Chien-Wei (Masaki) Lin, PhD

Assistant Professor

Locations

Biostatistics

Contact Information

Research Interests

Dr. Chien-Wei (Masaki) Lin is an Assistant Professor in the Division of Biostatistics at the Medical College of Wisconsin. He joined the division in the Summer of 2017. His research expertise is statistical data analysis using different types of omics data, including single nucleotide polymorphism (SNP), copy number variation (CNV), DNA methylation, gene expression, proteomics (peptide), and metabolomics. He is particularly interested in developing statistical methodologies/tools in the fields of statistical genetics, bioinformatics, power and sample size calculation, integrative/meta-analysis and supervised/unsupervised machine learning problems. His major collaboration research groups at MCW include the Department of Pediatrics and Department of Biomedical Engineering.

DNA methylation in the human frontal cortex reveals a putative mechanism for age-by-disease interactions.

(McKinney BC, Lin CW, Rahman T, Oh H, Lewis DA, Tseng G, Sibille E.) Transl Psychiatry. 2019 Jan 29;9(1):39.
RNASeqDesign: a framework for ribonucleic acid sequencing genomewide power calculation and study design issues

(Chien-Wei Lin, Serena G. Liao, Peng Liu, Mei‐Ling Ting Lee, Yong Seok Park, George C. Tseng.) Journal of the Royal Statistical Society. Series C, Applied statistics. .
MetaOmics: Analysis Pipeline and Browser-based Software Suite for Transcriptomic Meta-Analysis.

(Ma T, Huo Z, Kuo A, Zhu L, Fang Z, Zeng X, Lin CW, Liu S, Wang L, Liu P, Rahman T, Chang LC, Kim S, Li J, Park Y, Song C, Oesterreich S, Sibille E, Tseng GC.) Bioinformatics. 2018 Oct 10.
Temporal and Spatial Post-Transcriptional Regulation of Zebrafish mRNA by Long Noncoding RNA During Brain Vascular Assembly.

(Chowdhury TA, Koceja C, Eisa-Beygi S, Kleinstiver BP, Kumar SN, Lin CW, Li K, Prabhudesai S, Joung JK, Ramchandran R.) Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1562-1575.
Enhanced Molecular Aging in Late-Life Depression: the Senescent-Associated Secretory Phenotype.

(Diniz BS, Reynolds CF 3rd, Sibille E, Lin CW, Tseng G, Lotrich F, Aizenstein HJ, Butters MA.) Am J Geriatr Psychiatry. 2017 01;25(1):64-72.
Age-dependent increase in Kalirin-9 and Kalirin-12 transcripts in human orbitofrontal cortex.

(Grubisha MJ, Lin CW, Tseng GC, Penzes P, Sibille E, Sweet RA.) Eur J Neurosci. 2016 10;44(7):2483-2492.
Circulating biosignatures of late-life depression (LLD): Towards a comprehensive, data-driven approach to understanding LLD pathophysiology.

(Diniz BS, Lin CW, Sibille E, Tseng G, Lotrich F, Aizenstein HJ, Reynolds CF, Butters MA.) J Psychiatr Res. 2016 11;82:1-7.
Predisposition to treatment response in major depressive episode: A peripheral blood gene coexpression network analysis.

(Belzeaux R, Lin CW, Ding Y, Bergon A, Ibrahim EC, Turecki G, Tseng G, Sibille E.) J Psychiatr Res. 2016 10;81:119-26.
SMART: Statistical Metabolomics Analysis-An R Tool.

(Liang YJ, Lin YT, Chen CW, Lin CW, Chao KM, Pan WH, Yang HC.) Anal Chem. 2016 06 21;88(12):6334-41.
MetaKTSP: a meta-analytic top scoring pair method for robust cross-study validation of omics prediction analysis.

(Kim S, Lin CW, Tseng GC.) Bioinformatics. 2016 07 01;32(13):1966-73.
FRAS1-related extracellular matrix 3 (FREM3) single-nucleotide polymorphism effects on gene expression, amygdala reactivity and perceptual processing speed: An accelerated aging pathway of depression risk.

(Nikolova YS, Iruku SP, Lin CW, Conley ED, Puralewski R, French B, Hariri AR, Sibille E.) Front Psychol. 2015;6:1377.
Hypermethylation of BDNF and SST Genes in the Orbital Frontal Cortex of Older Individuals: A Putative Mechanism for Declining Gene Expression with Age.

(McKinney BC, Lin CW, Oh H, Tseng GC, Lewis DA, Sibille E.) Neuropsychopharmacology. 2015 Oct;40(11):2604-13.

Chien-Wei (Masaki) Lin, PhD