Microbiology & Immunology

Recent Publications

• Human Cytomegalovirus Disruption of Calcium Signaling in Neural Progenitor Cells and Organoids.

  (Sison SL, O'Brien BS, Johnson AJ, Seminary ER, Terhune SS, Ebert AD.) J Virol. 2019 Sep 01;93(17) PMID: 31217241 PMCID: PMC6694809 SCOPUS ID: 2-s2.0-85071355135 06/21/2019

• Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency.

  (Rak MA, Buehler J, Zeltzer S, Reitsma J, Molina B, Terhune S, Goodrum F.) J Virol. 2018 10 15;92(20) PMID: 30089695 PMCID: PMC6158428 SCOPUS ID: 2-s2.0-85052151483 08/10/2018

• Tumor Necrosis Factor Alpha Induces Reactivation of Human Cytomegalovirus Independently of Myeloid Cell Differentiation following Posttranscriptional Establishment of Latency.

  (Forte E, Swaminathan S, Schroeder MW, Kim JY, Terhune SS, Hummel M.) mBio. 2018 09 11;9(5) PMID: 30206173 PMCID: PMC6134100 SCOPUS ID: 2-s2.0-85055538738 09/13/2018

• Isomer-specific effect of microRNA miR-29b on nuclear morphology.

  (Kriegel AJ, Terhune SS, Greene AS, Noon KR, Pereckas MS, Liang M.) J Biol Chem. 2018 09 07;293(36):14080-14088 PMID: 30006350 PMCID: PMC6130969 SCOPUS ID: 2-s2.0-85053013199 07/15/2018

• Association of Mycobacterium Proteins with Lipid Droplets.

  (Armstrong RM, Carter DC, Atkinson SN, Terhune SS, Zahrt TC.) J Bacteriol. 2018 08 15;200(16) PMID: 29760207 PMCID: PMC6060360 SCOPUS ID: 2-s2.0-85050494395 05/16/2018

• Impact of RNA polymerase I inhibitor CX-5461 on viral kinase-dependent and -independent cytomegalovirus replication.

  (Westdorp KN, Terhune SS.) Antiviral Res. 2018 05;153:33-38 PMID: 29458130 PMCID: PMC6015744 SCOPUS ID: 2-s2.0-85043578832 02/20/2018

• Correction for Mounce et al., A Conserved Gammaherpesvirus Protein Kinase Targets Histone Deacetylases 1 and 2 To Facilitate Viral Replication in Primary Macrophages.

  (Mounce BC, Mboko WP, Bigley TM, Terhune SS, Tarakanova VL.) J Virol. 2018 01 01;92(1) PMID: 29242252 PMCID: PMC5730793 SCOPUS ID: 2-s2.0-85037989790 12/16/2017

• SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression.

  (Gonyo P, Bergom C, Brandt AC, Tsaih SW, Sun Y, Bigley TM, Lorimer EL, Terhune SS, Rui H, Flister MJ, Long RM, Williams CL.) Oncogene. 2017 12 14;36(50):6873-6883 PMID: 28806394 PMCID: PMC5730474 SCOPUS ID: 2-s2.0-85038242723 08/15/2017

• Cytomegalovirus Late Protein pUL31 Alters Pre-rRNA Expression and Nuclear Organization during Infection.

  (Westdorp KN, Sand A, Moorman NJ, Terhune SS.) J Virol. 2017 09 15;91(18) PMID: 28659485 PMCID: PMC5571270 SCOPUS ID: 2-s2.0-85028302530 07/01/2017

• Proteomic Screen for Cellular Targets of the Vaccinia Virus F10 Protein Kinase Reveals that Phosphorylation of mDia Regulates Stress Fiber Formation.

  (Greseth MD, Carter DC, Terhune SS, Traktman P.) Mol Cell Proteomics. 2017 04;16(4 suppl 1):S124-S143 PMID: 28183815 PMCID: PMC5393388 SCOPUS ID: 2-s2.0-85017129288 02/12/2017

• Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication.

  (Buehler J, Zeltzer S, Reitsma J, Petrucelli A, Umashankar M, Rak M, Zagallo P, Schroeder J, Terhune S, Goodrum F.) PLoS Pathog. 2016 05;12(5):e1005655 PMID: 27218650 PMCID: PMC4878804 SCOPUS ID: 2-s2.0-84973327135 05/25/2016

• Impact of a cytomegalovirus kinase inhibitor on infection and neuronal progenitor cell differentiation.

  (Bigley TM, McGivern JV, Ebert AD, Terhune SS.) Antiviral Res. 2016 May;129:67-73 PMID: 26875788 PMCID: PMC4957402 SCOPUS ID: 2-s2.0-84959527703 02/16/2016

• Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry.

  (Savaryn JP, Skinner OS, Fornelli L, Fellers RT, Compton PD, Terhune SS, Abecassis MM, Kelleher NL.) J Proteomics. 2016 Feb 16;134:76-84 PMID: 25952688 PMCID: PMC4633404 SCOPUS ID: 2-s2.0-84958173605 05/09/2015

• Antagonistic Relationship between Human Cytomegalovirus pUL27 and pUL97 Activities during Infection.

  (Bigley TM, Reitsma JM, Terhune SS.) J Virol. 2015 Oct;89(20):10230-46 PMID: 26223645 PMCID: PMC4580190 SCOPUS ID: 2-s2.0-84942155947 08/01/2015

• Proteomic identification of nuclear processes manipulated by cytomegalovirus early during infection.

  (Carter DM, Westdorp K, Noon KR, Terhune SS.) Proteomics. 2015 Jun;15(12):1995-2005 PMID: 25758553 PMCID: PMC4556115 SCOPUS ID: 2-s2.0-84931005724 03/12/2015

• The MprB extracytoplasmic domain negatively regulates activation of the Mycobacterium tuberculosis MprAB two-component system.

  (Bretl DJ, Bigley TM, Terhune SS, Zahrt TC.) J Bacteriol. 2014 Jan;196(2):391-406 PMID: 24187094 PMCID: PMC3911260 11/05/2013

• Inhibition of cellular STAT3 synergizes with the cytomegalovirus kinase inhibitor maribavir to disrupt infection.

  (Reitsma JM, Terhune SS.) Antiviral Res. 2013 Nov;100(2):321-7 PMID: 24070820 PMCID: PMC3845884 SCOPUS ID: 2-s2.0-84885352457 09/28/2013

• Human cytomegalovirus IE1 protein disrupts interleukin-6 signaling by sequestering STAT3 in the nucleus.

  (Reitsma JM, Sato H, Nevels M, Terhune SS, Paulus C.) J Virol. 2013 Oct;87(19):10763-76 PMID: 23903834 PMCID: PMC3807375 08/02/2013

• A conserved gammaherpesvirus protein kinase targets histone deacetylases 1 and 2 to facilitate viral replication in primary macrophages.

  (Mounce BC, Mboko WP, Bigley TM, Terhune SS, Tarakanova VL.) J Virol. 2013 Jul;87(13):7314-25 PMID: 23616648 PMCID: PMC3700300 04/26/2013

• Human cytomegalovirus pUL97 regulates the viral major immediate early promoter by phosphorylation-mediated disruption of histone deacetylase 1 binding.

  (Bigley TM, Reitsma JM, Mirza SP, Terhune SS.) J Virol. 2013 Jul;87(13):7393-408 PMID: 23616659 PMCID: PMC3700266 04/26/2013

• Human cytomegalovirus pUL29/28 and pUL38 repression of p53-regulated p21CIP1 and caspase 1 promoters during infection.

  (Savaryn JP, Reitsma JM, Bigley TM, Halligan BD, Qian Z, Yu D, Terhune SS.) J Virol. 2013 Mar;87(5):2463-74 PMID: 23236067 PMCID: PMC3571358 SCOPUS ID: 2-s2.0-84874743912 12/14/2012

• Discovery of host-viral protein complexes during infection.

  (Rowles DL, Terhune SS, Cristea IM.) Methods Mol Biol. 2013;1064:43-70 PMID: 23996249 PMCID: PMC4162421 SCOPUS ID: 2-s2.0-84884176527 09/03/2013

• A method for quantifying mechanical properties of tissue following viral infection.

  (Lam V, Bigley T, Terhune SS, Wakatsuki T.) PLoS One. 2012;7(8):e42197 PMID: 22870300 PMCID: PMC3411685 SCOPUS ID: 2-s2.0-84864560232 08/08/2012

• Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a.

  (Fehr AR, Gualberto NC, Savaryn JP, Terhune SS, Yu D.) PLoS Pathog. 2012;8(7):e1002789 PMID: 22792066 PMCID: PMC3390409 SCOPUS ID: 2-s2.0-84864614340 07/14/2012

• Ubiquitin and ubiquitin-modified proteins activate the Pseudomonas aeruginosa T3SS cytotoxin, ExoU.

  (Anderson DM, Schmalzer KM, Sato H, Casey M, Terhune SS, Haas AL, Feix JB, Frank DW.) Mol Microbiol. 2011 Dec;82(6):1454-67 PMID: 22040088 PMCID: PMC3237844 SCOPUS ID: 2-s2.0-83355166268 11/02/2011