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Medical College of Wisconsin School of Graduate Studies

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Medical College of Wisconsin School of Graduate Studies

Home /
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Nuoya Peng

Nuoya (Noah) Peng

Graduate Student

Locations

Biochemistry

Contact Information

npeng@mcw.edu

Biography

Mentor: Christian Kastrup, PhD
Year Entered MCW: 2022
Previous Education: BSc. Biochemistry, University of British Columbia, 2022

Research Interests

My interests lie with RNA therapeutics—utilizing lipid nanoparticles to deliver si/mRNA into blood cells. This allows for high efficiency and targeted expression or knockdown of specific proteins in blood cells such as platelets or megakaryocytes, or solid organs such as the liver. This technology can potentially enhance the hemostatic capability of blood or prevent thrombosis, with implications ranging from treating deadly bleeding disorders to mitigating lethal hemorrhage. Moreover, secretion of exogenous proteins from blood cells could improve their efficacy; on the contrary, whilst prevention of unfavorable protein secretion could counter many degenerative diseases.

Publications

Peng N, Yeh HH, Khavari A, Zhang-Gao H, Tenn C, Semple HA, Cau MF, Beckett A, Kastrup CJ. Efficacy and safety of CounterFlow in animal models of hemorrhage. Journal of Military, Veteran, and Family Health. 2023 Jan; In Press. Doi: https://doi.org/10.3138/jmvfh-2022-0014. Epub 2023 Jan 11.

Cau MF, Ali-Mohamad N, Baylis JR, Zenova V, Khavari A, Peng N, McFadden A, Donnellan F, Owen DR, Schaeffer DF, Nagaswami C, Litvinov RI, Weisel JW, Rezende-Neto J, Semple HA, Beckett A, Kastrup CJ. Percutaneous delivery of self-propelling hemostatic powder for managing non-compressible abdominal hemorrhage: a proof-of-concept study in swine. Injury. 2022 May;53(5):1603-1609. doi: 10.1016/j.injury.2022.01.024. Epub 2022 Jan 15. PMID: 35067343.