Dr. Sigmund is the James J. Smith & Catherine Welsch Smith Chair of Physiology at the Medical College of Wisconsin. Dr. Sigmund previously served as Professor and Roy J. Carver Chair in Hypertension Research; Director, Chair and Department Executive Officer, Department of Pharmacology; UIHC Center for Hypertension Research at the Roy J. and Lucille A. Carver College of Medicine at the University of Iowa. He has published over 250 papers, chapters, and reviews and has trained over 50 PhD students and postdoctoral fellows many of whom hold research and faculty positions nationally and internationally. He has held numerous leadership roles in prominent societies. He recently was elected to serve a two-year term as the new Chair-Elect of the American Heart Association Council on Hypertension and is currently the Chair of the Publications Committee of the American Physiological Society (APS). He was previously Associate Editor and Editor-in-Chief for several APS journals. He served on the External Scientific Review Board of the MCW Cardiovascular Center from 2016-2017 and now serves as its Associate Director.
Dr. Sigmund’s major areas of research focus on central nervous system and vascular mechanisms of blood pressure regulation by the renin-angiotensin system, the transcription factor PPAR-gamma, and its downstream effectors Cullin-3/RhoBTB1, investigating these using a combination of molecular biological, genetic and physiological approaches including the generation of unique transgenic and knockout models. Dr. Sigmund’s laboratory is located within the Cardiovascular Center in the Health Research Center and Medical Education buildings.