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MSTP students in the Sahoo lab
Medical Scientist Training Program
Nicholas Malcolm

Nicholas Malcolm

M3 Student

Faculty Advisor

  • John McCorvy, PhD, and Jonathan Marchant, PhD, Cell Biology, Neurobiology & Anatomy

Locations

  • Medical Scientist Training Program

Contact Information

Education

BS, Mathematics, Molecular Biology, University of Wisconsin-Parkside, 2018

Research Interests

Computational biology, drug discovery, statistical mechanics, protein dynamics and chronic pain

Research Experience

Medical College of Wisconsin, 2020-2024
Advisor: John McCorvy, PhD
Project: Investigating The Molecular Determinants Of Superagonism At The Mu-Opioid Receptor

Medical College of Wisconsin, 2017
Advisor: Jeffrey Medin, PhD
Project: Mitochondrial activity in mouse models of lysosomal storage disorders

UW - Parkside, 2016-2017
Advisor: Daphne Pham, PhD
Project: Inhibitors of ribonucleotide reductase oligomerization as a novel mosquito control mechanism 

Publications

Malcolm NJ, Palkovic B, Sprague DJ, Calkins MM, Lanham JK, Halberstadt AL, Stucke AG, McCorvy JD. Mu-opioid receptor selective superagonists produce prolonged respiratory depression. iScience. 2023 Jun 13;26(7):107121. doi: 10.1016/j.isci.2023.107121. PMID: 37416459; PMCID: PMC10320493.

Lewis V, Bonniwell EM, Lanham JK, Ghaffari A, Sheshbaradaran H, Cao AB, Calkins MM, Bautista-Carro MA, Arsenault E, Telfer A, Taghavi-Abkuh FF, Malcolm NJ, El Sayegh F, Abizaid A, Schmid Y, Morton K, Halberstadt AL, Aguilar-Valles A, McCorvy JD. A non-hallucinogenic LSD analog with therapeutic potential for mood disorders. Cell Rep. 2023 Mar 28;42(3):112203. doi: 10.1016/j.celrep.2023.112203. Epub 2023 Mar 6. PMID: 36884348; PMCID: PMC10112881.

Rohr CM, Sprague DJ, Park SK, Malcolm NJ, Marchant JS. Natural variation in the binding pocket of a parasitic flatworm TRPM channel resolves the basis for praziquantel sensitivity. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2217732120. doi: 10.1073/pnas.2217732120. Epub 2022 Dec 27. PMID: 36574686; PMCID: PMC9910428. 

Meeting Abstracts

Malcolm N, Palkovic B, Sprague D, Cavalco N, Calkins M, Lanham J, et al. Markovian Modeling of the Conformational Dynamics Involved in µ-Opioid Receptor Superagonism. Complexity in Proteins Gordon Research Conference (GRC); Holderness, NH. Jun 2023. [Poster] 

General Interests

Reading, tabletop games, miniature figurine painting, heavy metal, dogs, and horses

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