Scott S. Terhune, PhD

Professor

Locations

Microbiology & Immunology
TBRC C2890

Contact Information

General Interests

Human Cytomegalovirus Host-Cell Protein Interactions During Infection

Education

PhD, Cancer Biology, Northwestern University, 2000
Postdoctoral Fellow, Proteomics/Cytomegalovirus Biology, Princeton University, 2007

Learn more about the Terhune Lab

                
                    Research Experience
                

                    Antiviral Agents
Cell Cycle
Cyclin-Dependent Kinase Inhibitor p21
Cytomegalovirus
Histone Acetyltransferases
Histone Deacetylases
Host-Pathogen Interactions
Protein Kinases
Signal Transduction
STAT3 Transcription Factor
Tumor Suppressor Protein p53

            

                
                    Methodologies and Techniques
                

                    Cell Cycle
DNA, Viral
Drug Synergism
Protein Interaction Mapping
Proteomics
RNA, Viral
Virus Replication

            

                
                    Leadership Positions
                

                    Dept Representative, Faculty Council
Past Chair, Faculty Career Development Committee
Program Representative, IDP Executive Evaluation Committee
Vice Chair, Institutional Biosafety Committee

            

Research Interests

Our research focuses on determining the molecular functions of human cytomegalovirus (HCMV) proteins during infection and disease. HCMV is a member of the beta-herpesvirus family of viruses which includes HHV-6 and 7. Infection occurs upon exposure to virus-containing body fluids, is life-long and generally asymptomatic in healthy children and adults. However, during pregnancy, HCMV infection may result in congenital birth defects including hearing loss and neurological damage. In immunologically immature or compromised children and adults, infection often results in life threatening diseases. And, increasing evidence suggestions that persistent life-long HCMV infection is associated with numerous chronic diseases including atherosclerosis, immuno-senescence, cancer and possibly Alzheimer’s Disease.

Human Cytomegalovirus Disruption of Calcium Signaling in Neural Progenitor Cells and Organoids.

(Sison SL, O'Brien BS, Johnson AJ, Seminary ER, Terhune SS, Ebert AD.) J Virol. 2019 09 01;93(17) PMID: 31217241 PMCID: PMC6694809 SCOPUS ID: 2-s2.0-85071355135 06/21/2019
Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency.

(Rak MA, Buehler J, Zeltzer S, Reitsma J, Molina B, Terhune S, Goodrum F.) J Virol. 2018 10 15;92(20) PMID: 30089695 PMCID: PMC6158428 SCOPUS ID: 2-s2.0-85052151483 08/10/2018
Tumor Necrosis Factor Alpha Induces Reactivation of Human Cytomegalovirus Independently of Myeloid Cell Differentiation following Posttranscriptional Establishment of Latency.

(Forte E, Swaminathan S, Schroeder MW, Kim JY, Terhune SS, Hummel M.) mBio. 2018 09 11;9(5) PMID: 30206173 PMCID: PMC6134100 SCOPUS ID: 2-s2.0-85055538738 09/13/2018
Isomer-specific effect of microRNA miR-29b on nuclear morphology.

(Kriegel AJ, Terhune SS, Greene AS, Noon KR, Pereckas MS, Liang M.) J Biol Chem. 2018 09 07;293(36):14080-14088 PMID: 30006350 PMCID: PMC6130969 SCOPUS ID: 2-s2.0-85053013199 07/15/2018
Association of Mycobacterium Proteins with Lipid Droplets.

(Armstrong RM, Carter DC, Atkinson SN, Terhune SS, Zahrt TC.) J Bacteriol. 2018 08 15;200(16) PMID: 29760207 PMCID: PMC6060360 SCOPUS ID: 2-s2.0-85050494395 05/16/2018
Impact of RNA polymerase I inhibitor CX-5461 on viral kinase-dependent and -independent cytomegalovirus replication.

(Westdorp KN, Terhune SS.) Antiviral Res. 2018 05;153:33-38 PMID: 29458130 PMCID: PMC6015744 SCOPUS ID: 2-s2.0-85043578832 02/20/2018
Correction for Mounce et al., A Conserved Gammaherpesvirus Protein Kinase Targets Histone Deacetylases 1 and 2 To Facilitate Viral Replication in Primary Macrophages.

(Mounce BC, Mboko WP, Bigley TM, Terhune SS, Tarakanova VL.) J Virol. 2018 01 01;92(1) PMID: 29242252 PMCID: PMC5730793 SCOPUS ID: 2-s2.0-85037989790 12/16/2017
SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression.

(Gonyo P, Bergom C, Brandt AC, Tsaih SW, Sun Y, Bigley TM, Lorimer EL, Terhune SS, Rui H, Flister MJ, Long RM, Williams CL.) Oncogene. 2017 12 14;36(50):6873-6883 PMID: 28806394 PMCID: PMC5730474 SCOPUS ID: 2-s2.0-85038242723 08/15/2017
Cytomegalovirus Late Protein pUL31 Alters Pre-rRNA Expression and Nuclear Organization during Infection.

(Westdorp KN, Sand A, Moorman NJ, Terhune SS.) J Virol. 2017 09 15;91(18) PMID: 28659485 PMCID: PMC5571270 SCOPUS ID: 2-s2.0-85028302530 07/01/2017
Proteomic Screen for Cellular Targets of the Vaccinia Virus F10 Protein Kinase Reveals that Phosphorylation of mDia Regulates Stress Fiber Formation.

(Greseth MD, Carter DC, Terhune SS, Traktman P.) Mol Cell Proteomics. 2017 04;16(4 suppl 1):S124-S143 PMID: 28183815 PMCID: PMC5393388 SCOPUS ID: 2-s2.0-85017129288 02/12/2017
Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication.

(Buehler J, Zeltzer S, Reitsma J, Petrucelli A, Umashankar M, Rak M, Zagallo P, Schroeder J, Terhune S, Goodrum F.) PLoS Pathog. 2016 05;12(5):e1005655 PMID: 27218650 PMCID: PMC4878804 SCOPUS ID: 2-s2.0-84973327135 05/25/2016
Impact of a cytomegalovirus kinase inhibitor on infection and neuronal progenitor cell differentiation.

(Bigley TM, McGivern JV, Ebert AD, Terhune SS.) Antiviral Res. 2016 May;129:67-73 PMID: 26875788 PMCID: PMC4957402 SCOPUS ID: 2-s2.0-84959527703 02/16/2016

Scott S. Terhune, PhD