Ocular Immunology and Angiogenesis Laboratory at the Medical College of Wisconsin
Dr Chaurasia’s Ocular Immunology and Angiogenesis Lab is funded by NIH/NEI and focuses on the Molecular Basis of Eye Diseases for the development of a highly innovative basic and translational multidisciplinary research program in the identification and validation of novel biomarkers and targets and evaluate potential VEGF-independent Next-Generation Precision therapeutics/Medicine to treat Ocular Fibrotic and Angiogenic Diseases (OFADs).
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Research Overview
Research Areas
Role of S100 proteins in Diabetic Retinopathy
The S100 family of small Ca2+-binding proteins is involved in many inflammatory diseases, but their role in the retina is still unknown. Our preliminary studies identified for the first time a regulatory role of S100A9 protein in rodents and porcine retina along with human DR patients. The present study will evaluate the functional role of S100A9 in the retina and explore its possibility of being a novel VEGF-independent molecular target in DR pathogenesis.
Decorin Gene Therapy for Retinopathy of Prematurity
Decorin is a small leucine-rich proteoglycan that regulates the extracellular matrix and angiogenesis in many tissues, but its function in the retina remains unknown. Our pilot studies suggest a role for decorin in retinal structural integrity and microvasculature. The present study will characterize the functional role of Dcn in the retina and test the potential of AAV5-Dcn gene therapy for the treatment of retinopathy of prematurity using an established oxygen-induced retinopathy rat model.
Ossabaw minipig as a Translational Model for Diabetic Retinopathy
This is the first study to describe the ultrastructural neuronal and vascular changes in the retina of young Ossabaw pigs fed a Western diet, simulating early signs of diabetic retinopathy pathogenesis.
3D Characterization of Ultrastructural Retinal Changes with Focus Ion Beam-Scanning Electron Microscopy (FIB-SEM)
This study aims to quantify the 3D ultrastructure changes in the RPE cell damage, drusen volume and Bruch's membrane using FIB-SEM in the patients with age-related macular degeneration (AMD).
Ocular Immunology and Angiogenesis Lab Photos
RPE Function
Trypsin Digest-Retinal Microvasculature
Ocular Immunology
Isolectin Staining
Photoreceptors and RPE
Meet Our Team
Led by Lab Director and Principal Investigator Dr. Shyam Chaurasia, the team at the Ocular Immunology and Angiogenesis Laboratory specializes in ocular fibrotic and angiogenic diseases.
Shyam S. Chaurasia, MSc, PhD
Associate Professor of Ophthalmology & Visual Sciences; Associate Professor of Cell Biology, Neurobiology and Anatomy
Waylon Alvarado
Medical Student
Sanjay Chakka, PhD
Postdoctoral Researcher
Scholastica Go
Graduate Student
Yesenia G. Gomez
Research Technologist I
Shermaine W.Y. Low
Graduate Student
Amer Mohiuddin
Student Worker
Utkarsh Reddy, PhD
Postdoctoral Researcher
Chris M. Skumatz
Animal & Laboratory Research Program Manager
Anju Elizabeth Thomas, PhD
Research Associate I
Our Alumni
Nishant Sinha, PhD
Sangeeta Chaurasia, BSc, MA
Molly Beck, BS
Bina Mahaling, PhD
Khalid Al-Kirwi, MD
Sam Patterson, Undergraduate
Our Collaborators
Mike Iuvone, Emory University
Arakasubhra Ghosh, Narayana Nethralaya, India
Michael Sturek, Indiana University
Peter Heegard, Denmark
VA Barathi, Singapore Eye Research Institute
Rajamani Lakshminarayanan, Singapore Eye Research Institute
Walter Huzniker, A*Star, Singapore
Candice Floyd, University of Utah
Get Involved
Support OIAL
The OIAL could not exist without the generosity and support of many foundations, federal agencies and individual donors. Funds donated to the program are used to acquire new equipment and research consumables, to help train students and fellows, to enable the presentation of our research findings at scientific meetings and to fund positions for support staff.
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Join our Team
We are always looking for enthusiastic candidates with strong communication skills and lab experience. We encourage high school students, undergraduate students, graduate students, post doc, and medical students to browse our website and learn more about our research. We also have available positions for laboratory and animal technologists.
Current Openings
We do not have any open positions at this time. Please check back soon!
Resources for Interested Candidates
High School
Research Opportunity for Academic Development in Science (ROADS) program
Undergraduate
Program for Undergraduate Research Experience (PURE)
Summer Program for Undergraduate Research (SPUR)
Graduate
School of Graduate Studies (PhD Program)
Medical
Medical Student Summer Research Program (MSSRP)
Physician Scientist Pathway
Other area institutions
Marquette University, Milwaukee School of Engineering, University of Wisconsin, Milwaukee. These institutions offer collaborative undergraduate and graduate research programs.
Funding
We are fortunate to have a diverse array of funding sources for our research at the Eye Institute. We would like to acknowledge the National Institute of Health (NIH), the National Eye Institute (NEI), Research to Prevent Blindness, and the R.D. & Linda Peters Foundation for their long-term support of our research projects. We also gratefully thank the many other local and national foundations who have made contributions to advance our mission. Finally, we thank our patients for their philanthropic donations, which provide especially vital support for new projects and continued innovation.
Recent Publications
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Recent advances associated with cardiometabolic remodeling in diabetes-induced heart failure.
(Sharma G, Chaurasia SS, Carlson MA, Mishra PK.) Am J Physiol Heart Circ Physiol. 2024 Dec 01;327(6):H1327-H1342 PMID: 39453429 SCOPUS ID: 2-s2.0-85210105516 10/25/2024
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Retinal microglia-derived S100A9 incite NLRP3 inflammasome in a Western diet fed Ossabaw pig retina.
(Lim RR, Thomas A, Ramasubramanian A, Chaurasia SS.) bioRxiv. 2024 Oct 31 PMID: 39554084 PMCID: PMC11565851 11/18/2024
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Fabry Disease Rat Model Develops Age- and Sex-Dependent Anterior Segment Ocular Abnormalities.
(Erdman ME, Ch S, Mohiuddin A, Al-Kirwi K, Rasper MR, Sokupa S, Low SWY, Skumatz CMB, De Stefano V, Kassem IS, Chaurasia SS.) Invest Ophthalmol Vis Sci. 2024 Aug 01;65(10):14 PMID: 39110587 PMCID: PMC11314710 SCOPUS ID: 2-s2.0-85200939798 08/07/2024
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(Mohan RR, Gupta S, Kumar R, Sinha NR, Landreneau J, Sinha PR, Tandon A, Chaurasia SS, Hesemann NP.) Ocul Surf. 2024 Apr;32:13-25 PMID: 38191093 SCOPUS ID: 2-s2.0-85182147133 01/09/2024
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(Lim RR, Mahaling B, Tan A, Mehta M, Kaur C, Hunziker W, Kim JE, Barathi VA, Ghosh A, Chaurasia SS.) FASEB J. 2024 Mar 15;38(5):e23512 PMID: 38430220 PMCID: PMC11019659 SCOPUS ID: 2-s2.0-85186559682 03/02/2024
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(Shanbagh S, Gadde SG, Shetty R, Heymans S, Abilash VG, Chaurasia SS, Ghosh A.) Exp Eye Res. 2024 Jan;238:109713 PMID: 37952722 SCOPUS ID: 2-s2.0-85178139041 11/13/2023
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(Babu VS, Mallipatna A, Dudeja G, Shetty R, Nair AP, Tun SBB, Ho CEH, Chaurasia SS, Bhattacharya SS, Verma NK, Lakshminarayanan R, Guha N, Heymans S, Barathi VA, Ghosh A.) Transl Res. 2023 Nov;261:41-56 PMID: 37419277 SCOPUS ID: 2-s2.0-85167435325 07/08/2023
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(Low SWY, Lim RR, Grant DG, Patterson S, Chaurasia SS.) Res Sq. 2023 Aug 07 PMID: 37609321 PMCID: PMC10441459 08/23/2023
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Next-Generation Nanomedicine Approaches for the Management of Retinal Diseases.
(Mahaling B, Low SWY, Ch S, Addi UR, Ahmad B, Connor TB, Mohan RR, Biswas S, Chaurasia SS.) Pharmaceutics. 2023 Jul 22;15(7) PMID: 37514191 PMCID: PMC10383092 SCOPUS ID: 2-s2.0-85166338712 07/29/2023
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Mustard Gas Exposure Actuates SMAD2/3 Signaling to Promote Myofibroblast Generation in the Cornea.
(Sinha NR, Tripathi R, Balne PK, Suleiman L, Simkins K, Chaurasia SS, Mohan RR.) Cells. 2023 Jun 02;12(11) PMID: 37296653 PMCID: PMC10252656 SCOPUS ID: 2-s2.0-85163141524 06/10/2023
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(Shanbagh S, Matalia J, Kannan R, Shetty R, Panmand P, Muthu SO, Chaurasia SS, Deshpande V, Bhattacharya SS, Gopalakrishnan AV, Ghosh A.) Indian J Ophthalmol. 2023 May;71(5):2143-2151 PMID: 37203095 PMCID: PMC10391435 SCOPUS ID: 2-s2.0-85159765396 05/19/2023
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Mustard gas exposure instigates retinal Müller cell gliosis.
(Mahaling B, Sinha NR, Sokupa S, Addi UR, Mohan RR, Chaurasia SS.) Exp Eye Res. 2023 May;230:109461 PMID: 37023936 PMCID: PMC10157651 SCOPUS ID: 2-s2.0-85151717505 04/07/2023
Contact Us
Ocular Immunology and Angiogenesis Lab
(414) 955-2050
schaurasia@mcw.edu