James Verbsky, MD, PhD
Professor, Pediatrics (Rheumatology) and Microbiology & Immunology; Medical Director, Clinical Immunology Research Laboratory; Medical Director, Clinical and Translational Research
Locations
- Children's Wisconsin
Children's Corporate Center
Suite C465
Contact Information
General Interests
Education
MD, Washington University, 2000
Fellowship, Pediatric Rheumatology, Washington University
Research Interests
My research interests focus on immune regulation, and my research program is based on the premise of taking genetically defined immune deficiencies from humans and modeling these diseases in the laboratory. Since I see patients with immune deficiencies and inflammatory disorders, the first step in this program is to define the immune deficiency in these patients. Using genetic technologies, such as copy number variation analysis, targeted gene sequencing, and next generation genetic sequencing, we have been successful at defining several primary immune deficiencies, and have used these findings to model these diseases in the laboratory to help us understand immunity and immune regulation.
Publications
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(Cooperstein IB, Marwaha S, Ward A, Kobren SN, Carter JN, Undiagnosed Diseases Network, Wheeler MT, Marth GT.) Genome Med. 2025 Oct 21;17(1):127 PMID: 41121346 PMCID: PMC12539062 SCOPUS ID: 2-s2.0-105019725183 10/22/2025
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(Correll C, Burciu A, Bansal A, Dennos A, Narayanswamy D, Aubrun E, Schanberg LE, Yuhan L, Schneider R, Balevic S, Kimura Y, Beukelman T, CARRA Registry investigators.) Pediatr Rheumatol Online J. 2025 Oct 21;23(1):105 PMID: 41121260 PMCID: PMC12538899 SCOPUS ID: 2-s2.0-105019741968 10/22/2025
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(Ringold S, Ong MS, Tomlinson G, Natter MD, Schanberg LE, Del Gaizo V, Feldman BM, Murphy KL, Kimura Y, CARRA Registry STOP‐JIA Investigators.) Arthritis Rheumatol. 2025 Oct;77(10):1433-1441 PMID: 40344490 SCOPUS ID: 2-s2.0-105011142884 05/09/2025
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(Stewart R, Ezell KM, Bell DS, Corner B, McMinn A, Cogan JD, Hamid R, Rives L, Phillips JA 3rd, Paddu N, Srivastava G, Marom R, Ladha FA, Soler-Alfonso C, Franciskovich R, Koziura M, Pruthi S, Richard G, Sheedy CB, Undiagnosed Diseases Network, Cassini T.) Am J Med Genet A. 2025 Aug 21:e64233 PMID: 40838347 SCOPUS ID: 2-s2.0-105013894374 08/21/2025
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(Kobren SN, Moldovan MA, Reimers R, Traviglia D, Li X, Barnum D, Veit A, Corona RI, Carvalho Neto GV, Willett J, Berselli M, Ronchetti W, Nelson SF, Martinez-Agosto JA, Sherwood R, Krier J, Kohane IS, Undiagnosed Diseases Network, Sunyaev SR.) Nat Commun. 2025 Aug 07;16(1):7267 PMID: 40770127 PMCID: PMC12328722 SCOPUS ID: 2-s2.0-105013076026 08/07/2025
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(Fazal S, Dashnow H, Dohrn MF, Raposo J, Hiatt L, Danzi MC, Xu IRL, Toro C, Adams DR, Usdin K, Hayward B, Kobren SN, Sunyaev SR, Spillmann RC, Shashi V, Rebelo A, Bademci G, Undiagnosed Diseases Network, Tekin M, Quinlan AR, Zuchner S.) Genet Med. 2025 Aug;27(8):101462 PMID: 40417743 PMCID: PMC12318663 SCOPUS ID: 2-s2.0-105009588600 05/26/2025
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(Mannion ML, Aswani MS, Hearld KR, Smitherman EA, Timmerman L, Curtis JR, CARRA Registry Investigators.) Pediatr Rheumatol Online J. 2025 Jul 22;23(1):77 PMID: 40696394 PMCID: PMC12285171 SCOPUS ID: 2-s2.0-105012233236 07/23/2025
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(Jacovas VC, Zelnick M, McNulty S, Ross JE, Khurana N, Pan X, Nieto A, Martin S, McLean B, Elnagheeb MA, Cowan MJ, Puck JM, Hershfield M, Verbsky J, Walter J, Allenspach E, Chan AY, van Oers NSC, Ghosh R, Piazza M, Yuan B, Notarangelo LD, Johnson BA, Chinn IK.) medRxiv. 2025 Feb 13 PMID: 39990552 PMCID: PMC11844601 02/24/2025
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(Bosticardo M, Dobbs K, Delmonte OM, Martins AJ, Pala F, Kawai T, Kenney H, Magro G, Rosen LB, Yamazaki Y, Yu HH, Calzoni E, Lee YN, Liu C, Stoddard J, Niemela J, Fink D, Castagnoli R, Ramba M, Cheng A, Riley D, Oikonomou V, Shaw E, Belaid B, Keles S, Al-Herz W, Cancrini C, Cifaldi C, Baris S, Sharapova S, Schuetz C, Gennery AR, Freeman AF, Somech R, Choo S, Giliani SC, Güngör T, Drozdov D, Meyts I, Moshous D, Neven B, Abraham RS, El-Marsafy A, Kanariou M, King A, Licciardi F, Cruz-Muñoz ME, Palma P, Poli C, Adeli M, Algeri M, Alroqi FJ, Bastard P, Bergerson JRE, Booth C, Brett A, Burns SO, Butte MJ, Padem N, de la Morena M, Dbaibo G, de Ravin SS, Dimitrova D, Djidjik R, Dorna MB, Dutmer CM, Elfeky R, Facchetti F, Fuleihan RL, Geha RS, Gonzalez-Granado LI, Haljasmägi L, Ale H, Hayward A, Hifanova AM, Ip W, Kaplan B, Kapoor N, Karakoc-Aydiner E, Kärner J, Keller MD, Dávila Saldaña BJ, Kiykim A, Kuijpers TW, Kuznetsova EE, Latysheva EA, Leiding JW, Locatelli F, Alva-Lozada G, McCusker C, Celmeli F, Morsheimer M, Ozen A, Parvaneh N, Pasic S, Plebani A, Preece K, Prockop S, Sakovich IS, Starkova EE, Torgerson T, Verbsky J, Walter JE, Ward B, Wisner EL, Draper D, Myint-Hpu K, Truong PM, Lionakis MS, Similuk MB, Centralized Sequencing Program Group§§, Walkiewicz MA, Klion A, Holland SM, Oguz C, Bogunovic D, Kisand K, Su HC, Tsang JS, Kuhns D, Villa A, Rosenzweig SD, Pittaluga S, Notarangelo LD, Centralized Sequencing Program Group.) Sci Immunol. 2025 Jan 10;10(103):eadq1697 PMID: 39792639 PMCID: PMC12087669 SCOPUS ID: 2-s2.0-85215861817 01/10/2025
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(Randell RL, Schanberg LE, Beard C, Phillips T, Hornik CP, Cohen-Wolkowiez M, Balevic SJ, Rubinstein T, Vasquez N, Wahezi D, Tanner T, Peskin M, Rothschild E, Perfetto J, Guzman L, Buckley L, Patrick A, Datyner E, Blackmon B, Graham T, Henderson L, Lo M, Lee P, Sundel R, Meidan E, Halyabar O, Nigrovic P, Son MB, Hausmann J, McBrearty K, Cohen E, Chang M, Chang J, Dedeoglu F, Cidon M, Reyhan I, Haro S, Shaham B, Cancino A, Brown D, Marzan K, Weiss P, Lerman M, Moreno J, Canna S, Devine R, Torok K, Rosenkranz M, Patel J, Stapp H, Kienzle B, Newhall L, Klein-Gitelman M, Miller M, Hiskey M, Nolan B, Amoruso M, De Ranieri D, Patel P, Lytch A, Cooper A, Holland MJ, Favier L, Fox E, Ibarra M, Hoffart C, Jones J, Harris J, Srinivasalu H, Connor R, Sule S, Ronis T, Ogbonnaya-Whittesley S, Dizon B, Sherman M, Dunnock K, Angeles-Han S, Vega-Fernandez P, Quinlan-Waters M, Brunner H, Schulert G, Grom A, Henrickson M, Huggins J, Lovell D, Ting T, Ogbu E, Zeft A, Robinson A, Brooks E, Panupattanapong S, Parsons A, Edelheit B, Lapin B, Twachtman-Bassett J, Tory H, Fennell J, Jiang Y, Rodgers L, Swaffar C.) Acr Open Rheumatology. January 2025;7(1) SCOPUS ID: 2-s2.0-85216072708 01/01/2025
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(Chang MH, Barbar-Smiley F, Akoghlanian S, Drew J, Angeles-Han ST, Quinlan-Waters M, Bohnsack JF, Cooper AM, Edelheit B, Twachtman-Bassett J, Lerman MA, Nanda K, Rabinovich CE, Lo MS, CARRA Uveitis Workgroup and the CARRA Registry Investigators.) Pediatr Rheumatol Online J. 2024 Oct 07;22(1):88 PMID: 39375683 PMCID: PMC11457454 SCOPUS ID: 2-s2.0-85205784510 10/08/2024
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Maintenance of X chromosome inactivation after T cell activation requires NF-κB signaling.
(Forsyth KS, Toothacre NE, Jiwrajka N, Driscoll AM, Shallberg LA, Cunningham-Rundles C, Barmettler S, Farmer J, Verbsky J, Routes J, Beiting DP, Romberg N, May MJ, Anguera MC.) Sci Immunol. 2024 Oct 04;9(100):eado0398 PMID: 39365876 PMCID: PMC12088372 SCOPUS ID: 2-s2.0-85205806529 10/04/2024