Research Fellow in Pathology, Medical College of Wisconsin, Milwaukee, WI, 1996-1998
Postdoctoral Fellow in Biochemistry, Instituto de Química, Universidade de São Paulo, Brazil, 1993-1996
PhD, Biochemistry, Universidade de São Paulo, Brazil, 1992
BS, Clinical Biochemistry, Universidad de Concepción Chile, 1988
BS, Biochemistry, Universidad de Concepción Chile, 1986
Our project dealing with the fetal brain is supported by our discovery that a developmentally low tetrahydrobiopterin (BH4) cofactor in the fetal brain increases hypoxia-ischemia injury in specific brain regions and worsens motor disabilities in newborns. Our working hypothesis is that development of motor deficits can be explained by a two-hit model where transient low tetrahydrobiopterin represents an important vulnerability state of immature fetal brain neurons. In collaboration with the group of Dr. Tan (Wayne State University), we are testing the idea that BH4 is a critical neuronal developmental factor.
Our BH4 effects in cardiovascular health project examines the relationship between endothelial dysfunction and eNOS uncoupling in an animal model of atherosclerosis. While eNOS dysfunction is believed to be an important element promoting vascular dysfunction, it is yet unclear whether eNOS uncoupling controls a state of critical oxidant stress to promote disease. In this project we are examining the impact of BH4 in redox that could further support therapeutic effects in hypercholesterolemia. A second approach is to understand the role of BH4 in cardiomyocyte redox changes that could link BH4 deficiency with loss of function as could occur in heart failure.
Allison Kahlke, Research Technologist I
(Sánchez-Aranguren LC, Espinosa-González CT, González-Ortiz LM, Sanabria-Barrera SM, Riaño-Medina CE, Nuñez AF, Ahmed A, Vasquez-Vivar J, López M.) Front Physiol. 2018;9:83.
(Hardy M, Zielonka J, Karoui H, Sikora A, Michalski R, Podsiadły R, Lopez M, Vasquez-Vivar J, Kalyanaraman B, Ouari O.) Antioxid Redox Signal. 2018 May 20;28(15):1416-1432.
(Vasquez-Vivar J, Shi Z, Luo K, Thirugnanam K, Tan S.) Redox Biol. 2017 10;13:594-599.
(Zielonka J, Joseph J, Sikora A, Hardy M, Ouari O, Vasquez-Vivar J, Cheng G, Lopez M, Kalyanaraman B.) Chem Rev. 2017 Aug 09;117(15):10043-10120.
(Liu Y, Baumgardt SL, Fang J, Shi Y, Qiao S, Bosnjak ZJ, Vásquez-Vivar J, Xia Z, Warltier DC, Kersten JR, Ge ZD.) Sci Rep. 2017 Jun 08;7(1):3093.
(Yang M, Cooley BC, Li W, Chen Y, Vasquez-Vivar J, Scoggins NO, Cameron SJ, Morrell CN, Silverstein RL.) Blood. 2017 05 25;129(21):2917-2927.
(Stuehr DJ, Vasquez-Vivar J.) Nitric Oxide. 2017 02 28;63:29.
(Sethumadhavan S, Whitsett J, Bennett B, Ionova IA, Pieper GM, Vasquez-Vivar J.) Free Radic Biol Med. 2016 Apr;93:1-11.
(Mainali L, Vasquez-Vivar J, Hyde JS, Subczynski WK.) Appl Magn Reson. 2015 Aug 01;46(8):885-895.
(Baotic I, Weihrauch D, Procknow J, Vasquez-Vivar J, Ge ZD, Sudhakaran S, Warltier DC, Kersten JR.) Anesthesiology. 2015 Sep;123(3):582-9.
(Lakshmikanthan S, Zheng X, Nishijima Y, Sobczak M, Szabo A, Vasquez-Vivar J, Zhang DX, Chrzanowska-Wodnicka M.) EMBO Rep. 2015 May;16(5):628-37.
(Drobyshevsky A, Takada SH, Luo K, Derrick M, Yu L, Quinlan KA, Vasquez-Vivar J, Nogueira MI, Tan S.) J Neurochem. 2015 Feb;132(4):394-402.