Angela Mathison, PhD

Publications

• Enhanced interpretation of 935 hotspot and non-hotspot RAS variants using evidence-based structural bioinformatics.

  (Tripathi S, Dsouza NR, Mathison AJ, Leverence E, Urrutia R, Zimmermann MT.) Comput Struct Biotechnol J. 2022;20:117-127 PMID: 34976316 PMCID: PMC8688876 01/04/2022

• Enhanced interpretation of 935 hotspot and non-hotspot RAS variants using evidence-based structural bioinformatics

  (Tripathi S, Dsouza NR, Mathison AJ, Leverence E, Urrutia R, Zimmermann MT.) Computational and Structural Biotechnology Journal. January 2022;20:117-127 SCOPUS ID: 2-s2.0-85121238740 01/01/2022

• Computational modeling reveals key molecular properties and dynamic behavior of disruptor of telomeric silencing 1-like (DOT1L) and partnering complexes involved in leukemogenesis.

  (Stodola TJ, Chi YI, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R.) Proteins. 2022 01;90(1):282-298 PMID: 34414607 PMCID: PMC8671179 SCOPUS ID: 2-s2.0-85114677469 08/21/2021

• RNA Sequencing and Pathways Analyses of Middle Ear Epithelia From Patients With Otitis Media.

  (Stabenau KA, Zimmermann MT, Mathison A, Zeighami A, Samuels TL, Chun RH, Papsin BC, McCormick ME, Johnston N, Kerschner JE.) Laryngoscope. 2021 11;131(11):2590-2597 PMID: 33844317 SCOPUS ID: 2-s2.0-85104152095 04/13/2021

• KrasG12D induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells.

  (Mathison AJ, Kerketta R, de Assuncao TM, Leverence E, Zeighami A, Urrutia G, Stodola TJ, di Magliano MP, Iovanna JL, Zimmermann MT, Lomberk G, Urrutia R.) Genome Biol. 2021 10 14;22(1):289 PMID: 34649604 PMCID: PMC8518179 SCOPUS ID: 2-s2.0-85117299300 10/16/2021

• Effects of Subnormothermic Regulated Hepatic Reperfusion on Mitochondrial and Transcriptomic Profiles in a Porcine Model.

  (Kim J, Zimmerman MA, Shin WY, Boettcher BT, Lee JS, Park JI, Ali M, Yang M, Mishra J, Hagen CE, McGraw JE, Mathison A, Woehlck HJ, Lomberk G, Camara AKS, Urrutia RA, Stowe DF, Hong JC.) Ann Surg. 2021 Aug 13 PMID: 34387201 08/14/2021

• BMI1 maintains the Treg epigenomic landscape to prevent inflammatory bowel disease.

  (Gonzalez MM, Bamidele AO, Svingen PA, Sagstetter MR, Smyrk TC, Gaballa JM, Hamdan FH, Kosinsky RL, Gibbons HR, Sun Z, Ye Z, Nair A, Ramos GP, Braga Neto MB, Wixom AQ, Mathison AJ, Johnsen SA, Urrutia R, Faubion WA Jr.) J Clin Invest. 2021 06 15;131(12) PMID: 34128475 PMCID: PMC8203461 SCOPUS ID: 2-s2.0-85108220626 06/16/2021

• Correction to: Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction.

  (Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Basel DG, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R.) Orphanet J Rare Dis. 2021 Jun 01;16(1):247 PMID: 34074320 PMCID: PMC8170813 SCOPUS ID: 2-s2.0-85107273180 06/03/2021

• Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction.

  (Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Basel DG, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R.) Orphanet J Rare Dis. 2021 02 05;16(1):66 PMID: 33546721 PMCID: PMC7866879 SCOPUS ID: 2-s2.0-85100579633 02/07/2021

• Inactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks.

  (Urrutia G, de Assuncao TM, Mathison AJ, Salmonson A, Kerketta R, Zeighami A, Stodola TJ, Adsay V, Pehlivanoglu B, Dwinell MB, Zimmermann MT, Iovanna JL, Urrutia R, Lomberk G.) Front Cell Dev Biol. 2021;9:681153 PMID: 34249932 PMCID: PMC8261250 SCOPUS ID: 2-s2.0-85116952280 07/13/2021

• Interpreting Sequence Variation in PDAC-Predisposing Genes Using a Multi-Tier Annotation Approach Performed at the Gene, Patient, and Cohort Level.

  (Zimmermann MT, Mathison AJ, Stodola T, Evans DB, Abrudan JL, Demos W, Tschannen M, Aldakkak M, Geurts J, Lomberk G, Tsai S, Urrutia R.) Front Oncol. 2021;11:606820 PMID: 33747920 PMCID: PMC7973372 SCOPUS ID: 2-s2.0-85102941394 03/23/2021

• Inorganic arsenic promotes luminal to basal transition and metastasis of breast cancer.

  (Danes JM, de Abreu ALP, Kerketta R, Huang Y, Palma FR, Gantner BN, Mathison AJ, Urrutia RA, Bonini MG.) FASEB J. 2020 12;34(12):16034-16048 PMID: 33047385 PMCID: PMC8289339 SCOPUS ID: 2-s2.0-85092336914 10/14/2020