James Verbsky, MD, PhD

Professor, Pediatrics (Rheumatology) and Microbiology & Immunology; Medical Director, Clinical Immunology Research Laboratory; Medical Director, Clinical and Translational Research

Locations

Children's Wisconsin
Children's Corporate Center
Suite C465

Contact Information

General Interests

Primary Immune Deficiency, Immune Dysregulation Syndromes

Education

PhD, Immunology, Washington University, 2000
MD, Washington University, 2000
Fellowship, Pediatric Rheumatology, Washington University

Research Interests

My research interests focus on immune regulation, and my research program is based on the premise of taking genetically defined immune deficiencies from humans and modeling these diseases in the laboratory. Since I see patients with immune deficiencies and inflammatory disorders, the first step in this program is to define the immune deficiency in these patients. Using genetic technologies, such as copy number variation analysis, targeted gene sequencing, and next generation genetic sequencing, we have been successful at defining several primary immune deficiencies, and have used these findings to model these diseases in the laboratory to help us understand immunity and immune regulation.

Improved Disease Course Associated With Early Initiation of Biologics in Polyarticular Juvenile Idiopathic Arthritis: Trajectory Analysis of a Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans Study.

(Ong MS, Ringold S, Kimura Y, Schanberg LE, Tomlinson GA, Natter MD, CARRA Registry Investigators.) Arthritis Rheumatol. 2021 10;73(10):1910-1920 PMID: 34105303 SCOPUS ID: 2-s2.0-85113680508 06/10/2021
Internuclear Ophthalmoplegia in a Child With Deficiency of Adenosine Deaminase 2.

(Mandviwala MM, Verbsky JW, Khammar AJ, Walsh RD.) J Neuroophthalmol. 2021 Sep 30 PMID: 34629408 10/12/2021
Biologic Switching Among Nonsystemic Juvenile Idiopathic Arthritis Patients: A Cohort Study in the Childhood Arthritis and Rheumatology Research Alliance Registry.

(Mannion ML, Xie F, Horton DB, Ringold S, Correll CK, Dennos A, Beukelman T, CARRA Registry Investigators.) J Rheumatol. 2021 08;48(8):1322-1329 PMID: 32934124 SCOPUS ID: 2-s2.0-85104528863 09/17/2020
Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients.

(Le Coz C, Nguyen DN, Su C, Nolan BE, Albrecht AV, Xhani S, Sun D, Demaree B, Pillarisetti P, Khanna C, Wright F, Chen PA, Yoon S, Stiegler AL, Maurer K, Garifallou JP, Rymaszewski A, Kroft SH, Olson TS, Seif AE, Wertheim G, Grant SFA, Vo LT, Puck JM, Sullivan KE, Routes JM, Zakharova V, Shcherbina A, Mukhina A, Rudy NL, Hurst ACE, Atkinson TP, Boggon TJ, Hakonarson H, Abate AR, Hajjar J, Nicholas SK, Lupski JR, Verbsky J, Chinn IK, Gonzalez MV, Wells AD, Marson A, Poon GMK, Romberg N.) J Exp Med. 2021 07 05;218(7) PMID: 33951726 PMCID: PMC8105723 SCOPUS ID: 2-s2.0-85105296806 05/06/2021
Juvenile Spondyloarthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry: High Biologic Use, Low Prevalence of HLA-B27, and Equal Sex Representation in Sacroiliitis.

(Rumsey DG, Lougee A, Matsouaka R, Collier DH, Schanberg LE, Schenfeld J, Shiff NJ, Stoll ML, Stryker S, Weiss PF, Beukelman T, Childhood Arthritis and Rheumatology Research Alliance Registry Investigators.) Arthritis Care Res (Hoboken). 2021 07;73(7):940-946 PMID: 33331139 SCOPUS ID: 2-s2.0-85107125690 12/18/2020
Rituximab and antimetabolite treatment of granulomatous and lymphocytic interstitial lung disease in common variable immunodeficiency.

(Verbsky JW, Hintermeyer MK, Simpson PM, Feng M, Barbeau J, Rao N, Cool CD, Sosa-Lozano LA, Baruah D, Hammelev E, Busalacchi A, Rymaszewski A, Woodliff J, Chen S, Bausch-Jurken M, Routes JM.) J Allergy Clin Immunol. 2021 02;147(2):704-712.e17 PMID: 32745555 SCOPUS ID: 2-s2.0-85089870161 08/04/2020
Germline IKAROS dimerization haploinsufficiency causes hematologic cytopenias and malignancies.

(Kuehn HS, Niemela JE, Stoddard J, Mannurita SC, Shahin T, Goel S, Hintermeyer M, Heredia RJ, Garofalo M, Lucas L, Singh S, Tondo A, Jacobs Z, Gahl WA, Latour S, Verbsky J, Routes J, Cunningham-Rundles C, Boztug K, Gambineri E, Fleisher TA, Chandrakasan S, Rosenzweig SD.) Blood. 2021 01 21;137(3):349-363 PMID: 32845957 PMCID: PMC7819759 SCOPUS ID: 2-s2.0-85098538966 08/28/2020
Community poverty level influences time to first pediatric rheumatology appointment in Polyarticular Juvenile Idiopathic Arthritis

(Balmuri N, Soulsby WD, Cooley V, Gerber L, Lawson E, Goodman S, Onel K, Mehta B, Abel N, Abulaban K, Adams A, Adams M, Agbayani R, Aiello J, Akoghlanian S, Alejandro C, Allenspach E, Alperin R, Alpizar M, Amarilyo G, Ambler W, Anderson E, Ardoin S, Armendariz S, Baker E, Balboni I, Balevic S, Ballenger L, Ballinger S, Balmuri N, Barbar-Smiley F, Barillas-Arias L, Basiaga M, Baszis K, Becker M, Bell-Brunson H, Beltz E, Benham H, Benseler S, Bernal W, Beukelman T, Bigley T, Binstadt B, Black C, Blakley M, Bohnsack J, Boland J, Boneparth A, Bowman S, Bracaglia C, Brooks E, Brothers M, Brown A, Brunner H, Buckley M, Buckley M, Bukulmez H, Bullock D, Cameron B, Canna S, Cannon L, Carper P, Cartwright V, Cassidy E, Cerracchio L, Chalom E, Chang J, Chang-Hoftman A, Chauhan V, Chira P, Chinn T, Chundru K, Clairman H, Co D, Confair A, Conlon H, Connor R, Cooper A, Cooper J, Cooper S, Correll C, Corvalan R, Costanzo D, Cron R, Curiel-Duran L, Curington T, Curry M, Dalrymple A, Davis A, Davis C, Davis C, Davis T, De Benedetti F, De Ranieri D, Dean J, Dedeoglu F, DeGuzman M, Delnay N, Dempsey V, DeSantis E.) Pediatric Rheumatology. December 2021;19(1) SCOPUS ID: 2-s2.0-85112689252 12/01/2021
Patterns of etanercept use in juvenile idiopathic arthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry

(Beukelman T, Lougee A, Matsouaka RA, Collier D, Rumsey DG, Schenfeld J, Stryker S, Twilt M, Kimura Y, Abel N, Abulaban K, Adams A, Adams M, Agbayani R, Aiello J, Akoghlanian S, Alejandro C, Allenspach E, Alperin R, Alpizar M, Amarilyo G, Ambler W, Anderson E, Ardoin S, Armendariz S, Baker E, Balboni I, Balevic S, Ballenger L, Ballinger S, Balmuri N, Barbar-Smiley F, Barillas-Arias L, Basiaga M, Baszis K, Becker M, Bell-Brunson H, Beltz E, Benham H, Benseler S, Bernal W, Bigley T, Binstadt B, Black C, Blakley M, Bohnsack J, Boland J, Boneparth A, Bowman S, Bracaglia C, Brooks E, Brothers M, Brown A, Brunner H, Buckley M, Buckley M, Bukulmez H, Bullock D, Cameron B, Canna S, Cannon L, Carper P, Cartwright V, Cassidy E, Cerracchio L, Chalom E, Chang J, Chang-Hoftman A, Chauhan V, Chira P, Chinn T, Chundru K, Clairman H, Co D, Confair A, Conlon H, Connor R, Cooper A, Cooper J, Cooper S, Correll C, Corvalan R, Costanzo D, Cron R, Curiel-Duran L, Curington T, Curry M, Dalrymple A, Davis A, Davis C, Davis C, Davis T, De Benedetti F, De Ranieri D, Dean J, Dedeoglu F, DeGuzman M, Delnay N, Dempsey V, DeSantis E.) Pediatric Rheumatology. December 2021;19(1) SCOPUS ID: 2-s2.0-85113302791 12/01/2021
Role of GATA2 in Human NK Cell Development.

(Wang D, Uyemura B, Hashemi E, Bjorgaard S, Riese M, Verbsky J, Thakar MS, Malarkannan S.) Crit Rev Immunol. 2021;41(2):21-33 PMID: 34348000 SCOPUS ID: 2-s2.0-85113414587 08/05/2021
Clinical and histologic presentation of pediatric reactive granulomatous dermatitis.

(Akinshemoyin Vaughn OL, Siegel DH, Chiu YE, DeBord LC, Hogeling M, Hunt RD, Nguyen C, Sokumbi O, Verbsky JW, Arkin LM.) Pediatr Dermatol. 2020 May;37(3):498-503 PMID: 32115758 SCOPUS ID: 2-s2.0-85081024767 03/03/2020
Novel Hemizygous IL2RG p.(Pro58Ser) Mutation Impairs IL-2 Receptor Complex Expression on Lymphocytes Causing X-Linked Combined Immunodeficiency.

(Tuovinen EA, Grönholm J, Öhman T, Pöysti S, Toivonen R, Kreutzman A, Heiskanen K, Trotta L, Toiviainen-Salo S, Routes JM, Verbsky J, Mustjoki S, Saarela J, Kere J, Varjosalo M, Hänninen A, Seppänen MRJ.) J Clin Immunol. 2020 04;40(3):503-514 PMID: 32072341 PMCID: PMC7142052 SCOPUS ID: 2-s2.0-85079785911 02/20/2020

James Verbsky, MD, PhD