Philip Mosier, PhD
Assistant Professor, Department of Biopharmaceutical Sciences
Locations
- MCW School of Pharmacy
- HRC 2708
Contact Information
Education
1992–1997 University of Nebraska Medical Center, Omaha, NE
1998–2003 PhD, The Pennsylvania State University, State College, PA
2004–2009 postdoctoral training, Virginia Commonwealth University
Biography
Research Interests
• Computer-Aided Drug Design (CADD)
• Structural Biology
• G Protein-Coupled Receptors (GPCRs)
• Ligand-Gated Ion Channels (LGICs)
• Tyrosine Kinase Inhibitors (TKIs)
• Sigma Receptors
• Neuroscience
• Drugs of Abuse/Misuse
• Natural Products
• Infectious Diseases
• Glycoscience
• Hemostasis
• Cancer
Publications
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(Abatematteo FS, Mosier PD, Niso M, Brunetti L, Berardi F, Loiodice F, Contino M, Delprat B, Maurice T, Laghezza A, Abate C.) Eur J Med Chem. 2022 Jan 15;228:114038 PMID: 34902734 12/14/2021
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High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212.
(Niso M, Mosier PD, Marottoli R, Ferorelli S, Cassano G, Gasparre G, Leopoldo M, Berardi F, Abate C.) Future Med Chem. 2019 Oct;11(19):2547-2562 PMID: 31633399 10/22/2019
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Methylene Bridge to 5-HT3 Receptor Antagonists: Conformationally Constrained Phenylguanidines.
(Abdelkhalek AS, Alley GS, Alwassil OI, Khatri S, Mosier PD, Nyce HL, White MM, Schulte MK, Dukat M.) ACS Chem Neurosci. 2019 Mar 20;10(3):1380-1389 PMID: 30375852 10/31/2018
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(Etobayeva I, Linden SB, Alem F, Harb L, Rizkalla L, Mosier PD, Johnson AA, Temple L, Hakami RM, Nelson DC.) Viruses. 2018 May 21;10(5) PMID: 29883383 PMCID: PMC5977269 06/09/2018
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Complete Genome Sequences of Bacillus Phages Janet and OTooleKemple52.
(Kent B, Raymond T, Mosier PD, Johnson AA, the 2016–2017 VCU Phage Hunters.) Genome Announc. 2018 May 10;6(19) PMID: 29748396 PMCID: PMC5946042 05/12/2018
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Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.
(Che T, Majumdar S, Zaidi SA, Ondachi P, McCorvy JD, Wang S, Mosier PD, Uprety R, Vardy E, Krumm BE, Han GW, Lee MY, Pardon E, Steyaert J, Huang XP, Strachan RT, Tribo AR, Pasternak GW, Carroll FI, Stevens RC, Cherezov V, Katritch V, Wacker D, Roth BL.) Cell. 2018 Jan 11;172(1-2):55-67.e15 PMID: 29307491 PMCID: PMC5802374 SCOPUS ID: 2-s2.0-85039900111 01/09/2018
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(Chiang MJ, Musayev FN, Kosikova M, Lin Z, Gao Y, Mosier PD, Althufairi B, Ye Z, Zhou Q, Desai UR, Xie H, Safo MK.) Emerg Microbes Infect. 2017 Dec 06;6(12):e108 PMID: 29209052 PMCID: PMC5750462 12/07/2017
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(Sankarayanarayanan NV, Strebel TR, Boothello RS, Sheerin K, Raghuraman A, Sallas F, Mosier PD, Watermeyer ND, Oscarson S, Desai UR.) Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2312-2317 PMID: 28124818 PMCID: PMC5347859 01/27/2017
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(Alix K, Khatri S, Mosier PD, Casterlow S, Yan D, Nyce HL, White MM, Schulte MK, Dukat M.) ACS Chem Neurosci. 2016 Nov 16;7(11):1565-1574 PMID: 27533595 08/18/2016
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(Sarkar A, Yu W, Desai UR, MacKerell AD, Mosier PD.) Glycobiology. 2016 Oct;26(10):1041-1047 PMID: 27496757 PMCID: PMC5072149 08/09/2016
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Broad Spectrum Anti-Influenza Agents by Inhibiting Self-Association of Matrix Protein 1.
(Mosier PD, Chiang MJ, Lin Z, Gao Y, Althufairi B, Zhou Q, Musayev F, Safo MK, Xie H, Desai UR.) Sci Rep. 2016 Aug 30;6:32340 PMID: 27573445 PMCID: PMC5004101 08/31/2016
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(Joseph PR, Mosier PD, Desai UR, Rajarathnam K.) Biochem J. 2015 Nov 15;472(1):121-33 PMID: 26371375 PMCID: PMC4692082 09/16/2015