Raul A. Urrutia, MD

Publications

• Tumor suppressor Interferon Regulatory Factor 1 selectively blocks expression of endogenous retrovirus.

  (Stoltz KP, Jondle CN, Pulakanti K, Sylvester PA, Urrutia R, Rao S, Tarakanova VL.) Virology. 2019 01 02;526:52-60.

• Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis.

  (Martin-Mateos R, De Assuncao TM, Arab JP, Jalan-Sakrikar N, Yaqoob U, Greuter T, Verma VK, Mathison AJ, Cao S, Lomberk G, Mathurin P, Urrutia R, Huebert RC, Shah VH.) Cell Mol Gastroenterol Hepatol. 2019;7(1):197-209.

• Disruption of FOXP3-EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation.

  (Bamidele AO, Svingen PA, Sagstetter MR, Sarmento OF, Gonzalez M, Braga Neto MB, Kugathasan S, Lomberk G, Urrutia RA, Faubion WA Jr.) Cell Mol Gastroenterol Hepatol. 2019;7(1):55-71.

• Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis.

  (Santofimia-Castaño P, Lan W, Bintz J, Gayet O, Carrier A, Lomberk G, Neira JL, González A, Urrutia R, Soubeyran P, Iovanna J.) Sci Rep. 2018 Nov 19;8(1):16999.

• Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway.

  (Seo S, Mathison A, Grzenda A, Podratz J, Calvo E, Brimijoin S, Windebank A, Iovanna J, Lomberk G, Urrutia R.) Sci Rep. 2018 Oct 10;8(1):15077.

• Interplay between interferon regulatory factor 1 and BRD4 in the regulation of PD-L1 in pancreatic stellate cells.

  (Ebine K, Kumar K, Pham TN, Shields MA, Collier KA, Shang M, DeCant BT, Urrutia R, Hwang RF, Grimaldo S, Principe DR, Grippo PJ, Bentrem DJ, Munshi HG.) Sci Rep. 2018 Sep 05;8(1):13225.

• Co-occurrence of a maternally inherited duplication and a paternally inherited pathogenic variant in in a child with growth retardation and severe short stature: atypical Weaver syndrome or evidence of a dosage effect?

  (Polonis K, Blackburn PR, Urrutia RA, Lomberk GA, Kruisselbrink T, Cousin MA, Boczek NJ, Hoppman NL, Babovic-Vuksanovic D, Klee EW, Pichurin PN.) Cold Spring Harb Mol Case Stud. 2018 08;4(4).

• P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts.

  (Dou C, Liu Z, Tu K, Zhang H, Chen C, Yaqoob U, Wang Y, Wen J, van Deursen J, Sicard D, Tschumperlin D, Zou H, Huang WC, Urrutia R, Shah VH, Kang N.) Gastroenterology. 2018 06;154(8):2209-2221.e14.

• Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes.

  (Lomberk G, Blum Y, Nicolle R, Nair A, Gaonkar KS, Marisa L, Mathison A, Sun Z, Yan H, Elarouci N, Armenoult L, Ayadi M, Ordog T, Lee JH, Oliver G, Klee E, Moutardier V, Gayet O, Bian B, Duconseil P, Gilabert M, Bigonnet M, Garcia S, Turrini O, Delpero JR, Giovannini M, Grandval P, Gasmi M, Secq V, De Reyniès A, Dusetti N, Iovanna J, Urrutia R.) Nat Commun. 2018 05 17;9(1):1978.

• Assessing Human Genetic Variations in Glucose Transporter SLC2A10 and Their Role in Altering Structural and Functional Properties.

  (Zimmermann MT, Urrutia R, Cousin MA, Oliver GR, Klee EW.) Front Genet. 2018;9:276.

• Epigenetics of gastrointestinal diseases: notes from a workshop.

  (Marks DL, Olson RL, Urrutia R, Billadeau DD, Roy N, Calin GA, Fabbri M, Koutsioumpa M, Iliopoulos D, Ordog T, Huebert R, Sarmento O, Bamidele AO, Faubion W, Lomberk GL, Siveke J, Ahuja N, Iovanna J, Hlady RA, Robertson K, Kisiel J, Pin CL, Fernandez-Zapico ME.) Epigenetics. 2018;13(4):449-457.

• Vasodilator-stimulated phosphoprotein promotes liver metastasis of gastrointestinal cancer by activating a β1-integrin-FAK-YAP1/TAZ signaling pathway.

  (Xiang X, Wang Y, Zhang H, Piao J, Muthusamy S, Wang L, Deng Y, Zhang W, Kuang R, Billadeau DD, Huang S, Lai J, Urrutia R, Kang N.) NPJ Precis Oncol. 2018;2(1):2.