Angela Mathison, PhD

Publications

• Combined Targeting of G9a and Checkpoint Kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse.

  (Urrutia G, Salmonson A, Toro-Zapata J, de Assuncao TM, Mathison A, Dusetti N, Iovanna J, Urrutia R, Lomberk G.) Mol Cancer Res. 2020 03;18(3):448-462 PMID: 31822519 PMCID: PMC7056528 SCOPUS ID: 2-s2.0-85081130002 12/12/2019

• SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer.

  (He C, Danes JM, Hart PC, Zhu Y, Huang Y, de Abreu AL, O'Brien J, Mathison AJ, Tang B, Frasor JM, Wakefield LM, Ganini D, Stauder E, Zielonka J, Gantner BN, Urrutia RA, Gius D, Bonini MG.) Proc Natl Acad Sci U S A. 2019 11 19;116(47):23534-23541 PMID: 31591207 PMCID: PMC6876149 SCOPUS ID: 2-s2.0-85075260452 10/09/2019

• Aurora kinase B-phosphorylated HP1α functions in chromosomal instability.

  (Williams MM, Mathison AJ, Christensen T, Greipp PT, Knutson DL, Klee EW, Zimmermann MT, Iovanna J, Lomberk GA, Urrutia RA.) Cell Cycle. 2019 06;18(12):1407-1421 PMID: 31130069 PMCID: PMC6592258 SCOPUS ID: 2-s2.0-85067316375 05/28/2019

• Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis.

  (Martin-Mateos R, De Assuncao TM, Arab JP, Jalan-Sakrikar N, Yaqoob U, Greuter T, Verma VK, Mathison AJ, Cao S, Lomberk G, Mathurin P, Urrutia R, Huebert RC, Shah VH.) Cell Mol Gastroenterol Hepatol. 2019;7(1):197-209 PMID: 30539787 PMCID: PMC6282644 SCOPUS ID: 2-s2.0-85057853914 12/13/2018

• Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway.

  (Seo S, Mathison A, Grzenda A, Podratz J, Calvo E, Brimijoin S, Windebank A, Iovanna J, Lomberk G, Urrutia R.) Sci Rep. 2018 10 10;8(1):15077 PMID: 30305677 PMCID: PMC6180112 SCOPUS ID: 2-s2.0-85054625299 10/12/2018

• Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes.

  (Lomberk G, Blum Y, Nicolle R, Nair A, Gaonkar KS, Marisa L, Mathison A, Sun Z, Yan H, Elarouci N, Armenoult L, Ayadi M, Ordog T, Lee JH, Oliver G, Klee E, Moutardier V, Gayet O, Bian B, Duconseil P, Gilabert M, Bigonnet M, Garcia S, Turrini O, Delpero JR, Giovannini M, Grandval P, Gasmi M, Secq V, De Reyniès A, Dusetti N, Iovanna J, Urrutia R.) Nat Commun. 2018 05 17;9(1):1978 PMID: 29773832 PMCID: PMC5958058 SCOPUS ID: 2-s2.0-85047248746 05/19/2018

• Combined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe.

  (Mathison A, Salmonson A, Missfeldt M, Bintz J, Williams M, Kossak S, Nair A, de Assuncao TM, Christensen T, Buttar N, Iovanna J, Huebert R, Lomberk G.) Mol Cancer Res. 2017 08;15(8):984-997 PMID: 28442587 PMCID: PMC5705946 SCOPUS ID: 2-s2.0-85026643394 04/27/2017

• Functional validation reveals the novel missense V419L variant in TGFBR2 associated with Loeys-Dietz syndrome (LDS) impairs canonical TGF-β signaling.

  (Cousin MA, Zimmermann MT, Mathison AJ, Blackburn PR, Boczek NJ, Oliver GR, Lomberk GA, Urrutia RA, Deyle DR, Klee EW.) Cold Spring Harb Mol Case Stud. 2017 07;3(4) PMID: 28679693 PMCID: PMC5495030 SCOPUS ID: 2-s2.0-85037598912 07/07/2017

• The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD).

  (Sarmento OF, Svingen PA, Xiong Y, Sun Z, Bamidele AO, Mathison AJ, Smyrk TC, Nair AA, Gonzalez MM, Sagstetter MR, Baheti S, McGovern DP, Friton JJ, Papadakis KA, Gautam G, Xavier RJ, Urrutia RA, Faubion WA.) J Biol Chem. 2017 Jan 13;292(2):706-722 PMID: 27909059 PMCID: PMC5241744 SCOPUS ID: 2-s2.0-85009804809 12/03/2016

• Asymmetric Cancer Hallmarks in Breast Tumors on Different Sides of the Body.

  (Campoy EM, Laurito SR, Branham MT, Urrutia G, Mathison A, Gago F, Orozco J, Urrutia R, Mayorga LS, Roqué M.) PLoS One. 2016;11(7):e0157416 PMID: 27383829 PMCID: PMC4934783 SCOPUS ID: 2-s2.0-84978159641 07/08/2016

• Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production.

  (Guo Y, Fan Y, Zhang J, Lomberk GA, Zhou Z, Sun L, Mathison AJ, Garcia-Barrio MT, Zhang J, Zeng L, Li L, Pennathur S, Willer CJ, Rader DJ, Urrutia R, Chen YE.) J Clin Invest. 2015 Oct 01;125(10):3819-30 PMID: 26368306 PMCID: PMC4607137 SCOPUS ID: 2-s2.0-84943222952 09/15/2015

• Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes.

  (Mathison A, Escande C, Calvo E, Seo S, White T, Salmonson A, Faubion WA Jr, Buttar N, Iovanna J, Lomberk G, Chini EN, Urrutia R.) Endocrinology. 2015 Oct;156(10):3581-95 PMID: 26248217 PMCID: PMC4588811 SCOPUS ID: 2-s2.0-84943616432 08/08/2015