Raul A. Urrutia, MD

Publications

• Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons.

  (Allison RL, Adelman JW, Abrudan J, Urrutia RA, Zimmermann MT, Mathison AJ, Ebert AD.) Genes (Basel). 2022 01 27;13(2) PMID: 35205286 PMCID: PMC8871895 SCOPUS ID: 2-s2.0-85124092767 02/26/2022

• Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons

  (Allison RL, Adelman JW, Abrudan J, Urrutia RA, Zimmermann MT, Mathison AJ, Ebert AD.) Genes. February 2022;13(2) SCOPUS ID: 2-s2.0-85124092767 02/01/2022

• Enhanced interpretation of 935 hotspot and non-hotspot RAS variants using evidence-based structural bioinformatics

  (Tripathi S, Dsouza NR, Mathison AJ, Leverence E, Urrutia R, Zimmermann MT.) Computational and Structural Biotechnology Journal. January 2022;20:117-127 SCOPUS ID: 2-s2.0-85121238740 01/01/2022

• Computational modeling reveals key molecular properties and dynamic behavior of disruptor of telomeric silencing 1-like (DOT1L) and partnering complexes involved in leukemogenesis.

  (Stodola TJ, Chi YI, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R.) Proteins. 2022 01;90(1):282-298 PMID: 34414607 PMCID: PMC8671179 SCOPUS ID: 2-s2.0-85114677469 08/21/2021

• KrasG12D induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells.

  (Mathison AJ, Kerketta R, de Assuncao TM, Leverence E, Zeighami A, Urrutia G, Stodola TJ, di Magliano MP, Iovanna JL, Zimmermann MT, Lomberk G, Urrutia R.) Genome Biol. 2021 10 14;22(1):289 PMID: 34649604 PMCID: PMC8518179 SCOPUS ID: 2-s2.0-85117299300 10/16/2021

• Effects of Subnormothermic Regulated Hepatic Reperfusion on Mitochondrial and Transcriptomic Profiles in a Porcine Model.

  (Kim J, Zimmerman MA, Shin WY, Boettcher BT, Lee JS, Park JI, Ali M, Yang M, Mishra J, Hagen CE, McGraw JE, Mathison A, Woehlck HJ, Lomberk G, Camara AKS, Urrutia RA, Stowe DF, Hong JC.) Ann Surg. 2021 Aug 13 PMID: 34387201 PMCID: PMC8840998 08/14/2021

• P2T2: Protein Panoramic annoTation Tool for the interpretation of protein coding genetic variants.

  (DeVoe E, Oliver GR, Zenka R, Blackburn PR, Cousin MA, Boczek NJ, Kocher JA, Urrutia R, Klee EW, Zimmermann MT.) JAMIA Open. 2021 Jul;4(3):ooab065 PMID: 34377961 PMCID: PMC8346652 SCOPUS ID: 2-s2.0-85118188543 08/12/2021

• BMI1 maintains the Treg epigenomic landscape to prevent inflammatory bowel disease.

  (Gonzalez MM, Bamidele AO, Svingen PA, Sagstetter MR, Smyrk TC, Gaballa JM, Hamdan FH, Kosinsky RL, Gibbons HR, Sun Z, Ye Z, Nair A, Ramos GP, Braga Neto MB, Wixom AQ, Mathison AJ, Johnsen SA, Urrutia R, Faubion WA Jr.) J Clin Invest. 2021 06 15;131(12) PMID: 34128475 PMCID: PMC8203461 SCOPUS ID: 2-s2.0-85108220626 06/16/2021

• Correction to: Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction.

  (Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Basel DG, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R.) Orphanet J Rare Dis. 2021 Jun 01;16(1):247 PMID: 34074320 PMCID: PMC8170813 SCOPUS ID: 2-s2.0-85107273180 06/03/2021

• Corrigendum to: Homotypic cell cannibalism, a cell-death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer (EMBO Molecular Medicine, (2012), 4, 9, (964-979), 10.1002/emmm.201201255)

  (Cano CE, José Sandí M, Hamidi T, Calvo EL, Turrini O, Bartholin L, Loncle C, Secq V, Garcia S, Lomberk G, Kroemer G, Urrutia R, Iovanna JL.) EMBO Molecular Medicine. 7 May 2021;13(5) SCOPUS ID: 2-s2.0-85105133639 05/07/2021

• Inactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks.

  (Urrutia G, de Assuncao TM, Mathison AJ, Salmonson A, Kerketta R, Zeighami A, Stodola TJ, Adsay V, Pehlivanoglu B, Dwinell MB, Zimmermann MT, Iovanna JL, Urrutia R, Lomberk G.) Front Cell Dev Biol. 2021;9:681153 PMID: 34249932 PMCID: PMC8261250 SCOPUS ID: 2-s2.0-85116952280 07/13/2021

• LPCAT1-TERT fusions are uniquely recurrent in epithelioid trophoblastic tumors and positively regulate cell growth.

  (Oliver GR, Marcano-Bonilla S, Quist J, Tolosa EJ, Iguchi E, Swanson AA, Hoppman NL, Schwab T, Sigafoos A, Prodduturi N, Voss JS, Knight SM, Zhang J, Fadra N, Urrutia R, Zimmerman M, Egan JB, Bilyeu AG, Jen J, Veras E, Al-Safi R, Block M, Kerr S, Fernandez-Zapico ME, Schoolmeester JK, Klee EW.) PLoS One. 2021;16(5):e0250518 PMID: 34033669 PMCID: PMC8148365 SCOPUS ID: 2-s2.0-85106573389 05/26/2021