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Research Bench Lab

Microbiology & Immunology

Home /
Departments /
Microbiology & Immunology /
Research /
Terhune Laboratory

Research focus

Uncovering molecular mechanisms of viral protein function
Cytomegalovirus manipulation of cellular stress response pathways
Coordinated manipulation of cell cycle to support viral replication
Use of advanced tools to define host-pathogen interactions

Learn More

terhunelab

Scott S. Terhune, PhD

Associate Professor

sterhune@mcw.edu

Human Cytomegalovirus Host-Cell Protein Interactions During Infection

Dr. Scott Terhune discusses the research in his laboratory.

"The Biology Behind Cytomegalovirus Antiviral Resistance"
Source: Children's Hospital of Wisconsin Grand Rounds, 4/8/11

Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency.

(Rak MA, Buehler J, Zeltzer S, Reitsma J, Molina B, Terhune S, Goodrum F.) J Virol. 2018 10 15;92(20).
Tumor Necrosis Factor Alpha Induces Reactivation of Human Cytomegalovirus Independently of Myeloid Cell Differentiation following Posttranscriptional Establishment of Latency.

(Forte E, Swaminathan S, Schroeder MW, Kim JY, Terhune SS, Hummel M.) MBio. 2018 09 11;9(5).
Isomer-specific effect of microRNA miR-29b on nuclear morphology.

(Kriegel AJ, Terhune SS, Greene AS, Noon KR, Pereckas MS, Liang M.) J Biol Chem. 2018 09 07;293(36):14080-14088.
Association of Mycobacterium Proteins with Lipid Droplets.

(Armstrong RM, Carter DC, Atkinson SN, Terhune SS, Zahrt TC.) J Bacteriol. 2018 Aug 15;200(16).
Impact of RNA polymerase I inhibitor CX-5461 on viral kinase-dependent and -independent cytomegalovirus replication.

(Westdorp KN, Terhune SS.) Antiviral Res. 2018 05;153:33-38.
Correction for Mounce et al., A Conserved Gammaherpesvirus Protein Kinase Targets Histone Deacetylases 1 and 2 To Facilitate Viral Replication in Primary Macrophages.

(Mounce BC, Mboko WP, Bigley TM, Terhune SS, Tarakanova VL.) J Virol. 2018 01 01;92(1).
SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression.

(Gonyo P, Bergom C, Brandt AC, Tsaih SW, Sun Y, Bigley TM, Lorimer EL, Terhune SS, Rui H, Flister MJ, Long RM, Williams CL.) Oncogene. 2017 12 14;36(50):6873-6883.
Cytomegalovirus Late Protein pUL31 Alters Pre-rRNA Expression and Nuclear Organization during Infection.

(Westdorp KN, Sand A, Moorman NJ, Terhune SS.) J Virol. 2017 09 15;91(18).
Proteomic Screen for Cellular Targets of the Vaccinia Virus F10 Protein Kinase Reveals that Phosphorylation of mDia Regulates Stress Fiber Formation.

(Greseth MD, Carter DC, Terhune SS, Traktman P.) Mol Cell Proteomics. 2017 04;16(4 suppl 1):S124-S143.
Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication.

(Buehler J, Zeltzer S, Reitsma J, Petrucelli A, Umashankar M, Rak M, Zagallo P, Schroeder J, Terhune S, Goodrum F.) PLoS Pathog. 2016 05;12(5):e1005655.
Impact of a cytomegalovirus kinase inhibitor on infection and neuronal progenitor cell differentiation.

(Bigley TM, McGivern JV, Ebert AD, Terhune SS.) Antiviral Res. 2016 May;129:67-73.
Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry.

(Savaryn JP, Skinner OS, Fornelli L, Fellers RT, Compton PD, Terhune SS, Abecassis MM, Kelleher NL.) J Proteomics. 2016 Feb 16;134:76-84.
Antagonistic Relationship between Human Cytomegalovirus pUL27 and pUL97 Activities during Infection.

(Bigley TM, Reitsma JM, Terhune SS.) J Virol. 2015 Oct;89(20):10230-46.
Proteomic identification of nuclear processes manipulated by cytomegalovirus early during infection.

(Carter DM, Westdorp K, Noon KR, Terhune SS.) Proteomics. 2015 Jun;15(12):1995-2005.
The MprB extracytoplasmic domain negatively regulates activation of the Mycobacterium tuberculosis MprAB two-component system.

(Bretl DJ, Bigley TM, Terhune SS, Zahrt TC.) J Bacteriol. 2014 Jan;196(2):391-406.
Inhibition of cellular STAT3 synergizes with the cytomegalovirus kinase inhibitor maribavir to disrupt infection.

(Reitsma JM, Terhune SS.) Antiviral Res. 2013 Nov;100(2):321-7.
Human cytomegalovirus IE1 protein disrupts interleukin-6 signaling by sequestering STAT3 in the nucleus.

(Reitsma JM, Sato H, Nevels M, Terhune SS, Paulus C.) J Virol. 2013 Oct;87(19):10763-76.
A conserved gammaherpesvirus protein kinase targets histone deacetylases 1 and 2 to facilitate viral replication in primary macrophages.

(Mounce BC, Mboko WP, Bigley TM, Terhune SS, Tarakanova VL.) J Virol. 2013 Jul;87(13):7314-25.
Human cytomegalovirus pUL97 regulates the viral major immediate early promoter by phosphorylation-mediated disruption of histone deacetylase 1 binding.

(Bigley TM, Reitsma JM, Mirza SP, Terhune SS.) J Virol. 2013 Jul;87(13):7393-408.
Human cytomegalovirus pUL29/28 and pUL38 repression of p53-regulated p21CIP1 and caspase 1 promoters during infection.

(Savaryn JP, Reitsma JM, Bigley TM, Halligan BD, Qian Z, Yu D, Terhune SS.) J Virol. 2013 Mar;87(5):2463-74.
Discovery of host-viral protein complexes during infection.

(Rowles DL, Terhune SS, Cristea IM.) Methods Mol Biol. 2013;1064:43-70.
A method for quantifying mechanical properties of tissue following viral infection.

(Lam V, Bigley T, Terhune SS, Wakatsuki T.) PLoS One. 2012;7(8):e42197.
Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a.

(Fehr AR, Gualberto NC, Savaryn JP, Terhune SS, Yu D.) PLoS Pathog. 2012;8(7):e1002789.
Ubiquitin and ubiquitin-modified proteins activate the Pseudomonas aeruginosa T3SS cytotoxin, ExoU.

(Anderson DM, Schmalzer KM, Sato H, Casey M, Terhune SS, Haas AL, Feix JB, Frank DW.) Mol Microbiol. 2011 Dec;82(6):1454-67.
The HtrA-like serine protease PepD interacts with and modulates the Mycobacterium tuberculosis 35-kDa antigen outer envelope protein.

(White MJ, Savaryn JP, Bretl DJ, He H, Penoske RM, Terhune SS, Zahrt TC.) PLoS One. 2011 Mar 22;6(3):e18175.