Diane S. Book, MD

Associate Professor

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Location

Neuroscience Center – Specialty Clinics
900 N. 92nd St.
Milwaukee, WI 53226

Specialties

Behavioral Neurology
Neurology

Neurology-Appointment by Referral Only

(414) 955-6688

I approach patients from the perspective of doctor as teacher- as originally defined 700 years ago. I see every patient encounter as an opportunity to teach them how to heal, to recover, and how to stay well in the future.

Overview

Diseases and Conditions

Alzheimer's Disease
Alzheimer's-Related Dementias
Aphasia
Cerebrovascular Disease
Dementia
Ischemic Stroke
Memory Disorders
Memory Loss
Stroke
Transient Ischemic Attack
CADASIL
Degenerative Dementia
Vascular Cognitive Impairment
Frontal Temporal Dementia
Lewy Body Dementia
Cerebrovascular Accident (CVA)
Stroke from Intracranial Atherosclerotic Disease or Carotid Disease
TIA from Intracranial Atherosclerotic Disease or Carotid Disease

Treatments and Services

Acute Stroke Therapy
Evaluation and Managment of Degenerative Dementias
Stroke Evaluation and Management
Virtual Visit

Patients Ages Seen

Adult
Senior

Languages

English

Hospital Affiliations

Froedtert Hospital – Milwaukee

Board Certifications

Neurology

Clinic Locations

Neuroscience Center – Specialty Clinics

900 N. 92nd St.
Milwaukee, WI 53226
(414) 805-5400
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Biography

Dr. Book is a specialist in cerebrovascular disorders including stroke, having co-founded the Froedtert & the Medical College of Wisconsin Stroke Program, and also in the dementias including Alzheimer’s Disease and vascular cognitive disorders. She has expanded her interests in stroke care quality to encompass patient safety and quality across Neurology.

Education and Training

Doctor of Medicine - Medical College of Wisconsin - Milwaukee, WI (1991)
Residency in Neurology - Medical College of Wisconsin - Milwaukee, WI (1995)
Fellowship in Stroke/Dementia - Medical College of Wisconsin Affiliated Hospitals - Milwaukee, WI (1996)
Certificate in LEAN Healthcare - University of Michigan - Ann Arbor, MI (2013)

Semantic network activation facilitates oral word reading in chronic aphasia.

(Pillay SB, Gross WL, Heffernan J, Book DS, Binder JR.) Brain Lang. 2022 Oct;233:105164 PMID: 35933744 PMCID: PMC9948519 SCOPUS ID: 2-s2.0-85135407900 08/08/2022
The Neural Basis of Successful Word Reading in Aphasia.

(Pillay SB, Gross WL, Graves WW, Humphries C, Book DS, Binder JR.) J Cogn Neurosci. 2018 Apr;30(4):514-525 PMID: 29211656 PMCID: PMC9926535 SCOPUS ID: 2-s2.0-85042764522 12/07/2017
Lesion localization of speech comprehension deficits in chronic aphasia.

(Pillay SB, Binder JR, Humphries C, Gross WL, Book DS.) Neurology. 2017 Mar 07;88(10):970-975 PMID: 28179469 PMCID: PMC5333516 SCOPUS ID: 2-s2.0-85014816931 02/10/2017
Surface errors without semantic impairment in acquired dyslexia: a voxel-based lesion-symptom mapping study.

(Binder JR, Pillay SB, Humphries CJ, Gross WL, Graves WW, Book DS.) Brain. 2016 May;139(Pt 5):1517-26 PMID: 26966139 PMCID: PMC5006249 SCOPUS ID: 2-s2.0-84966648862 03/12/2016
Cerebral localization of impaired phonological retrieval during rhyme judgment.

(Pillay SB, Stengel BC, Humphries C, Book DS, Binder JR.) Ann Neurol. 2014 Nov;76(5):738-46 PMID: 25164766 PMCID: PMC4214892 SCOPUS ID: 2-s2.0-84912085803 08/29/2014
Closure of patent foramen ovale versus medical therapy after cryptogenic stroke.

(Carroll JD, Saver JL, Thaler DE, Smalling RW, Berry S, MacDonald LA, Marks DS, Tirschwell DL, RESPECT Investigators.) N Engl J Med. 2013 Mar 21;368(12):1092-100 PMID: 23514286 03/22/2013
Effects of clopidogrel added to aspirin in patients with recent lacunar stroke.

(SPS3 Investigators, Benavente OR, Hart RG, McClure LA, Szychowski JM, Coffey CS, Pearce LA.) N Engl J Med. 2012 Aug 30;367(9):817-25 PMID: 22931315 PMCID: PMC4067036 08/31/2012
High-dose atorvastatin after stroke or transient ischemic attack.

(Amarenco P, Bogousslavsky J, Callahan A 3rd, Goldstein LB, Hennerici M, Rudolph AE, Sillesen H, Simunovic L, Szarek M, Welch KM, Zivin JA, Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators.) N Engl J Med. 2006 Aug 10;355(6):549-59 PMID: 16899775 08/11/2006
Clipping the Eagle's wings: treatment of an unusual cause of transient cerebral ischemia.

(Varelas PN, Sinson G, Rand S, Book D.) Neurology. 2005 Jan 25;64(2):393-4 PMID: 15668456 SCOPUS ID: 2-s2.0-12544250987 01/26/2005
Design and baseline characteristics of the stroke prevention by aggressive reduction in cholesterol levels (SPARCL) study.

(Amarenco P, Bogousslavsky J, Callahan AS, Goldstein L, Hennerici M, Sillsen H, Welch MA, Zivin J, SPARCL Investigators.) Cerebrovasc Dis. 2003;16(4):389-95 PMID: 14584489 SCOPUS ID: 2-s2.0-0141676273 10/31/2003
Markers of increased risk of intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator therapy for acute ischemic stroke in clinical practice: the Multicenter rt-PA Stroke Survey.

(Tanne D, Kasner SE, Demchuk AM, Koren-Morag N, Hanson S, Grond M, Levine SR.) Circulation. 2002 Apr 09;105(14):1679-85 PMID: 11940547 SCOPUS ID: 2-s2.0-0037046216 04/10/2002
Initial clinical experience with IV tissue plasminogen activator for acute ischemic stroke: a multicenter survey. The t-PA Stroke Survey Group.

(Tanne D, Bates VE, Verro P, Kasner SE, Binder JR, Patel SC, Mansbach HH, Daley S, Schultz LR, Karanjia PN, Scott P, Dayno JM, Vereczkey-Porter K, Benesch C, Book D, Coplin WM, Dulli D, Levine SR.) Neurology. 1999 Jul 22;53(2):424-7 PMID: 10430444 SCOPUS ID: 2-s2.0-0033595255 08/03/1999