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Xiao Chen, MD, PhD

Xiao Chen

Xiao Chen, MD, PhD

Assistant Professor

Locations

  • Medical College of Wisconsin
    Department of Medicine
    Division of Hematology and Oncology

Biography

Dr. Xiao Chen is Associate Professor of Medicine at the Medical College of Wisconsin, Division of Hematology and Oncology. He obtained his medical degree from Fujian Medical University in China and PhD degree in immunology from the Technical University of Dresden in Germany.

Research Interests

Dr. Chen has a long-standing commitment to hematological and immunological research with a particular interest and expertise in graft-versus-host disease (GVHD). Allogeneic hematopoietic stem cell transplantation (HSCT) is a life-saving treatment for many hematological malignancies. Each year, thousands of patients diagnosed with leukemia, lymphoma, and multiple myeloma will depend on a stem cell transplant for a second chance at life. Unfortunately, GVHD remains a serious and frequently fatal complication following allogeneic HSCT. The long term research goal of Dr. Chen’s lab is to find ways to augment the beneficial graft-versus-leukemia (GVL) effect while minimizing GVHD in order to make allogeneic HSCT a more effective and safer treatment for cancer patients. One of research projects in the lab has focused on how micronutrients such as vitamin A and vitamin D regulate GVHD risk after allogeneic HSCT. Ongoing research uses genetic, dietary, and pharmacological approaches to explore novel strategies to prevent and treat GVHD without compromising the GVL effect by targeting the retinoic acid receptor (RAR) and vitamin D receptor (VDR) signaling pathways. Dr. Chen also has a strong interest in tumor immunology and cellular immunotherapy.

Publications