Christian Kastrup, PhD

Publications

• Self-propelling thrombin powder enables hemostasis with no observable recurrent bleeding or thrombosis over 3 days in a porcine model of upper GI bleeding.

  (Ali-Mohamad N, Cau MF, Zenova V, Baylis JR, Beckett A, McFadden A, Donnellan F, Kastrup CJ.) Gastrointest Endosc. 2023 Aug;98(2):245-248 PMID: 37061138 04/16/2023

• Elimination of fibrin polymer formation or crosslinking, but not fibrinogen deficiency, is protective against diet-induced obesity and associated pathologies.

  (Hur WS, King KC, Patel YN, Nguyen YV, Wei Z, Yang Y, Juang LJ, Leung J, Kastrup CJ, Wolberg AS, Luyendyk JP, Flick MJ.) J Thromb Haemost. 2022 Dec;20(12):2873-2886 PMID: 36111375 PMCID: PMC9669152 09/17/2022

• Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage.

  (Bao G, Gao Q, Cau M, Ali-Mohamad N, Strong M, Jiang S, Yang Z, Valiei A, Ma Z, Amabili M, Gao ZH, Mongeau L, Kastrup C, Li J.) Nat Commun. 2022 Aug 26;13(1):5035 PMID: 36028516 PMCID: PMC9418157 08/27/2022

• Hemostatic powders for gastrointestinal bleeding: a review of old, new, and emerging agents in a rapidly advancing field.

  (Jiang SX, Chahal D, Ali-Mohamad N, Kastrup C, Donnellan F.) Endosc Int Open. 2022 Aug;10(8):E1136-E1146 PMID: 36238531 PMCID: PMC9552790 10/15/2022

• Percutaneous delivery of self-propelling thrombin-containing powder increases survival from noncompressible truncal hemorrhage in a swine model of coagulopathy and hypothermia.

  (Cau MF, Ali-Mohamad N, Yeh H, Baylis JR, Peng H, Gao HZ, Rezende-Neto J, Grecov D, White NJ, Tenn C, Semple HA, Beckett A, Kastrup CJ.) J Trauma Acute Care Surg. 2022 Aug 01;93(2S Suppl 1):S86-S93 PMID: 35545803 05/13/2022

• Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery to Hepatocytes and Hepatic Stellate Cells.

  (Ferraresso F, Strilchuk AW, Juang LJ, Poole LG, Luyendyk JP, Kastrup CJ.) Mol Pharm. 2022 Jul 04;19(7):2175-2182 PMID: 35642083 PMCID: PMC9621687 06/02/2022

• Percutaneous delivery of self-propelling hemostatic powder for managing non-compressible abdominal hemorrhage: a proof-of-concept study in swine.

  (Cau MF, Ali-Mohamad N, Baylis JR, Zenova V, Khavari A, Peng N, McFadden A, Donnellan F, Owen DR, Schaeffer DF, Nagaswami C, Litvinov RI, Weisel JW, Rezende-Neto J, Semple HA, Beckett A, Kastrup CJ.) Injury. 2022 May;53(5):1603-1609 PMID: 35067343 01/25/2022

• Suppression of fibrin(ogen)-driven pathologies in disease models through controlled knockdown by lipid nanoparticle delivery of siRNA.

  (Juang LJ, Hur WS, Silva LM, Strilchuk AW, Francisco B, Leung J, Robertson MK, Groeneveld DJ, La Prairie B, Chun EM, Cap AP, Luyendyk JP, Palumbo JS, Cullis PR, Bugge TH, Flick MJ, Kastrup CJ.) Blood. 2022 Mar 03;139(9):1302-1311 PMID: 34958662 PMCID: PMC8900269 12/28/2021

• Hypofibrinogenemia with preserved hemostasis and protection from thrombosis in mice with an Fga truncation mutation.

  (Hur WS, Paul DS, Bouck EG, Negrón OA, Mwiza JM, Poole LG, Cline-Fedewa HM, Clark EG, Juang LJ, Leung J, Kastrup CJ, Ugarova TP, Wolberg AS, Luyendyk JP, Bergmeier W, Flick MJ.) Blood. 2022 Mar 03;139(9):1374-1388 PMID: 34905618 PMCID: PMC8900273 12/15/2021

• Videoconferencing for Large Animal Trauma Experiments During COVID-19: A Cross-Continent Experience.

  (Ali-Mohamad N, Cau MF, Baylis JR, Semple H, Kastrup CJ, Beckett A.) Mil Med. 2022 Mar 01 PMID: 35231116 PMCID: PMC9383491 03/02/2022

• Aortic intimal resident macrophages are essential for maintenance of the non-thrombogenic intravascular state.

  (Hernandez GE, Ma F, Martinez G, Firozabadi NB, Salvador J, Juang LJ, Leung J, Zhao P, López DA, Ardehali R, Beaudin AE, Kastrup CJ, Pellegrini M, Flick MJ, Iruela-Arispe ML.) Nat Cardiovasc Res. 2022 Jan;1(1):67-84 PMID: 35599984 PMCID: PMC9121812 05/24/2022

• Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier.

  (Silva LM, Doyle AD, Greenwell-Wild T, Dutzan N, Tran CL, Abusleme L, Juang LJ, Leung J, Chun EM, Lum AG, Agler CS, Zuazo CE, Sibree M, Jani P, Kram V, Martin D, Moss K, Lionakis MS, Castellino FJ, Kastrup CJ, Flick MJ, Divaris K, Bugge TH, Moutsopoulos NM.) Science. 2021 Dec 24;374(6575):eabl5450 PMID: 34941394 12/24/2021