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Research Bench Lab

Microbiology & Immunology

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Microbiology & Immunology /
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Terhune Laboratory

Location

Microbiology & Immunology

TBRC C2890

General Interests

Human Cytomegalovirus Host-Cell Protein Interactions During Infection

View Scott S. Terhune Bio

Scott Terhune Laboratory

Research Bench Lab

Research Areas

Our research focuses on determining the molecular functions of human cytomegalovirus (HCMV) proteins during infection and disease. HCMV is a member of the beta-herpesvirus family of viruses which includes HHV-6 and 7. Infection occurs upon exposure to virus-containing body fluids, is life-long and generally asymptomatic in healthy children and adults. However, during pregnancy, HCMV infection may result in congenital birth defects including hearing loss and neurological damage. In immunologically immature or compromised children and adults, infection often results in life threatening diseases. And, increasing evidence suggestions that persistent life-long HCMV infection is associated with numerous chronic diseases including atherosclerosis, immuno-senescence, cancer and possibly Alzheimer’s Disease.

Current Members

Katie Cataldo

Research Technologist II

kcataldo@mcw.edu

Megan Schumacher

Research Technologist I

mschumacher@mcw.edu

Rebekah Mokry

Graduate Student

Suzette Rosas

Graduate Student

Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo.

(Maranto C, Udhane V, Jia J, Verma R, Müller-Newen G, LaViolette PS, Pereckas M, Sabharwal L, Terhune S, Pattabiraman N, Njar VCO, Imig JD, Wang L, Nevalainen MT.) Cancers (Basel). 2020 Nov 18;12(11) PMID: 33217941 PMCID: PMC7724566 SCOPUS ID: 2-s2.0-85096199725 11/22/2020
Network mechanisms and dysfunction within an integrated computational model of progression through mitosis in the human cell cycle.

(Terhune SS, Jung Y, Cataldo KM, Dash RK.) PLoS Comput Biol. 2020 04;16(4):e1007733 PMID: 32251461 PMCID: PMC7162553 SCOPUS ID: 2-s2.0-85083620688 04/07/2020
Erratum for Rak et al., Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency.

(Rak MA, Buehler J, Zeltzer S, Reitsma J, Molina B, Terhune S, Goodrum F.) J Virol. 2020 03 17;94(7) PMID: 32184335 PMCID: PMC7081901 SCOPUS ID: 2-s2.0-85082001595 03/19/2020
Nitric oxide circumvents virus-mediated metabolic regulation during human cytomegalovirus infection

(Mokry RL, Schumacher ML, Hogg N, Terhune SS.) mBio. November-December 2020;11(6):1-25 SCOPUS ID: 2-s2.0-85098068781 11/01/2020
Human Cytomegalovirus Disruption of Calcium Signaling in Neural Progenitor Cells and Organoids.

(Sison SL, O'Brien BS, Johnson AJ, Seminary ER, Terhune SS, Ebert AD.) J Virol. 2019 09 01;93(17) PMID: 31217241 PMCID: PMC6694809 SCOPUS ID: 2-s2.0-85071355135 06/21/2019
Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency.

(Rak MA, Buehler J, Zeltzer S, Reitsma J, Molina B, Terhune S, Goodrum F.) J Virol. 2018 10 15;92(20) PMID: 30089695 PMCID: PMC6158428 SCOPUS ID: 2-s2.0-85052151483 08/10/2018
Tumor Necrosis Factor Alpha Induces Reactivation of Human Cytomegalovirus Independently of Myeloid Cell Differentiation following Posttranscriptional Establishment of Latency.

(Forte E, Swaminathan S, Schroeder MW, Kim JY, Terhune SS, Hummel M.) mBio. 2018 09 11;9(5) PMID: 30206173 PMCID: PMC6134100 SCOPUS ID: 2-s2.0-85055538738 09/13/2018
Isomer-specific effect of microRNA miR-29b on nuclear morphology.

(Kriegel AJ, Terhune SS, Greene AS, Noon KR, Pereckas MS, Liang M.) J Biol Chem. 2018 09 07;293(36):14080-14088 PMID: 30006350 PMCID: PMC6130969 SCOPUS ID: 2-s2.0-85053013199 07/15/2018
Association of Mycobacterium Proteins with Lipid Droplets.

(Armstrong RM, Carter DC, Atkinson SN, Terhune SS, Zahrt TC.) J Bacteriol. 2018 08 15;200(16) PMID: 29760207 PMCID: PMC6060360 SCOPUS ID: 2-s2.0-85050494395 05/16/2018
Impact of RNA polymerase I inhibitor CX-5461 on viral kinase-dependent and -independent cytomegalovirus replication.

(Westdorp KN, Terhune SS.) Antiviral Res. 2018 05;153:33-38 PMID: 29458130 PMCID: PMC6015744 SCOPUS ID: 2-s2.0-85043578832 02/20/2018
Correction for Mounce et al., A Conserved Gammaherpesvirus Protein Kinase Targets Histone Deacetylases 1 and 2 To Facilitate Viral Replication in Primary Macrophages.

(Mounce BC, Mboko WP, Bigley TM, Terhune SS, Tarakanova VL.) J Virol. 2018 01 01;92(1) PMID: 29242252 PMCID: PMC5730793 SCOPUS ID: 2-s2.0-85037989790 12/16/2017
SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression.

(Gonyo P, Bergom C, Brandt AC, Tsaih SW, Sun Y, Bigley TM, Lorimer EL, Terhune SS, Rui H, Flister MJ, Long RM, Williams CL.) Oncogene. 2017 12 14;36(50):6873-6883 PMID: 28806394 PMCID: PMC5730474 SCOPUS ID: 2-s2.0-85038242723 08/15/2017
Cytomegalovirus Late Protein pUL31 Alters Pre-rRNA Expression and Nuclear Organization during Infection.

(Westdorp KN, Sand A, Moorman NJ, Terhune SS.) J Virol. 2017 09 15;91(18) PMID: 28659485 PMCID: PMC5571270 SCOPUS ID: 2-s2.0-85028302530 07/01/2017
Proteomic Screen for Cellular Targets of the Vaccinia Virus F10 Protein Kinase Reveals that Phosphorylation of mDia Regulates Stress Fiber Formation.

(Greseth MD, Carter DC, Terhune SS, Traktman P.) Mol Cell Proteomics. 2017 04;16(4 suppl 1):S124-S143 PMID: 28183815 PMCID: PMC5393388 SCOPUS ID: 2-s2.0-85017129288 02/12/2017
Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication.

(Buehler J, Zeltzer S, Reitsma J, Petrucelli A, Umashankar M, Rak M, Zagallo P, Schroeder J, Terhune S, Goodrum F.) PLoS Pathog. 2016 05;12(5):e1005655 PMID: 27218650 PMCID: PMC4878804 SCOPUS ID: 2-s2.0-84973327135 05/25/2016
Impact of a cytomegalovirus kinase inhibitor on infection and neuronal progenitor cell differentiation.

(Bigley TM, McGivern JV, Ebert AD, Terhune SS.) Antiviral Res. 2016 May;129:67-73 PMID: 26875788 PMCID: PMC4957402 SCOPUS ID: 2-s2.0-84959527703 02/16/2016
Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry.

(Savaryn JP, Skinner OS, Fornelli L, Fellers RT, Compton PD, Terhune SS, Abecassis MM, Kelleher NL.) J Proteomics. 2016 Feb 16;134:76-84 PMID: 25952688 PMCID: PMC4633404 SCOPUS ID: 2-s2.0-84958173605 05/09/2015
Antagonistic Relationship between Human Cytomegalovirus pUL27 and pUL97 Activities during Infection.

(Bigley TM, Reitsma JM, Terhune SS.) J Virol. 2015 Oct;89(20):10230-46 PMID: 26223645 PMCID: PMC4580190 SCOPUS ID: 2-s2.0-84942155947 08/01/2015
Proteomic identification of nuclear processes manipulated by cytomegalovirus early during infection.

(Carter DM, Westdorp K, Noon KR, Terhune SS.) Proteomics. 2015 Jun;15(12):1995-2005 PMID: 25758553 PMCID: PMC4556115 SCOPUS ID: 2-s2.0-84931005724 03/12/2015
The MprB extracytoplasmic domain negatively regulates activation of the Mycobacterium tuberculosis MprAB two-component system.

(Bretl DJ, Bigley TM, Terhune SS, Zahrt TC.) J Bacteriol. 2014 Jan;196(2):391-406 PMID: 24187094 PMCID: PMC3911260 11/05/2013
Inhibition of cellular STAT3 synergizes with the cytomegalovirus kinase inhibitor maribavir to disrupt infection.

(Reitsma JM, Terhune SS.) Antiviral Res. 2013 Nov;100(2):321-7 PMID: 24070820 PMCID: PMC3845884 SCOPUS ID: 2-s2.0-84885352457 09/28/2013
Human cytomegalovirus IE1 protein disrupts interleukin-6 signaling by sequestering STAT3 in the nucleus.

(Reitsma JM, Sato H, Nevels M, Terhune SS, Paulus C.) J Virol. 2013 Oct;87(19):10763-76 PMID: 23903834 PMCID: PMC3807375 08/02/2013
A conserved gammaherpesvirus protein kinase targets histone deacetylases 1 and 2 to facilitate viral replication in primary macrophages.

(Mounce BC, Mboko WP, Bigley TM, Terhune SS, Tarakanova VL.) J Virol. 2013 Jul;87(13):7314-25 PMID: 23616648 PMCID: PMC3700300 04/26/2013
Human cytomegalovirus pUL97 regulates the viral major immediate early promoter by phosphorylation-mediated disruption of histone deacetylase 1 binding.

(Bigley TM, Reitsma JM, Mirza SP, Terhune SS.) J Virol. 2013 Jul;87(13):7393-408 PMID: 23616659 PMCID: PMC3700266 04/26/2013
Discovery of host-viral protein complexes during infection.

(Rowles DL, Terhune SS, Cristea IM.) Methods Mol Biol. 2013;1064:43-70 PMID: 23996249 PMCID: PMC4162421 SCOPUS ID: 2-s2.0-84884176527 09/03/2013