Raul A. Urrutia, MD

Publications

• Genetic variants in DGAT1 cause diverse clinical presentations of malnutrition through a specific molecular mechanism.

  (Gupta A, Dsouza NR, Zarate YA, Lombardo R, Hopkin R, Linehan AR, Simpson J, McCarrier J, Agre KE, Gavrilova RH, Stephens MC, Grothe RM, Monaghan KG, Xie Y, Basel D, Urrutia RA, Cole CR, Klee EW, Zimmermann MT.) Eur J Med Genet. 2019 Nov 25:103817 PMID: 31778854 SCOPUS ID: 2-s2.0-85076241133 11/30/2019

• SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer.

  (He C, Danes JM, Hart PC, Zhu Y, Huang Y, de Abreu AL, O'Brien J, Mathison AJ, Tang B, Frasor JM, Wakefield LM, Ganini D, Stauder E, Zielonka J, Gantner BN, Urrutia RA, Gius D, Bonini MG.) Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23534-23541 PMID: 31591207 PMCID: PMC6876149 SCOPUS ID: 2-s2.0-85075260452 10/09/2019

• Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma.

  (Santofimia-Castaño P, Xia Y, Peng L, Velázquez-Campoy A, Abián O, Lan W, Lomberk G, Urrutia R, Rizzuti B, Soubeyran P, Neira JL, Iovanna J.) Cells. 2019 Nov 17;8(11) PMID: 31744261 PMCID: PMC6912534 11/21/2019

• Modeling post-translational modifications and cancer-associated mutations that impact the heterochromatin protein 1α-importin α heterodimers.

  (Zimmermann MT, Williams MM, Klee EW, Lomberk GA, Urrutia R.) Proteins. 2019 Nov;87(11):904-916 PMID: 31152607 PMCID: PMC6790107 SCOPUS ID: 2-s2.0-85067403924 06/04/2019

• ErbB3-binding protein 1 (EBP1) represses HNF4α-mediated transcription and insulin secretion in pancreatic β-cells.

  (Han EH, Singh P, Lee IK, Urrutia R, Chi YI.) J Biol Chem. 2019 Sep 20;294(38):13983-13994 PMID: 31362984 PMCID: PMC6755798 SCOPUS ID: 2-s2.0-85072530867 08/01/2019

• Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine.

  (Lomberk G, Dusetti N, Iovanna J, Urrutia R.) Nat Commun. 2019 08 28;10(1):3875 PMID: 31462645 PMCID: PMC6713756 SCOPUS ID: 2-s2.0-85071625821 08/30/2019

• Precision Medicine and Precision Public Health: Academic Education and Community Engagement.

  (Meurer JR, Whittle JC, Lamb KM, Kosasih MA, Dwinell MR, Urrutia RA.) Am J Prev Med. 2019 Aug;57(2):286-289 PMID: 31326012 SCOPUS ID: 2-s2.0-85068737878 07/22/2019

• Aurora kinase B-phosphorylated HP1α functions in chromosomal instability.

  (Williams MM, Mathison AJ, Christensen T, Greipp PT, Knutson DL, Klee EW, Zimmermann MT, Iovanna J, Lomberk GA, Urrutia RA.) Cell Cycle. 2019 Jun;18(12):1407-1421 PMID: 31130069 PMCID: PMC6592258 SCOPUS ID: 2-s2.0-85067316375 05/28/2019

• CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis.

  (Ligresti G, Caporarello N, Meridew JA, Jones DL, Tan Q, Choi KM, Haak AJ, Aravamudhan A, Roden AC, Prakash YS, Lomberk G, Urrutia RA, Tschumperlin DJ.) JCI Insight. 2019 May 16;5 PMID: 31095524 PMCID: PMC6629126 SCOPUS ID: 2-s2.0-85070659965 05/17/2019

• Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis.

  (Martin-Mateos R, De Assuncao TM, Arab JP, Jalan-Sakrikar N, Yaqoob U, Greuter T, Verma VK, Mathison AJ, Cao S, Lomberk G, Mathurin P, Urrutia R, Huebert RC, Shah VH.) Cell Mol Gastroenterol Hepatol. 2019;7(1):197-209 PMID: 30539787 PMCID: PMC6282644 SCOPUS ID: 2-s2.0-85057853914 12/13/2018

• Disruption of FOXP3-EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation.

  (Bamidele AO, Svingen PA, Sagstetter MR, Sarmento OF, Gonzalez M, Braga Neto MB, Kugathasan S, Lomberk G, Urrutia RA, Faubion WA Jr.) Cell Mol Gastroenterol Hepatol. 2019;7(1):55-71 PMID: 30510991 PMCID: PMC6260395 SCOPUS ID: 2-s2.0-85056879256 12/05/2018

• Combined Targeting of G9a and Checkpoint kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse.

  (Urrutia G, Salmonson A, Toro-Zapata JA, de Assuncao TM, Mathison A, Dusetti N, Iovanna J, Urrutia R, Lomberk G.) Mol Cancer Res. 2019 Dec 10 PMID: 31822519 12/12/2019