Christian Kastrup, PhD

Publications

• Depletion of Fibrinogen Suppresses Growth of Primary Tumors and Metastasis of Pancreatic Ductal Adenocarcinoma.

  (Chowdhury NN, Mitchell DK, Kangro K, Eldridge K, Abrahams S, Ferraresso F, Juang LJ, Gampala S, Brewster K, Revenko A, Kastrup C, Territo PR, Clapp DW, Wang J, Belgodere JA, Saeed O, Choi SR, Han B, Wolberg AS, Cao S, Zhang C, Flick MJ, Fishel ML.) Gastroenterology. 2025 Dec 23 PMID: 41432649 PMCID: PMC12731649 12/23/2025

• Preclinical safety and bleeding evaluation in swine for a small interfering RNA-lipid nanoparticle that prevents excess fibrinogen synthesis.

  (Seadler MS, Ferraresso F, Turner HM, Ketelboeter LM, Zhang Y, Badior K, Hayssen WG, Chen T, Haugen AL, Cau MF, Robertson M, Skaer C, Bansal M, Murphy PB, de Moya M, Dyer MR, Kastrup CJ.) J Thromb Haemost. 2025 Oct 10 PMID: 41076269 PMCID: PMC12766900 SCOPUS ID: 2-s2.0-105024948193 10/12/2025

• Reversing PAI-1 deficiency in blood using mRNA lipid nanoparticles.

  (Ferraresso F, Skaer CW, Badior K, Pulente SM, Paul M, Ketelboeter L, Chen THS, Cullis PR, Gupta S, Shapiro A, Mulvihill EE, Kastrup CJ.) Mol Ther Methods Clin Dev. 2025 Sep 11;33(3):101557 PMID: 40917690 PMCID: PMC12410550 09/08/2025

• Encapsulation of Fibrinogen With Calcium Carbonate for Hemorrhage Control.

  (Peng HT, Bonnici T, Kastrup C, Beckett A.) Mil Med. 2025 Sep 01;190(Supplement_2):662-669 PMID: 40984119 09/23/2025

• CounterFlow Hemostatic Gauze Provides Military Medics Confidence and Demonstrates Effective Hemorrhage Control in a Live Tissue Simulation.

  (Ali-Mohamad N, Singh K, Cau MF, Tenn C, Bince D, Kamide C, Peng H, Semple H, Kastrup CJ, Beckett A.) Mil Med. 2025 Sep 01;190(9-10):e1929-e1936 PMID: 40156908 03/30/2025

• Aquaporin-4 and Caveolin-1 as Mediators of Fibrinogen-Driven Cerebrovascular Pathology in Cerebral Amyloid Angiopathy.

  (Singh V, Rochakim N, Ferraresso F, Garg K, Choudhury A, Kastrup CJ, Ahn HJ.) bioRxiv. 2025 Jul 24 PMID: 39605467 PMCID: PMC11601418 11/28/2024

• Targeting autophagy and plasminogen activator inhibitor-1 increases survival and remodels the tumor microenvironment in glioblastoma.

  (Shifman SG, O'Connor JL, Radin DP, Sharma A, Infante L, Ferraresso F, Kastrup CJ, Lawrence DA, Tsirka SE.) J Exp Clin Cancer Res. 2025 Jul 19;44(1):214 PMID: 40684232 PMCID: PMC12275254 07/20/2025

• Emulsion-Based Encapsulation of Fibrinogen with Calcium Carbonate for Hemorrhage Control.

  (Peng HT, Bonnici T, Chen Y, Kastrup C, Beckett A.) J Funct Biomater. 2025 Mar 03;16(3) PMID: 40137365 PMCID: PMC11942888 03/26/2025

• Genetic engineering of megakaryocytes from blood progenitor cells using messenger RNA lipid nanoparticles.

  (Leung J, Primbetova A, Strong C, Hay BN, Hsu HH, Hagner A, Foster LJ, Devine D, Cullis PR, Zandstra PW, Kastrup CJ.) J Thromb Haemost. 2025 Jan;23(1):306-313 PMID: 39341369 09/29/2024

• Rap1A Modulates Store-Operated Calcium Entry in the Lung Endothelium: A Novel Mechanism Controlling NFAT-Mediated Vascular Inflammation and Permeability.

  (Kosuru R, Romito O, Sharma GP, Ferraresso F, Ghadrdoost Nakhchi B, Yang K, Mammoto T, Mammoto A, Kastrup CJ, Zhang DX, Goldspink PH, Trebak M, Chrzanowska M.) Arterioscler Thromb Vasc Biol. 2024 Nov;44(11):2271-2287 PMID: 39324266 PMCID: PMC11495542 SCOPUS ID: 2-s2.0-85206451357 09/26/2024

• Regulation of hepatic inclusions and fibrinogen biogenesis by SEL1L-HRD1 ERAD.

  (Song Z, Thepsuwan P, Hur WS, Torres M, Wu SA, Wei X, Tushi NJ, Wei J, Ferraresso F, Paton AW, Paton JC, Zheng Z, Zhang K, Fang D, Kastrup CJ, Jaiman S, Flick MJ, Sun S.) Nat Commun. 2024 Oct 26;15(1):9244 PMID: 39455574 PMCID: PMC11512042 SCOPUS ID: 2-s2.0-85207624408 10/26/2024

• Protein is expressed in all major organs after intravenous infusion of mRNA-lipid nanoparticles in swine.

  (Ferraresso F, Badior K, Seadler M, Zhang Y, Wietrzny A, Cau MF, Haugen A, Rodriguez GG, Dyer MR, Cullis PR, Jan E, Kastrup CJ.) Mol Ther Methods Clin Dev. 2024 Sep 12;32(3):101314 PMID: 39253356 PMCID: PMC11382111 09/10/2024