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Medical College of Wisconsin School of Graduate Studies U1-Research 2F Microscope Lab-Grad-hero
Robin Witt

Robin Witt

Graduate Student

Program

  • Biochemistry

Contact Information

Biography

Mentor: Brian Volkman, PhD 
Year Entered MCW: 2023
Previous Education: University of Wisconsin-Whitewater

Research Interests

Robin is interested in the regulation of the immune system through mechanistic regulation of receptor chemistries via structural determination. Using NMR spectroscopy and cryo-EM, Robin is investigating drug-receptor interaction and unique physiological and structural changes based on disease states and inhibition.

Previously, Robin completed her Bachelor of Science degree in Chemistry at the University of Wisconsin-Whitewater. For four years, she studied under the direction of Dr. Christopher Veldkamp looking at chemokine structural determination, where she published two articles. Robin started at the Medical College of Wisconsin in 2023, where she continued her work in structural biology, gained more experience in NMR spectroscopy, cryo-EM, and protein purification under the direction of Dr. Brian Volkman.

Publications

Structural Insights into Molecular Recognition by Human Chemokine CCL19. Eric M. Lewandowski, Kyle G. Kroeck, Lian M.C. Jacobs, Tyler G. Fenske, Robin N. Witt, Alyssa M. Hintz, Elizabeth R. Ramsden, Xiujun Zhang, Francis Peterson, Brian F. Volkman, Christopher T. Veldkamp, and Yu Chen. Biochemistry 2022 61 (5), 311-318. DOI: 10.1021/acs.biochem.1c00759.

NMR indicates the N-termini of PSGL1 and CCR7 bind competitively to the chemokine CCL21. Robin N. Witt, Kaileigh S. Nickel, John R. Binns, Alexander M. Gray, Alyssa M. Hintz, Noah F. Kofron, Steven F. Steigleder, Francis C. Peterson, and Christopher T. Veldkamp. Biochemistry and Biophysical Reports 2023 35, 101524. DOI: 10.1016/j.bbrep.2023.101524.