Our world-class investigators use translational, basic and applied research to pursue cutting-edge developments.
Investigating, contributing and collaborating
The Redox Biology Program unites researchers from many disciplines who are interested in the role of redox processes in physiology and pathology. These scientists have extensive research experience and technological skills, and laboratories containing cutting-edge resources. They are well funded with federal grant awards and are invested in transferring basic science knowledge to the clinical arena.
Redox Biology Activity at MCW
Many biological processes involve the movement of electrons, and every time an electron moves, something gets reduced and something gets oxidized.
Redox processes are essential to respiration and the generation of cellular ATP. Overt cellular damage can result from the overexposure of cells to environmental oxidants or the overproduction of similar oxidants by the cell itself (often termed "oxidative stress"). However, it has become clear that redox reactions in cells, and the control of redox homeostasis, modulate a plethora of cellular signaling events through protein post-translational modifications.
The control of apoptosis, proliferation and migration of cells has been shown to be modulated at multiple levels by redox processes, usually (though not exclusively) through the oxidation/reduction/modification of protein thiol groups.
Areas of Expertise
Areas of expertise include biochemistry, bioenergetics, cancer, cardiovascular, chemistry, diabetes, EPR (electron paramagnetic resonance) spin trapping, fetal brain injury, free radical chemistry and biochemistry, inflammation, nitric oxide and its interactions, pain, redox methodology and stem cells.
We are grateful for the generous support of our sponsors.