James Verbsky, MD, PhD

Associate Professor, Pediatrics (Rheumatology) and Microbiology & Immunology; Medical Director, Clinical Immunology Research Laboratory; Medical Director, Clinical and Translational Research

Locations

Children's Hospital of Wisconsin
Children's Corporate Center
Suite C465

Contact Information

General Interests

Primary Immune Deficiency, Immune Dysregulation Syndromes

Education

PhD, Immunology, Washington University, 2000
MD, Washington University, 2000
Fellowship, Pediatric Rheumatology, Washington University

Research Interests

My research interests focus on immune regulation, and my research program is based on the premise of taking genetically defined immune deficiencies from humans and modeling these diseases in the laboratory. Since I see patients with immune deficiencies and inflammatory disorders, the first step in this program is to define the immune deficiency in these patients. Using genetic technologies, such as copy number variation analysis, targeted gene sequencing, and next generation genetic sequencing, we have been successful at defining several primary immune deficiencies, and have used these findings to model these diseases in the laboratory to help us understand immunity and immune regulation.

Serum S100A8/A9 and S100A12 Levels in Children With Polyarticular Forms of Juvenile Idiopathic Arthritis: Relationship to Maintenance of Clinically Inactive Disease During Anti-Tumor Necrosis Factor Therapy and Occurrence of Disease Flare After Discontinuation of Therapy.

(Hinze CH, Foell D, Johnson AL, Spalding SJ, Gottlieb BS, Morris PW, Kimura Y, Onel K, Li SC, Grom AA, Taylor J, Brunner HI, Huggins JL, Nocton JJ, Haines KA, Edelheit BS, Shishov M, Jung LK, Williams CB, Tesher MS, Costanzo DM, Zemel LS, Dare JA, Passo MH, Ede KC, Olson JC, Cassidy EA, Griffin TA, Wagner-Weiner L, Weiss JE, Vogler LB, Rouster-Stevens KA, Beukelman T, Cron RQ, Kietz D, Schikler K, Mehta J, Ting TV, Verbsky JW, Eberhard AB, Huang B, Giannini EH, Lovell DJ.) Arthritis Rheumatol. 2019 Mar;71(3):451-459.
CTLA4 Message Reflects Pathway Disruption in Monogenic Disorders and Under Therapeutic Blockade.

(Garcia-Perez JE, Baxter RM, Kong DS, Tobin R, McCarter M, Routes JM, Verbsky J, Jordan MB, Dutmer CM, Hsieh EWY.) Front Immunol. 2019;10:998.
Damaging BTK Variant Demonstrated by Carrier, Allele-Specific BTK Expression in B Cells and Monocytes.

(Bausch-Jurken MT, Hintermeyer M, Woodliff J, Chen S, Rymaszewski A, Verbsky J, Routes J.) J Clin Immunol. 2019 Jan;39(1):23-25.
Identification of molecular signatures of cystic fibrosis disease status with plasma-based functional genomics.

(Levy H, Jia S, Pan A, Zhang X, Kaldunski M, Nugent ML, Reske M, Feliciano RA, Quintero D, Renda MM, Woods KJ, Murkowski K, Johnson K, Verbsky J, Dasu T, Ideozu JE, McColley S, Quasney MW, Dahmer MK, Avner E, Farrell PM, Cannon CL, Jacob H, Simpson PM, Hessner MJ.) Physiol Genomics. 2019 01 01;51(1):27-41.
Risk, Timing, and Predictors of Disease Flare After Discontinuation of Anti-Tumor Necrosis Factor Therapy in Children With Polyarticular Forms of Juvenile Idiopathic Arthritis With Clinically Inactive Disease.

(Lovell DJ, Johnson AL, Huang B, Gottlieb BS, Morris PW, Kimura Y, Onel K, Li SC, Grom AA, Taylor J, Brunner HI, Huggins JL, Nocton JJ, Haines KA, Edelheit BS, Shishov M, Jung LK, Williams CB, Tesher MS, Costanzo DM, Zemel LS, Dare JA, Passo MH, Ede KC, Olson JC, Cassidy EA, Griffin TA, Wagner-Weiner L, Weiss JE, Vogler LB, Rouster-Stevens KA, Beukelman T, Cron RQ, Kietz D, Schikler K, Schmidt KM, Mehta J, Wahezi DM, Ting TV, Verbsky JW, Eberhard BA, Spalding S, Chen C, Giannini EH.) Arthritis Rheumatol. 2018 09;70(9):1508-1518.
Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency.

(Boutboul D, Kuehn HS, Van de Wyngaert Z, Niemela JE, Callebaut I, Stoddard J, Lenoir C, Barlogis V, Farnarier C, Vely F, Yoshida N, Kojima S, Kanegane H, Hoshino A, Hauck F, Lhermitte L, Asnafi V, Roehrs P, Chen S, Verbsky JW, Calvo KR, Husami A, Zhang K, Roberts J, Amrol D, Sleaseman J, Hsu AP, Holland SM, Marsh R, Fischer A, Fleisher TA, Picard C, Latour S, Rosenzweig SD.) J Clin Invest. 2018 07 02;128(7):3071-3087.
Newborn Screening for Severe Combined Immunodeficiency.

(Routes J, Verbsky J.) Curr Allergy Asthma Rep. 2018 05 10;18(6):34.
Correction to: Use of Genetic Testing for Primary Immunodeficiency Patients.

(Heimall JR, Hagin D, Hajjar J, Henrickson SE, Hernandez-Trujillo HS, Itan Y, Kobrynski L, Paris K, Torgerson TR, Verbsky JW, Wasserman RL, Hsieh EWY, Bleesing JJ, Chou JS, Lawrence MG, Marsh RA, Rosenzweig SD, Orange JS, Abraham RS.) J Clin Immunol. 2018 May;38(4):540-541.
Use of Genetic Testing for Primary Immunodeficiency Patients.

(Heimall JR, Hagin D, Hajjar J, Henrickson SE, Hernandez-Trujillo HS, Tan Y, Kobrynski L, Paris K, Torgerson TR, Verbsky JW, Wasserman RL, Hsieh EWY, Blessing JJ, Chou JS, Lawrence MG, Marsh RA, Rosenzweig SD, Orange JS, Abraham RS.) J Clin Immunol. 2018 04;38(3):320-329.
Low Serum IgE Is a Sensitive and Specific Marker for Common Variable Immunodeficiency (CVID).

(Lawrence MG, Palacios-Kibler TV, Workman LJ, Schuyler AJ, Steinke JW, Payne SC, McGowan EC, Patrie J, Fuleihan RL, Sullivan KE, Lugar PL, Hernandez CL, Beakes DE, Verbsky JW, Platts-Mills TAE, Cunningham-Rundles C, Routes JM, Borish L.) J Clin Immunol. 2018 04;38(3):225-233.
Corrigendum: IRAK4 Deficiency in a Patient with Recurrent Pneumococcal Infections: Case Report and Review of the Literature.

(Gobin KS, Hintermeyer M, Boisson B, Chrabieh M, Ghandil P, Puel A, Picard C, Casanova JL, Routes J, Verbsky J.) Front Pediatr. 2018;6:42.
A Practical Approach to Newborn Screening for Severe Combined Immunodeficiency Using the T Cell Receptor Excision Circle Assay.

(Thakar MS, Hintermeyer MK, Gries MG, Routes JM, Verbsky JW.) Front Immunol. 2017;8:1470.

James Verbsky, MD, PhD