Research Lab Bench

Biophysics

People

The Department of Biophysics is composed of primary—as well as emeritus, secondary, and adjunct—faculty with broadly based research interests. The department  also employs a highly specialized scientific, engineering, technical, and administrative staff.

Primary Faculty

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Balaraman Kalyanaraman, PhD

Professor and Chair; Harry R. & Angeline E. Quadracci Professor in Parkinson’s Research; Founder, Free Radical Research Center

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William E. Antholine, PhD

Associate Professor

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Jimmy B. Feix, PhD

Professor

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Neil Hogg, PhD

Professor; Associate Dean of Academic Affairs

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Candice S. Klug, PhD

Professor; Director, National Biomedical EPR Center; Program Director, Biophysics Graduate Program

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Michael T. Lerch, PhD

Assistant Professor

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Shi-Jiang Li, PhD

Professor

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Kathleen M. Schmainda, PhD

Robert C. Olson, MD, Professor in Radiology; Section of Imaging Research, Division of Imaging Sciences

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Jeannette Vasquez Vivar, PhD

Professor; Associate Director, Redox Biology Program

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Jacek Zielonka, PhD, DSc

Assistant Professor; Research Director, Free Radical Research Center

Secondary Faculty

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Piero G. Antuono, MD

Professor of Neurology, Pharmacology and Toxicology

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Jeffrey R. Binder, MD

Vice Chair for Research, Professor of Neurology, Professor of Cell Biology, Neurobiology and Anatomy, Professor of Biophysics, Director of Stroke and Neurobehavior Programs, Department of Neurology, Director of Language Imaging Laboratory, Department of Neurology

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Marcelo Bonini, PhD

Associate Professor

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Matthew D. Budde, , PhD

Assistant Professor

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Joseph Carroll, PhD

Richard O. Schultz, MD / Ruth Works Professor of Ophthalmology Professor of Ophthalmology & Visual Sciences, Biophysics, and Cell Biology, Neurobiology and Anatomy Director, Advanced Ocular Imaging Program

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Edgar A. DeYoe, PhD

Principal Investigator; Professor, Department of Radiology; Professor, Department of Cell Biology, Neurobiology & Anatomy; Associate Professor, Department of Biophysics; Graduate Faculty, Programs in Cell & Developmental Biology, Neuroscience and Biophysics; Section of Imaging Research, Division of Imaging Sciences

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Andrew S. Greene, PhD

Professor and Interim Vice Chair of Clinical and Research Affairs

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Kevin M. Koch, PhD

Associate Professor of Radiology & Biomedical Engineering; Director, Center for Imaging Research (CIR); Co-Vice Chair, Imaging Research; Section of Imaging Research, Division of Imaging Sciences

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Peter S. LaViolette, PhD, MS

Associate Professor of Radiology and Biomedical Engineering; Director, Quantitative Imaging Laboratory, Medical College of Wisconsin; Section of Imaging Research, Division of Imaging Sciences

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Andrew S. Nencka, PhD

Associate Professor of Radiology; Associate Director, Center for Imaging Research (CIR); Section of Imaging Research, Division of Imaging Sciences

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Eric Paulson, PhD

Associate Professor, Radiation Oncology, Radiology and Biophysics

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Christopher Pawela, PhD

Assistant Professor

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Reza Shaker, MD

Joseph E. Geenen Professor & Chief

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Yang Wang, MD, PhD

Associate Professor; Section of Imaging Research, Division of Imaging Sciences

Emeritus Faculty

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James S. Hyde, PhD

The James S. Hyde Professor of Biophysics, Emeritus; Founder, National Biomedical EPR Center

Adjunct Faculty

Brian Bennett, DPhil

Chair and Professor, Physics, Marquette University

Jay Goldberg, PhD, PE

Professor, Biomedical Engineering, Marquette University

Wendy E. Huddleston, PT, PhD

Associate Professor, College of Health Sciences, University of Wisconsin-Milwaukee

Richard R. Mett, PhD

Adjunct Professor; RF Engineer

Daniel B. Rowe, PhD

Professor, Computational Sciences, Marquette University

Robert A. Strangeway, PhD

Adjunct Professor; Microwave Engineer

Postdoctoral Fellows

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Sarah Oehm, PhD

Postdoctoral Fellow (Kalyanaraman Lab)

(414) 955-4048

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Natalia Stein, PhD

Postdoctoral Fellow (Subczynski Lab)

nstein@mcw.edu

(414) 955-4044

Scientific Staff

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Mona Al-Gizawiy, PhD

Research Scientist I (Schmainda Lab)

malgizawiy@mcw.edu

(414) 955-7491

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Gang (Jeff) Chen, PhD

Research Scientist II (Li Lab)

gachen@mcw.edu

(414) 955-4041

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Gang Cheng, PhD

Research Scientist II (Kalyanaraman Lab)

gcheng@mcw.edu

(414) 955-4040

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Christian Elliehausen

Research Technologist I (Hogg Lab)

celliehausen@mcw.edu

(414) 955-3604

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Christine Jennings

Research Technologist II (Lerch Lab)

cjennings@mcw.edu

(414) 955-4010

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Allison Kahlke

Research Technologist II (Vasquez Vivar Lab)

akahlke@mcw.edu

(414) 955-4688

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Laxman Mainali, PhD

Research Scientist II (Subczynski Lab)

lmainali@mcw.edu

(414) 955-4933

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Cathy Marszalkowski

Clinical Research Coordinator II (Schmainda Lab)

cmars@mcw.edu

(414) 955-1183

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Melissa Prah

Engineer II (Schmainda Lab)

mprah@mcw.edu

(414) 955-5704

John Schneider

Research Technologist I (Klug Lab)

johnschneider@mcw.edu

(414) 955-5846

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Monika Zielonka

Research Technologist III (Kalyanaraman Lab); Lab Manager, Redox & Bioenergetics Shared Resource

mzielonka@mcw.edu

(414) 955-2954

Engineering and Technical Staff

Administration and Administrative Support Staff

Alumni

We are proud of our long history of successful alumni, who have gone on to become professors, researchers, scientists, engineers, and clinicians, and are leaders in their fields.

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A–J
Peter Bandettini
Magnetic Resonance Imaging of Human Brain Activation Using Endogenous Susceptibility Contrast (1994)
Advisor: James S. Hyde, PhD

Barry Belanger
The Measurement of Scattered Radiation in Clinical Diagnostic X-Ray Procedures Employing Area Beam Detectors: A Practical Method for Scatter Correction in Digital Fluoroscopy (1987)
Advisor: Charles R. Wilson, PhD

The Continuous Distribution of Restricted Water Diffusion Rates in Brain Tumors (2003)
Advisor: James S. Hyde, PhD

Raoqiong (Tong) Bennett
Power Spectral Density Imaging to Expand the Nyquist Limit (2001)
Advisor: Robert W. Cox, PhD

Michael Bigelow
Mechanisms of Stone Crystal Attachment to Inner Medullary Collecting Duct Cells (1996)

Rasmus Birn
Functional Magnetic Resonance Imaging in the Presence of Task-Induced Motion (1999)
Advisor: Robert W. Cox, PhD

Bharat Biswal
Physiological Fluctuations in Functional MRI (1996)
Advisor: James S. Hyde, PhD

Katarzyna Broniowska
Transport-Dependent Effects of S-Nitrosothiols at the Protein, Cellular and Organ Levels (2008)
Advisor: Neil Hogg, PhD

Adam Buchaklian
Structure and Dynamics of the MsbA Homodimer Using Site-Directed Spin Labeling Electron Paramagnetic Resonance Spectroscopy (2007)
Advisor: Candice S. Klug, PhD

Ching-Fang Chang
Multifaceted Effects of NO on Breast Tumor Bioenergetics and Chemosensitivity (2014)
Advisor: Neil Hogg, PhD

Guangyu Chen
Imaging Analysis of Brain Network and Its Application to Alzheimer's Disease (2013)
Advisor: Shi-Jiang Li, PhD

James Christensen
Position and Velocity Measurement in Magnetic Resonance Imaging Using the Spatially Inhomogeneous Reception Fields of Local RF Coil Arrays (1991)
Advisor: James S. Hyde, PhD

Alexander Cohen
Diffusion Weighted Imaging and Magnetic Resonance Elastography for the Extraction of Tissue Characteristics in the Brain and Body (2014)
Advisor: Kathleen M. Schmainda, PhD

Moses Darpolor
An Assessment of Vascular Normalization in 9L Gliosarcoma Brain Tumor Using Dynamic Susceptibility Contrast (DSC) Imaging and Dynamic Contrast Enhancement (DCE) Imaging (2006)
Advisor: Kathleen M. Schmainda, PhD

Ritobrato Datta
Distributed Topography of Human Visual Attention (2006)
Advisor: Edgar A. DeYoe, PhD

Zhen Ding
The Metabolism of S-Nitrosothiols and the Role of Nitric Oxide in Macrophage Activation (2013)
Advisor: Neil Hogg, PhD

Ali Ersoz
Advanced Data Acquisition and Reconstruction Techniques for Fast Radial Magnetic Resonance Imaging (2016)
Advisor: L. Tugan Muftuler, PhD

Eric Ferguson
The Homocysteine Thiolactone Adduct of Low-Density Lipoprotein (1998)
Advisor: Balaraman Kalyanaraman, PhD

Timothy Flewelen
Oxidative Stress in Sickle Cell Disease: The contribution of Cell-Free Hemoglobin in Plasma (2012)
Advisor: Neil Hogg, PhD

Derek Francis
Structural Dynamics of Visual Arrestin (2008)
Advisor: Candice S. Klug, PhD

Wolfgang Gaggl
High Resolution Reduced Field-of-View Diffusion Tensor MR Imaging Using Spatially Selective RF Pulses (2012)
Advisor: Robert Prost, PhD

Steven Goss
Antioxidant Effect of Nitric Oxide on Human Low-Density Lipoprotein (1998)
Advisor: Balaraman Kalyanaraman, PhD

William Gross
Using fMRI to Improve Outcome in the Surgical Treatment of Temporal Lobe Epilepsy (2011)
Advisor: Jeffrey R. Binder, MD

Andrew Hahn
Mathematical Models to Improve Complex-Valued fMRI in the Presence of Motion, Confounding Physiologic Phenomena, and Temporal Variations in Bulk B0Magnetic Field Inhomogeneity
Advisor: Daniel B. Rowe, PhD

Mariam Hartley
Roles of Metals and Metal Ligands in the Active Site of Vibrio proteolyticus Aminopeptidase (2010)
Advisor: Brian Bennett, PhD

Amy Herlihy
Application of Non-Linear Gradient Fields to Magnetic Resonance Imaging (1997)
Advisor: Andrzej Jesmanowicz, PhD

Andrew Huettner
Magnetic Resonance Imaging RF Pulse Design Techniques Applied to Neuroimaging and Musculoskeletal Imaging (2016)
Advisor: Andrew Nencka, PhD

Michael Ibrahim
Mathematical and Pharmacokinetics Modeling of MRI Contrast Agents' Transport into the Intervertebral Discs (1994)
Advisor: Victor M. Haughton, MD

Donald Jacobson
Measurement of Compact and Cancellous Bone Density in the Proximal Femur with Quantitative Computed Tomography (1989)
Advisor: Charles R. Wilson, PhD

Todd Jensen
Detection of Brain Tumor Invasion Within Edema Using Multiparametric Imaging and Computational Intelligence (2008)
Advisor: Kathleen M. Schmainda, PhD
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Heather Kaminski
CM15 Modification: Further Development of AMPs as Novel Antibiotics
Advisor: Jimmy B. Feix, PhD

Nick Kettenhofen
Development and Application of a Novel Fluorescent Labeling Strategy for the Assessment of Protein S-Nitrosation (2009)
Advisor: Neil Hogg, PhD

Changseon Kim
Dual-Energy Computed Radiography for the Quantitative Bone Mineral Densitometry (1995)
Advisor: Charles R. Wilson, PhD

Young Ro Kim
Evaluation of Fractional Blood Volume Measurement Methods Using Intravascular T1 Contrast Agent and a Rat Tumor Model (2001)
Advisor: Kathleen M. Schmainda, PhD

Aaron Kittell
The Development and Application of Non-Adiabatic Rapid Sweep Electron Paramagnetic Resonance (NARS EPR)
Spectroscopy
(2012)
Advisor: James S. Hyde, PhD

Candice Klug
Structural and Stability Studies on the Ferric Enterobactin Receptor FepA Using Advanced EPR Spectroscopy Techniques (1998)
Advisor: Jimmy B. Feix, PhD

Jack Knight-Scott
Simultaneous Measurement of the Longitudinal and Transverse Relaxation Times for In Vivo Single-Voxel Proton Magnetic Resonance Spectroscopy (1996)
Advisor: Shi-Jiang Li, PhD

Hanane Koteiche
Probing the Active Site of Phosphoribulokinase Using Spin Labeling Electron Paramagnetic Resonance Spectroscopy (1997)
Advisor: James S. Hyde, PhD

Jason Kowalski
Structural Insights into Biological Copper from the Perpendicular Region of the CuII Electron Paramagnetic (Spin) Resonance Spectrum at 1–2 GHz (2010)
Advisor: Brian Bennett, PhD

Peter Kufahl
Expansion of the Acute Cocaine fMRI Study in Human Brain: Expectation Control and Multivariate Statistical Processing (2006)
Advisor: Shi-Jiang Li, PhD

Amit Kumar
Characterization of Substrate Binding in Leucine Aminopeptidase from Vibrio proteolyticus (2006)
Advisor: Brian Bennett, DPhil

Mike Larson
Examining phosphatidylethanolamine externalization on cells and microparticles in hemolysis and hemolytic anemia (2013)
Advisor: Neil Hogg, PhD

Peter LaViolette
Advanced Brain Tumor Characterization Using MRI (2011)
Advisor: Kathleen M. Schmainda, PhD

Rupeng Li
High Resolution Functional MRI Investigation of Cortical Plasticity Following Peripheral Nerve Injury and Repair (2012)
Advisor: James S. Hyde, PhD

Wenjun Li
An Investigation of Early Detection, Neurodegeneration, and Drug Treatment of Alzheimer’s Disease Using Resting-State Imaging Techniques (2012)
Advisor: Shi-Jiang Li, PhD

Zhu Li
Reducing Susceptibility Artifacts with 8-Shimmed Background Gradient Compensation Method and Its Application in fMRI Study of Human Cocaine Abuse (2002)
Advisor: Shi-Jiang Li, PhD

Jun Liu
Structure-Function Relationship of the Escherichia coli Ferric Enterobactin Receptor, FepA: Molecular Genetic and Electron Paramagnetic Resonance Spin Label Studies (1994)
Advisor: Jimmy B. Feix, PhD

Xiping Liu
Pharmacological MRI Investigation of Levo-Tetrahydropalmatine Treatment Mechanisms on Drug Addiction (2009)
Advisor: Shi-Jiang Li, PhD

Hanbing Lu
fMRI at Subcortical Resolution in Rat Whisker Barrel Cortex (2003)
Advisor: James S. Hyde, PhD

Wen-Ming Luh
Comparison of Simultaneously Measured Cerebral Blood Flow and Blood Oxygenation Using Pulsed Arterial Spin Labeling in High Resolution MRI (1998)
Advisor: James S. Hyde, PhD

Feng Luo
Investigation of the Pharmacological MRI Signal Induced by Cocaine or Heroin in Rat Brain (2004)
Advisor: Shi-Jiang Li, PhD

Mahadevappa Mahesh
Study of the Accuracy of Bone Mineral Measurements Using Dual-Energy X-Ray Absorptiometry (1993)
Advisor: Charles R. Wilson, PhD

Hassane Mchaourab
Methodology and Theory of Multiquantum EPR, ELDOR, and ENDOR with Application to a Spin-Labeled Analog of the ION-Channel Peptide Cecropin AD (1993)
Advisor: James S. Hyde, PhD

Karen Medler (2011)

Mary Elizabeth Meyerand
Single-Shot Magnetic Resonance Imaging Using Time Encoding (1996)
Advisor: Andrzej Jesmanowicz, PhD

Nikolai Mickevicius
Imaging Framework to Support Real-Time Online Adaptive Replanning on the MR-Linac (2017)
Advisor: Eric Paulson, PhD

Paul Nagy
Quantitative Pinhole Focal Spot Measurements: Projection and Dynamic Characteristics (1999)
Advisor: Charles R. Wilson, PhD

Jana Narasimhan
Effect of Copper and Gallium Compounds on Ribonucleotide Reductase (1992)
Advisor: William E. Antholine, PhD

Andrew Nencka
Improving the fcMRI BOLD Signal Through the Characterization of Processing Effects (2009)
Advisor: Daniel B. Rowe, PhD

Kent Ogden
Maximum Likelihood Estimation in Dual-Energy Digital Chest Radiography: Simultaneous Correction of Scatter Radiation and Resolution Degradation Via the Expectation Maximization Algorithm (1999)
Advisor: Charles R. Wilson, PhD

P–Z

Arvind Pathak
The Assessment of Brain Tumor Angiogenesis Using Susceptibility Contrast Agent Based Functional Magnetic Resonance Imaging (2001)
Advisor: Kathleen M. Schmainda, PhD

Eric Paulson
Development and Application of Perfusion and Susceptibility-Weighted MRI Methods for the Assessment of Gliomas (2008)
Advisor: Kathleen M. Schmainda, PhD

Christopher Pawela
Functional MRI of Sensorimotor and Visual Networks in Rat Brain Before and After Deafferentation Induced Neuroplasticity (2008)
Advisor: James S. Hyde, PhD

Suzanne L. Pendl
The Left Angular Gyrus and Event Knowledge: A Multimodal Investigation (2015)
Advisor: Jeffrey R. Binder, MD

Siveshigan Pillay
Anesthetic and Ascending Arousal System Modulation of Cortical Functional Integration and Bold Functional Connectivity in the Rat Brain (2013)
Advisor: Anthony G. Hudetz, PhD

Carol Popp Weingarten
Electron-Electron Double Resonance and Saturation-Recovery Studies of Nitroxide Electron and Nuclear Spin-Lattice Relaxation Times and Heisenberg Exchange Rates: Lateral Diffusion in Model Membranes (1982)
Advisor: James S. Hyde, PhD

Douglas Prah
The Development of Diffusion and Contrast Agent MRI Biomarkers for the Evaluation of Neoplasms (2008)
Advisor: Kathleen M. Schmainda, PhD

Robert Prost
Two Dimensional Chemical Shift Imaging of Glutamate and Glutamine at 0.5 T with Application to Neurodegenerative Disease (1999)
Advisor: Shi-Jiang Li, PhD

Alexander M. Puckett
A Neuroimaging Based Model of Cortical Visual Attention in Humans (2013)
Advisor: Edgar A. DeYoe, PhD

Chad Quarles
The Morphological and Functional Assessment of Brain Tumor Vasculature Using Dynamic Susceptibility Contrast Magnetic Resonance Imaging (2004)
Advisor: Kathleen M. Schmainda, PhD

Marija Raguz
Function of Cholesterol in the Eye Lens (2010)
Advisor: W. Karol Subczynski, PhD

Danielle Reitsma
Investigating fMRI Visual Field Maps in Human Visual Cortex with Central Damage (2013)
Advisor: Edgar A. DeYoe, PhD

Richard Riese
Adherence of Kidney Stone Microcrystallites to Renal Papillary Collecting Tubule Cells in Primary Culture (1990)
Advisor: Neil S. Mandel, PhD

Vinai Roopchansingh
Compensation of Static and Dynamic Magnetic Field Perturbations in Functional Magnetic Resonance Imaging (2004)
Advisor: Andrzej Jesmanowicz, PhD

Andrew Salzwedel
Exploring the Neural Machinery of Color Vision: A BOLD fMRI-based Investigation (2014)
Advisor: Edgar A DeYoe, PhD

Kathryn (Westfahl) Schultz
Biochemical and Biophysical Characterization of Five Key Mutations in the ABC Transporter MsbA (2011)
Advisor: Candice Klug, PhD

Tiesong Shang
Mitochondria Signaling in Chemically-Induced Parkinsonism: Free Radical Dependent and Independent Pathway (2005)
Advisor: Balaraman Kalyanaraman, PhD

Daniel Shefchik
Mapping Relaxivity and B-field Parameters in EPI Warped Space to Inform Functional MRI Studies (2015)
Advisor: James S. Hyde, PhD

Melvin Siedband
Commutated Ion Chambers for Measurement of Field Uniformity (1995)
Advisor: Charles R. Wilson, PhD

Nathan Skinner
Assessment of Spinal Cord Injury in a Rat Model using an Orthogonal Filter-Probe Diffusion Encoding Scheme (2017)
Advisor: Matthew D. Budde, PhD

Allen Song
Diffusion Weighted fMRI: A Study of Signal Origin (1995)
Advisor: James S. Hyde, PhD

Netanya Spencer
S-Nitrosothiols, Nitric Oxide, and Heme Proteins (2003)
Advisor: Neil Hogg, PhD

Benjamin Stengel
Organization of Conceptual Knowledge within the Cerebral Cortex (2012)
Advisor: Jeffrey R. Binder, PhD

Melissa Wagner Schuman
The Relative Activity of the L and M Cone Photoreceptors and the Cause and Prevention of Myopia (2010)
Advisor: Jay Neitz, PhD

Eric Wong
The Design and Applications of Local Gradient Coils for Magnetic Resonance Imaging (1991)
Advisor: James S. Hyde, PhD

James Wu
Pharmacokinetic Study of In Vivo Fluid Dynamics Using Magnetic Resonance Imaging Contrast Agents (1992)
Advisor: James S. Hyde, PhD

Jun Xie
fMRI and Functional Connectivity Study of Human Heroin Addiction (2008)
Advisor: Shi-Jiang Li, PhD

Guofan Xu
Arterial Spin Labeling Magnetic Resonance Imaging & Functional Synchrony of Blood Oxygenation Level Dependent Signal Analysis in Early Detection of Alzheimer's Disease Onset (2006)
Advisor: Shi-Jiang Li, PhD

Xingyu Xu
Masters Degree, 2013

Zhang Xu
MR Pulse Sequence Design of the Intra-Shot Adapted Keyhole (ISAK) Acquisition Method and Its Applications in Functional MRI (2018)
Advisor: Shi-Jiang Li, PhD

Jun-Jie Yin
Mathematical Models of Spin Dynamics in Spin-Labeled Membranous Systems with Experimental Verifications Using CW ELDOR and Pulse Saturation Recovery Electron Spin Resonance (1987)
Advisor: James S. Hyde, PhD

Hua Yuan
Structural Investigation of Copper Binding Sites in Proteins: Particulate Methane Monooxygenase (1998)
Advisor: William E. Antholine, PhD

Rongyan Zhang
Functional MRI Using Magnetization Transfer (1998)
Advisor: Robert W. Cox, PhD

Yanhong Zhang
The Transport and Metabolism of S-Nitrosothiols (2004)
Advisor: Neil Hogg, PhD

Hongtao Zhao
Detection of Superoxide by ESR Spin Trapping and Hydroethidine Fluorescence (2005)
Advisor: Balaraman Kalyanaraman, PhD

Xiaoli Zhao
Applying Sensitivity Encoding to Spectroscopic Imaging (2002)
Advisor: Shi-Jiang Li, PhD

Xiaoguang Zhu
Development and Application of Non-Invasive Imaging Methods for the Evaluation of Acute Myocardial Infarction (2010)
Advisor: Ming Zhao, PhD

Ya Zhuo
EPR Spectroscopy Studies of Non-visual Arrestins (2014)
Advisor: Candice Klug, PhD

Zhan Xu
MR Pulse Sequence Design of the Intra-Shot Adapted Keyhole (ISAK) Acquisition Method and Its Applications in Functional MRI (2018)
Advisor: Shi-Jiang Li