Shyam S. Chaurasia, MSc, PhD

Associate Professor

Locations

EI 827

Contact Information

Education

Doctor of Philosophy (PhD), Life Sciences
Master of Science (MSc), Biochemistry
Bachelor of Science (BSc), Biochemistry

Biography

Dr. Shyam S. Chaurasia was born in Gwalior, also described as the “The Medieval Majestic Indian City with Music in its Soul.” He received his bachelor’s and master’s degrees in Science with Biochemistry as his major from the esteemed Nagpur University. He obtained a PhD degree from a globally ranked School of Life Sciences, Devi Ahilya University, Indore, India. He was awarded the prestigious Department of Biotechnology sponsored Postdoctoral Fellowship, and completed his Postdoctoral training in ophthalmology/neurosciences from Emory University, Atlanta, GA.

Dr. Chaurasia took his first faculty appointment in 2006 as a scientist at the Cole Eye Institute, Cleveland Clinic, Cleveland, OH. In 2009, he decided to move to Singapore and joined the Singapore Eye Research Institute, Singapore, and Institute of Molecular and Cellular Biology, A*STAR agency as an extramurally funded principal scientist/investigator. Later, he decided to return to the United States and took his first academic appointment as Assistant Professor on a tenure-track and successfully launched NIH/NEI-funded “Ocular Immunology & Angiogenesis Lab,” studying basic and translational research in vision sciences at the University of Missouri, Columbia, MO. In 2021, he joined as an associate professor in the Department of Ophthalmology and Visual Sciences/Eye Institute at MCW.

Honors and Awards

2020, Electron Microscopy Excellence Award, University of Missouri, Columbia, MO
2019, Electron Microscopy Excellence Award, University of Missouri, Columbia, MO
2018, Appeared on the local NBC News Channel in the Prime Time News, KOMU News Channel (NBC channel affiliate), Columbia, MO
2017, Electron Microscopy Excellence Award, University of Missouri, Columbia, MO
2011, Outstanding Young Research Award, Singapore Eye Research Institute, Singapore
2007, Association for Research in Vision and Ophthalmology (ARVO) Travel Award, ARVO, Rockville, MD
2006, Pineal Cell Biology Travel Award, Gordon Research Conferences, Buellton, CA
2005, X European Pineal and Biological Rhythm Society Congress Travel Award, European Pineal and Biological Rhythm Society Congress Travel Award, Frankfurt, Germany
2004, Pineal Cell Biology Travel Award, Gordon Research Conferences, Oxford, UK
2003, Mentor, BRAIN Summer Research Program, Center for Behavioral Neuroscience, Emory University, Atlanta, GA

Research Interests

Dr. Chaurasia’s Ocular Immunology and Angiogenesis Lab is funded by NIH/NEI and focuses on the Molecular Basis of Eye Diseases for the development of a highly innovative basic and translational multidisciplinary research program in the identification and validation of novel biomarkers and targets, and evaluate potential VEGF-independent Next-Generation Precision therapeutics/Medicine to treat Ocular Fibrotic and Angiogenic Diseases (OFADs). Dr. Chaurasia has substantial experience in basic and translational vision sciences, as evident from published more than 100 peer-reviewed research papers and 150+ scientific abstracts and presentations at the national and international level.

Research Experience

Diabetic Retinopathy & Diabetic Macular Edema
Age-related Macular Degeneration
Retinopathy of Prematurity
Fibrotic Eye Diseases
Nanomedicine & Wound healing therapeutics in the Eye
Next-Gen Tools in Precision Medicine for Retinal Degenerative Diseases
Countermeasures Against Chemical Threats (CounterACT)

Glutathione is a potential therapeutic target for acrolein toxicity in the cornea.

(Gupta S, Kamil S, Sinha PR, Rodier JT, Chaurasia SS, Mohan RR.) Toxicol Lett. 2021 Apr 01;340:33-42 PMID: 33421550 01/10/2021
A Novel Topical Ophthalmic Formulation to Mitigate Acute Mustard Gas Keratopathy In Vivo: A Pilot Study.

(Tripathi R, Balne PK, Sinha NR, Martin LM, Kamil S, Landreneau JR, Gupta S, Rodier JT, Sinha PR, Hesemann NP, Hofmann AC, Fink MK, Chaurasia SS, Mohan RR.) Transl Vis Sci Technol. 2020 11;9(12):6 PMID: 33200047 PMCID: PMC7645241 11/18/2020
A rabbit model for evaluating ocular damage from acrolein toxicity in vivo.

(Gupta S, Fink MK, Martin LM, Sinha PR, Rodier JT, Sinha NR, Hesemann NP, Chaurasia SS, Mohan RR.) Ann N Y Acad Sci. 2020 11;1480(1):233-245 PMID: 33067838 10/18/2020
MicroRNA-15b Targets VEGF and Inhibits Angiogenesis in Proliferative Diabetic Retinopathy.

(Yang Y, Liu Y, Li Y, Chen Z, Xiong Y, Zhou T, Tao W, Xu F, Yang H, Ylä-Herttuala S, Chaurasia SS, Adam WC, Yang K.) J Clin Endocrinol Metab. 2020 11 01;105(11) PMID: 32797181 08/17/2020
NOD-like Receptors in the Eye: Uncovering Its Role in Diabetic Retinopathy.

(Lim RR, Wieser ME, Ganga RR, Barathi VA, Lakshminarayanan R, Mohan RR, Hainsworth DP, Chaurasia SS.) Int J Mol Sci. 2020 Jan 30;21(3) PMID: 32019187 PMCID: PMC7037099 02/06/2020
Is sex a biological variable in corneal wound healing?

(Tripathi R, Giuliano EA, Gafen HB, Gupta S, Martin LM, Sinha PR, Rodier JT, Fink MK, Hesemann NP, Chaurasia SS, Mohan RR.) Exp Eye Res. 2019 10;187:107705 PMID: 31226339 06/22/2019
Characterization of a functionally active primary microglial cell culture from the pig retina.

(Lim RR, Hainsworth DP, Mohan RR, Chaurasia SS.) Exp Eye Res. 2019 08;185:107670 PMID: 31103710 05/20/2019
Correlation between systemic S100A8 and S100A9 levels and severity of diabetic retinopathy in patients with type 2 diabetes mellitus.

(Lim RR, Vaidya T, Gadde SG, Yadav NK, Sethu S, Hainsworth DP, Mohan RR, Ghosh A, Chaurasia SS.) Diabetes Metab Syndr. 2019 Mar - Apr;13(2):1581-1589 PMID: 31336525 07/25/2019
Decorin antagonizes corneal fibroblast migration via caveolae-mediated endocytosis of epidermal growth factor receptor.

(Mohan RR, Tripathi R, Sharma A, Sinha PR, Giuliano EA, Hesemann NP, Chaurasia SS.) Exp Eye Res. 2019 03;180:200-207 PMID: 30611736 01/07/2019
Young Ossabaw Pigs Fed a Western Diet Exhibit Early Signs of Diabetic Retinopathy.

(Lim RR, Grant DG, Olver TD, Padilla J, Czajkowski AM, Schnurbusch TR, Mohan RR, Hainsworth DP, Walters EM, Chaurasia SS.) Invest Ophthalmol Vis Sci. 2018 05 01;59(6):2325-2338 PMID: 29847637 PMCID: PMC5937800 05/31/2018
The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy.

(Chaurasia SS, Lim RR, Parikh BH, Wey YS, Tun BB, Wong TY, Luu CD, Agrawal R, Ghosh A, Mortellaro A, Rackoczy E, Mohan RR, Barathi VA.) Sci Rep. 2018 02 12;8(1):2847 PMID: 29434227 PMCID: PMC5809448 02/13/2018
Novel Combination BMP7 and HGF Gene Therapy Instigates Selective Myofibroblast Apoptosis and Reduces Corneal Haze In Vivo.

(Gupta S, Fink MK, Ghosh A, Tripathi R, Sinha PR, Sharma A, Hesemann NP, Chaurasia SS, Giuliano EA, Mohan RR.) Invest Ophthalmol Vis Sci. 2018 02 01;59(2):1045-1057 PMID: 29490341 PMCID: PMC5822743 03/01/2018

Shyam S. Chaurasia, MSc, PhD