
Jeannette Vasquez Vivar, PhD
Professor; Associate Director, Redox Biology Program
Locations
- Biophysics
TBRC C0790
Contact Information
Education
Postdoctoral Fellow in Biochemistry, Instituto de Química, Universidade de São Paulo, Brazil, 1993-1996
PhD, Biochemistry, Universidade de São Paulo, Brazil, 1992
BS, Clinical Biochemistry, Universidad de Concepción Chile, 1988
BS, Biochemistry, Universidad de Concepción Chile, 1986
Biography
Research Experience
- Antioxidants
- Arginine
- Ascorbic Acid
- Biomarkers
- Biopterin
- Blotting, Western
- Cerebral Palsy
- Electron Spin Resonance Spectroscopy
- Endothelial Cells
- Ethidium
- Free Radicals
- Free Radicals, Electron Paramagnetic Resonance Spin Trapping
Methodologies and Techniques
- Brain Diseases, Metabolic, Inborn
- Cells, Cultured
- Electron Spin Resonance Spectroscopy
- Energy Metabolism
- Fluorescent Dyes
- Folic Acid Antagonists
- HPLC, chromatography electrochemical, UV and fluorescence detection (Pterins, Neurotransmitters, Glutathione, 2-Hydroxyethidium)
- Kinetics
- NADP
- Oxygen Consumption
- Reactive Oxygen Species
- Spin Trapping
Leadership Positions
- Associate Director, Redox Biology Program
MCW Program / Core Facilities
- Redox Biology
Research Interests
Research Projects
Our project dealing with the fetal brain is supported by our discovery that a developmentally low tetrahydrobiopterin (BH4) cofactor in the fetal brain increases hypoxia-ischemia injury in specific brain regions and worsens motor disabilities in newborns. Our working hypothesis is that development of motor deficits can be explained by a two-hit model where transient low tetrahydrobiopterin represents an important vulnerability state of immature fetal brain neurons. In collaboration with the group of Dr. Tan (Wayne State University), we are testing the idea that BH4 is a critical neuronal developmental factor.
Our BH4 effects in cardiovascular health project examines the relationship between endothelial dysfunction and eNOS uncoupling in an animal model of atherosclerosis. While eNOS dysfunction is believed to be an important element promoting vascular dysfunction, it is yet unclear whether eNOS uncoupling controls a state of critical oxidant stress to promote disease. In this project we are examining the impact of BH4 in redox that could further support therapeutic effects in hypercholesterolemia. A second approach is to understand the role of BH4 in cardiomyocyte redox changes that could link BH4 deficiency with loss of function as could occur in heart failure.
Publications
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(Singh B, Kosuru R, Lakshmikanthan S, Sorci-Thomas M, Zhang D, Sparapani R, Vasquez-Vivar J, Chrzanowska M.) Arterioscler Thromb Vasc Biol. 2020 Dec 03:ATVBAHA120315401 PMID: 33267664 12/04/2020
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(Herrera NA, Duchatsch F, Kahlke A, Amaral SL, Vasquez-Vivar J.) Free Radic Biol Med. 2020 05 20;152:689-696 PMID: 31978540 SCOPUS ID: 2-s2.0-85078237606 01/25/2020
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(Vasquez-Vivar J, Shi Z, Jeong JW, Luo K, Sharma A, Thirugnanam K, Tan S.) Redox Biol. 2020 01;29:101407 PMID: 31926630 PMCID: PMC6928344 SCOPUS ID: 2-s2.0-85076556552 01/14/2020
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Treatment of Cells and Tissues with Chromate Maximizes Mitochondrial 2Fe2S EPR Signals.
(Antholine WE, Vasquez-Vivar J, Quirk BJ, Whelan HT, Wu PK, Park JI, Myers CR.) Int J Mol Sci. 2019 Mar 06;20(5) PMID: 30845710 PMCID: PMC6429069 SCOPUS ID: 2-s2.0-85062628835 03/09/2019
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(Hardy M, Zielonka J, Karoui H, Sikora A, Michalski R, Podsiadły R, Lopez M, Vasquez-Vivar J, Kalyanaraman B, Ouari O.) Antioxid Redox Signal. 2018 05 20;28(15):1416-1432 PMID: 29037049 PMCID: PMC5910052 SCOPUS ID: 2-s2.0-85045516114 10/19/2017
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(Shi Z, Vasquez-Vivar J, Luo K, Yan Y, Northington F, Mehrmohammadi M, Tan S.) Dev Neurosci. 2018;40(5-6):534-546 PMID: 31163416 SCOPUS ID: 2-s2.0-85066972526 06/05/2019
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(Sánchez-Aranguren LC, Espinosa-González CT, González-Ortiz LM, Sanabria-Barrera SM, Riaño-Medina CE, Nuñez AF, Ahmed A, Vasquez-Vivar J, López M.) Front Physiol. 2018;9:83 PMID: 29563877 PMCID: PMC5845757 03/23/2018
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(Vasquez-Vivar J, Shi Z, Luo K, Thirugnanam K, Tan S.) Redox Biol. 2017 10;13:594-599 PMID: 28803128 PMCID: PMC5554922 SCOPUS ID: 2-s2.0-85027861384 08/15/2017
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(Zielonka J, Joseph J, Sikora A, Hardy M, Ouari O, Vasquez-Vivar J, Cheng G, Lopez M, Kalyanaraman B.) Chem Rev. 2017 Aug 09;117(15):10043-10120 PMID: 28654243 PMCID: PMC5611849 SCOPUS ID: 2-s2.0-85027303022 06/28/2017
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(Liu Y, Baumgardt SL, Fang J, Shi Y, Qiao S, Bosnjak ZJ, Vásquez-Vivar J, Xia Z, Warltier DC, Kersten JR, Ge ZD.) Sci Rep. 2017 06 08;7(1):3093 PMID: 28596578 PMCID: PMC5465102 SCOPUS ID: 2-s2.0-85020486126 06/10/2017
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Platelet CD36 promotes thrombosis by activating redox sensor ERK5 in hyperlipidemic conditions.
(Yang M, Cooley BC, Li W, Chen Y, Vasquez-Vivar J, Scoggins NO, Cameron SJ, Morrell CN, Silverstein RL.) Blood. 2017 05 25;129(21):2917-2927 PMID: 28336528 PMCID: PMC5445574 SCOPUS ID: 2-s2.0-85019661296 03/25/2017
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Nitric oxide synthases-from genes to function.
(Stuehr DJ, Vasquez-Vivar J.) Nitric Oxide. 2017 02 28;63:29 PMID: 28137371 PMCID: PMC5495577 SCOPUS ID: 2-s2.0-85010723274 02/01/2017