Department of Pharmacology and Toxicology
Welcome to the Department of Pharmacology and Toxicology at the Medical College of Wisconsin is dedicated to quality in research, graduate and postdoctoral training and medical education. The research interests of our faculty are broadly based in cardiovascular pharmacology, neuropharmacology, cancer pharmacology, toxicology and molecular pharmacology. The research programs in the Department of Pharmacology and Toxicology are also multidisciplinary in nature and have strong associations with researchers of other basic science and clinical departments.
John D. Imig, PhD
Professor, Pharmacology and Toxicology
Can a research laboratory make major breakthroughs and develop novel therapeutics for cardiovascular and kidney diseases? The answer is a resounding, YES!
Dr. Imig’s research has focused on a class of fatty acids, arachidonic acid metabolites that have been targeted by drugs for the treatment of pain, fever, blood clotting, and asthma. Utilizing animal models of cardiovascular and kidney diseases his laboratory has demonstrated that arachidonic acid metabolites called epoxyeicosatrienoic acids (EETs) and the enzyme soluble epoxide hydrolase are not properly regulated during disease states. Over the past decade his laboratory was a major driving force in the development of drugs that inhibit the soluble epoxide hydrolase enzyme and one of these drugs is currently being tested in humans for the treatment of chronic obstructive pulmonary disease (COPD). More recently, the laboratory has focused on developing EET-based drugs for the treatment of hypertension, acute renal failure, and chronic kidney disease. These novel small molecule EET analogs are demonstrating great potential and could one day in the near future be used to treat cardiovascular and kidney diseases in humans.