Christian Kastrup, PhD

Publications

• Contraction of blood clots occurs during hemostasis and hemorrhagic shock to promote closure of lacerations.

  (Ferraresso M, Ali-Mohamad N, Cau MF, Seadler M, Turner H, Ferraresso F, Zhang Y, Carver TW, Nagaswami C, Beckett A, Peng HT, Litvinov RI, Weisel JW, Bacca M, Kastrup CJ.) Biomaterials. 2026 Nov;334:124288 PMID: 42143432 SCOPUS ID: 2-s2.0-105038719723 05/17/2026

• Plasmin-mediated fibrinolysis is required for hematopoietic recovery after 5-FU-induced myeloablation.

  (Nguyen TP, Jiang YG, Ogan BM, Doyle AD, Tran DT, Ward JM, Zhang A, Ferrer de Oliveira R, Ferraresso F, Bledsoe JR, Kastrup CJ, Flick MJ, Rowe RG, Bugge TH, Silva LM.) Blood Adv. 2026 Sep 22;10(18):6079-6089 PMID: 42314039 06/18/2026

• Antifibrinolytic strategies improve liver regeneration in mice and reduce posthepatectomy liver failure in patients.

  (Li Z, Wei Z, Groeneveld DJ, Strilchuk AW, Flick MJ, Dong Y, Podrascanin V, Truty MJ, Kendrick ML, Cleary SP, Warner SG, Smoot RL, Assinger A, Kastrup CJ, Karanicolas P, Luyendyk JP, Starlinger PP.) Blood. 2026 Sep 03;148(10):1359-1363 PMID: 42275251 SCOPUS ID: 2-s2.0-105044916565 06/11/2026

• Engineering the blood: Lipid nanoparticle platforms for ex vivo immune and hematopoietic cell therapies.

  (Byeon Y, Peng N, Oh EB, Kim E, Gu D, Kang H, Badior KE, Chang TS, Kastrup CJ, Lee H.) J Control Release. 2026 Jul 27;398:115211 PMID: 42508766 SCOPUS ID: 2-s2.0-105046373176 07/28/2026

• Clot contraction of whole blood diminishes during storage and can be restored by adding platelets.

  (Turner H, Seadler M, Zhang Y, Ferraresso M, Kastrup C.) Transfusion. 2026 Jul 06 PMID: 42411053 07/07/2026

• SORTing out gene editing therapies for neuromuscular disorders.

  (Ferraresso F, Skaer CW, Kastrup CJ.) Mol Ther. 2026 Jul 01;34(7):3731-3732 PMID: 42341746 PMCID: PMC13330019 SCOPUS ID: 2-s2.0-105042616020 06/25/2026

• Precipitation-Based Encapsulation of Fibrinogen in Calcium Carbonate for Non-Compressible Hemorrhage Control.

  (Peng HT, Bonnici T, Tenn C, Kastrup CJ, Beckett A.) Pharmaceuticals (Basel). 2026 Jun 11;19(6) PMID: 42356540 PMCID: PMC13304839 06/26/2026

• The fibrinogen αC region promotes arterial thrombosis in the context of hypofibrinogenemia.

  (Lee RH, Ferraresso F, Couzens A, Jameson AT, Hanes HE, Casini A, Neerman-Arbez M, Nieswandt B, Kastrup CJ, Bergmeier W, Flick MJ, Hur WS.) Blood. 2026 Jun 04;147(23):2821-2827 PMID: 41790575 PMCID: PMC13277649 SCOPUS ID: 2-s2.0-105035344912 03/06/2026

• Engineering tough blood clots for rapid haemostasis and enhanced regeneration.

  (Jiang S, Bao G, Yang Z, Wu J, Yang X, Kim JEJ, Jiang R, Zhan Y, Nottegar A, Liu Y, Gao ZH, Beckett A, Nijnik A, Long R, Kastrup C, Li J.) Nature. 2026 May;653(8115):723-730 PMID: 42056507 SCOPUS ID: 2-s2.0-105037472839 04/30/2026

• Plasmid DNA vaccines encapsulated in lipid nanoparticles elicit STING-dependent type 1 interferon release.

  (Moseman JE, Brinkman HM, Choe JA, Shim D, Burger JC, Ferraresso F, Rastogi I, Kastrup CJ, Murphy WL, McNeel DG.) Mol Ther Adv. 2026 Mar 12;34(1):201698 PMID: 42137264 PMCID: PMC13148951 05/15/2026

• Neonatal and pediatric thymic grafts generate similar human T-cell chimerism in humanized mice.

  (Del Rio NM, Huang L, Holm AM, Blashka W, Smith NA, Saha S, Bell AJ, Richardson J, Badior KE, Kastrup CJ, Brown ME.) Front Immunol. 2026;17:1852823 PMID: 42519337 PMCID: PMC13381199 SCOPUS ID: 2-s2.0-105046309382 07/28/2026

• Local delivery of tranexamic acid for hemorrhage control in trauma: a narrative review.

  (Peng HT, Kastrup CJ, Tenn C, Beckett A.) Front Drug Deliv. 2026;6:1771095 PMID: 41799410 PMCID: PMC12960590 03/09/2026