Nan Zhu, PhD

Publications

• Investigation of Genetic Dependencies Using CRISPR-Cas9-based Competition Assays.

  (Deshpande A, Chen BR, Zhao L, Saddoris K, Kerr M, Zhu N, Mali P, Deshpande AJ.) J Vis Exp. 2019 01 07(143) PMID: 30663717 01/22/2019

• PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development.

  (Yu M, Chen Y, Zeng H, Zheng Y, Fu G, Zhu W, Broeckel U, Aggarwal P, Turner A, Neale G, Guy C, Zhu N, Chi H, Wen R, Wang D.) Nat Commun. 2017 11 13;8(1):1457 PMID: 29133930 PMCID: PMC5684131 SCOPUS ID: 2-s2.0-85034212045 11/15/2017

• Metabolically Derived Lysine Acylations and Neighboring Modifications Tune the Binding of the BET Bromodomains to Histone H4.

  (Olp MD, Zhu N, Smith BC.) Biochemistry. 2017 10 17;56(41):5485-5495 PMID: 28945351 PMCID: PMC5970795 09/26/2017

• Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia.

  (Danis E, Yamauchi T, Echanique K, Zhang X, Haladyna JN, Riedel SS, Zhu N, Xie H, Orkin SH, Armstrong SA, Bernt KM, Neff T.) Cell Rep. 2016 Mar 01;14(8):1953-65 PMID: 26904942 PMCID: PMC4790111 02/26/2016

• DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.

  (Chen CW, Koche RP, Sinha AU, Deshpande AJ, Zhu N, Eng R, Doench JG, Xu H, Chu SH, Qi J, Wang X, Delaney C, Bernt KM, Root DE, Hahn WC, Bradner JE, Armstrong SA.) Nat Med. 2015 Apr;21(4):335-43 PMID: 25822366 PMCID: PMC4390532 03/31/2015

• AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.

  (Deshpande AJ, Deshpande A, Sinha AU, Chen L, Chang J, Cihan A, Fazio M, Chen CW, Zhu N, Koche R, Dzhekieva L, Ibáñez G, Dias S, Banka D, Krivtsov A, Luo M, Roeder RG, Bradner JE, Bernt KM, Armstrong SA.) Cancer Cell. 2014 Dec 08;26(6):896-908 PMID: 25464900 PMCID: PMC4291116 12/04/2014

• CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma.

  (Huang CH, Lujambio A, Zuber J, Tschaharganeh DF, Doran MG, Evans MJ, Kitzing T, Zhu N, de Stanchina E, Sawyers CL, Armstrong SA, Lewis JS, Sherr CJ, Lowe SW.) Genes Dev. 2014 Aug 15;28(16):1800-14 PMID: 25128497 PMCID: PMC4197965 08/17/2014

• Notch pathway activation targets AML-initiating cell homeostasis and differentiation.

  (Lobry C, Ntziachristos P, Ndiaye-Lobry D, Oh P, Cimmino L, Zhu N, Araldi E, Hu W, Freund J, Abdel-Wahab O, Ibrahim S, Skokos D, Armstrong SA, Levine RL, Park CY, Aifantis I.) J Exp Med. 2013 Feb 11;210(2):301-19 PMID: 23359070 PMCID: PMC3570103 01/30/2013

• STAT5 is crucial to maintain leukemic stem cells in acute myelogenous leukemias induced by MOZ-TIF2.

  (Tam WF, Hähnel PS, Schüler A, Lee BH, Okabe R, Zhu N, Pante SV, Raffel G, Mercher T, Wernig G, Bockamp E, Sasca D, Kreft A, Robinson GW, Hennighausen L, Gilliland DG, Kindler T.) Cancer Res. 2013 Jan 01;73(1):373-84 PMID: 23149921 PMCID: PMC3916953 11/15/2012

• Polycomb repressive complex 2 is required for MLL-AF9 leukemia.

  (Neff T, Sinha AU, Kluk MJ, Zhu N, Khattab MH, Stein L, Xie H, Orkin SH, Armstrong SA.) Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5028-33 PMID: 22396593 PMCID: PMC3324004 03/08/2012

• Chromatin-modifying enzymes as modulators of reprogramming.

  (Onder TT, Kara N, Cherry A, Sinha AU, Zhu N, Bernt KM, Cahan P, Marcarci BO, Unternaehrer J, Gupta PB, Lander ES, Armstrong SA, Daley GQ.) Nature. 2012 Mar 04;483(7391):598-602 PMID: 22388813 PMCID: PMC3501145 03/06/2012

• Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains.

  (Trowbridge JJ, Sinha AU, Zhu N, Li M, Armstrong SA, Orkin SH.) Genes Dev. 2012 Feb 15;26(4):344-9 PMID: 22345515 PMCID: PMC3289882 02/22/2012