
Balaraman Kalyanaraman, PhD
Harry R. & Angeline E. Quadracci Professor in Parkinson’s Research
Locations
- Biophysics
MFRC 2034
Contact Information
Education
Visiting Fellow, Chemistry, Laboratory of Environmental Biophysics, National Institute of Environmental Sciences, Research Triangle Park, NC, 1978-1981
PhD, Chemistry, University of Alabama, Tuscaloosa, AL, 1978
MS, Chemistry, Indian Institute of Technology, Mumbai (formerly Bombay), India, 1972
BS, Chemistry, Loyola College, University of Madras, Chennai, India, 1970
Biography
In 1981, I joined the Biophysics section of the Department of Radiology at the Medical College of Wisconsin. I became an assistant professor of radiology in 1994, associate professor of biophysics in 1989, and professor of biophysics in 1994. I served as director of the Biophysics Research Institute from 2000 to 2003, and as chair of the Department of Biophysics from 2003 to 2022. Also, I have served as an associate editor for Free Radicals in Biology and Medicine, Free Radical Research and Biochemical Journal.
Research Interests
My research interests are centered on the application of EPR in free radical biology and understanding the role of oxidants and antioxidants in signal transduction and apoptosis. My specific research areas are outlined below.
- Chemistry and Biophysics
- Detection of reactive oxygen and nitrogen species by EPR spin-trapping, fluorescence, optical stopped-flow, and HPLC techniques
- Syntheses of mitochondrially targeted spin traps, spin labels, and ROS-specific fluorescence probes
- EPR studies of mitochondria
- Mechanism of Signal Transduction/Cell Signaling
- Mitochondrial STAT3 and redox signaling
- Oxidant-induced iron signaling and apoptosis
- Chemotherapeutic drug (e.g., doxorubicin) toxicity and prevention; mechanism of apoptosis in tumor cells and normal cells
- Mechanism of Disease
- Role of mitochondria-derived oxidants in chemically induced Parkinsonism (e.g., MPTP, rotenone) in cell culture and animal models; mechanism of protein aggregation, proteosomal dysfunction, and apoptotic neuronal cell death
- Targeting of metabolism, bioenergetics, and redox signaling in cancer
- Development of new mitochondria-targeted antitumor and antiproliferative drugs
My research projects include the following:
-
Chemoprevention of Lung Cancer by Targeting Lonidamine to Mitochondria
The goal is to examine the efficacy and mechanism of a novel mitochondrial targeting agent (Mito-LON) in treating lung cancer and brain metastasis.
- Chemoprevention of Lung Cancer with Mitochondria-targeted Honokiol
The goal is to evaluate the chemopreventive potential of Mito-HNK, a mitochondria-targeted compound, using both in vitro and in vivo models of lung adenocarcinoma (LUAD) and determine its mechanism of action, to determine its efficacy for inhibiting LUAD progression and metastasis and its suitability for human clinical trials.
Lab Members
Donna McAllister, Research Associate I
Laura McOlash, Research Technologist III
Publications
-
Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo.
(Murphy MP, Bayir H, Belousov V, Chang CJ, Davies KJA, Davies MJ, Dick TP, Finkel T, Forman HJ, Janssen-Heininger Y, Gems D, Kagan VE, Kalyanaraman B, Larsson NG, Milne GL, Nyström T, Poulsen HE, Radi R, Van Remmen H, Schumacker PT, Thornalley PJ, Toyokuni S, Winterbourn CC, Yin H, Halliwell B.) Nat Metab. 2022 Jun;4(6):651-662 PMID: 35760871 PMCID: PMC9711940 06/28/2022
-
Chemoprevention of Lung Cancer with a Combination of Mitochondria-Targeted Compounds.
(Zhang Q, Xiong D, Pan J, Wang Y, Hardy M, Kalyanaraman B, You M.) Cancers (Basel). 2022 May 21;14(10) PMID: 35626143 PMCID: PMC9140024 SCOPUS ID: 2-s2.0-85130231561 05/29/2022
-
(Huang M, Xiong D, Pan J, Zhang Q, Wang Y, Myers CR, Johnson BD, Hardy M, Kalyanaraman B, You M.) Adv Sci (Weinh). 2022 Apr;9(12):e2101267 PMID: 35243806 PMCID: PMC9036031 SCOPUS ID: 2-s2.0-85125564839 03/05/2022
-
(Kalyanaraman B.) FASEB J. 2022 Apr;36(4):e22226 PMID: 35233843 PMCID: PMC9242412 SCOPUS ID: 2-s2.0-85125582482 03/03/2022
-
(Cheng G, Hardy M, You M, Kalyanaraman B.) Sci Rep. 2022 Mar 24;12(1):5143 PMID: 35332210 PMCID: PMC8948292 SCOPUS ID: 2-s2.0-85127039662 03/26/2022
-
Functionalized polyanhydride nanoparticles for improved treatment of mitochondrial dysfunction.
(Schlichtmann BW, Kalyanaraman B, Schlichtmann RL, Panthani MG, Anantharam V, Kanthasamy AG, Mallapragada SK, Narasimhan B.) J Biomed Mater Res B Appl Biomater. 2022 Feb;110(2):450-459 PMID: 34312984 SCOPUS ID: 2-s2.0-85111244735 07/28/2021
-
The Chemistry of HNO: Mechanisms and Reaction Kinetics.
(Michalski R, Smulik-Izydorczyk R, Pięta J, Rola M, Artelska A, Pierzchała K, Zielonka J, Kalyanaraman B, Sikora AB.) Front Chem. 2022;10:930657 PMID: 35864868 PMCID: PMC9294461 07/23/2022
-
Therapeutic Targeting of Tumor Cells and Tumor Immune Microenvironment Vulnerabilities.
(Kalyanaraman B, Cheng G, Hardy M.) Front Oncol. 2022;12:816504 PMID: 35756631 PMCID: PMC9214210 SCOPUS ID: 2-s2.0-85133350425 06/28/2022
-
Functionalized polyanhydride nanoparticles for improved treatment of mitochondrial dysfunction
(Schlichtmann BW, Kalyanaraman B, Schlichtmann RL, Panthani MG, Anantharam V, Kanthasamy AG, Mallapragada SK, Narasimhan B.) Journal of Biomedical Materials Research - Part B Applied Biomaterials. February 2022;110(2):450-459 SCOPUS ID: 2-s2.0-85111244735 02/01/2022
-
(Kalyanaraman B.) RSC Chem Biol. 2021 Oct 07;2(5):1402-1414 PMID: 34704045 PMCID: PMC8496060 10/28/2021
-
(Chelimsky G, Simpson P, Zhang L, Bierer D, Komas S, Kalyanaraman B, Chelimsky T.) Pain Res Manag. 2021;2021:6627864 PMID: 34426756 PMCID: PMC8380178 SCOPUS ID: 2-s2.0-85113790316 08/25/2021
-
(Siarkiewicz P, Michalski R, Sikora A, Smulik-Izydorczyk R, Szala M, Grzelakowska A, Modrzejewska J, Bailey A, Nycz JE, Kalyanaraman B, Malecki JG, Zielonka J, Podsiadły R.) Dyes and Pigments. August 2021;192 SCOPUS ID: 2-s2.0-85105322458 08/01/2021