Raul A. Urrutia, MD

Publications

• Modeling post-translational modifications and cancer-associated mutations that impact the heterochromatin protein 1α-importin α heterodimers.

  (Zimmermann MT, Williams MM, Klee EW, Lomberk GA, Urrutia R.) Proteins. 2019 Nov;87(11):904-916.

• ErbB3-binding protein 1 (EBP1) represses HNF4α-mediated transcription and insulin secretion in pancreatic β-cells.

  (Han EH, Singh P, Lee IK, Urrutia R, Chi YI.) J Biol Chem. 2019 Sep 20;294(38):13983-13994.

• Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine.

  (Lomberk G, Dusetti N, Iovanna J, Urrutia R.) Nat Commun. 2019 08 28;10(1):3875.

• Precision Medicine and Precision Public Health: Academic Education and Community Engagement.

  (Meurer JR, Whittle JC, Lamb KM, Kosasih MA, Dwinell MR, Urrutia RA.) Am J Prev Med. 2019 Aug;57(2):286-289.

• Aurora kinase B-phosphorylated HP1α functions in chromosomal instability.

  (Williams MM, Mathison AJ, Christensen T, Greipp PT, Knutson DL, Klee EW, Zimmermann MT, Iovanna J, Lomberk GA, Urrutia RA.) Cell Cycle. 2019 Jun;18(12):1407-1421.

• CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis.

  (Ligresti G, Caporarello N, Meridew JA, Jones DL, Tan Q, Choi KM, Haak AJ, Aravamudhan A, Roden AC, Prakash YS, Lomberk G, Urrutia RA, Tschumperlin DJ.) JCI Insight. 2019 May 16;5.

• Tumor suppressor Interferon Regulatory Factor 1 selectively blocks expression of endogenous retrovirus.

  (Stoltz KP, Jondle CN, Pulakanti K, Sylvester PA, Urrutia R, Rao S, Tarakanova VL.) Virology. 2019 01 02;526:52-60.

• Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis.

  (Martin-Mateos R, De Assuncao TM, Arab JP, Jalan-Sakrikar N, Yaqoob U, Greuter T, Verma VK, Mathison AJ, Cao S, Lomberk G, Mathurin P, Urrutia R, Huebert RC, Shah VH.) Cell Mol Gastroenterol Hepatol. 2019;7(1):197-209.

• Disruption of FOXP3-EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation.

  (Bamidele AO, Svingen PA, Sagstetter MR, Sarmento OF, Gonzalez M, Braga Neto MB, Kugathasan S, Lomberk G, Urrutia RA, Faubion WA Jr.) Cell Mol Gastroenterol Hepatol. 2019;7(1):55-71.

• Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis.

  (Santofimia-Castaño P, Lan W, Bintz J, Gayet O, Carrier A, Lomberk G, Neira JL, González A, Urrutia R, Soubeyran P, Iovanna J.) Sci Rep. 2018 11 19;8(1):16999.

• Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway.

  (Seo S, Mathison A, Grzenda A, Podratz J, Calvo E, Brimijoin S, Windebank A, Iovanna J, Lomberk G, Urrutia R.) Sci Rep. 2018 10 10;8(1):15077.

• Interplay between interferon regulatory factor 1 and BRD4 in the regulation of PD-L1 in pancreatic stellate cells.

  (Ebine K, Kumar K, Pham TN, Shields MA, Collier KA, Shang M, DeCant BT, Urrutia R, Hwang RF, Grimaldo S, Principe DR, Grippo PJ, Bentrem DJ, Munshi HG.) Sci Rep. 2018 09 05;8(1):13225.