Activity and Expertise

Redox Biology Activity at MCW

Savitha Sethumadhavan, PhD

The Redox Biology Program unites researchers from many disciplines who are interested in the role of redox processes in physiology and pathology. These scientists have extensive research experience and technological skills, and laboratories containing cutting-edge resources. They are well funded with federal grant awards and are invested in transferring basic science knowledge to the clinical arena.

Many biological processes involve the movement of electrons, and every time an electron moves, something gets reduced and something gets oxidized.

Redox processes are essential to respiration and the generation of cellular ATP. Overt cellular damage can result from the overexposure of cells to environmental oxidants or the overproduction of similar oxidants by the cell itself (often termed "oxidative stress"). However, it has become clear that redox reactions in cells, and the control of redox homeostasis, modulate a plethora of cellular signaling events through protein post-translational modifications.

The control of apoptosis, proliferation and migration of cells have been shown to be modulated at multiple levels by redox processes, usually (though not exclusively) through the oxidation/reduction/modification of protein thiol groups.


Areas of Expertise

  • Biochemistry
  • Bioenergetics
  • Cancer
  • Cardiovascular
  • Chemistry
  • Diabetes
  • EPR Spin Trapping
  • Fetal Brain Injury
  • Free Radical Chemistry and Biochemistry
  • Inflammation
  • Nitric Oxide and its Interactions
  • Pain
  • Redox Methodology
  • Stem Cells

Researchers

The Redox Biology Program is made up of scientists focusing on many disciplines, including nutrition, polyphenolics, cancer, metabolism, cardiovascular, diabetes, inflammation, aging, neuroscience, cell and molecular biology, cell signaling and bioenergetics.

Directors

Neil Hogg, PhD

Neil Hogg, PhD

Professor
Department of Biophysics Director, Redox Biology Program

Full Bio | Email Dr. Hogg

Jeannette Vasquez-Vivar, PhD

Jeannette Vasquez-Vivar, PhD

Professor
Department of Biophysics, Associate Director Redox Biology Program

Full Bio | Email Dr. Vasquez-Vivar

Scientists

Ivor Benjamin

Ivor Benjamin, MD

Professor
Departments of Medicine, Physiology, Pharmacology and Toxicology, Cell Biology and Surgery; Director, Cardiovascular Center

Full Bio

Martin Bienengraeber, PhD

Martin Bienengraeber, PhD

Adjunct Professor
Departments of Anesthesiology, Pharmacology and Toxicology

John Corbett

John Corbett, PhD

Professor and Chair
Department of Biochemistry

Full Bio

Albert Girotti, PhD

Albert Girotti, PhD

Professor
Department of Biochemistry

Full Bio

David Gutterman, MD

David Gutterman, MD

Northwestern Mutual Professor in Cardiology
Departments of Medicine and Physiology

Full Bio

David Harder, PhD

David Harder, PhD

Professor
Departments of Physiology, Medicine and Pediatrics

Full Bio

Cheryl Hillery

Cheryl Hillery, MD

Associate Professor
Departments of Pediatrics and Medicine

Balaraman Kalyanaraman, PhD

Balaraman Kalyanaraman, PhD

Professor and Chair, Harry R. & Angeline E. Quadracci Professor in Parkinson's Research
Department of Biophysics

Full Bio

Kirkwood Pritchard, Jr., PhD

Kirkwood Pritchard, Jr., PhD

Professor
Departments of Surgery, Pharmacology and Toxicology

Full Bio

Roy Silverstein

Roy Silverstein, MD

Professor and Chair
Department of Medicine

Full Bio

Brian Smith

Brian Smith, PhD

Assistant Professor
Department of Biochemistry

Full Bio

Cheryl L. Stucky, PhD

Cheryl L. Stucky, PhD

Professor, Director Neuroscience Doctoral Program
Department of Cell Biology, Neurobiology and Anatomy

Full Bio

Jim Thomas, MD

James Thomas, MD, PhD

Section Head, Solid Tumor Oncology
Department of Medicine, Division of Hematology and Oncology

Full Bio

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