header-logo
GettyImages-758308167-hero
Biostatistics
Paul Auer

Paul Auer, PhD

Cancer Center Scholar; Director, Biostatistics Shared Resource, Cancer Center; Professor, Data Science Institute, Biostatistics

Locations

  • MEB M1400
    Division of Biostatistics

Contact Information

Education

PhD, Purdue University, West Lafayette, IN, 2010
MPS, Cornell University, Ithaca, NY, 2003
BA, SUNY Geneseo, Geneseo, NY, 2001

Biography

Research Experience:
Statistical Genetics; GWAS, Complex Trait Genetics, Rare-Variants, Whole-Genome Sequencing

Research Interests

Dr. Auer is a statistical geneticist with expertise in the analysis of whole genome sequencing and multi-omic data. He has collaborated on several large-scale projects focused on understanding the genetic basis of complex diseases such as stroke, heart disease, and cancer. He collaborates with faculty in the Department of Physiology, the Center of International Blood & Marrow Transplant Research, and the MCW Cancer Center. His current research interests include multi-omic data analysis for predicting phenotypic states and disease outcomes and developing methods to detect clonal mosaicism.

Publications

  • Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification.

    (Zanti M, O'Mahony DG, Parsons MT, Dorling L, Dennis J, Boddicker NJ, Chen W, Hu C, Naven M, Yiangou K, Ahearn TU, Ambrosone CB, Andrulis IL, Antoniou AC, Auer PL, Baynes C, Bodelon C, Bogdanova NV, Bojesen SE, Bolla MK, Brantley KD, Camp NJ, Campbell A, Castelao JE, Cessna MH, Chang-Claude J, Chen F, Chenevix-Trench G, NBCS Collaborators, Conroy DM, Czene K, De Nicolo A, Domchek SM, Dörk T, Dunning AM, Eliassen AH, Evans DG, Fasching PA, Figueroa JD, Flyger H, Gago-Dominguez M, García-Closas M, Glendon G, González-Neira A, Grassmann F, Hadjisavvas A, Haiman CA, Hamann U, Hart SN, Hartman MBA, Ho WK, Hodge JM, Hoppe R, Howell SJ, kConFab Investigators, Jakubowska A, Khusnutdinova EK, Ko YD, Kraft P, Kristensen VN, Lacey JV, Li J, Lim GH, Lindström S, Lophatananon A, Luccarini C, Mannermaa A, Martinez ME, Mavroudis D, Milne RL, Muir K, Nathanson KL, Nuñez-Torres R, Obi N, Olson JE, Palmer JR, Panayiotidis MI, Patel AV, Pharoah PDP, Polley EC, Rashid MU, Ruddy KJ, Saloustros E, Sawyer EJ, Schmidt MK, Southey MC, Tan VK, Teo SH, Teras LR, Torres D, Trentham-Dietz A, Truong T, Vachon CM, Wang Q, Weitzel JN, Yadav S, Yao S, Zirpoli GR, Cline MS, Devilee P, Tavtigian SV, Goldgar DE, Couch FJ, Easton DF, Spurdle AB, Michailidou K.) Nat Commun. 2025 May 25;16(1):4852 PMID: 40413188 PMCID: PMC12103537 05/25/2025

  • Genetic study of von Willebrand factor antigen levels ≤ 50 IU/dL identifies variants associated with increased risk of von Willebrand disease and bleeding.

    (Friedman RK, Heath AS, Huffman JE, Baker JT, Hasbani NR, Gagliano Taliun SA, Chen MH, Howard TE, Lewis JP, Pankratz N, Patil S, Reiner AP, Thibord F, Yanek LR, Yao J, Chen HH, Curran JE, Faraday N, Guo X, Wheeler MM, Ryan KA, Zhou X, Cho K, Almasy L, Auer PL, Becker LC, Wilson PWF, Boerwinkle E, O'Connell JR, Rich SS, Samuels DC, National Heart, Lung and Blood Institute (NHLBI) Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Hematology & Hemostasis Working Group, VA Million Veteran Program, Blangero J, Fornage M, Kooperberg C, Mathias RA, Mitchell BD, Rotter JI, Johnson AD, Smith NL, Coban-Akdemir ZH, Below JE, Morrison AC, Johnsen JM, de Vries PS.) J Thromb Haemost. 2025 May 12 PMID: 40368142 05/15/2025

  • A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer.

    (Farazi M, Yang X, Gehl CJ, Barnett GC, Burnet NG, Chang-Claude J, Parker CC, Dunning AM, Azria D, Choudhury A, Rancati T, De Ruysscher D, Seibold P, Sperk E, Talbot CJ, Veldeman L, Webb AJ, Elliott R, Aguado-Barrera ME, Carballo AM, Fuentes-Ríos O, Gómez-Caamaño A, Peleteiro P, Vega A, Ostrer H, Rosenstein BS, Saito S, Parliament M, Usmani N, Marples B, Chen Y, Morrow G, Messing E, Janelsins MC, Hall W, West CML, Auer PL, Kerns SL.) Cancer Epidemiol Biomarkers Prev. 2025 May 02;34(5):795-804 PMID: 40029246 PMCID: PMC12048210 SCOPUS ID: 2-s2.0-105004381541 03/03/2025

  • EndoPRS: Incorporating endophenotype information to improve polygenic risk scores for clinical endpoints-A study in asthma.

    (Kharitonova EV, Sun Q, Ockerman F, Chen B, Zhou LY, Hysong MR, Tuftin B, Cao H, Mathias RA, Auer PL, Ober C, Raffield LM, Reiner AP, Cox NJ, Kelada SNP, Tao R, Li Y.) Am J Hum Genet. 2025 May 01;112(5):1199-1214 PMID: 40203832 PMCID: PMC12120184 04/10/2025

  • Early life trauma patterns and adult epigenome-wide and NR3C1-specific DNA methylation in the Sister Study.

    (Woo JMP, Lawrence KG, Xu Z, Auer PL, Simanek AM, Konkel RH, Taylor JA, Meier HCS, Sandler DP.) Am J Epidemiol. 2025 Apr 11 PMID: 40233982 04/16/2025

  • Donor telomeres and their magnitude of shortening post-allogeneic haematopoietic cell transplant impact survival for patients with early-stage leukaemia or myelodysplastic syndrome.

    (Gadalla SM, Katki HA, Lai TP, Auer PL, Dagnall CL, Bupp C, Hutchinson AA, Anderson JJ, Mendez KJW, Spellman SR, Stewart V, Savage SA, Lee SJ, Levine JE, Saber W, Aviv A.) EBioMedicine. 2025 Apr;114:105641 PMID: 40058159 PMCID: PMC11930427 SCOPUS ID: 2-s2.0-86000327346 03/10/2025

  • Characterization of the phenotypic consequences of the Duffy-null genotype.

    (Hysong MR, Shuey MM, Huffman JE, Auer P, Reiner A, Raffield LM.) Blood Adv. 2025 Mar 25;9(6):1452-1462 PMID: 39825822 PMCID: PMC11960523 01/18/2025

  • Chromatin State Maps of Blood Pressure-Relevant Renal Segments Reveal Potential Regulatory Role for SNPs.

    (Ray A, Yang C, Stelloh C, Tutaj M, Liu P, Liu Y, Qiu Q, Auer PL, Lin CW, Widlansky ME, Geurts AM, Cowley AW Jr, Liang M, Kwitek AE, Greene AS, Rao S.) Hypertension. 2025 Mar;82(3):476-488 PMID: 39723540 SCOPUS ID: 2-s2.0-85213707759 12/26/2024

  • Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood.

    (Jakubek YA, Ma X, Stilp AM, Yu F, Bacon J, Wong JW, Aguet F, Ardlie K, Arnett DK, Barnes K, Bis JC, Blackwell T, Becker LC, Boerwinkle E, Bowler RP, Budoff MJ, Carson AP, Chen J, Cho MH, Coresh J, Cox NJ, de Vries PS, DeMeo DL, Fardo DW, Fornage M, Guo X, Hall ME, Heard-Costa N, Hidalgo B, Irvin MR, Johnson AD, Jorgenson E, Kenny EE, Kessler MD, Levy D, Li Y, Lima JAC, Liu Y, Locke AE, Loos RJF, Machiela MJ, Mathias RA, Mitchell BD, Murabito JM, Mychaleckyj JC, North KE, Orchard P, Parker SCJ, Pershad Y, Peyser PA, Pratte KA, Psaty BM, Raffield LM, Redline S, Regeneron Genetics Center, Rich SS, Rotter JI, Shah SJ, Smith JA, Smith AP, Smith A, Taub MA, Tiwari HK, Tracy R, Tuftin B, NHLBI Trans-Omics for Precision Medicine Consortium, Bick AG, Sankaran VG, Reiner AP, Scheet P, Auer PL.) Am J Hum Genet. 2025 Feb 06;112(2):276-290 PMID: 39809269 PMCID: PMC11866972 01/15/2025

  • A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies.

    (Li X, Chen H, Selvaraj MS, Van Buren E, Zhou H, Wang Y, Sun R, McCaw ZR, Yu Z, Jiang MZ, DiCorpo D, Gaynor SM, Dey R, Arnett DK, Benjamin EJ, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Brody JA, Cade BE, Carson AP, Carlson JC, Chami N, Chen YI, Curran JE, de Vries PS, Fornage M, Franceschini N, Freedman BI, Gu C, Heard-Costa NL, He J, Hou L, Hung YJ, Irvin MR, Kaplan RC, Kardia SLR, Kelly TN, Konigsberg I, Kooperberg C, Kral BG, Li C, Li Y, Lin H, Liu CT, Loos RJF, Mahaney MC, Martin LW, Mathias RA, Mitchell BD, Montasser ME, Morrison AC, Naseri T, North KE, Palmer ND, Peyser PA, Psaty BM, Redline S, Reiner AP, Rich SS, Sitlani CM, Smith JA, Taylor KD, Tiwari HK, Vasan RS, Viali S, Wang Z, Wessel J, Yanek LR, Yu B, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Dupuis J, Meigs JB, Auer PL, Raffield LM, Manning AK, Rice KM, Rotter JI, Peloso GM, Natarajan P, Li Z, Liu Z, Lin X.) Nat Comput Sci. 2025 Feb;5(2):125-143 PMID: 39920506 PMCID: PMC11981678 02/08/2025

  • Alterations of T Cell Subsets Associated with Sickle Cell Trait.

    (Reiner AP, Raffield LM, Ekunwe L, Olson NC, Auer PL, Doyle MF.) Blood Genom Discov. 2025;9(1) PMID: 39720621 PMCID: PMC11665108 12/25/2024

  • The Relationship of Duffy Gene Polymorphism with High-Sensitivity C-Reactive Protein, Mortality, and Cardiovascular Outcomes in Black Individuals.

    (Ha ET, Haessler J, Taylor KD, Tuftin B, Briggs M, Parikh MA, Peterson SJ, Gerszten RE, Wilson JG, Kelsey K, Tahir UA, Seeman T, Rich SS, Carson AP, Post WS, Kooperberg C, Rotter JI, Raffield LM, Auer P, Reiner AP.) Genes (Basel). 2024 Oct 27;15(11) PMID: 39596582 PMCID: PMC11594091 11/27/2024

Publications of Paul L. Auer PhD from the Faculty Collaboration Database

© 2025 Medical College of Wisconsin.  All rights reserved.  | Terms and Privacy | Web Accessibility Statement

Non-Discrimination, Anti-Harassment, and Legal Compliance Statement
The Medical College of Wisconsin (MCW) is committed to fostering a diverse community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual's race, color, national origin, religion, age, disability, sex, gender identity/expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, military status, or other legally protected classification. MCW maintains full compliance with all applicable federal, state, and local laws and regulations in pursuit of our missions. Consistent with federal guidance, we affirm our commitment to individual merit, fairness, and equal treatment in all aspects of academic and institutional decision-making.

MCW's policies, federal and state laws, and regulations prohibit unlawful discrimination and harassment. Employees, learners, students, applicants, or other members of the MCW community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic.