Kelly J. Henrickson, MD

Professor, Pediatrics (Infectious Diseases) and Microbiology & Immunology; Director, Midwest Respiratory Virus Program

Contact Information

Biography

General Interests

Negative strand respiratory virus molecular epidemiology and natural history

Education

MD, University of Washington, Seattle, 1984

Research Interests

I have been interested in molecular evolution, antigenic variation of surface glycoprotein’s, epidemiology and natural history of parainfluenza and influenza viruses and the development of rapid molecular diagnostic assays. My most recent awards from the NIAID include working on advances in molecular diagnostics for influenza subtyping (including avian and swine) (2006-2011), bioterrorism agents (2003-2012), and working on multiplex point of care diagnostic assays for community acquired respiratory viruses (2008-2014). Other funded research grants and contracts include a BARDA contract for evaluating influenza diagnostic assays (2010-2015) and the development of molecular diagnostic assays for community acquired pneumonia and sepsis including influenza virus type A and B. In addition my most recent work includes close collaborations with the NIH to describe the epidemiology and evolution of the 2009 pandemic H1N1 virus and extending the knowledge base for paramyxovirus genomic data (1st author on NIAID white paper-2010). My laboratory has developed more than a dozen multiplex molecular diagnostic assays to bioterrorism agents, viruses and respiratory pathogens.

henrickson_figure1

Figure 1. Respiratory virus epidemiology in Southeast Wisconsin

Establishment of a lethal aged mouse model of human respiratory syncytial virus infection.

(Zhang K, Li C, Luo YS, Wen L, Yuan S, Wang D, Ho-Yin Wong B, Zhao X, Chiu MC, Ye ZW, Sun Z, Zhao H, Zhang X, Hu M, Yang D, Shuai H, Wang Y, He J, Bose ME, Henrickson KJ, Huang JD, Zheng B, Chu H, Zhou J.) Antiviral Res. 2018 Nov 29;161:125-133.
Simulated Respiratory Secretion for Use in the Development of Influenza Diagnostic Assays.

(Bose ME, McCaul KC, Mei H, Sasman A, He J, Kramp W, Shively R, Yan K, Henrickson KJ.) PLoS One. 2016;11(11):e0166800.
Sequencing and analysis of globally obtained human respiratory syncytial virus A and B genomes.

(Bose ME, He J, Shrivastava S, Nelson MI, Bera J, Halpin RA, Town CD, Lorenzi HA, Noyola DE, Falcone V, Gerna G, De Beenhouwer H, Videla C, Kok T, Venter M, Williams JV, Henrickson KJ.) PLoS One. 2015;10(3):e0120098.
Complete genome sequences of one human respiratory syncytial antigenic group a virus from china and its four mouse-adapted isolates.

(Zhang K, He J, Li C, Bose ME, Henrickson KJ, Zhou J, Zheng BJ.) Genome Announc. 2015 Mar 05;3(2).
The Underrecognized Burden of Respiratory Syncytial Virus Among Infants Presenting to US Emergency Departments.

(Makari D, Staat MA, Henrickson KJ, Wu X, Ambrose CS.) Clin Pediatr (Phila). 2015 Jun;54(6):594-7.
Analytical reactivity of 13 commercially available rapid influenza diagnostic tests with H3N2v and recently circulating influenza viruses.

(Bose ME, Sasman A, Mei H, McCaul KC, Kramp WJ, Chen LM, Shively R, Williams TL, Beck ET, Henrickson KJ.) Influenza Other Respir Viruses. 2014 Jul;8(4):474-81.
Distribution of respiratory syncytial virus subtypes A and B among infants presenting to the emergency department with lower respiratory tract infection or apnea.

(Jafri HS, Wu X, Makari D, Henrickson KJ.) Pediatr Infect Dis J. 2013 Apr;32(4):335-40.
Genome sequencing and phylogenetic analysis of 39 human parainfluenza virus type 1 strains isolated from 1997-2010.

(Beck ET, He J, Nelson MI, Bose ME, Fan J, Kumar S, Henrickson KJ.) PLoS One. 2012;7(9):e46048.
Update on influenza diagnostics: lessons from the novel H1N1 influenza A pandemic.

(Kumar S, Henrickson KJ.) Clin Microbiol Rev. 2012 Apr;25(2):344-61.
Whole genome sequencing and evolutionary analysis of human respiratory syncytial virus A and B from Milwaukee, WI 1998-2010.

(Rebuffo-Scheer C, Bose M, He J, Khaja S, Ulatowski M, Beck ET, Fan J, Kumar S, Nelson MI, Henrickson KJ.) PLoS One. 2011;6(10):e25468.
H1N1 hemagglutinin-inhibition seroprevalence in Emergency Department Health Care workers after the first wave of the 2009 influenza pandemic.

(Kumar S, Fan J, Melzer-Lange M, Trost J, Havens PL, Willoughby RE, Chusid MJ, Henrickson KJ.) Pediatr Emerg Care. 2011 Sep;27(9):804-7.
Phylogeography of the spring and fall waves of the H1N1/09 pandemic influenza virus in the United States.

(Nelson MI, Tan Y, Ghedin E, Wentworth DE, St George K, Edelman L, Beck ET, Fan J, Lam TT, Kumar S, Spiro DJ, Simonsen L, Viboud C, Holmes EC, Henrickson KJ, Musser JM.) J Virol. 2011 Jan;85(2):828-34.

Kelly J. Henrickson, MD