Kathleen M. Schmainda, PhD
MSEE, Electrical Engineering, MIT, 1989
PhD, Medical Engineering, Harvard-MIT, 1993
MA, Postdoctoral Fellowship in MRI, Massachusetts General Hospital, 1993-1995
Honors and Awards
1993-1994 - Sterling Winthrop Fellow, Health Sciences and Technology, Harvard-MIT, Cambridge, MA
1998 - Featured in Milwaukee Business Journal's "40 Under 40"
1999 - American Society of Neuroradiology Meeting, Magna Cum Laude, awarded to "Diffusion magnetic resonance imaging in stroke: A comparison of spin-echo and FLAIR spin echo diffusion sensitive techniques," JL Ulmer, AT Olson, LL Latour, OB Nordling, KM Donahue
2001 - 101st Annual Scientific Meeting of American Roentgen Ray Society, Seattle, Washington, Scientific Exhibit Gold Medal awarded to "Physiologic magnetic resonance imaging of the brain: A conceptual approach to contrast mechanisms and measureable physiologic parameters," JL Ulmer, JM Strottmann, RW Prost, KM Schmainda, BB Biswal, LP Mark, DL Daniels
2004 - International Society of Magnetic Resonance in Medicine Meeting, Young Investigator Moore Award, awarded to "Intravoxel distribution of DWI decay rates reveals C6 glioma invasion in rat brain," *KM Bennett, JS Hyde, SD Rand, R Bennett, HGJ Krouwer, KJ Rebro, KM Schmainda
2004 - International Society of Magnetic Resonance in Medicine Meeting, First Place Poster Award, Cancer Imaging and Spectroscopy, awarded to "The anti-angiogenic drug, SU11657 decreases brain tumor size and normalizes perfusion as indicated by DSC-MRI perfusion parameters," *CC Quarles, FC Wu, M Darpolor, SD Rand, HGJ Krouwer, KM Schmainda
2004 - American Society of Neuroradiology Meeting, Summa Cum Laude, awarded to "Lesion-induced neurovascular uncoupling can mimic cortical reorganization by BOLD fMRI," JL Ulmer, L Hacein-Bey, VP Mathews, EA DeYoe, RW Prost, KM Schmainda, WM Mueller, HGJ Krouwer
10/19/2007 - United States Patent (#6,807,441 B2) for “Evaluation of Tumor Angiogenesis Using Magnetic Resonance Imaging.” Inventor: KM Schmainda
6/2007 - Bayer Best Paper Award to Dr. Schmainda’s graduate student, Eric Paulson, at 45th Annual Meeting of American Society of Neuroradiology Meeting, Chicago, for “Correction of confounding leakage and residual susceptibility effects in dynamic susceptibility contrast MR imaging using dual-echo SPIRAL.” Authors: *ES Paulson, *D Prah, KM Schmainda
5/2008 - 3rd Place Poster Award to Dr. Schmainda’s graduate student, Douglas Prah, at 16th Annual Meeting of International Society of Magnetic Resonance in Medicine, Toronto, for “In vitro mitochondrial labeling using mito-carboxy proxyl (Mito-CP) enhanced magnetic resonance imaging.” Authors: *D Prah, *ES Paulson, J Zielonka, MJ Hardy, J Joseph, B Kalyanaraman, KM Schmainda
5/2009 - 1st Place Poster Award in Cancer Imaging, to Dr. Schmainda’s post-doctoral fellow, Dr. Elllingson, at 17th Annual Meeting for International Society of Magnetic Resonance in Medicine, Honolulu, for “Cytotoxic and anti-angiogenic treatment responses in gliomas using functional diffusion maps (fDMs) in FLAIR abnormal regions.” Authors: *B Ellingson, M Malkin, SD Rand, A Hoyt, J ConnellyJ, *B Bedekar, S Kurpad, KM Schmainda
7/28/2009 - United States Patent (#7,567,8321 B2) for “MRI method for measuring tumor hemodynamic parameters in the presence of contrast agent extravasation.” Inventors: KM Schmainda, C Quarles, BD Ward
8/27/2009 - United States Patent (#0214437-A1) for “In vivo mitochondrial labeling using positively-charged nitroxide enhanced gadolinium chelate magnetic resonance imaging.” Inventors: B Kalyanaraman, KM Schmainda, J Joseph, M Lopez, *D Prah, MJ Hardy
5/2010 - International Society of Magnetic Resonance in Medicine Meeting, Young Investigator Moore Award, awarded for “Validation of Functional Diffusion Maps (fDMs) as a Biomarker for Human Glioma Cellularity.” *BE Ellingson, MG Malkin, SD Rand, JM Connelly, C Quinsey, *PS LaViolette, *DP Bedekar, KM Schmainda
5/2012 - Merit Award, International Society of Magnetic Resonance in Medicine Meeting, awarded for “Precise ex-vivo histological validation of heightened cellularity in regions of dark ADC in three cases of high-grade glioma.” *PS LaViolette, E Cochran, M *Al-Gizawiy, S Rand, J Connelly, M Malkin, W Mueller, KM Schmainda
5/2013 - Summa Cum Laude Merit Award ISMRM Summa Cum Laude Merit Award, awarded for “The relationship between short and long diffusion time ADC values in rat brain tumors” *A Cohen, PS LaViolette, KM Schmainda, May 2013, p 0446.
10/2013 - United States Patent (#12/601,241) for “Multiparameter Perfusion Imaging with Leakage Correction”, Inventors: KM Schmainda, ES Paulson, D Prah, Issue Date: October 2, 2013
4/2016 - Elected to the American Institute for Medical and Biological Engineering (AIMBE) College of Fellows
9/2016-2018 - Robert C Olson MD Endowed Chair in Radiology, Medical College of Wisconsin, Milwaukee, WI. (Relinquished endowment in order to switch primary appointment to Biophysics.)
11/2016 - Distinguished Investigator of the Academy of Radiology Research, Radiological Society of North America, Chicago IL
8/28/2019 - Nominated as 1 of 16 semifinal candidates for “Most Influential Radiology Researcher” in the 2019 edition of the Minnies, AuntMinne.com (a large comprehensive community website for medical imaging professionals worldwide)
8/28/2019 - Nominated as 1 of 15 semifinal candidates nominated for “Scientific Paper of the Year” in the 2019 edition of the Minnies. The paper nominated is “Moving toward a consensus DSC-MRI protocol: Validation of a low-flip angle single-dose option as a reference standard for brain tumors.” Schmainda KM et al, American Journal of Neuroradiology, April 2019
9/5/2019 - Dean’s Award for Clinical and Translational Research 2019. Unanimously chosen to receive this prestigious award based on contributions to translational research and collaboration
11/20/2019 - Outstanding Graduate School Educator 2018-2019, MCW Graduate School of Biomedical Sciences
4/2020 - Elected as a Fellow of the International Society of Magnetic Resonance in Medicine, to be inducted at the 2020 Annual Meeting in Sydney, Australia
* Indicates student or staff under Dr. Schmainda
A primary focus of our laboratory is the development of MRI methods to assess brain tumor angiogenesis and invasion. Angiogenesis is the process of new vessel formation that enables tumors to grow and spread. Invasion describes the process whereby tumor cells enter and spread to other parts of the brain, making brain tumors very difficult to treat.
The methods developed in our laboratory can provide information about the normal brain and the vascular structure of tumors, the amount of blood volume in the brain and tumor (cerebral blood volume [CBV]), and the perfusion or delivery of blood to the tumor (cerebral blood flow [CB]). In addition, by using MRI methods capable of measuring the micromolecular movement of tissue water (i.e., diffusion), we have demonstrated the potential to track tumor progression and, possibly, invasion.
These vascular and diffusion parameters provide information about tumor biology that is not currently available with standard MRI used in clinical practice. Measurement of these parameters holds promise for providing a more complete assessment of the primary tumor and tumor spread, and for evaluating novel (e.g., anti-angiogenic) therapies. Studies performed in our laboratory address issues ranging from characterizing the basic biophysical relationships between the MRI signal and tumor biology to translating these methods to the clinical setting.
Mona Al-Gizawiy, PhD, Research Scientist I
Cathy Marszalkowski, Clinical Research Coordinator II
Melissa Prah, Engineer II
Robert Wujek, Graduate Student
(Huang S, Michalek JE, Reardon DA, Wen PY, Floyd JR, Fox PT, Clarke GD, Jerabek PA, Schmainda KM, Muzi M, Hyun H, Lee EQ, Brenner AJ.) Sci Rep. 2021 04 07;11(1):7632 PMID: 33828310 PMCID: PMC8027395 SCOPUS ID: 2-s2.0-85104042152 04/09/2021
(Schmainda KM, Prah MA, Marques H, Kim E, Barboriak DP, Boxerman JL.) Neuro Oncol. 2021 02 25;23(2):314-323 PMID: 32678438 PMCID: PMC7906067 SCOPUS ID: 2-s2.0-85102322282 07/18/2020
(Bovi JA, Prah MA, Retzlaff AA, Schmainda KM, Connelly JM, Rand SD, Marszalkowski CS, Mueller WM, Siker ML, Schultz CJ.) Int J Radiat Oncol Biol Phys. 2020 11 15;108(4):979-986 PMID: 32599030 SCOPUS ID: 2-s2.0-85089292279 07/01/2020
(Boxerman JL, Quarles CC, Hu LS, Erickson BJ, Gerstner ER, Smits M, Kaufmann TJ, Barboriak DP, Huang RH, Wick W, Weller M, Galanis E, Kalpathy-Cramer J, Shankar L, Jacobs P, Chung C, van den Bent MJ, Chang S, Al Yung WK, Cloughesy TF, Wen PY, Gilbert MR, Rosen BR, Ellingson BM, Schmainda KM, Jumpstarting Brain Tumor Drug Development Coalition Imaging Standardization Steering Committee.) Neuro Oncol. 2020 09 29;22(9):1262-1275 PMID: 32516388 PMCID: PMC7523451 SCOPUS ID: 2-s2.0-85092332195 06/10/2020
(Bell LC, Semmineh N, An H, Eldeniz C, Wahl R, Schmainda KM, Prah MA, Erickson BJ, Korfiatis P, Wu C, Sorace AG, Yankeelov TE, Rutledge N, Chenevert TL, Malyarenko D, Liu Y, Brenner A, Hu LS, Zhou Y, Boxerman JL, Yen YF, Kalpathy-Cramer J, Beers AL, Muzi M, Madhuranthakam AJ, Pinho M, Johnson B, Quarles CC.) Tomography. 2020 06;6(2):203-208 PMID: 32548297 PMCID: PMC7289259 SCOPUS ID: 2-s2.0-85086686948 06/18/2020
(Alhajala HS, Markley JL, Kim JH, Al-Gizawiy MM, Schmainda KM, Kuo JS, Chitambar CR.) Oncotarget. 2020 Apr 28;11(17):1531-1544 PMID: 32391122 PMCID: PMC7197450 05/12/2020
(Zhang Q, Cheng G, Pan J, Zielonka J, Xiong D, Myers CR, Feng L, Shin SS, Kim YH, Bui D, Hu M, Bennett B, Schmainda K, Wang Y, Kalyanaraman B, You M.) Cell Commun Signal. 2020 04 07;18(1):58 PMID: 32264893 PMCID: PMC7140380 SCOPUS ID: 2-s2.0-85083071315 04/09/2020
Performance of Standardized Relative CBV for Quantifying Regional Histologic Tumor Burden in Recurrent High-Grade Glioma: Comparison against Normalized Relative CBV Using Image-Localized Stereotactic Biopsies.
(Hoxworth JM, Eschbacher JM, Gonzales AC, Singleton KW, Leon GD, Smith KA, Stokes AM, Zhou Y, Mazza GL, Porter AB, Mrugala MM, Zimmerman RS, Bendok BR, Patra DP, Krishna C, Boxerman JL, Baxter LC, Swanson KR, Quarles CC, Schmainda KM, Hu LS.) AJNR Am J Neuroradiol. 2020 03;41(3):408-415 PMID: 32165359 PMCID: PMC7077911 SCOPUS ID: 2-s2.0-85082097097 03/14/2020
(Lee TS, Feeney MB, Schmainda KM, Sherley JL, Prentice DA.) Issues Law Med. 2020;35(1):3-61 PMID: 33950608 SCOPUS ID: 2-s2.0-85105541954 05/06/2021
Quantitative Delta T1 (dT1) as a Replacement for Adjudicated Central Reader Analysis of Contrast-Enhancing Tumor Burden: A Subanalysis of the American College of Radiology Imaging Network 6677/Radiation Therapy Oncology Group 0625 Multicenter Brain Tumor Trial.
(Schmainda KM, Prah MA, Zhang Z, Snyder BS, Rand SD, Jensen TR, Barboriak DP, Boxerman JL.) AJNR Am J Neuroradiol. 2019 07;40(7):1132-1139 PMID: 31248863 PMCID: PMC6620020 SCOPUS ID: 2-s2.0-85069294543 06/30/2019
(Schmainda KM, Prah MA, Hu LS, Quarles CC, Semmineh N, Rand SD, Connelly JM, Anderies B, Zhou Y, Liu Y, Logan B, Stokes A, Baird G, Boxerman JL.) AJNR Am J Neuroradiol. 2019 04;40(4):626-633 PMID: 30923088 PMCID: PMC6461489 SCOPUS ID: 2-s2.0-85064588009 03/30/2019
(Bell LC, Semmineh N, An H, Eldeniz C, Wahl R, Schmainda KM, Prah MA, Erickson BJ, Korfiatis P, Wu C, Sorace AG, Yankeelov TE, Rutledge N, Chenevert TL, Malyarenko D, Liu Y, Brenner A, Hu LS, Zhou Y, Boxerman JL, Yen YF, Kalpathy-Cramer J, Beers AL, Muzi M, Madhuranthakam AJ, Pinho M, Johnson B, Quarles CC.) Tomography. 2019 03;5(1):110-117 PMID: 30854448 PMCID: PMC6403027 SCOPUS ID: 2-s2.0-85069176881 03/12/2019