades M, Yang Z, Hwang G, Skampardoni I, Wang R, Davatzikos C.) Biol Psychiatry. 2024 Oct 01;96(7):564-584 PMID: 38718880 PMCID: PMC11374488 SCOPUS ID: 2-s2.0-85195576462 05/09/2024

• Genetic and Clinical Correlates of AI-Based Brain Aging Patterns in Cognitively Unimpaired Individuals.

  (Skampardoni I, Nasrallah IM, Abdulkadir A, Wen J, Melhem R, Mamourian E, Erus G, Doshi J, Singh A, Yang Z, Cui Y, Hwang G, Ren Z, Pomponio R, Srinivasan D, Govindarajan ST, Parmpi P, Wittfeld K, Grabe HJ, Bülow R, Frenzel S, Tosun D, Bilgel M, An Y, Marcus DS, LaMontagne P, Heckbert SR, Austin TR, Launer LJ, Sotiras A, Espeland MA, Masters CL, Maruff P, Fripp J, Johnson SC, Morris JC, Albert MS, Bryan RN, Yaffe K, Völzke H, Ferrucci L, Benzinger TLS, Ezzati A, Shinohara RT, Fan Y, Resnick SM, Habes M, Wolk D, Shou H, Nikita K, Davatzikos C.) JAMA Psychiatry. 2024 May 01;81(5):456-467 PMID: 38353984 PMCID: PMC10867779 SCOPUS ID: 2-s2.0-85185283495 02/14/2024

• The genetic architecture of multimodal human brain age.

  (Wen J, Zhao B, Yang Z, Erus G, Skampardoni I, Mamourian E, Cui Y, Hwang G, Bao J, Boquet-Pujadas A, Zhou Z, Veturi Y, Ritchie MD, Shou H, Thompson PM, Shen L, Toga AW, Davatzikos C.) Nat Commun. 2024 Mar 23;15(1):2604 PMID: 38521789 PMCID: PMC10960798 SCOPUS ID: 2-s2.0-85188443845 03/24/2024

• Tau-neurodegeneration mismatch reveals vulnerability and resilience to comorbidities in Alzheimer's continuum.

  (Lyu X, Duong MT, Xie L, de Flores R, Richardson H, Hwang G, Wisse LEM, DiCalogero M, McMillan CT, Robinson JL, Xie SX, Lee EB, Irwin DJ, Dickerson BC, Davatzikos C, Nasrallah IM, Yushkevich PA, Wolk DA, Das SR, Alzheimer's Disease Neuroimaging Initiative.) Alzheimers Dement. 2024 Mar;20(3):1586-1600 PMID: 38050662 PMCID: PMC10984442 SCOPUS ID: 2-s2.0-85161816922 12/05/2023

• Genomic loci influence patterns of structural covariance in the human brain.

  (Wen J, Nasrallah IM, Abdulkadir A, Satterthwaite TD, Yang Z, Erus G, Robert-Fitzgerald T, Singh A, Sotiras A, Boquet-Pujadas A, Mamourian E, Doshi J, Cui Y, Srinivasan D, Skampardoni I, Chen J, Hwang G, Bergman M, Bao J, Veturi Y, Zhou Z, Yang S, Dazzan P, Kahn RS, Schnack HG, Zanetti MV, Meisenzahl E, Busatto GF, Crespo-Facorro B, Pantelis C, Wood SJ, Zhuo C, Shinohara RT, Gur RC, Gur RE, Koutsouleris N, Wolf DH, Saykin AJ, Ritchie MD, Shen L, Thompson PM, Colliot O, Wittfeld K, Grabe HJ, Tosun D, Bilgel M, An Y, Marcus DS, LaMontagne P, Heckbert SR, Austin TR, Launer LJ, Espeland M, Masters CL, Maruff P, Fripp J, Johnson SC, Morris JC, Albert MS, Bryan RN, Resnick SM, Fan Y, Habes M, Wolk D, Shou H, Davatzikos C.) Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2300842120 PMID: 38127979 PMCID: PMC10756284 SCOPUS ID: 2-s2.0-85181179290 12/21/2023